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The map label for this gene is argH [H]

Identifier: 91790225

GI number: 91790225

Start: 4634664

End: 4636205

Strand: Reverse

Name: argH [H]

Synonym: Bpro_4391

Alternate gene names: 91790225

Gene position: 4636205-4634664 (Counterclockwise)

Preceding gene: 91790226

Following gene: 91790224

Centisome position: 89.15

GC content: 63.04

Gene sequence:

>1542_bases
ATGCCAACTTTCAAAGTCCCGATGACATCCACTACCCTTCATGAAACTCTGCTGACCGAAGCCCGGTTGAGCGCTCCCCC
GGCCGCACGGCTGGTCAAATACCACGACCTGCCAGGCCTGGAGCGCGAGAAGAAGCAGTTCCAGGAGTTTGTCGCAGTCG
ACATGGCGCACACCACCATGCTGGTGGAGGAAGGCATCATCTCAACAGCAGCCGGCCGCGCCATCCTTCAGCAGCTGCTT
GCGATCCGCCGCATGGAGCCGGCTGACTTTCCCACGGACGTTCGCAAGGGAAGTTTCCTGCTGCAGATCGAGTCCTACCT
CTTTGCGGCAATCGGCGAGGACGTAGGCGGGCAGATGCACACAGGCCGTAGCCGTATCGACCAGGGCGCCACCGTCCGGC
GGCTTTACAAGCGCAACCGCATGCTCGATGTGATGGACCAGCTCAACGGCCTGCAGGACGCCATCGCCCAGCAGGCGCGG
CGCCATGCTCGCACCATCATGCCCGGTTACACCCACCTTCAACATGCGCAGCCCTGGGTCTTCGGCCATTACCTGCTGAG
CTTCAGCTCGCGGCTGCACGACAGCTTCGAGCGGCTGGCCCAGGCGTATGGCCGCGTCAACCGCAACCCGCTGGGCGCGG
TCGGCCTGGCTGGAACCTCCTGGCCACTGAACCGCATGCGCACCACCGCGCTGCTGGGTTTTGATGGGCTGGTGGAAAAC
TCCAAGCTGGGACGCGAGGCCTACTACGCGGCCGAGGCCATCGGTGCTCTGGCCTTTGTCATGGCGGACCTCAACGACCT
AGCGACCGATCTGCACCTTTGGTCCAGCACAGAGTTCGGCTTGGTCGAAAGCGACGACAGCTATTGCGGCACAAGCAGCA
TCTTTCCTCAGAAGAAAAATCCGGCGGGCCTTGAAACCATTAAAAAGGCCGCCGGCTCGGCCGTAACCTGGCTGGCCACC
GCGCTGGCCACCTTCCGTGCGGAGGGAACGGGTGACCAAGCCATGCGCGAACTGCCGCTGATCGATGAGGCACTCGCAAC
CACTGAAGGCATGCTTGACCTCTTCACCGGGGTAATCGAGACGCTGATCGTGCATGACGACCGTATGGCCGAATCACTCA
GCGGCAGCTGGTGTACGGCCAGTAACCTTGCCGATGTGATCGTACGCGAGCGCGGCCTTTCGTTTCGCCAAGTGCATCAC
ATCGTGGCGCGTGTCGTGCGCAACTGCATTGCGCAAGGAACTGCACCGGCTGATTTGACAAGCGCACTGCTCGATGAGGC
TGCGTTAGAAACCGCCGGCCTTGAGCTCAGGCTCGGCGATGAGGCCGTGCGCGATGCGCTTGATCCAAGGCGTTTTGTCG
AAACCCGGGTCACCGACGGCAGCGTAGCGCCGCTGCAGGTCGCCCGTCTGCTGGCGCATGCGCAGAGCGAGCGTGTTGCC
GACAAGCGCTGGGTGGAGGAGGCGCGCGCCCGCCTGGCACGGGCTCAGAGCGAACTGAACCAGGCCGTCGGCCGGCTTGT
CGCTGCCGTGGAAACTGTATGA

Upstream 100 bases:

>100_bases
TTCAACTCATCGGCCAACGCAAGGGCGTCAAGGGTCTGACCGTCTATAGCGACGAGATCGTCGAATTTAACAACGCAACC
GTCACCCGCTAACCCACTTG

Downstream 100 bases:

>100_bases
ACGCTGACCTCGTCGCCCGCGTACAGAACCTGAGCGTGGCCTTCTGCGGCGACGTCGGCGCCCCCATGGCGGTGCGCGAT
GTCTCTTTCGAGGTGGCGCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MPTFKVPMTSTTLHETLLTEARLSAPPAARLVKYHDLPGLEREKKQFQEFVAVDMAHTTMLVEEGIISTAAGRAILQQLL
AIRRMEPADFPTDVRKGSFLLQIESYLFAAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQAR
RHARTIMPGYTHLQHAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTSWPLNRMRTTALLGFDGLVEN
SKLGREAYYAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVESDDSYCGTSSIFPQKKNPAGLETIKKAAGSAVTWLAT
ALATFRAEGTGDQAMRELPLIDEALATTEGMLDLFTGVIETLIVHDDRMAESLSGSWCTASNLADVIVRERGLSFRQVHH
IVARVVRNCIAQGTAPADLTSALLDEAALETAGLELRLGDEAVRDALDPRRFVETRVTDGSVAPLQVARLLAHAQSERVA
DKRWVEEARARLARAQSELNQAVGRLVAAVETV

Sequences:

>Translated_513_residues
MPTFKVPMTSTTLHETLLTEARLSAPPAARLVKYHDLPGLEREKKQFQEFVAVDMAHTTMLVEEGIISTAAGRAILQQLL
AIRRMEPADFPTDVRKGSFLLQIESYLFAAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQAR
RHARTIMPGYTHLQHAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTSWPLNRMRTTALLGFDGLVEN
SKLGREAYYAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVESDDSYCGTSSIFPQKKNPAGLETIKKAAGSAVTWLAT
ALATFRAEGTGDQAMRELPLIDEALATTEGMLDLFTGVIETLIVHDDRMAESLSGSWCTASNLADVIVRERGLSFRQVHH
IVARVVRNCIAQGTAPADLTSALLDEAALETAGLELRLGDEAVRDALDPRRFVETRVTDGSVAPLQVARLLAHAQSERVA
DKRWVEEARARLARAQSELNQAVGRLVAAVETV
>Mature_512_residues
PTFKVPMTSTTLHETLLTEARLSAPPAARLVKYHDLPGLEREKKQFQEFVAVDMAHTTMLVEEGIISTAAGRAILQQLLA
IRRMEPADFPTDVRKGSFLLQIESYLFAAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQARR
HARTIMPGYTHLQHAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTSWPLNRMRTTALLGFDGLVENS
KLGREAYYAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVESDDSYCGTSSIFPQKKNPAGLETIKKAAGSAVTWLATA
LATFRAEGTGDQAMRELPLIDEALATTEGMLDLFTGVIETLIVHDDRMAESLSGSWCTASNLADVIVRERGLSFRQVHHI
VARVVRNCIAQGTAPADLTSALLDEAALETAGLELRLGDEAVRDALDPRRFVETRVTDGSVAPLQVARLLAHAQSERVAD
KRWVEEARARLARAQSELNQAVGRLVAAVETV

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=307, Percent_Identity=34.2019543973941, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI68303542, Length=307, Percent_Identity=34.2019543973941, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI68303547, Length=305, Percent_Identity=33.7704918032787, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI68303549, Length=307, Percent_Identity=32.2475570032573, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790398, Length=378, Percent_Identity=32.5396825396825, Blast_Score=169, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321806, Length=301, Percent_Identity=35.5481727574751, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI221473854, Length=377, Percent_Identity=30.5039787798408, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI78706858, Length=377, Percent_Identity=30.5039787798408, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 56310; Mature: 56179

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFKVPMTSTTLHETLLTEARLSAPPAARLVKYHDLPGLEREKKQFQEFVAVDMAHTTM
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVEEGIISTAAGRAILQQLLAIRRMEPADFPTDVRKGSFLLQIESYLFAAIGEDVGGQMH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEHHHHHHHHHHHHHCCCCCC
TGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQARRHARTIMPGYTHLQHAQPWV
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
FGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTSWPLNRMRTTALLGFDGLVEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCHHHHCC
SKLGREAYYAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVESDDSYCGTSSIFPQKKN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCC
PAGLETIKKAAGSAVTWLATALATFRAEGTGDQAMRELPLIDEALATTEGMLDLFTGVIE
CCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TLIVHDDRMAESLSGSWCTASNLADVIVRERGLSFRQVHHIVARVVRNCIAQGTAPADLT
HHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
SALLDEAALETAGLELRLGDEAVRDALDPRRFVETRVTDGSVAPLQVARLLAHAQSERVA
HHHHHHHHHHHCCCEEEECHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DKRWVEEARARLARAQSELNQAVGRLVAAVETV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTFKVPMTSTTLHETLLTEARLSAPPAARLVKYHDLPGLEREKKQFQEFVAVDMAHTTM
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LVEEGIISTAAGRAILQQLLAIRRMEPADFPTDVRKGSFLLQIESYLFAAIGEDVGGQMH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEHHHHHHHHHHHHHCCCCCC
TGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQARRHARTIMPGYTHLQHAQPWV
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
FGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTSWPLNRMRTTALLGFDGLVEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCHHHHCC
SKLGREAYYAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVESDDSYCGTSSIFPQKKN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCC
PAGLETIKKAAGSAVTWLATALATFRAEGTGDQAMRELPLIDEALATTEGMLDLFTGVIE
CCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TLIVHDDRMAESLSGSWCTASNLADVIVRERGLSFRQVHHIVARVVRNCIAQGTAPADLT
HHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
SALLDEAALETAGLELRLGDEAVRDALDPRRFVETRVTDGSVAPLQVARLLAHAQSERVA
HHHHHHHHHHHCCCEEEECHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DKRWVEEARARLARAQSELNQAVGRLVAAVETV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]