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The map label for this gene is yngE [H]

Identifier: 91789998

GI number: 91789998

Start: 4375118

End: 4376725

Strand: Reverse

Name: yngE [H]

Synonym: Bpro_4160

Alternate gene names: 91789998

Gene position: 4376725-4375118 (Counterclockwise)

Preceding gene: 91789999

Following gene: 91789997

Centisome position: 84.16

GC content: 63.5

Gene sequence:

>1608_bases
ATGACCATCCTCGATACCAATTTGAACCCCCGCTCGGCCGATTTTCAGGCCAACGCCGACGCCATGCGCGCGCTGGTGGA
CGACCTCCATGTGCAGATTGCCAAGGCGGCGGCCGGCGGTGGTGACGCCGCGCGCGCCAAGCACACGGCCCGCGGCAAGC
TGCTGCCGCGCGAGCGCGTGCAGATGCTGCTGGACCCGGGCACACCATTCCTTGAATTGGCGCCGCTGGCCGCGCACGGC
ATGTACCACGGCGATGCGCCCTGCGCCGGCCTCATTGCGGGCATAGGCCGCGTCAGTGGCGTGGACTGCATGATCGTCTG
CAATGACGCCACCGTCAAAGGCGGCACCTACTACCCGCTCACGGTCAAAAAACATTTGCGGGCCCAGGAAATCGCGCAGC
AGAACTGCTTGCCCTGTGTTTACCTGGTGGACTCGGGCGGCGCCAATTTGCCGAACCAGGACGAGGTGTTTCCTGACCGC
GATCACTTCGGCCGCATCTTTTACAACCAGGCCAATATGAGCGCGCAGGGCATCGCACAGATTGCCGTGGTGATGGGCTC
CTGCACGGCGGGCGGTGCGTATGTGCCTGCCATGAGCGACGAAAGCATCATCGTCAAGAACCAGGGCACGATTTTTCTGG
GTGGGCCGCCCCTGGTCAAGGCGGCGACGGGCGAAGTCGTCAGCGCCGAGGACCTGGGCGGTGGCGATGTGCACACCCGC
CTGTCGGGCGTGGCCGATCATCTGGCGCAAAACGACATGCATGCGCTGGCGCTGGCCCGTGCCTCCGTCAAGAATTTGAA
TAAAAACAAGGCCTCAGCCCAGACGGTACAGGCGTCAATAGCTCCTAAATTCATGGCAAAAGAGCTGTACGGCGTGATTC
CCGTGGACACGCGCAAACCCTTCGACGTGCGCGAGATCATCGCCCGCATCGTCGATGGCAGCGAGTTCGACGAGTTCAAG
GCGCGTTACGGCGCCACGCTGGTCTGCGGCTTCGCGCATATCGAGGGCATGCCGGTCGGCATCATTGCCAACAATGGCAT
TTTGTTCAGCGAGTCGGCGCTCAAGGCCACGCATTTCATCGAGCTGTGCTGCCAGCGCAAGATTCCGCTGGTGTTCTTGC
AGAACATCACCGGCTTCATGGTGGGCCGCAAGTACGAAAACGAAGGCATCGCGCGCAATGGCGCCAAGATGGTCACGGCC
GTGGCCACGGCGGCGGTGCCCAAGTTCACCATCATCATCGGCGGCAGCTTTGGCGCGGGCAACTACGGCATGTGCGGCCG
CGCCTATTCGCCGCGCTTCCTCTGGATGTGGCCGAACGCGCGCATCAGCGTGATGGGCGGCGACCAGGCCGCCGGCGTAC
TGGCAACGGTCAAGCGCGACGGCATTGAAGCCAAGGGCGGCGCCTGGTCGCCCGAGGAGGAAGAGGCCTTCAAGGCGCCG
ATACGCCAGCAGTACGAACACCAGGGCCACCCCTACTATGCGACGGCGCGGCTCTGGGATGACGGTGTGATCGACCCGGC
CGATACGCGCCGTGTGCTGGCGCTGGGCTTGAGCGCTGCGCGCAATGCGCCGATTCCAGAGACCAAGTTTGGTTTGTTCA
GGATGTAA

Upstream 100 bases:

>100_bases
TGACGGTGACCGGCAAAATCCAGAAGTTCAAGATTCGCGACGAAATGAAGCACCAGCTGGGGCTGGAAGAAGACAAAACC
GCTTGAAAGAGACAGTCTGA

Downstream 100 bases:

>100_bases
GCCATGGCTGCAATTCAAATTACCCAAGCGGGGCCGCTGCTGACCCTCACCCTGAGTCGTCCGGAGGTGCGCAATGCTTT
CAACGATGAAGTGATCGCCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTILDTNLNPRSADFQANADAMRALVDDLHVQIAKAAAGGGDAARAKHTARGKLLPRERVQMLLDPGTPFLELAPLAAHG
MYHGDAPCAGLIAGIGRVSGVDCMIVCNDATVKGGTYYPLTVKKHLRAQEIAQQNCLPCVYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQANMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLAQNDMHALALARASVKNLNKNKASAQTVQASIAPKFMAKELYGVIPVDTRKPFDVREIIARIVDGSEFDEFK
ARYGATLVCGFAHIEGMPVGIIANNGILFSESALKATHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAAVPKFTIIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGDQAAGVLATVKRDGIEAKGGAWSPEEEEAFKAP
IRQQYEHQGHPYYATARLWDDGVIDPADTRRVLALGLSAARNAPIPETKFGLFRM

Sequences:

>Translated_535_residues
MTILDTNLNPRSADFQANADAMRALVDDLHVQIAKAAAGGGDAARAKHTARGKLLPRERVQMLLDPGTPFLELAPLAAHG
MYHGDAPCAGLIAGIGRVSGVDCMIVCNDATVKGGTYYPLTVKKHLRAQEIAQQNCLPCVYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQANMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLAQNDMHALALARASVKNLNKNKASAQTVQASIAPKFMAKELYGVIPVDTRKPFDVREIIARIVDGSEFDEFK
ARYGATLVCGFAHIEGMPVGIIANNGILFSESALKATHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAAVPKFTIIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGDQAAGVLATVKRDGIEAKGGAWSPEEEEAFKAP
IRQQYEHQGHPYYATARLWDDGVIDPADTRRVLALGLSAARNAPIPETKFGLFRM
>Mature_534_residues
TILDTNLNPRSADFQANADAMRALVDDLHVQIAKAAAGGGDAARAKHTARGKLLPRERVQMLLDPGTPFLELAPLAAHGM
YHGDAPCAGLIAGIGRVSGVDCMIVCNDATVKGGTYYPLTVKKHLRAQEIAQQNCLPCVYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQANMSAQGIAQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADHLAQNDMHALALARASVKNLNKNKASAQTVQASIAPKFMAKELYGVIPVDTRKPFDVREIIARIVDGSEFDEFKA
RYGATLVCGFAHIEGMPVGIIANNGILFSESALKATHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAAVPKFTIIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGDQAAGVLATVKRDGIEAKGGAWSPEEEEAFKAPI
RQQYEHQGHPYYATARLWDDGVIDPADTRRVLALGLSAARNAPIPETKFGLFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=66.4165103189493, Blast_Score=719, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=489, Percent_Identity=31.6973415132924, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI295821216, Length=510, Percent_Identity=30.3921568627451, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=60, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=60.2251407129456, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=489, Percent_Identity=33.1288343558282, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI25147362, Length=489, Percent_Identity=33.1288343558282, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=63.7023593466425, Blast_Score=719, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57170; Mature: 57039

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILDTNLNPRSADFQANADAMRALVDDLHVQIAKAAAGGGDAARAKHTARGKLLPRERV
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
QMLLDPGTPFLELAPLAAHGMYHGDAPCAGLIAGIGRVSGVDCMIVCNDATVKGGTYYPL
HEEECCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIAQQNCLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQANMSAQGIAQ
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
HHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLAQNDMHALALARASVKNLNKNKASAQTVQASIAPKFMAKELYGVIPVDTRKP
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCC
FDVREIIARIVDGSEFDEFKARYGATLVCGFAHIEGMPVGIIANNGILFSESALKATHFI
CCHHHHHHHHHCCCCHHHHHHHHCCEEEEEEHHHCCCEEEEEECCCEEEECHHHHHHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAAVPKFTIIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGDQAAGVLATVKRDGIEAKGGAWSPEEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEHHHCCCCCCCCCCCCCHHHHHHHH
IRQQYEHQGHPYYATARLWDDGVIDPADTRRVLALGLSAARNAPIPETKFGLFRM
HHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TILDTNLNPRSADFQANADAMRALVDDLHVQIAKAAAGGGDAARAKHTARGKLLPRERV
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
QMLLDPGTPFLELAPLAAHGMYHGDAPCAGLIAGIGRVSGVDCMIVCNDATVKGGTYYPL
HEEECCCCCCEEECHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIAQQNCLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQANMSAQGIAQ
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGGDVHTR
HHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLAQNDMHALALARASVKNLNKNKASAQTVQASIAPKFMAKELYGVIPVDTRKP
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCC
FDVREIIARIVDGSEFDEFKARYGATLVCGFAHIEGMPVGIIANNGILFSESALKATHFI
CCHHHHHHHHHCCCCHHHHHHHHCCEEEEEEHHHCCCEEEEEECCCEEEECHHHHHHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAAVPKFTIIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGDQAAGVLATVKRDGIEAKGGAWSPEEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEHHHCCCCCCCCCCCCCHHHHHHHH
IRQQYEHQGHPYYATARLWDDGVIDPADTRRVLALGLSAARNAPIPETKFGLFRM
HHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]