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The map label for this gene is cytR [H]

Identifier: 91790198

GI number: 91790198

Start: 4604011

End: 4605060

Strand: Reverse

Name: cytR [H]

Synonym: Bpro_4363

Alternate gene names: 91790198

Gene position: 4605060-4604011 (Counterclockwise)

Preceding gene: 91790200

Following gene: 91790197

Centisome position: 88.55

GC content: 57.71

Gene sequence:

>1050_bases
ATGCCCACTTTATCGATCGACGATACGACGGAACGGCCAACCGGCAGACGACCAAAGATGGCCGATATAGCGCGCATGGC
AGGAGTCGACATCTCGACCGTCAGCCGCGCCTTGGCAGGAAGCCCGCGCGTCACCAAGGAGACCAGGGCGCTGATCGATC
AGATTGTGCGCGACACCGGGTACGTGCTGAACGAAGCAGCCCGCAATCTGCGGGATGGCCGCGCTAATCAGGTGCTTGTC
ATCGTTTCGGACATCGCTGCACCGTTCTATTCTGATGTTGTTCAGGGCATCGTCGAGACGCTAGCGGAACGTGGAATCAA
TGTTTTGTTGGGCGTTACGCTGCGTCAGGCCAAGCGCGAGGCAAAACTGGGGAAGCAACTGCTGACCGGCGTGGTGGATG
GCATCATCACGGTCACCGGGAGTGTACCCAAGCCGATCCTCAACATGCAGGGCTTCGACCGCAAAGTCGTCGCGATATCG
CGACCCGTACCGCACGAGGGCGTCACGTGCGTGACAATCGATAACTACGCTGCCGCCAAGGAAGTGATGGCACACCTCTA
TGCGATGGGGCATCGGCGTATTGTCCACATCGGCGGACCGAATCACTCCGAGACATACCGTGACCGTAGTGCAGCGTACG
TCGATTTCATGCGCGATCATGGCCTCGTCGAACTGACGAACGTACGCTCAACCGACTCTTTCAATGATGATGCTGAGTCT
GGTTTCGAGATCATGAAATCCATGCTCAACGATGGCTCACGCCCCACGGCTGTCTTCTGTGCCACCGACGAGCTTGCGAT
AAGCGCTATGGCAGCTGCTCGACAAGCCAACCGAAACATACCAGGTGACGTGTCGTTCTTTGGGTTTGACGACCTGAAAT
TGGCGGGGCTGATGCATCCCCCGCTGTCGACAGTGTCCGTCCCACGCTTCGAGATGGGGAGAAGGGGAGCGGAAGAGCTT
TTCCGCCAGATCTACAAGGGTGAGATGCCATCGACCAAAATTGTGCTCGAGCATCGACTGGTACTGCGGGACAGTGTGGC
GAAGATCTGA

Upstream 100 bases:

>100_bases
AGGTCACAACGGACCCCAAACCCCTCTTGTGTGCACTTACACGCAACAGCACCTTACAAGCGAGCACGCTACCATCTTGG
ACCCATTGAACGGACGGAAC

Downstream 100 bases:

>100_bases
TGATCTGATTGGCACATCCGTGGTGATGCCCGCGCTTGCCGCTGACGATCGGAAATTAGGGTCGCAACTAGTTCTATAGC
CAGATCGTTGCAGGGACTGC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MPTLSIDDTTERPTGRRPKMADIARMAGVDISTVSRALAGSPRVTKETRALIDQIVRDTGYVLNEAARNLRDGRANQVLV
IVSDIAAPFYSDVVQGIVETLAERGINVLLGVTLRQAKREAKLGKQLLTGVVDGIITVTGSVPKPILNMQGFDRKVVAIS
RPVPHEGVTCVTIDNYAAAKEVMAHLYAMGHRRIVHIGGPNHSETYRDRSAAYVDFMRDHGLVELTNVRSTDSFNDDAES
GFEIMKSMLNDGSRPTAVFCATDELAISAMAAARQANRNIPGDVSFFGFDDLKLAGLMHPPLSTVSVPRFEMGRRGAEEL
FRQIYKGEMPSTKIVLEHRLVLRDSVAKI

Sequences:

>Translated_349_residues
MPTLSIDDTTERPTGRRPKMADIARMAGVDISTVSRALAGSPRVTKETRALIDQIVRDTGYVLNEAARNLRDGRANQVLV
IVSDIAAPFYSDVVQGIVETLAERGINVLLGVTLRQAKREAKLGKQLLTGVVDGIITVTGSVPKPILNMQGFDRKVVAIS
RPVPHEGVTCVTIDNYAAAKEVMAHLYAMGHRRIVHIGGPNHSETYRDRSAAYVDFMRDHGLVELTNVRSTDSFNDDAES
GFEIMKSMLNDGSRPTAVFCATDELAISAMAAARQANRNIPGDVSFFGFDDLKLAGLMHPPLSTVSVPRFEMGRRGAEEL
FRQIYKGEMPSTKIVLEHRLVLRDSVAKI
>Mature_348_residues
PTLSIDDTTERPTGRRPKMADIARMAGVDISTVSRALAGSPRVTKETRALIDQIVRDTGYVLNEAARNLRDGRANQVLVI
VSDIAAPFYSDVVQGIVETLAERGINVLLGVTLRQAKREAKLGKQLLTGVVDGIITVTGSVPKPILNMQGFDRKVVAISR
PVPHEGVTCVTIDNYAAAKEVMAHLYAMGHRRIVHIGGPNHSETYRDRSAAYVDFMRDHGLVELTNVRSTDSFNDDAESG
FEIMKSMLNDGSRPTAVFCATDELAISAMAAARQANRNIPGDVSFFGFDDLKLAGLMHPPLSTVSVPRFEMGRRGAEELF
RQIYKGEMPSTKIVLEHRLVLRDSVAKI

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=31.4024390243902, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=27.7439024390244, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787948, Length=337, Percent_Identity=25.5192878338279, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=26.7267267267267, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787906, Length=341, Percent_Identity=27.5659824046921, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789068, Length=339, Percent_Identity=27.4336283185841, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1789456, Length=335, Percent_Identity=29.2537313432836, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787580, Length=333, Percent_Identity=26.4264264264264, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788474, Length=329, Percent_Identity=27.6595744680851, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=25.7142857142857, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786540, Length=328, Percent_Identity=25, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790689, Length=331, Percent_Identity=25.9818731117825, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786268, Length=299, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38199; Mature: 38068

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLSIDDTTERPTGRRPKMADIARMAGVDISTVSRALAGSPRVTKETRALIDQIVRDTG
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YVLNEAARNLRDGRANQVLVIVSDIAAPFYSDVVQGIVETLAERGINVLLGVTLRQAKRE
HHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHH
AKLGKQLLTGVVDGIITVTGSVPKPILNMQGFDRKVVAISRPVPHEGVTCVTIDNYAAAK
HHHHHHHHHHHHHHHHEECCCCCCCHHCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHH
EVMAHLYAMGHRRIVHIGGPNHSETYRDRSAAYVDFMRDHGLVELTNVRSTDSFNDDAES
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
GFEIMKSMLNDGSRPTAVFCATDELAISAMAAARQANRNIPGDVSFFGFDDLKLAGLMHP
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHCCCC
PLSTVSVPRFEMGRRGAEELFRQIYKGEMPSTKIVLEHRLVLRDSVAKI
CCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTLSIDDTTERPTGRRPKMADIARMAGVDISTVSRALAGSPRVTKETRALIDQIVRDTG
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YVLNEAARNLRDGRANQVLVIVSDIAAPFYSDVVQGIVETLAERGINVLLGVTLRQAKRE
HHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHH
AKLGKQLLTGVVDGIITVTGSVPKPILNMQGFDRKVVAISRPVPHEGVTCVTIDNYAAAK
HHHHHHHHHHHHHHHHEECCCCCCCHHCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHH
EVMAHLYAMGHRRIVHIGGPNHSETYRDRSAAYVDFMRDHGLVELTNVRSTDSFNDDAES
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
GFEIMKSMLNDGSRPTAVFCATDELAISAMAAARQANRNIPGDVSFFGFDDLKLAGLMHP
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHCCCC
PLSTVSVPRFEMGRRGAEELFRQIYKGEMPSTKIVLEHRLVLRDSVAKI
CCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]