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The map label for this gene is cynR [H]

Identifier: 92112791

GI number: 92112791

Start: 737261

End: 738205

Strand: Direct

Name: cynR [H]

Synonym: Csal_0659

Alternate gene names: 92112791

Gene position: 737261-738205 (Clockwise)

Preceding gene: 92112790

Following gene: 92112792

Centisome position: 19.94

GC content: 63.17

Gene sequence:

>945_bases
ATGAAACCATTCAAGTCGCGTGCCCTGGAGTACCTCGATGCTGCTGTTCATCATGGGTCTCTCCGGCGTGCCGCCGCTCA
ACTCGGGGTCAATCCCTCGGCGCTGAGCCGTCAACTGCGCGCCCTGGAAGAAGAATTGGGCACACCGTTGCTGGTGCGGA
CGTCGCGTGTCGCGCTGACGCCGGCAGGAGAGCTGGTGCTGCAACATTACCGGGACCAGCGTGCCGCCGAACGTGCCACG
CTTTCGCGTTTGCAGGCCTTGCAGAATCTGGAGCGCGGCGAGGTGCGCATCGCCGTGGGCGAGGGGTTCATCGCCGATCT
GATCTCGGCGCCGCTGCAGAACTTCCTTGCCACCTATCCGGGGCTGGAGATCGAAGTCAGCATGGCGGGACTGACCGAGG
CAATCATGCTGGTCAAGGAAGATGCCGTGGATCTGGCCCTGCTGTATGCGCCTCCCGATGATCCGCACCTGGTCTCGCAT
ATCGACAGGCGACAGCCGCTCGACCTGATCATGCCGGCCGAGCATCCCCTGGCGCGTTCACCGACACCGCTGCCGCTTGC
GGATATTGCCGACCATCCGCTGGCGTTGATCGACGGCCACACCGGCATGGGCCAACTGGTCGATATGGCGCTTTATGCGG
CACATCTGTCCTACCGGCCGAGGATGAAGACCAATTCAGTCTCGGTTCTCAAGAATTTTGTGCGTTCGGGCTTGGGCGTG
ACGTTCATGCCGGAGCTCACGGTGCTCGAAGAGATCCATGAGGGCAGTATCGTGGCGCGCGAGGTCGATGCCAGCGTGCT
GCGTGATGCCAGGGCGCGAATCGTCACCCGGGCGGAACGGCCGTTGACGATCGCGGCGCAGGCCTTCATCAAGCACTTGC
GCCGCAGCATGCGCTTTTTCAGCGCCGATGCGCCGCGGGTTCTGGACACGCAGACGTTGCCTTGA

Upstream 100 bases:

>100_bases
ATTGGAATCAATCCCATCGCCGGGGTGGCATGGTGTGTCCGAGCGCCGGGCCGTTTGCCCGAAGCGGGCATGGAACCAGT
CGTCGCCGAGCGAGGGAGTC

Downstream 100 bases:

>100_bases
AAGCAACACTCAATCGCTTGAAAGGTCAACAACGCAACGGCTAGCGTTGGCATGTCGTCGTGGTTCGACACCGATCCCTC
TCGACTCTGCATAACAACAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKPFKSRALEYLDAAVHHGSLRRAAAQLGVNPSALSRQLRALEEELGTPLLVRTSRVALTPAGELVLQHYRDQRAAERAT
LSRLQALQNLERGEVRIAVGEGFIADLISAPLQNFLATYPGLEIEVSMAGLTEAIMLVKEDAVDLALLYAPPDDPHLVSH
IDRRQPLDLIMPAEHPLARSPTPLPLADIADHPLALIDGHTGMGQLVDMALYAAHLSYRPRMKTNSVSVLKNFVRSGLGV
TFMPELTVLEEIHEGSIVAREVDASVLRDARARIVTRAERPLTIAAQAFIKHLRRSMRFFSADAPRVLDTQTLP

Sequences:

>Translated_314_residues
MKPFKSRALEYLDAAVHHGSLRRAAAQLGVNPSALSRQLRALEEELGTPLLVRTSRVALTPAGELVLQHYRDQRAAERAT
LSRLQALQNLERGEVRIAVGEGFIADLISAPLQNFLATYPGLEIEVSMAGLTEAIMLVKEDAVDLALLYAPPDDPHLVSH
IDRRQPLDLIMPAEHPLARSPTPLPLADIADHPLALIDGHTGMGQLVDMALYAAHLSYRPRMKTNSVSVLKNFVRSGLGV
TFMPELTVLEEIHEGSIVAREVDASVLRDARARIVTRAERPLTIAAQAFIKHLRRSMRFFSADAPRVLDTQTLP
>Mature_314_residues
MKPFKSRALEYLDAAVHHGSLRRAAAQLGVNPSALSRQLRALEEELGTPLLVRTSRVALTPAGELVLQHYRDQRAAERAT
LSRLQALQNLERGEVRIAVGEGFIADLISAPLQNFLATYPGLEIEVSMAGLTEAIMLVKEDAVDLALLYAPPDDPHLVSH
IDRRQPLDLIMPAEHPLARSPTPLPLADIADHPLALIDGHTGMGQLVDMALYAAHLSYRPRMKTNSVSVLKNFVRSGLGV
TFMPELTVLEEIHEGSIVAREVDASVLRDARARIVTRAERPLTIAAQAFIKHLRRSMRFFSADAPRVLDTQTLP

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=30.2904564315353, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787879, Length=243, Percent_Identity=30.4526748971193, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790399, Length=255, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789440, Length=262, Percent_Identity=24.4274809160305, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786401, Length=307, Percent_Identity=26.0586319218241, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=252, Percent_Identity=24.2063492063492, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=251, Percent_Identity=27.0916334661355, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789639, Length=244, Percent_Identity=24.5901639344262, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=273, Percent_Identity=27.8388278388278, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787530, Length=260, Percent_Identity=24.6153846153846, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34545; Mature: 34545

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFKSRALEYLDAAVHHGSLRRAAAQLGVNPSALSRQLRALEEELGTPLLVRTSRVALT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCEEEEC
PAGELVLQHYRDQRAAERATLSRLQALQNLERGEVRIAVGEGFIADLISAPLQNFLATYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
GLEIEVSMAGLTEAIMLVKEDAVDLALLYAPPDDPHLVSHIDRRQPLDLIMPAEHPLARS
CCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCEECCCCCCCCCC
PTPLPLADIADHPLALIDGHTGMGQLVDMALYAAHLSYRPRMKTNSVSVLKNFVRSGLGV
CCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
TFMPELTVLEEIHEGSIVAREVDASVLRDARARIVTRAERPLTIAAQAFIKHLRRSMRFF
EECCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SADAPRVLDTQTLP
CCCCCCCCCCCCCC
>Mature Secondary Structure
MKPFKSRALEYLDAAVHHGSLRRAAAQLGVNPSALSRQLRALEEELGTPLLVRTSRVALT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCEEEEC
PAGELVLQHYRDQRAAERATLSRLQALQNLERGEVRIAVGEGFIADLISAPLQNFLATYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
GLEIEVSMAGLTEAIMLVKEDAVDLALLYAPPDDPHLVSHIDRRQPLDLIMPAEHPLARS
CCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCEECCCCCCCCCC
PTPLPLADIADHPLALIDGHTGMGQLVDMALYAAHLSYRPRMKTNSVSVLKNFVRSGLGV
CCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
TFMPELTVLEEIHEGSIVAREVDASVLRDARARIVTRAERPLTIAAQAFIKHLRRSMRFF
EECCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SADAPRVLDTQTLP
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]