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The map label for this gene is adk

Identifier: 92112985

GI number: 92112985

Start: 960502

End: 961158

Strand: Direct

Name: adk

Synonym: Csal_0857

Alternate gene names: 92112985

Gene position: 960502-961158 (Clockwise)

Preceding gene: 92112984

Following gene: 92112986

Centisome position: 25.98

GC content: 63.77

Gene sequence:

>657_bases
ATGCGTTTGATCTTGTTGGGCGCCCCGGGCGCAGGCAAGGGCACCCAGGCCCAATTCATCTGTGAGCGTTTCGACATTCC
GCAGATCTCCACCGGAGATATGCTGCGTGCGGCGGTCAAGGAAGGCAGTGAACTCGGGCTCAAGGTCAAGGAGATCATGA
ACAGCGGCGGCCTGGTGTCCGACGATATCATCATCGCCCTGGTCAAGGAGCGCATCGCCCAGCCGGATTGTGCCAATGGC
TTCCTGTTCGACGGCTTCCCGCGGACGATTCCCCAGGCCGATGCCATGAAGGAAGCCAACGTCAAGCTCGACCACGTGCT
GGAAGTGGCCGTCGACGACGAGGAAATCGTCACGCGCCTGGCGGGCCGCCGTGTCCATCCCGGCTCGGGGCGCGTCTATC
ACGTGGACTACAATCCGCCCAAGGAAGAAGGCAAGGACGATGTCACCGGCGAAGCGCTGATCCAGCGTGACGATGACCGC
GAGGCCACCGTGCGCAACCGTCTGTCGGTCTACCACGAGCAGACCGAGCCCCTGGTGCAGTACTATCGCGAGTGGGCACA
GCAGGACCCGCAGACCGCGCCTGCCTACCATCGCGTGGAAGGCACCGGCAGCGTCGAGGCGATTCGCCAGCAGGTGCTGA
CGGCGCTCGAAGGCTGA

Upstream 100 bases:

>100_bases
AGGTATCGTCATGGGCCATTCCAGCGGCCATGACGAATGCGGGTGACATGCACCATGGTCGATAACGAAGACGGTATCCC
TCGTTCAAGGAGCACTATCG

Downstream 100 bases:

>100_bases
GCGCGACCTCCAGCGTGAGCGCGGCCACGGCGCCGCGCGTATCGACGACACACGTCAAGGAAAGCGCGAAACCGCACGCG
GGCCGCTTTGCCAATGGCTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLILLGAPGAGKGTQAQFICERFDIPQISTGDMLRAAVKEGSELGLKVKEIMNSGGLVSDDIIIALVKERIAQPDCANG
FLFDGFPRTIPQADAMKEANVKLDHVLEVAVDDEEIVTRLAGRRVHPGSGRVYHVDYNPPKEEGKDDVTGEALIQRDDDR
EATVRNRLSVYHEQTEPLVQYYREWAQQDPQTAPAYHRVEGTGSVEAIRQQVLTALEG

Sequences:

>Translated_218_residues
MRLILLGAPGAGKGTQAQFICERFDIPQISTGDMLRAAVKEGSELGLKVKEIMNSGGLVSDDIIIALVKERIAQPDCANG
FLFDGFPRTIPQADAMKEANVKLDHVLEVAVDDEEIVTRLAGRRVHPGSGRVYHVDYNPPKEEGKDDVTGEALIQRDDDR
EATVRNRLSVYHEQTEPLVQYYREWAQQDPQTAPAYHRVEGTGSVEAIRQQVLTALEG
>Mature_218_residues
MRLILLGAPGAGKGTQAQFICERFDIPQISTGDMLRAAVKEGSELGLKVKEIMNSGGLVSDDIIIALVKERIAQPDCANG
FLFDGFPRTIPQADAMKEANVKLDHVLEVAVDDEEIVTRLAGRRVHPGSGRVYHVDYNPPKEEGKDDVTGEALIQRDDDR
EATVRNRLSVYHEQTEPLVQYYREWAQQDPQTAPAYHRVEGTGSVEAIRQQVLTALEG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=51.5957446808511, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=51.5957446808511, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=42.5531914893617, Blast_Score=165, Evalue=2e-41,
Organism=Homo sapiens, GI310110345, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI53832003, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI8051579, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI53832001, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI22749187, Length=200, Percent_Identity=26.5, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=26.457399103139, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=26.457399103139, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI237858799, Length=142, Percent_Identity=24.6478873239437, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI21450759, Length=142, Percent_Identity=24.6478873239437, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI7706497, Length=226, Percent_Identity=24.7787610619469, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=66.0287081339713, Blast_Score=277, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=45.2127659574468, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=188, Percent_Identity=36.1702127659575, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=29.9539170506912, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=203, Percent_Identity=51.2315270935961, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6321018, Length=190, Percent_Identity=41.0526315789474, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=26.7281105990783, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=49.1803278688525, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=40.2173913043478, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=40.2173913043478, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=30.1675977653631, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=30.1675977653631, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHRSD (Q1QZ94)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572913.1
- ProteinModelPortal:   Q1QZ94
- SMR:   Q1QZ94
- STRING:   Q1QZ94
- GeneID:   4027821
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0857
- NMPDR:   fig|290398.4.peg.737
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   CSAL290398:CSAL_0857-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24107; Mature: 24107

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAQFICERFDIPQISTGDMLRAAVKEGSELGLKVKEIMNSGGLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHCCCCCCC
DDIIIALVKERIAQPDCANGFLFDGFPRTIPQADAMKEANVKLDHVLEVAVDDEEIVTRL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHEEEHCCHHHHHHHH
AGRRVHPGSGRVYHVDYNPPKEEGKDDVTGEALIQRDDDREATVRNRLSVYHEQTEPLVQ
HCCCCCCCCCEEEEECCCCCHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
YYREWAQQDPQTAPAYHRVEGTGSVEAIRQQVLTALEG
HHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAQFICERFDIPQISTGDMLRAAVKEGSELGLKVKEIMNSGGLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCHHHHHHCCCCCCC
DDIIIALVKERIAQPDCANGFLFDGFPRTIPQADAMKEANVKLDHVLEVAVDDEEIVTRL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHEEEHCCHHHHHHHH
AGRRVHPGSGRVYHVDYNPPKEEGKDDVTGEALIQRDDDREATVRNRLSVYHEQTEPLVQ
HCCCCCCCCCEEEEECCCCCHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
YYREWAQQDPQTAPAYHRVEGTGSVEAIRQQVLTALEG
HHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA