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The map label for this gene is proA

Identifier: 91790413

GI number: 91790413

Start: 4855766

End: 4857076

Strand: Reverse

Name: proA

Synonym: Bpro_4584

Alternate gene names: 91790413

Gene position: 4857076-4855766 (Counterclockwise)

Preceding gene: 91790414

Following gene: 91790412

Centisome position: 93.4

GC content: 64.99

Gene sequence:

>1311_bases
ATGAACGCGCCCGACTCCCCCAACGCCCTGGCAGCCCGCAGCGAACTCACGGACCTGATGCAGCGCATGGGTTCCGGGGC
AAAAGTGGCGTCAGCCCACATGGCGCGTGCGTCAGCGGCTGTTAAAAACTGGGCGCTGTCAAAGCTGGCCACCTTGCTCC
GCCAGAATGTCAAGGCCCTGGATAACGCCAACCAGCGTGACCTGGCGCGCGCCCAGGCGGCCGGGCTGGCCGGTCCCCTG
CTGGACCGGCTCAGGCTGAGCCCCAAAGACATAGAGACCGTGGCCCTGGGCTGCGAGCAGCTTGCTGCCATGCCCGACGT
GATTGGCGAGATCATCGGCATGAAAGAGCAGCCCAGCGGCATCCGCGTCGGGCAGATGCGCGTGCCCATCGGCGTGTTCG
GCATGATTTATGAAAGCCGCCCCAACGTGACGATTGAAGCGGCGTCGCTGGCCATCAAGAGCGGCAACGCCTGCATCTTG
CGCGGCGGCTCCGAGGCCATCGAGTCCAACAAGGCGCTGGCCTCGCTGGTGCAGCAGGCGCTGCTTGACGCCGGGCTGCC
GGCAGACGCGGTGCAACTGGTGCCGACGACCGACCGCGAAGCCGTGGGCCTGCTCATCGCGATGCCGCAGTATGTGGACG
TCATCATTCCGCGCGGCGGCAAGGGCCTGATTGAACGCATCAGCCGCGAGGCCAAGGTGCCGGTCATCAAGCACCTGGAC
GGCAACTGCCATGTGTATGTCGACGACCCCTGCGACATCGACATGGCGGTCCGGGTGGCCGACAACGCCAAGACCCAGAA
ATACAGTCCCTGCAACGCCAGCGAAGGTTTGCTGGTGGCGCGCGGCGTGGCCGCCGGCTTCCTGCCAAAAATCGGCGCAG
TTTATGCGGCCAAGGGTGTGGAAATGCGTTGCGATGCCGAAGCCCGGGCCCTTCTTGCCGGCGTGGCGGGCGCCAACCTC
CAGCCCGTGTCCGAGCAGGACTGGTATGAGGAGTATCTGGCACCCATCATCAGCATCAAGGTGGTGGCCGGCATTGACGA
AGCGATCGCCCACATCAACCAGTACTCCAGCCACCACACCGACGCCATCCTGACGCGCGACCACATGCACGCCCAGCGAT
TTTTGCGCGAGGTGGATTCAGCCAGCGTCATGGTGAATGCGAGCACCCGCTTCGCGGATGGTTTCGAGTTCGGGCTGGGC
GCAGAAATCGGCATCAGCACCGACAAGTTCCACGCCCGCGGGCCGGTCGGCATTGAGGGCCTGACCTCCCTCAAGTATGT
GGTGCTGGGCAACGGGGAAGTGCGGACCTGA

Upstream 100 bases:

>100_bases
ATGCAGCGCCGCGGCGTACTTGCCGCATCCTGATGCCGTGGCGGCCGCGGTTTGCGGCAAGCGATGTTCTGGCGATCCTG
ATTAGAGGCAAAATAGCGGG

Downstream 100 bases:

>100_bases
GTCGCCGCACCCCTGGCCAGCGGCGGTTGCCATCCGTCTTTTGAGATTTTGGCTGTGCACCTTGTAACCGCCCTGCGCAT
CCCAATATCCCTAGGATTCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKALDNANQRDLARAQAAGLAGPL
LDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACIL
RGGSEAIESNKALASLVQQALLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLD
GNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGVEMRCDAEARALLAGVAGANL
QPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLG
AEIGISTDKFHARGPVGIEGLTSLKYVVLGNGEVRT

Sequences:

>Translated_436_residues
MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKALDNANQRDLARAQAAGLAGPL
LDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACIL
RGGSEAIESNKALASLVQQALLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLD
GNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGVEMRCDAEARALLAGVAGANL
QPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLG
AEIGISTDKFHARGPVGIEGLTSLKYVVLGNGEVRT
>Mature_436_residues
MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKALDNANQRDLARAQAAGLAGPL
LDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACIL
RGGSEAIESNKALASLVQQALLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLD
GNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGVEMRCDAEARALLAGVAGANL
QPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLG
AEIGISTDKFHARGPVGIEGLTSLKYVVLGNGEVRT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=392, Percent_Identity=39.5408163265306, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI21361368, Length=392, Percent_Identity=39.5408163265306, Blast_Score=255, Evalue=5e-68,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=43.1654676258993, Blast_Score=348, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17569969, Length=390, Percent_Identity=40.7692307692308, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17569967, Length=390, Percent_Identity=40.7692307692308, Blast_Score=279, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=37.0629370629371, Blast_Score=276, Evalue=4e-75,
Organism=Drosophila melanogaster, GI21357643, Length=416, Percent_Identity=40.3846153846154, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_POLSJ (Q122S5)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_551365.1
- ProteinModelPortal:   Q122S5
- SMR:   Q122S5
- STRING:   Q122S5
- GeneID:   4012742
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_4584
- NMPDR:   fig|296591.1.peg.5314
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q122S5
- ProtClustDB:   PRK00197
- BioCyc:   PSP296591:BPRO_4584-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46242; Mature: 46242

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNANQRDLARAQAAGLAGPLLDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSG
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACILRGGSEAIESNKALASLVQQA
CEEEEEECCHHHEEEEEECCCCEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
LLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLD
HHHCCCCCCCEEEECCCCHHHHEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCEEEECC
GNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGV
CCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCC
EMRCDAEARALLAGVAGANLQPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHT
CEEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
DAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLGAEIGISTDKFHARGPVGIEG
CCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC
LTSLKYVVLGNGEVRT
CCCEEEEEECCCCCCC
>Mature Secondary Structure
MNAPDSPNALAARSELTDLMQRMGSGAKVASAHMARASAAVKNWALSKLATLLRQNVKAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNANQRDLARAQAAGLAGPLLDRLRLSPKDIETVALGCEQLAAMPDVIGEIIGMKEQPSG
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IRVGQMRVPIGVFGMIYESRPNVTIEAASLAIKSGNACILRGGSEAIESNKALASLVQQA
CEEEEEECCHHHEEEEEECCCCEEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
LLDAGLPADAVQLVPTTDREAVGLLIAMPQYVDVIIPRGGKGLIERISREAKVPVIKHLD
HHHCCCCCCCEEEECCCCHHHHEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCEEEECC
GNCHVYVDDPCDIDMAVRVADNAKTQKYSPCNASEGLLVARGVAAGFLPKIGAVYAAKGV
CCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCC
EMRCDAEARALLAGVAGANLQPVSEQDWYEEYLAPIISIKVVAGIDEAIAHINQYSSHHT
CEEECHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
DAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEFGLGAEIGISTDKFHARGPVGIEG
CCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC
LTSLKYVVLGNGEVRT
CCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA