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The map label for this gene is lysR [H]

Identifier: 91790183

GI number: 91790183

Start: 4586113

End: 4587039

Strand: Direct

Name: lysR [H]

Synonym: Bpro_4348

Alternate gene names: 91790183

Gene position: 4586113-4587039 (Clockwise)

Preceding gene: 91790182

Following gene: 91790192

Centisome position: 88.19

GC content: 55.23

Gene sequence:

>927_bases
ATGGATCAAAGAATCACACTACGCCACCTCGAAGCGTTTCGCGCCGTCATGGTGCGAAGGTCAGTCACGGGGGCGGCGGA
AATGCTCGAGGTCACCCAGCCTGTAGTGACACGCCTGATTGCCGATCTTGAGGAACGCATCGCAATCCCTCTCTTTACGC
GCACTAAGGGACGCCTGGTGCCGACTCCAGAGGCCGCGCTGCTGTTCAAAGACGTGCATCAGTCTTTGGTAGGAATCGAG
CGCATTGCTAACGCGGCATCCAATATCAAGGCGCTGAAGCTCGGGCACCTCGAAATCGCTGCTGCCCCATCCATGGCGCT
CACCTTCCTGCCCCACGCGATAGCAAGTTTTACGCGCGAACATCCCGATGCCCTGGTGTCCATGCATATGCACAGTTCGT
CCATCGTAATCGACATGGTTCAGAGTAATCGCTGCGATTTAGGGTTCGCCATCATGCCCATGCGTACAACGCGCCACGGC
AACAGCGAAATCTTGGTGTCAGCGAAGTCTGTCGGCGTAGTGCCAATCCACCACCGCCTTGCAAGTCGCCAAGTTTTACG
CCCGGAGGATTTCGAAGGTGAGAGCTTCATCTCCTACCCGCCCTTGATGGATGCGCGCACCAAGATTGATTCGCTGATGC
TGTCGTACGGTGTGAATCGCCGCATCAACGTCGAGACCCCGATTTCTGCCGTCATCACCAAGTTGGTCGAAGCGGGCGCC
GGTGTCTCCATCATTGATCCGCTGACGGCAAGTTTTTACACGGGGGGCTTGCTGAAGTTTATTCCATTTGAGGTTGAGCA
CGTCAATGATTACTCTCTCGTCATTTCGGAACGCAATTCATCCACACTTATCCTCAAGCCGTTCATTGATCATGCTCGCC
GGGAGATTCGTAAGATGGTGCCCGCGCACCTAATTGTTCGTAGCTAA

Upstream 100 bases:

>100_bases
CCCGCAAGAGATCTCCTGCAATATCTAGAGTCCGCTGCTGACACGATACAGGACGCATGCCGGTGACGAATAGGCCACGT
GGCCGGAAAGTACTACGACT

Downstream 100 bases:

>100_bases
GTGCTAAGCTTCCACGAAAACCTGACCCGAAGTTACCCTCGAAACTTGGATCTACTGAACTCGTAGAACGTCAAATCCGT
CAGCAGGCGCTCATCGGCCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDQRITLRHLEAFRAVMVRRSVTGAAEMLEVTQPVVTRLIADLEERIAIPLFTRTKGRLVPTPEAALLFKDVHQSLVGIE
RIANAASNIKALKLGHLEIAAAPSMALTFLPHAIASFTREHPDALVSMHMHSSSIVIDMVQSNRCDLGFAIMPMRTTRHG
NSEILVSAKSVGVVPIHHRLASRQVLRPEDFEGESFISYPPLMDARTKIDSLMLSYGVNRRINVETPISAVITKLVEAGA
GVSIIDPLTASFYTGGLLKFIPFEVEHVNDYSLVISERNSSTLILKPFIDHARREIRKMVPAHLIVRS

Sequences:

>Translated_308_residues
MDQRITLRHLEAFRAVMVRRSVTGAAEMLEVTQPVVTRLIADLEERIAIPLFTRTKGRLVPTPEAALLFKDVHQSLVGIE
RIANAASNIKALKLGHLEIAAAPSMALTFLPHAIASFTREHPDALVSMHMHSSSIVIDMVQSNRCDLGFAIMPMRTTRHG
NSEILVSAKSVGVVPIHHRLASRQVLRPEDFEGESFISYPPLMDARTKIDSLMLSYGVNRRINVETPISAVITKLVEAGA
GVSIIDPLTASFYTGGLLKFIPFEVEHVNDYSLVISERNSSTLILKPFIDHARREIRKMVPAHLIVRS
>Mature_308_residues
MDQRITLRHLEAFRAVMVRRSVTGAAEMLEVTQPVVTRLIADLEERIAIPLFTRTKGRLVPTPEAALLFKDVHQSLVGIE
RIANAASNIKALKLGHLEIAAAPSMALTFLPHAIASFTREHPDALVSMHMHSSSIVIDMVQSNRCDLGFAIMPMRTTRHG
NSEILVSAKSVGVVPIHHRLASRQVLRPEDFEGESFISYPPLMDARTKIDSLMLSYGVNRRINVETPISAVITKLVEAGA
GVSIIDPLTASFYTGGLLKFIPFEVEHVNDYSLVISERNSSTLILKPFIDHARREIRKMVPAHLIVRS

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=296, Percent_Identity=33.7837837837838, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI157672245, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788887, Length=257, Percent_Identity=26.4591439688716, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787530, Length=234, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788481, Length=244, Percent_Identity=26.2295081967213, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34148; Mature: 34148

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQRITLRHLEAFRAVMVRRSVTGAAEMLEVTQPVVTRLIADLEERIAIPLFTRTKGRLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
PTPEAALLFKDVHQSLVGIERIANAASNIKALKLGHLEIAAAPSMALTFLPHAIASFTRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHH
HPDALVSMHMHSSSIVIDMVQSNRCDLGFAIMPMRTTRHGNSEILVSAKSVGVVPIHHRL
CCHHHHHEEECCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEHHHHHH
ASRQVLRPEDFEGESFISYPPLMDARTKIDSLMLSYGVNRRINVETPISAVITKLVEAGA
HHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCC
GVSIIDPLTASFYTGGLLKFIPFEVEHVNDYSLVISERNSSTLILKPFIDHARREIRKMV
CCEEECHHHHHHHCCCHHEECCEEEEECCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHC
PAHLIVRS
CHHHEECC
>Mature Secondary Structure
MDQRITLRHLEAFRAVMVRRSVTGAAEMLEVTQPVVTRLIADLEERIAIPLFTRTKGRLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
PTPEAALLFKDVHQSLVGIERIANAASNIKALKLGHLEIAAAPSMALTFLPHAIASFTRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHH
HPDALVSMHMHSSSIVIDMVQSNRCDLGFAIMPMRTTRHGNSEILVSAKSVGVVPIHHRL
CCHHHHHEEECCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEHHHHHH
ASRQVLRPEDFEGESFISYPPLMDARTKIDSLMLSYGVNRRINVETPISAVITKLVEAGA
HHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCC
GVSIIDPLTASFYTGGLLKFIPFEVEHVNDYSLVISERNSSTLILKPFIDHARREIRKMV
CCEEECHHHHHHHCCCHHEECCEEEEECCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHC
PAHLIVRS
CHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]