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The map label for this gene is mmgC [H]

Identifier: 91790028

GI number: 91790028

Start: 4403436

End: 4404617

Strand: Reverse

Name: mmgC [H]

Synonym: Bpro_4190

Alternate gene names: 91790028

Gene position: 4404617-4403436 (Counterclockwise)

Preceding gene: 91790029

Following gene: 91790027

Centisome position: 84.7

GC content: 63.45

Gene sequence:

>1182_bases
ATGACCAACCTGCCAGGACTTGACTTCCAGCTCGGCGAAGAGACCGACGCCCTGCGTGACGCCGTGCGTGAATTTGCGCA
AGCCGAAATCGCGCCGCGCGCCGCCGAACTTGACCGCAACGACCAGTTCCCGATGGACCTGTGGCAAAAAATGGGCGCGC
TGGGCGTGCTCGGCATCACCGTCGGCGAAGAATATGGCGGCGCAGGCATGGGCTACCTGGCCCACATGGTGGCCATGGAA
GAGATCAGCCGGGCCAGCGCCTCCGTGGGGCTGTCCTATGGGGCGCACAGCAATCTGTGCGTCAACCAGATCAAGCGCAA
CGGCACCGACGCGCAGCGCCAGAAATACCTGCCCAAGCTGATTTCCGGCGAGCACGTCGGCGCGCTGGCCATGAGCGAGC
CCGGCGCCGGCAGCGACGTGATTTCGATGAAGCTCAAGGCCGAGGACAATGGCGGCTACTACCTGCTCAACGGCAGCAAG
ATGTGGATCACCAACGGCCCCGACGCCGATACCCTGGTGGTCTACGCGAAAACCGAGCCTGAGCTGGGCGCCCGCGGCGT
GACCGCCTTCCTGATCGAAAAGGGCATGAAGGGCTTTTCGGTGGCGCAAAAGCTCGACAAGCTCGGCATGCGCGGCAGCC
ACACCGGCGAGCTGGTGTTCAGCAATGTCGAAGTGCCGGCGCAAAACATCCTGGGCGGCCTCAATAGCGGCGCCAAGGTG
CTGATGAGCGGCCTTGACTACGAACGCGCCGTGCTGACGGGCGGACCGCTGGGCATCATGCAGGCGGTGATGGACAACGT
GGTGCCCTACATCCACGACCGCAAGCAGTTTGGCCAGAGCATTGGCGAATTCCAGCTGATCCAGGGCAAGGTCGCCGACA
TGTACACCGTGCTGCAGGCCGGGCGCTCCTTCGCCTATACCGTGGCCAAAAACCTGGACATGCGGGGCGCGGAGCATGCA
CGCCAGGTCCGCAAGGACTGCGCTTCCGTCATTCTCTGGTGCGCCGAAAAGGCCACCTGGATGGCCGGCGAGGGTGTGCA
GATTTTTGGCGGCAACGGCTACATCAACGACTACCCGCTCGGACGCCTCTGGCGCGACGCCAAACTTTATGAAATCGGTG
CCGGCACCAGCGAGATCCGCCGCATGCTGATAGGCCGTGAACTGTTTGCCGAAACCTGCTGA

Upstream 100 bases:

>100_bases
CTCGTTCCCGTGCCCAAGACCTACTGACAACCCGCAAGAACCAGCCCGGTCGCCCCCATGCACCTGGCTACCTCTGTAAC
CTCCCGCGAAAGACGCCATC

Downstream 100 bases:

>100_bases
GGCCCGTACCCTGGCGCAACGAATGGCCAAGGGATGACCCTGTGAGGCCGCCCGGCCTGCAACTGATTAAGATCGTTCCC
ATGACAGCATCACTTGAAAG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTNLPGLDFQLGEETDALRDAVREFAQAEIAPRAAELDRNDQFPMDLWQKMGALGVLGITVGEEYGGAGMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIKRNGTDAQRQKYLPKLISGEHVGALAMSEPGAGSDVISMKLKAEDNGGYYLLNGSK
MWITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSVAQKLDKLGMRGSHTGELVFSNVEVPAQNILGGLNSGAKV
LMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRKQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMRGAEHA
RQVRKDCASVILWCAEKATWMAGEGVQIFGGNGYINDYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETC

Sequences:

>Translated_393_residues
MTNLPGLDFQLGEETDALRDAVREFAQAEIAPRAAELDRNDQFPMDLWQKMGALGVLGITVGEEYGGAGMGYLAHMVAME
EISRASASVGLSYGAHSNLCVNQIKRNGTDAQRQKYLPKLISGEHVGALAMSEPGAGSDVISMKLKAEDNGGYYLLNGSK
MWITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSVAQKLDKLGMRGSHTGELVFSNVEVPAQNILGGLNSGAKV
LMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRKQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMRGAEHA
RQVRKDCASVILWCAEKATWMAGEGVQIFGGNGYINDYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETC
>Mature_392_residues
TNLPGLDFQLGEETDALRDAVREFAQAEIAPRAAELDRNDQFPMDLWQKMGALGVLGITVGEEYGGAGMGYLAHMVAMEE
ISRASASVGLSYGAHSNLCVNQIKRNGTDAQRQKYLPKLISGEHVGALAMSEPGAGSDVISMKLKAEDNGGYYLLNGSKM
WITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSVAQKLDKLGMRGSHTGELVFSNVEVPAQNILGGLNSGAKVL
MSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRKQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMRGAEHAR
QVRKDCASVILWCAEKATWMAGEGVQIFGGNGYINDYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETC

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=61.8181818181818, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=64.367816091954, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=38.1578947368421, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=35.0923482849604, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=32.7319587628866, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI21361497, Length=383, Percent_Identity=35.7702349869452, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=34.1968911917098, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=34.1968911917098, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI76496475, Length=356, Percent_Identity=35.6741573033708, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4557235, Length=356, Percent_Identity=35.6741573033708, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=30.6493506493506, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=33.0749354005168, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=34.0720221606648, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=24.6527777777778, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=24.6527777777778, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38505218, Length=281, Percent_Identity=20.2846975088968, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=27.8350515463918, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.4611398963731, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=25.5255255255255, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082384, Length=253, Percent_Identity=24.5059288537549, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=60.2597402597403, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=33.2446808510638, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=34.020618556701, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=32.5520833333333, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=33.160621761658, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=32.6478149100257, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=31.151832460733, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=38.1625441696113, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.2394366197183, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=29.639175257732, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=33.0909090909091, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=35.5633802816901, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=29.4906166219839, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=30.4812834224599, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=26.2295081967213, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=60.9254498714653, Blast_Score=463, Evalue=1e-131,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=38.5826771653543, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.007874015748, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=33.5078534031414, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=32.9048843187661, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=32.5581395348837, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=30.4123711340206, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24652780, Length=312, Percent_Identity=24.6794871794872, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42534; Mature: 42403

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLPGLDFQLGEETDALRDAVREFAQAEIAPRAAELDRNDQFPMDLWQKMGALGVLGIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCCCEEEEEE
VGEEYGGAGMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIKRNGTDAQRQKYLPKL
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
ISGEHVGALAMSEPGAGSDVISMKLKAEDNGGYYLLNGSKMWITNGPDADTLVVYAKTEP
HCCCCCCEEEECCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCEEEEEEECCC
ELGARGVTAFLIEKGMKGFSVAQKLDKLGMRGSHTGELVFSNVEVPAQNILGGLNSGAKV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCCHHH
LMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRKQFGQSIGEFQLIQGKVADMYTVLQA
HHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHC
GRSFAYTVAKNLDMRGAEHARQVRKDCASVILWCAEKATWMAGEGVQIFGGNGYINDYPL
CCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCH
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETC
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNLPGLDFQLGEETDALRDAVREFAQAEIAPRAAELDRNDQFPMDLWQKMGALGVLGIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCCCEEEEEE
VGEEYGGAGMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIKRNGTDAQRQKYLPKL
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
ISGEHVGALAMSEPGAGSDVISMKLKAEDNGGYYLLNGSKMWITNGPDADTLVVYAKTEP
HCCCCCCEEEECCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCEEEEEEECCC
ELGARGVTAFLIEKGMKGFSVAQKLDKLGMRGSHTGELVFSNVEVPAQNILGGLNSGAKV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCCCHHH
LMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRKQFGQSIGEFQLIQGKVADMYTVLQA
HHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHC
GRSFAYTVAKNLDMRGAEHARQVRKDCASVILWCAEKATWMAGEGVQIFGGNGYINDYPL
CCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCH
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETC
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]