Click here to switch to the map view.

The map label for this gene is holA [H]

Identifier: 91790429

GI number: 91790429

Start: 4877981

End: 4879105

Strand: Reverse

Name: holA [H]

Synonym: Bpro_4600

Alternate gene names: 91790429

Gene position: 4879105-4877981 (Counterclockwise)

Preceding gene: 91790430

Following gene: 91790428

Centisome position: 93.82

GC content: 67.02

Gene sequence:

>1125_bases
ATGGTATCCCTACCCTCCAACCTGGCCCCCGCGCAACTGTCCGAGCACCTCAAGCGCGGCTTGAAAAGCCTTTACACGCT
GCATGGCGATGAGCCCTTGCTGGTGCAGGAGTTCGCCGATGCCCTGCGCGCGGCGGCCCGGGAGCAGGGCTACACCGAAC
GCACCGTACACACGGTGGCCGGGGCGCATTTCGACTGGAGCGAGGTGCTGGCCAGTGGCGGCTCGCTGAGCCTGTTTGCC
GACAGGCAGATTGTCGAGATCCGCATTCCCAGCGGCAAACCCGGCAAGGACGGGTCGGTCGCGCTGCAGCAGCTGGCCGA
GCGCGCCCAGGGCGACGACTCCACGCTCACGCTGGTGCTGCTGCCCCGGCTGGACAGCATGACCGCCAAGGGCGCCTGGT
TTGGCGCGCTCGACAGCTTTGGCGTCACGGTGAAGTTCGACCCGATTGACCGGCGCAACCTGCCGCAATGGATTGCCCAG
CGCCTGCAACAGCAGGGCCAGCGCGTGGCGGCAGGTGAAGAAGGCCAGCGCACCCTGCAGTTTTTTGCCGACCGGGTGGA
AGGCAACCTGCTGGCCGCGCACCAGGAGATCCAGAAGCTGGGCTTGCTGTACCCCGCCCAGGAAGACGGCATCCTCAGTT
TTGACCAGGTGGAAAACGCGGTGCTGAATGTGGCGCGCTATGACGTGTTCAAGCTGTCGGAGGCCGTGCTTGGCGGCCAG
GCGGTGCGCGTGGCGCGCATGCTCGACGGCCTGCAGTCCGAGGGCGAGTCTGAAGTGCTGGTGCACTGGGCGCTGAGTGA
AGACATCCGCAGCATGAAGCGGGTGAAAGACGCGATCCAGGCCGGCCGGCCCATGCCGATGGCCCTGCGCGAAAACCGCG
TCTGGGGCATCAAGGAAAAACTGTTTGAACGTGTGCTGCCCCAGATGGGCGACACCACGCTGGCCAACCTGCTGCATGCC
GCGCACAAGGTCGACGGCATCGTCAAGGGCCTGAAGCAGCCCGACTGGCCGGCCGACGGCTGGCAGGCCCTGCACCGGCT
GGCCGGCATGGTCTGCCGGGAGTGCGCGGCACCGTCCGCTGCGCCTCGCGGGTTGCGCAATCCGGTGGAGATCGCACGGG
GCTAG

Upstream 100 bases:

>100_bases
GGTTATGCAACCTGTTGAAGCTGTGTAGTCAGTGGTCGTACGTGAGCCGTGTGCGGTGAAAGTCGCAAGCTCGGTTCGAT
GGGGGGGATATCATCGAGAG

Downstream 100 bases:

>100_bases
AGGCATGCAGCACACGGCCTCGCTCTCCAAAAAACTCGTTCGCATAGGCGCCAGCCTGCTGGTCGTTTCGCTGATCTCCA
TCGGGCTGACCCTTTGGGTG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MVSLPSNLAPAQLSEHLKRGLKSLYTLHGDEPLLVQEFADALRAAAREQGYTERTVHTVAGAHFDWSEVLASGGSLSLFA
DRQIVEIRIPSGKPGKDGSVALQQLAERAQGDDSTLTLVLLPRLDSMTAKGAWFGALDSFGVTVKFDPIDRRNLPQWIAQ
RLQQQGQRVAAGEEGQRTLQFFADRVEGNLLAAHQEIQKLGLLYPAQEDGILSFDQVENAVLNVARYDVFKLSEAVLGGQ
AVRVARMLDGLQSEGESEVLVHWALSEDIRSMKRVKDAIQAGRPMPMALRENRVWGIKEKLFERVLPQMGDTTLANLLHA
AHKVDGIVKGLKQPDWPADGWQALHRLAGMVCRECAAPSAAPRGLRNPVEIARG

Sequences:

>Translated_374_residues
MVSLPSNLAPAQLSEHLKRGLKSLYTLHGDEPLLVQEFADALRAAAREQGYTERTVHTVAGAHFDWSEVLASGGSLSLFA
DRQIVEIRIPSGKPGKDGSVALQQLAERAQGDDSTLTLVLLPRLDSMTAKGAWFGALDSFGVTVKFDPIDRRNLPQWIAQ
RLQQQGQRVAAGEEGQRTLQFFADRVEGNLLAAHQEIQKLGLLYPAQEDGILSFDQVENAVLNVARYDVFKLSEAVLGGQ
AVRVARMLDGLQSEGESEVLVHWALSEDIRSMKRVKDAIQAGRPMPMALRENRVWGIKEKLFERVLPQMGDTTLANLLHA
AHKVDGIVKGLKQPDWPADGWQALHRLAGMVCRECAAPSAAPRGLRNPVEIARG
>Mature_374_residues
MVSLPSNLAPAQLSEHLKRGLKSLYTLHGDEPLLVQEFADALRAAAREQGYTERTVHTVAGAHFDWSEVLASGGSLSLFA
DRQIVEIRIPSGKPGKDGSVALQQLAERAQGDDSTLTLVLLPRLDSMTAKGAWFGALDSFGVTVKFDPIDRRNLPQWIAQ
RLQQQGQRVAAGEEGQRTLQFFADRVEGNLLAAHQEIQKLGLLYPAQEDGILSFDQVENAVLNVARYDVFKLSEAVLGGQ
AVRVARMLDGLQSEGESEVLVHWALSEDIRSMKRVKDAIQAGRPMPMALRENRVWGIKEKLFERVLPQMGDTTLANLLHA
AHKVDGIVKGLKQPDWPADGWQALHRLAGMVCRECAAPSAAPRGLRNPVEIARG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=347, Percent_Identity=27.9538904899135, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 41036; Mature: 41036

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLPSNLAPAQLSEHLKRGLKSLYTLHGDEPLLVQEFADALRAAAREQGYTERTVHTVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GAHFDWSEVLASGGSLSLFADRQIVEIRIPSGKPGKDGSVALQQLAERAQGDDSTLTLVL
CCCCCHHHHHHCCCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
LPRLDSMTAKGAWFGALDSFGVTVKFDPIDRRNLPQWIAQRLQQQGQRVAAGEEGQRTLQ
ECCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHH
FFADRVEGNLLAAHQEIQKLGLLYPAQEDGILSFDQVENAVLNVARYDVFKLSEAVLGGQ
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
AVRVARMLDGLQSEGESEVLVHWALSEDIRSMKRVKDAIQAGRPMPMALRENRVWGIKEK
HHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHH
LFERVLPQMGDTTLANLLHAAHKVDGIVKGLKQPDWPADGWQALHRLAGMVCRECAAPSA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
APRGLRNPVEIARG
CCCCCCCCHHHCCC
>Mature Secondary Structure
MVSLPSNLAPAQLSEHLKRGLKSLYTLHGDEPLLVQEFADALRAAAREQGYTERTVHTVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GAHFDWSEVLASGGSLSLFADRQIVEIRIPSGKPGKDGSVALQQLAERAQGDDSTLTLVL
CCCCCHHHHHHCCCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
LPRLDSMTAKGAWFGALDSFGVTVKFDPIDRRNLPQWIAQRLQQQGQRVAAGEEGQRTLQ
ECCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHH
FFADRVEGNLLAAHQEIQKLGLLYPAQEDGILSFDQVENAVLNVARYDVFKLSEAVLGGQ
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
AVRVARMLDGLQSEGESEVLVHWALSEDIRSMKRVKDAIQAGRPMPMALRENRVWGIKEK
HHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHH
LFERVLPQMGDTTLANLLHAAHKVDGIVKGLKQPDWPADGWQALHRLAGMVCRECAAPSA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
APRGLRNPVEIARG
CCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]