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The map label for this gene is mvaB [H]

Identifier: 91789993

GI number: 91789993

Start: 4369381

End: 4370301

Strand: Reverse

Name: mvaB [H]

Synonym: Bpro_4155

Alternate gene names: 91789993

Gene position: 4370301-4369381 (Counterclockwise)

Preceding gene: 91789994

Following gene: 91789992

Centisome position: 84.04

GC content: 62.11

Gene sequence:

>921_bases
ATGAAACTTCCATCCAAAGTCAAAATCGTCGATGTCGGCCCGCGCGACGGCTTGCAAAACGAAAAAGCACCGGTGCCTGC
CGCCGTGAAGATCGAGCTGGTGCACCGCCTGCAGGACGCCGGCCTCACTGAAATCGAAGTCACCAGTTTTGTCTCGCCCA
AATGGGTGCCGCAGATGGCCGACAACGCGGAAGTGATGGCCGGCATACGGCGCAAGCCGGGCGTGCGCTATTCGGTGCTG
ACGCCCAACATGAAAGGCTTTGAGGCGGCGCTCGCGCCGGCGCGTGAGTTGTGGCCCGATGAGATCGTGGTGTTTGCCGC
CGCCAGCGAGGCCTTCAGCCAGCGCAACATCAATTGCTCCATCACCGAGAGCATTGAACGATTCCGCCCGGTGGTGGAGG
CGGCCAAGGCCCACAACATCTATGTCCGCGGCGCCATCTCCTGCACCGTCGGATGTCCCTACGAAGGCGAGATCGCACCG
CAACGAGTCGAGCTGGTGGCGCGCCTCATGAAGGACATCGGCGTGCAGCACATCGGCGTGGCCGACACCATTGGCGTGGG
CACGCCCCTGAAGGTGCAGCGCGCCCTGGAGGCTGCGCTCAAGCACTATGCGCTTGACGACGTGTCGGGCCACTTCCACG
ATACCTACGGGCAGGCCCTGAGCAACACCCTGGCATCCCTGCAGATGGGTGTCTGGCAATTCGATACCTCGTCGGCCGGT
CTCGGCGGCTGCCCGTTTGCCAAAGGTGCCACCGGCAACGTGGCCACTGAAGATGTGGTGTACCTGCTGCACGGCATGGG
TATCGAGACCGGCATTGACATGGACAAGCTGATCGATGCCGGGAAATTCATCAGCGATTTCCTGGAGCGCAAGCCCAACT
CACGCGCGGCGACCGCGCTCCTTAACAAACGACTGAACTAA

Upstream 100 bases:

>100_bases
CTTCGACACGCTCAGGACAGGCCAAGGCCGGTTCCGCGGCCCCTGCTTGGCTGAGAACCGGTCCCCGGCTCGCGACCACC
CTATCTCCTGAAGGAGCCCC

Downstream 100 bases:

>100_bases
TGTGTAATCACATAAGCGACGGCTTGACCATTTTCCGCCGGGCTGACCCTGCACAATCCAGCCGGGGCCGCGGAACCGGC
TTAGCCGGGCCGCAGGCGCA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKLPSKVKIVDVGPRDGLQNEKAPVPAAVKIELVHRLQDAGLTEIEVTSFVSPKWVPQMADNAEVMAGIRRKPGVRYSVL
TPNMKGFEAALAPARELWPDEIVVFAAASEAFSQRNINCSITESIERFRPVVEAAKAHNIYVRGAISCTVGCPYEGEIAP
QRVELVARLMKDIGVQHIGVADTIGVGTPLKVQRALEAALKHYALDDVSGHFHDTYGQALSNTLASLQMGVWQFDTSSAG
LGGCPFAKGATGNVATEDVVYLLHGMGIETGIDMDKLIDAGKFISDFLERKPNSRAATALLNKRLN

Sequences:

>Translated_306_residues
MKLPSKVKIVDVGPRDGLQNEKAPVPAAVKIELVHRLQDAGLTEIEVTSFVSPKWVPQMADNAEVMAGIRRKPGVRYSVL
TPNMKGFEAALAPARELWPDEIVVFAAASEAFSQRNINCSITESIERFRPVVEAAKAHNIYVRGAISCTVGCPYEGEIAP
QRVELVARLMKDIGVQHIGVADTIGVGTPLKVQRALEAALKHYALDDVSGHFHDTYGQALSNTLASLQMGVWQFDTSSAG
LGGCPFAKGATGNVATEDVVYLLHGMGIETGIDMDKLIDAGKFISDFLERKPNSRAATALLNKRLN
>Mature_306_residues
MKLPSKVKIVDVGPRDGLQNEKAPVPAAVKIELVHRLQDAGLTEIEVTSFVSPKWVPQMADNAEVMAGIRRKPGVRYSVL
TPNMKGFEAALAPARELWPDEIVVFAAASEAFSQRNINCSITESIERFRPVVEAAKAHNIYVRGAISCTVGCPYEGEIAP
QRVELVARLMKDIGVQHIGVADTIGVGTPLKVQRALEAALKHYALDDVSGHFHDTYGQALSNTLASLQMGVWQFDTSSAG
LGGCPFAKGATGNVATEDVVYLLHGMGIETGIDMDKLIDAGKFISDFLERKPNSRAATALLNKRLN

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=297, Percent_Identity=55.5555555555556, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI109150422, Length=300, Percent_Identity=54, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI109150427, Length=300, Percent_Identity=54, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=51.4925373134328, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17510563, Length=300, Percent_Identity=45.6666666666667, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6320071, Length=241, Percent_Identity=26.5560165975104, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=55.6701030927835, Blast_Score=339, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33047; Mature: 33047

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPSKVKIVDVGPRDGLQNEKAPVPAAVKIELVHRLQDAGLTEIEVTSFVSPKWVPQMA
CCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCHHHC
DNAEVMAGIRRKPGVRYSVLTPNMKGFEAALAPARELWPDEIVVFAAASEAFSQRNINCS
CCHHHHHHHHCCCCCEEEEECCCCCCHHHHHCCHHHCCCCCEEEEEECHHHHHHCCCCEE
ITESIERFRPVVEAAKAHNIYVRGAISCTVGCPYEGEIAPQRVELVARLMKDIGVQHIGV
HHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
ADTIGVGTPLKVQRALEAALKHYALDDVSGHFHDTYGQALSNTLASLQMGVWQFDTSSAG
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCC
LGGCPFAKGATGNVATEDVVYLLHGMGIETGIDMDKLIDAGKFISDFLERKPNSRAATAL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LNKRLN
HHHCCC
>Mature Secondary Structure
MKLPSKVKIVDVGPRDGLQNEKAPVPAAVKIELVHRLQDAGLTEIEVTSFVSPKWVPQMA
CCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCHHHC
DNAEVMAGIRRKPGVRYSVLTPNMKGFEAALAPARELWPDEIVVFAAASEAFSQRNINCS
CCHHHHHHHHCCCCCEEEEECCCCCCHHHHHCCHHHCCCCCEEEEEECHHHHHHCCCCEE
ITESIERFRPVVEAAKAHNIYVRGAISCTVGCPYEGEIAPQRVELVARLMKDIGVQHIGV
HHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
ADTIGVGTPLKVQRALEAALKHYALDDVSGHFHDTYGQALSNTLASLQMGVWQFDTSSAG
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCC
LGGCPFAKGATGNVATEDVVYLLHGMGIETGIDMDKLIDAGKFISDFLERKPNSRAATAL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LNKRLN
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]