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The map label for this gene is uppS [H]

Identifier: 92112700

GI number: 92112700

Start: 628815

End: 629573

Strand: Direct

Name: uppS [H]

Synonym: Csal_0567

Alternate gene names: 92112700

Gene position: 628815-629573 (Clockwise)

Preceding gene: 92112699

Following gene: 92112701

Centisome position: 17.01

GC content: 65.35

Gene sequence:

>759_bases
ATGACCTCACAGCCGTTTTCCCCATCCCGCGCGGGCGAGTTGCCGCGCCACGTGGCGGTCATCATGGACGGTAACAATCG
CTGGGCGCGTGCGCATGGGCTGTCCGGCATTCGCGGCCATCGTGCCGGCGTCGAGGCGGTCCGCGCCGTGATCGGCCGGG
CCGCCGAACGCGGCATCGGCACGCTGACCCTGTTCGCCTTTTCCAGCGAGAACTGGAAACGGCCGGCGAGCGAGGTCAGC
GCGTTGATGGAGCTGTTCCTGTGGGCGCTCAAGCGTGAAGTGAAAAAGCTCCACGCGCACGATATCCGCCTGACAGTGAT
CGGTGACCGCGCGGAGTTTTCCGATGCCATACAGCAGTATATCGCCCGTGCCGAAGCGTTGACCCGCGACAACCGCGGTC
TTCACCTGGTCATCGCCGCCAACTATGGCGGGCGGTGGGACATCGCCCACGCTGCACGCCGGCTGGCGGAACGCGTGGCG
TGTGGCGAGTTGTCGCCCGAGGCGGTCGACGAAGAATCTCTGGGGGCGGAGGTCAGCCTGGCCGACGAAGCGCCGGTCGA
CCTCTGCATCCGTACCAGCGGCGAGCAACGCATTTCCAATTTTCTGCTGTGGCAGCTTGCCTATGCGGAGTTCTATTTCA
CGCCCGAGCTGTGGCCCGACTTCGGCGCCGAGGCATTCGACGCCGCGCTGGACGCCTATGGCGCGCGTCAGCGTCGTTTC
GGCATGACTCAGGAACAAATCGAGGCCCATGGTGCTTAG

Upstream 100 bases:

>100_bases
GATCGACAAGCTTCTGGAAACCAAGGAACACGACCTGCTGCAGGTCTAAGAGGGTGGCCGACGGGCAGGGCGCCCGTCGG
TCTCCACGCAACGGGATCCC

Downstream 100 bases:

>100_bases
GCAACGTATTCTCACGGCGCTGGTGATGGCGCCGTTGGCGCTGCTCGGCCTGTTCGGGCTTTCCGGCGCCCCCTTCGCCC
TGTTCACGGGGGCCGTCCTG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTSQPFSPSRAGELPRHVAVIMDGNNRWARAHGLSGIRGHRAGVEAVRAVIGRAAERGIGTLTLFAFSSENWKRPASEVS
ALMELFLWALKREVKKLHAHDIRLTVIGDRAEFSDAIQQYIARAEALTRDNRGLHLVIAANYGGRWDIAHAARRLAERVA
CGELSPEAVDEESLGAEVSLADEAPVDLCIRTSGEQRISNFLLWQLAYAEFYFTPELWPDFGAEAFDAALDAYGARQRRF
GMTQEQIEAHGA

Sequences:

>Translated_252_residues
MTSQPFSPSRAGELPRHVAVIMDGNNRWARAHGLSGIRGHRAGVEAVRAVIGRAAERGIGTLTLFAFSSENWKRPASEVS
ALMELFLWALKREVKKLHAHDIRLTVIGDRAEFSDAIQQYIARAEALTRDNRGLHLVIAANYGGRWDIAHAARRLAERVA
CGELSPEAVDEESLGAEVSLADEAPVDLCIRTSGEQRISNFLLWQLAYAEFYFTPELWPDFGAEAFDAALDAYGARQRRF
GMTQEQIEAHGA
>Mature_251_residues
TSQPFSPSRAGELPRHVAVIMDGNNRWARAHGLSGIRGHRAGVEAVRAVIGRAAERGIGTLTLFAFSSENWKRPASEVSA
LMELFLWALKREVKKLHAHDIRLTVIGDRAEFSDAIQQYIARAEALTRDNRGLHLVIAANYGGRWDIAHAARRLAERVAC
GELSPEAVDEESLGAEVSLADEAPVDLCIRTSGEQRISNFLLWQLAYAEFYFTPELWPDFGAEAFDAALDAYGARQRRFG
MTQEQIEAHGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=215, Percent_Identity=35.3488372093023, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI45580742, Length=215, Percent_Identity=35.3488372093023, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=242, Percent_Identity=57.0247933884297, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71993029, Length=218, Percent_Identity=34.4036697247706, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=34.1121495327103, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=31.6742081447964, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=35.3982300884956, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27899; Mature: 27768

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQPFSPSRAGELPRHVAVIMDGNNRWARAHGLSGIRGHRAGVEAVRAVIGRAAERGIG
CCCCCCCCCHHCCCCCEEEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TLTLFAFSSENWKRPASEVSALMELFLWALKREVKKLHAHDIRLTVIGDRAEFSDAIQQY
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHH
IARAEALTRDNRGLHLVIAANYGGRWDIAHAARRLAERVACGELSPEAVDEESLGAEVSL
HHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHCCHHHCCCEEEE
ADEAPVDLCIRTSGEQRISNFLLWQLAYAEFYFTPELWPDFGAEAFDAALDAYGARQRRF
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHC
GMTQEQIEAHGA
CCCHHHHHHCCC
>Mature Secondary Structure 
TSQPFSPSRAGELPRHVAVIMDGNNRWARAHGLSGIRGHRAGVEAVRAVIGRAAERGIG
CCCCCCCCHHCCCCCEEEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TLTLFAFSSENWKRPASEVSALMELFLWALKREVKKLHAHDIRLTVIGDRAEFSDAIQQY
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHH
IARAEALTRDNRGLHLVIAANYGGRWDIAHAARRLAERVACGELSPEAVDEESLGAEVSL
HHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHCCHHHCCCEEEE
ADEAPVDLCIRTSGEQRISNFLLWQLAYAEFYFTPELWPDFGAEAFDAALDAYGARQRRF
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHC
GMTQEQIEAHGA
CCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]