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The map label for this gene is kbl [C]

Identifier: 91790201

GI number: 91790201

Start: 4607462

End: 4608664

Strand: Direct

Name: kbl [C]

Synonym: Bpro_4366

Alternate gene names: 91790201

Gene position: 4607462-4608664 (Clockwise)

Preceding gene: 91790199

Following gene: 91790202

Centisome position: 88.6

GC content: 58.94

Gene sequence:

>1203_bases
ATGCTTACCACCGCTCATTTCTACGCGTCTCTCCGAGAGGAGTTGCAGCAAATCGAGGCCGCTGGCCTATTTAAGGTTGA
ACGGCCGATCACCTCCGCCCAAAGCAGCATCGTTTCAACCGCTGACTCAACCGAGGTCATCAACCTCTGTGCGAATAACT
ACCTGGGGCTGTCTTCCCACCGCGGAATACTAGAAGCCGCGCATGCAGCCCTAGCCACCCGTGGTTTCGGCCTGAGTTCG
GTGCGGTTCATTTGCGGCACTCAGGACATCCACAAAGAGCTAGAGGCACGGCTGTCGAAGTTCCTGGGTACCGAGGACAC
GATCCTCTACGGCTCGGCCTTTGATGCCAATGGGGGTCTCTTCGAGACCTTACTAGGCGCGGAGGATGCAATCATCAGCG
ACGAGCTCAACCACGCCTCAATCATCGACGGCATCCGCCTGTGCAAAGCTAAGCGCTACCGTTATCGGCACGACGACATA
GAGGATCTGCGGCACCAGCTGCGGGAGGCCGACGCCGCGGGCTCGCGACACAAGCTTGTGTTCACAGACGGCGTCTTCTC
CATGGACGGCACTATTGCGCGCTTGGACGAGATTCGCGCCGTGTGCGACGAGTTCGGCGCCTTGTTGGGAGTTGACGACT
CCCATGCCACCGGTTTTATCGGCAAGACAGGGCGCGGAACGCATGAATACCGAGGCCTGTTCGGCAAGATCGACATTATT
ACCGGCACTCTCGGCAAGGCGCTTGGCGGCGCATCCGGTGGATTTACAAGCTCGAAGGCAGAAGTGATCGCATTGCTGCG
TCAGCGCTCTCGGCCTTACCTCTTCTCCAACACGCTTGCACCTGTCATCGTCGGCGCGAGCATCAAGGTGCTTGACTTGC
TTGAGGCAGACACCTGCTTGCGCGACAACCTCGAAGAAAACACTCGCTACTTCCGCGCCGGCCTCGCGGCGCGCGGATTC
GACCTGAAGGCGGGCACTCAGCCCATCATCCCTGTGATGGTGTACGACGCAGAGACGTCGCAGCGCCTTGCGCGTCGTCT
GCTGGAGCTGGGTGTCTACGTTACCGGCTTCTTCTACCCGGTAGTTCCGAAAGGGCAGGCACGCATTCGCGTGCAGATCA
GTGCCCAACACACCAAACAACAGCTCAATACCGCTCTCGATGCCTTTGCGCAAGCAGGTAAAGAATTGGGAGTCACGGCA
TGA

Upstream 100 bases:

>100_bases
GATTTGCATATTCACGAATTGTTCGATATAGTGGACATACGGCGTTTATTAGTGGAAATCGCCAAAATGATGAATAACCC
GATCCTAGCAGGACTACCCA

Downstream 100 bases:

>100_bases
GGACGCAACCCAGAATTCTCATCATTGGTGCCAACGGACAACTCGGCACCGAACTCTCAACCGCACTCGCTGAGCGCCAC
GGCTCATACAACGTAATCAC

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLTTAHFYASLREELQQIEAAGLFKVERPITSAQSSIVSTADSTEVINLCANNYLGLSSHRGILEAAHAALATRGFGLSS
VRFICGTQDIHKELEARLSKFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLCKAKRYRYRHDDI
EDLRHQLREADAAGSRHKLVFTDGVFSMDGTIARLDEIRAVCDEFGALLGVDDSHATGFIGKTGRGTHEYRGLFGKIDII
TGTLGKALGGASGGFTSSKAEVIALLRQRSRPYLFSNTLAPVIVGASIKVLDLLEADTCLRDNLEENTRYFRAGLAARGF
DLKAGTQPIIPVMVYDAETSQRLARRLLELGVYVTGFFYPVVPKGQARIRVQISAQHTKQQLNTALDAFAQAGKELGVTA

Sequences:

>Translated_400_residues
MLTTAHFYASLREELQQIEAAGLFKVERPITSAQSSIVSTADSTEVINLCANNYLGLSSHRGILEAAHAALATRGFGLSS
VRFICGTQDIHKELEARLSKFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLCKAKRYRYRHDDI
EDLRHQLREADAAGSRHKLVFTDGVFSMDGTIARLDEIRAVCDEFGALLGVDDSHATGFIGKTGRGTHEYRGLFGKIDII
TGTLGKALGGASGGFTSSKAEVIALLRQRSRPYLFSNTLAPVIVGASIKVLDLLEADTCLRDNLEENTRYFRAGLAARGF
DLKAGTQPIIPVMVYDAETSQRLARRLLELGVYVTGFFYPVVPKGQARIRVQISAQHTKQQLNTALDAFAQAGKELGVTA
>Mature_400_residues
MLTTAHFYASLREELQQIEAAGLFKVERPITSAQSSIVSTADSTEVINLCANNYLGLSSHRGILEAAHAALATRGFGLSS
VRFICGTQDIHKELEARLSKFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLCKAKRYRYRHDDI
EDLRHQLREADAAGSRHKLVFTDGVFSMDGTIARLDEIRAVCDEFGALLGVDDSHATGFIGKTGRGTHEYRGLFGKIDII
TGTLGKALGGASGGFTSSKAEVIALLRQRSRPYLFSNTLAPVIVGASIKVLDLLEADTCLRDNLEENTRYFRAGLAARGF
DLKAGTQPIIPVMVYDAETSQRLARRLLELGVYVTGFFYPVVPKGQARIRVQISAQHTKQQLNTALDAFAQAGKELGVTA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=391, Percent_Identity=52.9411764705882, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI284448556, Length=417, Percent_Identity=49.1606714628297, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=35.4223433242507, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI83977442, Length=374, Percent_Identity=33.6898395721925, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI83977440, Length=374, Percent_Identity=33.6898395721925, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI83977444, Length=374, Percent_Identity=33.6898395721925, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI119220554, Length=367, Percent_Identity=33.5149863760218, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4502025, Length=361, Percent_Identity=33.5180055401662, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI40316939, Length=361, Percent_Identity=33.5180055401662, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI5454084, Length=278, Percent_Identity=27.6978417266187, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=61.9289340101523, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=32.0113314447592, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=56.78391959799, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI32566772, Length=403, Percent_Identity=31.5136476426799, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17560914, Length=392, Percent_Identity=29.5918367346939, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560912, Length=394, Percent_Identity=30.2030456852792, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=316, Percent_Identity=23.1012658227848, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=316, Percent_Identity=23.1012658227848, Blast_Score=101, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=28.3783783783784, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320438, Length=381, Percent_Identity=27.5590551181102, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323954, Length=265, Percent_Identity=29.811320754717, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24662918, Length=395, Percent_Identity=54.4303797468354, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17137420, Length=342, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17136286, Length=377, Percent_Identity=32.0954907161804, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24653280, Length=279, Percent_Identity=27.5985663082437, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653276, Length=279, Percent_Identity=27.5985663082437, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653278, Length=279, Percent_Identity=27.5985663082437, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43429; Mature: 43429

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTAHFYASLREELQQIEAAGLFKVERPITSAQSSIVSTADSTEVINLCANNYLGLSSH
CCCHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
RGILEAAHAALATRGFGLSSVRFICGTQDIHKELEARLSKFLGTEDTILYGSAFDANGGL
CHHHHHHHHHHHHCCCCCCHHHHECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
FETLLGAEDAIISDELNHASIIDGIRLCKAKRYRYRHDDIEDLRHQLREADAAGSRHKLV
HHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
FTDGVFSMDGTIARLDEIRAVCDEFGALLGVDDSHATGFIGKTGRGTHEYRGLFGKIDII
EECCEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
TGTLGKALGGASGGFTSSKAEVIALLRQRSRPYLFSNTLAPVIVGASIKVLDLLEADTCL
ECHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHH
RDNLEENTRYFRAGLAARGFDLKAGTQPIIPVMVYDAETSQRLARRLLELGVYVTGFFYP
HCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEE
VVPKGQARIRVQISAQHTKQQLNTALDAFAQAGKELGVTA
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHCCHHCCCCC
>Mature Secondary Structure
MLTTAHFYASLREELQQIEAAGLFKVERPITSAQSSIVSTADSTEVINLCANNYLGLSSH
CCCHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
RGILEAAHAALATRGFGLSSVRFICGTQDIHKELEARLSKFLGTEDTILYGSAFDANGGL
CHHHHHHHHHHHHCCCCCCHHHHECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
FETLLGAEDAIISDELNHASIIDGIRLCKAKRYRYRHDDIEDLRHQLREADAAGSRHKLV
HHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
FTDGVFSMDGTIARLDEIRAVCDEFGALLGVDDSHATGFIGKTGRGTHEYRGLFGKIDII
EECCEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
TGTLGKALGGASGGFTSSKAEVIALLRQRSRPYLFSNTLAPVIVGASIKVLDLLEADTCL
ECHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCHHHHHHHHHHHH
RDNLEENTRYFRAGLAARGFDLKAGTQPIIPVMVYDAETSQRLARRLLELGVYVTGFFYP
HCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEE
VVPKGQARIRVQISAQHTKQQLNTALDAFAQAGKELGVTA
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]