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The map label for this gene is lon [H]

Identifier: 91790163

GI number: 91790163

Start: 4562876

End: 4564195

Strand: Direct

Name: lon [H]

Synonym: Bpro_4327

Alternate gene names: 91790163

Gene position: 4562876-4564195 (Clockwise)

Preceding gene: 91790160

Following gene: 91790164

Centisome position: 87.74

GC content: 61.21

Gene sequence:

>1320_bases
ATGAGTGACGATGACATGGATGAGAAGCCGTCAGGCTTCGAGAAGATACGAAGAACCGTTCGCGGTGAAAGCCTTGACAG
CCAAAGTTGCAGCATTGAGATTTTTCTTCCCCAGCACCTGGTGGATCATTTCAATGACGAGGCAAGAATGCTGGATGAGG
CAAAACGTAAAGTAGCCAGGGAAGGCCGGGAAAGGCAGGCCTCCCGGTATGAAATGGCCGATCGCGCGAGCGAAGAGAAA
GCGGCGGCCGCGCCGGCCTTGGCTGCGGCGCCGGTTCCGGCAAAAACCGCTCCCCCTGAATCGCTTGTGCCCGGCATCGA
TTTCGACCCCCAGCTCAAACATCTGGTCTACGCCACAACGGAGCCCGAGGCGGTGGTTCTCCGGACCAAGCTGATGGCCG
ATGAGGAGATCAGGGTGCGAGACCTGGAGATCGTGGATCGACTGAAGGCCAAGGGGCCCTTGCGCAGGATCATCAATCCC
TTCCAGTGCGATCCCAGCCTGGCGCCTTTCGACAGGCTGGCGGGCCGGCATCCCCATTTTGGGCCGGTGATTGATTTCGT
CAAAATCCAGGTCGTCCGATGCCGGGCGAATGCAAAACCCCTGCGGATACCCCCTATCCTGCTGTTCGGCGGACCGGGGC
TGGGCAAGTCACATTTCACACGCGACCTGGCGGCCGCCCTGGGCACCGTCTGCCGCCGCTGCGCCTGGGATGGCGCGGTC
TCCAATGCCACCCTACTGGGCTCGGACAGAAAGTGGTCGAACTCGGCCATAGGCGTTTTGTTCGATCTCCTGTGTCTGGG
CGACTGCGCCAACCCGGTGGTGCTGCTCGATGAGCTGGACAAGGTGGGTCGGGACACCAAAGACGATCCCCTGGCGCCCT
TACACAGCCTGCTGGAACCCAGCACGGCCACGCAGGTTCGCGATGCCTCCCTGGATTTCGTCTTCGACGCCAGTCTGGTG
ACCTGGATTGGCACCGCGAACAGCGTGATGCTCATCCCCTCCTCGCTGCGGTCGCGGTTTAGGGAGTTTCACATCGGCCA
CCCCACGGCCGAGCAGGCCCTCACACTGGCGTTCTCGGTGGCGGCTAACGCGATTGAGAAAACGGCATCCCCGGACTTTG
CACCGCCCAAACGGGAGGTGGTACTGCGGATTGCCCACCTGACCCCCAGGGAAATCTACCAGGTCGTCGAGGAGGCGGTG
GGAAGAGCCGCGCTCAATGTGCGTACATGGCTCGAGGTGAATGATCTGCCTGCGGAGCTGATCCCGCTTGATGGGGACTC
ACGGCTGGAATGTGAAGGTGGCGTGAGGTATTTGCATTAA

Upstream 100 bases:

>100_bases
AGCTTCCTCTTTAAATCAGAGGGGTTCGGGCATATAGAGCTTGCGGATGACTAGTTAAGGCAAGTGGCTCGGACTCCTCC
CCCATCAGCAGGAGTCCGAA

Downstream 100 bases:

>100_bases
CGGACGGTCCGTTGTGTACTGCCCAGAACGTTCAGTCCAAGGAGCTTTTAGCAATGGACCCAAGACCTCTTATTGCGCTT
GACGGTGATGGGGTCCTGCT

Product: AAA ATPase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSDDDMDEKPSGFEKIRRTVRGESLDSQSCSIEIFLPQHLVDHFNDEARMLDEAKRKVAREGRERQASRYEMADRASEEK
AAAAPALAAAPVPAKTAPPESLVPGIDFDPQLKHLVYATTEPEAVVLRTKLMADEEIRVRDLEIVDRLKAKGPLRRIINP
FQCDPSLAPFDRLAGRHPHFGPVIDFVKIQVVRCRANAKPLRIPPILLFGGPGLGKSHFTRDLAAALGTVCRRCAWDGAV
SNATLLGSDRKWSNSAIGVLFDLLCLGDCANPVVLLDELDKVGRDTKDDPLAPLHSLLEPSTATQVRDASLDFVFDASLV
TWIGTANSVMLIPSSLRSRFREFHIGHPTAEQALTLAFSVAANAIEKTASPDFAPPKREVVLRIAHLTPREIYQVVEEAV
GRAALNVRTWLEVNDLPAELIPLDGDSRLECEGGVRYLH

Sequences:

>Translated_439_residues
MSDDDMDEKPSGFEKIRRTVRGESLDSQSCSIEIFLPQHLVDHFNDEARMLDEAKRKVAREGRERQASRYEMADRASEEK
AAAAPALAAAPVPAKTAPPESLVPGIDFDPQLKHLVYATTEPEAVVLRTKLMADEEIRVRDLEIVDRLKAKGPLRRIINP
FQCDPSLAPFDRLAGRHPHFGPVIDFVKIQVVRCRANAKPLRIPPILLFGGPGLGKSHFTRDLAAALGTVCRRCAWDGAV
SNATLLGSDRKWSNSAIGVLFDLLCLGDCANPVVLLDELDKVGRDTKDDPLAPLHSLLEPSTATQVRDASLDFVFDASLV
TWIGTANSVMLIPSSLRSRFREFHIGHPTAEQALTLAFSVAANAIEKTASPDFAPPKREVVLRIAHLTPREIYQVVEEAV
GRAALNVRTWLEVNDLPAELIPLDGDSRLECEGGVRYLH
>Mature_438_residues
SDDDMDEKPSGFEKIRRTVRGESLDSQSCSIEIFLPQHLVDHFNDEARMLDEAKRKVAREGRERQASRYEMADRASEEKA
AAAPALAAAPVPAKTAPPESLVPGIDFDPQLKHLVYATTEPEAVVLRTKLMADEEIRVRDLEIVDRLKAKGPLRRIINPF
QCDPSLAPFDRLAGRHPHFGPVIDFVKIQVVRCRANAKPLRIPPILLFGGPGLGKSHFTRDLAAALGTVCRRCAWDGAVS
NATLLGSDRKWSNSAIGVLFDLLCLGDCANPVVLLDELDKVGRDTKDDPLAPLHSLLEPSTATQVRDASLDFVFDASLVT
WIGTANSVMLIPSSLRSRFREFHIGHPTAEQALTLAFSVAANAIEKTASPDFAPPKREVVLRIAHLTPREIYQVVEEAVG
RAALNVRTWLEVNDLPAELIPLDGDSRLECEGGVRYLH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=154, Percent_Identity=35.0649350649351, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI21396489, Length=175, Percent_Identity=30.2857142857143, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786643, Length=182, Percent_Identity=29.1208791208791, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17505831, Length=177, Percent_Identity=29.9435028248588, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17556486, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319449, Length=254, Percent_Identity=25.1968503937008, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221513036, Length=176, Percent_Identity=30.6818181818182, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666867, Length=176, Percent_Identity=30.6818181818182, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 48343; Mature: 48212

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDDMDEKPSGFEKIRRTVRGESLDSQSCSIEIFLPQHLVDHFNDEARMLDEAKRKVAR
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHH
EGRERQASRYEMADRASEEKAAAAPALAAAPVPAKTAPPESLVPGIDFDPQLKHLVYATT
HHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECC
EPEAVVLRTKLMADEEIRVRDLEIVDRLKAKGPLRRIINPFQCDPSLAPFDRLAGRHPHF
CCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCC
GPVIDFVKIQVVRCRANAKPLRIPPILLFGGPGLGKSHFTRDLAAALGTVCRRCAWDGAV
CHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNATLLGSDRKWSNSAIGVLFDLLCLGDCANPVVLLDELDKVGRDTKDDPLAPLHSLLEP
CCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHCC
STATQVRDASLDFVFDASLVTWIGTANSVMLIPSSLRSRFREFHIGHPTAEQALTLAFSV
CHHHHHHCCCCCEEECCHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHH
AANAIEKTASPDFAPPKREVVLRIAHLTPREIYQVVEEAVGRAALNVRTWLEVNDLPAEL
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEE
IPLDGDSRLECEGGVRYLH
EECCCCCCEECCCCCEECC
>Mature Secondary Structure 
SDDDMDEKPSGFEKIRRTVRGESLDSQSCSIEIFLPQHLVDHFNDEARMLDEAKRKVAR
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHHH
EGRERQASRYEMADRASEEKAAAAPALAAAPVPAKTAPPESLVPGIDFDPQLKHLVYATT
HHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECC
EPEAVVLRTKLMADEEIRVRDLEIVDRLKAKGPLRRIINPFQCDPSLAPFDRLAGRHPHF
CCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHCCCCCCC
GPVIDFVKIQVVRCRANAKPLRIPPILLFGGPGLGKSHFTRDLAAALGTVCRRCAWDGAV
CHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNATLLGSDRKWSNSAIGVLFDLLCLGDCANPVVLLDELDKVGRDTKDDPLAPLHSLLEP
CCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHCC
STATQVRDASLDFVFDASLVTWIGTANSVMLIPSSLRSRFREFHIGHPTAEQALTLAFSV
CHHHHHHCCCCCEEECCHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHH
AANAIEKTASPDFAPPKREVVLRIAHLTPREIYQVVEEAVGRAALNVRTWLEVNDLPAEL
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEE
IPLDGDSRLECEGGVRYLH
EECCCCCCEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA