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The map label for this gene is aroE [H]

Identifier: 92112427

GI number: 92112427

Start: 332550

End: 333416

Strand: Direct

Name: aroE [H]

Synonym: Csal_0293

Alternate gene names: 92112427

Gene position: 332550-333416 (Clockwise)

Preceding gene: 92112426

Following gene: 92112428

Centisome position: 9.0

GC content: 63.32

Gene sequence:

>867_bases
ATGCGCCTTGGGTTGATCGGCAAGGGCATCATGAATTCCAGTTCGCCCGACCTGCACGTGCGGCTGGGCAAGCTGACCGG
CATTCCCGCTAGCTACGATCTTTTCGACACGCTGGTGACGCAGATCGACTCGCTGGAGAGCCAGGTTCGCGAGGTCATGG
CGACCGGTTATCGCGGCGTCAACGTCACCTATCCTTACAAGGAGGAGGCGGTGCGTCTGGCAACGCGCGTTGGCGAGGGC
GCGCGCTTGGTCGGCGCTGCCAACACCCTGGTCTTCCAAGACGACGAGATCCAGGCCGAGAACACTGATTTCACCGGCTT
CATCAGTGGTTATCGGGCCACCGTCGGTGATCGTCCTCCCGGTCGTGTGTTACTGATAGGCACTGGCGGCGTGGGCAAGG
CGGTCGCCTTCGGTCTGGCCAAGCTGGGCGCCGATGAGGTATTGCTGATGGACCTCGACCTTGAAAAGGCCGAACGTCTC
GCCCGAGAACTCGACCACGCCGGCTTCTCGGCTGCAGCGGTTGCACCCGAGGCACTGGAGGCGACCGCCGCGCGCTGTGA
TGGGGTGGTCAACTGCACGCCGATCGGCCATGAGAAGAGCCCGGGTTACCCACTGCCTCCAGCGCTCATTCGCGCCGACC
AGTGGATCTTCGATGCCGTCTACGTGCCGGCGGTCACCGAGTTCATCGCCGCCGCCCGGGCGGCAGGGGCCCAAGTCGTC
AGCGGTGTCAGTCTGTTCGTCTTCCAGGGCGTGGATGCCTTCAAGTTCTTCTGCGAGGATGCCGACAAGCGGTCGCTGGC
CGACGCTCAGGCCGCGACCCTGTTCGATCATTACAAGCAGACCTTGCTGCAGGAGAAGAATGCATGA

Upstream 100 bases:

>100_bases
GTCAATGCGCCGATCCGCCTGGCGGCCCAGGCCGGCCAGCAACGTTGATTTCACGGCGCCCGCCGGGCGCCGGATTGACC
TGACATTGAAGGAGTGAGCC

Downstream 100 bases:

>100_bases
GAGCGCATAAGATCCTGGTACTGCATGGCCCCAACCTCAATCAGCTGGGTATCCGCCAGCCGGAAATCTACGGCCACGAG
ACGCTCGACGACATCAATAG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NAD(+)-dependent quinate dehydrogenase; QDH [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MRLGLIGKGIMNSSSPDLHVRLGKLTGIPASYDLFDTLVTQIDSLESQVREVMATGYRGVNVTYPYKEEAVRLATRVGEG
ARLVGAANTLVFQDDEIQAENTDFTGFISGYRATVGDRPPGRVLLIGTGGVGKAVAFGLAKLGADEVLLMDLDLEKAERL
ARELDHAGFSAAAVAPEALEATAARCDGVVNCTPIGHEKSPGYPLPPALIRADQWIFDAVYVPAVTEFIAAARAAGAQVV
SGVSLFVFQGVDAFKFFCEDADKRSLADAQAATLFDHYKQTLLQEKNA

Sequences:

>Translated_288_residues
MRLGLIGKGIMNSSSPDLHVRLGKLTGIPASYDLFDTLVTQIDSLESQVREVMATGYRGVNVTYPYKEEAVRLATRVGEG
ARLVGAANTLVFQDDEIQAENTDFTGFISGYRATVGDRPPGRVLLIGTGGVGKAVAFGLAKLGADEVLLMDLDLEKAERL
ARELDHAGFSAAAVAPEALEATAARCDGVVNCTPIGHEKSPGYPLPPALIRADQWIFDAVYVPAVTEFIAAARAAGAQVV
SGVSLFVFQGVDAFKFFCEDADKRSLADAQAATLFDHYKQTLLQEKNA
>Mature_288_residues
MRLGLIGKGIMNSSSPDLHVRLGKLTGIPASYDLFDTLVTQIDSLESQVREVMATGYRGVNVTYPYKEEAVRLATRVGEG
ARLVGAANTLVFQDDEIQAENTDFTGFISGYRATVGDRPPGRVLLIGTGGVGKAVAFGLAKLGADEVLLMDLDLEKAERL
ARELDHAGFSAAAVAPEALEATAARCDGVVNCTPIGHEKSPGYPLPPALIRADQWIFDAVYVPAVTEFIAAARAAGAQVV
SGVSLFVFQGVDAFKFFCEDADKRSLADAQAATLFDHYKQTLLQEKNA

Specific function: Catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. Seems to play a key role in the quinate degradation pathway [H]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=256, Percent_Identity=30.078125, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787983, Length=264, Percent_Identity=25.7575757575758, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=277, Percent_Identity=24.187725631769, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.24 [H]

Molecular weight: Translated: 30711; Mature: 30711

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGLIGKGIMNSSSPDLHVRLGKLTGIPASYDLFDTLVTQIDSLESQVREVMATGYRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NVTYPYKEEAVRLATRVGEGARLVGAANTLVFQDDEIQAENTDFTGFISGYRATVGDRPP
EEECCCHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
GRVLLIGTGGVGKAVAFGLAKLGADEVLLMDLDLEKAERLARELDHAGFSAAAVAPEALE
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCHHHHH
ATAARCDGVVNCTPIGHEKSPGYPLPPALIRADQWIFDAVYVPAVTEFIAAARAAGAQVV
HHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVSLFVFQGVDAFKFFCEDADKRSLADAQAATLFDHYKQTLLQEKNA
HHHHHEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLGLIGKGIMNSSSPDLHVRLGKLTGIPASYDLFDTLVTQIDSLESQVREVMATGYRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NVTYPYKEEAVRLATRVGEGARLVGAANTLVFQDDEIQAENTDFTGFISGYRATVGDRPP
EEECCCHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
GRVLLIGTGGVGKAVAFGLAKLGADEVLLMDLDLEKAERLARELDHAGFSAAAVAPEALE
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCHHHHH
ATAARCDGVVNCTPIGHEKSPGYPLPPALIRADQWIFDAVYVPAVTEFIAAARAAGAQVV
HHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGVSLFVFQGVDAFKFFCEDADKRSLADAQAATLFDHYKQTLLQEKNA
HHHHHEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA