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The map label for this gene is bioA [C]

Identifier: 91790124

GI number: 91790124

Start: 4520501

End: 4521859

Strand: Direct

Name: bioA [C]

Synonym: Bpro_4286

Alternate gene names: 91790124

Gene position: 4520501-4521859 (Clockwise)

Preceding gene: 91790122

Following gene: 91790125

Centisome position: 86.93

GC content: 67.11

Gene sequence:

>1359_bases
ATGCGCTTCACTGACCTTGAGCAACCGACAACGGCCGCCGGCCCCCGCATGGATGCCGCCTGGCTCGACGCCCACTGGAT
GCCCTACACCGCCAACCGCAGCTTCAAGGCCAACCCGCGCATGGTGGTGGAGGCCAGTGGGGCCTACCTGACGGATGCCG
GGGGACGCAAGATTTTTGACGGCCTTTCGGGCCTCTGGTGCTCGGGCTTGGGCCACTGCCGGCGCGAAATCACCGAGGCC
GTGAGCCGCCAGGTCAGCAAGCTCGACTACGCACCGGCCTTCCAGTTCGGCCACCCGCTGGCCTTCGAGCTGGCCAACAA
GATCAAGGAACTGACGCCCCAAGGGCTGGACTACGTGTTCTTCACCGGCTCGGGCTCCGAGGCGGCCGACACCTCGCTCA
AGATGGCGCGGGCTTACTGGCGCGCCAAGGGCCAGGCCGGCAAAACGCGCCTGATCGGCCGCGAGAAGGGCTACCACGGC
GTCAACTTCGGCGGCATTTCGGTCGGCGGCATCGCGGCCAACCGCAAGCTGTTTGGCCAAGGGGTCGAGGCCGACCACCT
GCCGCACACCCAGCCGCCGACCGGCTCCTTTCACCGCGGTATGCCGCCCACCGGCGCCGAGCTGGCCGACCGCCTGCTCG
ACGTGATCGCGCTGCACGACGCGTCCAACATCGCCGCCGTGATCGTCGAACCCTTCTCCGGTTCGGCCGGCGTGGTGATT
CCGCCGCAGGGCTATTTGCAGCGCCTGCGCGAGATCTGCACCGCGCACAACATCCTGCTGATTTTTGACGAGGTCATCAC
CGGCTTTGGCCGCTGCGGCGCCTGGACCGGCGCCGAGGCCTTTGGCGTGGTGCCCGACATCATGAACATCGCCAAGCAGG
TGACCAATGGCGCGCAGCCGCTGGGCGCCGTGGTCGCGACAAAAGACATCTACGACACCTTCATGGACGCGGGCGGCCCG
GAGTACATGATCGAGTTCCCGCACGGCTACACCTACTCGGCCCACCCAGTGGCCTGCGCCGCCGGCGTGGCCGCGCTCGA
TGTGCTGCAGAAGGAAGACATGATCGGCCGCGTCAAGGCGCTGGCGCCGCATTTCGAGAACGCCGTGCACAGCCTCAAAG
GCAGCAAGCATGTGGCCGACATCCGCAACTACGGCCTGGCCGCCGGCTTCACGATTGCCGCGCTGCCGGGCGAGCCGGCA
CGCCGCCCCTACGAGATTGCGATGAACTGCTGGAAGAAGGGCTTCTACGTGCGCTACGGCGGCGACACCATCCAGCTGGC
CCCGCCCTTCATCAGCGAAAAGGCCGAGATCGACCGGCTGATCAACGCGCTGGGCGATGCGCTGGCCGAAACGGCATAA

Upstream 100 bases:

>100_bases
AGAATGTCCTCATCGCCTCGCCAAAGGGCTCGCGGGCTCTCGGGCTCTCGCGAGAGGCCGCTCCCCACCATTTCCTGACC
CTAAACACCGGAGAAAGCAC

Downstream 100 bases:

>100_bases
GCAGCCCCTCACACTGCACACATACTGCACGCGCACTGCACGCGCAGCGTTCGCTGCGGTAATTCGCTATTGTTTTTAGC
ATCTCCTTCGCATACCCTGA

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRFTDLEQPTTAAGPRMDAAWLDAHWMPYTANRSFKANPRMVVEASGAYLTDAGGRKIFDGLSGLWCSGLGHCRREITEA
VSRQVSKLDYAPAFQFGHPLAFELANKIKELTPQGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTRLIGREKGYHG
VNFGGISVGGIAANRKLFGQGVEADHLPHTQPPTGSFHRGMPPTGAELADRLLDVIALHDASNIAAVIVEPFSGSAGVVI
PPQGYLQRLREICTAHNILLIFDEVITGFGRCGAWTGAEAFGVVPDIMNIAKQVTNGAQPLGAVVATKDIYDTFMDAGGP
EYMIEFPHGYTYSAHPVACAAGVAALDVLQKEDMIGRVKALAPHFENAVHSLKGSKHVADIRNYGLAAGFTIAALPGEPA
RRPYEIAMNCWKKGFYVRYGGDTIQLAPPFISEKAEIDRLINALGDALAETA

Sequences:

>Translated_452_residues
MRFTDLEQPTTAAGPRMDAAWLDAHWMPYTANRSFKANPRMVVEASGAYLTDAGGRKIFDGLSGLWCSGLGHCRREITEA
VSRQVSKLDYAPAFQFGHPLAFELANKIKELTPQGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTRLIGREKGYHG
VNFGGISVGGIAANRKLFGQGVEADHLPHTQPPTGSFHRGMPPTGAELADRLLDVIALHDASNIAAVIVEPFSGSAGVVI
PPQGYLQRLREICTAHNILLIFDEVITGFGRCGAWTGAEAFGVVPDIMNIAKQVTNGAQPLGAVVATKDIYDTFMDAGGP
EYMIEFPHGYTYSAHPVACAAGVAALDVLQKEDMIGRVKALAPHFENAVHSLKGSKHVADIRNYGLAAGFTIAALPGEPA
RRPYEIAMNCWKKGFYVRYGGDTIQLAPPFISEKAEIDRLINALGDALAETA
>Mature_452_residues
MRFTDLEQPTTAAGPRMDAAWLDAHWMPYTANRSFKANPRMVVEASGAYLTDAGGRKIFDGLSGLWCSGLGHCRREITEA
VSRQVSKLDYAPAFQFGHPLAFELANKIKELTPQGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTRLIGREKGYHG
VNFGGISVGGIAANRKLFGQGVEADHLPHTQPPTGSFHRGMPPTGAELADRLLDVIALHDASNIAAVIVEPFSGSAGVVI
PPQGYLQRLREICTAHNILLIFDEVITGFGRCGAWTGAEAFGVVPDIMNIAKQVTNGAQPLGAVVATKDIYDTFMDAGGP
EYMIEFPHGYTYSAHPVACAAGVAALDVLQKEDMIGRVKALAPHFENAVHSLKGSKHVADIRNYGLAAGFTIAALPGEPA
RRPYEIAMNCWKKGFYVRYGGDTIQLAPPFISEKAEIDRLINALGDALAETA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=28.8461538461538, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI37574042, Length=441, Percent_Identity=28.7981859410431, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI13994255, Length=447, Percent_Identity=26.6219239373602, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI226442705, Length=441, Percent_Identity=28.1179138321995, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI226442709, Length=406, Percent_Identity=29.3103448275862, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=28.8753799392097, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI24119277, Length=398, Percent_Identity=28.1407035175879, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=432, Percent_Identity=30.5555555555556, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI145693181, Length=413, Percent_Identity=29.7820823244552, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=29.126213592233, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=29.1770573566085, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789016, Length=434, Percent_Identity=26.4976958525346, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1787560, Length=437, Percent_Identity=27.4599542334096, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=30.03003003003, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=26.8018018018018, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=26.2773722627737, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=27.5395033860045, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=227, Percent_Identity=29.5154185022026, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=25.5220417633411, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=26.6524520255864, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=411, Percent_Identity=25.0608272506083, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357415, Length=447, Percent_Identity=28.1879194630872, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=27.1461716937355, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356575, Length=432, Percent_Identity=26.6203703703704, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI161085790, Length=439, Percent_Identity=26.1958997722096, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48593; Mature: 48593

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFTDLEQPTTAAGPRMDAAWLDAHWMPYTANRSFKANPRMVVEASGAYLTDAGGRKIFD
CCCCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCCCCCCCEEEEECCCEEECCCCHHHHH
GLSGLWCSGLGHCRREITEAVSRQVSKLDYAPAFQFGHPLAFELANKIKELTPQGLDYVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCEEE
FTGSGSEAADTSLKMARAYWRAKGQAGKTRLIGREKGYHGVNFGGISVGGIAANRKLFGQ
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCEECCHHHHCC
GVEADHLPHTQPPTGSFHRGMPPTGAELADRLLDVIALHDASNIAAVIVEPFSGSAGVVI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
PPQGYLQRLREICTAHNILLIFDEVITGFGRCGAWTGAEAFGVVPDIMNIAKQVTNGAQP
CCHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHCCCCC
LGAVVATKDIYDTFMDAGGPEYMIEFPHGYTYSAHPVACAAGVAALDVLQKEDMIGRVKA
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAPHFENAVHSLKGSKHVADIRNYGLAAGFTIAALPGEPARRPYEIAMNCWKKGFYVRYG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEC
GDTIQLAPPFISEKAEIDRLINALGDALAETA
CCEEEECCCHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFTDLEQPTTAAGPRMDAAWLDAHWMPYTANRSFKANPRMVVEASGAYLTDAGGRKIFD
CCCCCCCCCCCCCCCCCCHHHHCCCCCCEECCCCCCCCCCEEEEECCCEEECCCCHHHHH
GLSGLWCSGLGHCRREITEAVSRQVSKLDYAPAFQFGHPLAFELANKIKELTPQGLDYVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCEEE
FTGSGSEAADTSLKMARAYWRAKGQAGKTRLIGREKGYHGVNFGGISVGGIAANRKLFGQ
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCEECCHHHHCC
GVEADHLPHTQPPTGSFHRGMPPTGAELADRLLDVIALHDASNIAAVIVEPFSGSAGVVI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEE
PPQGYLQRLREICTAHNILLIFDEVITGFGRCGAWTGAEAFGVVPDIMNIAKQVTNGAQP
CCHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHCCCCC
LGAVVATKDIYDTFMDAGGPEYMIEFPHGYTYSAHPVACAAGVAALDVLQKEDMIGRVKA
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAPHFENAVHSLKGSKHVADIRNYGLAAGFTIAALPGEPARRPYEIAMNCWKKGFYVRYG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEC
GDTIQLAPPFISEKAEIDRLINALGDALAETA
CCEEEECCCHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]