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The map label for this gene is ttcA

Identifier: 91789928

GI number: 91789928

Start: 4298222

End: 4299157

Strand: Direct

Name: ttcA

Synonym: Bpro_4089

Alternate gene names: 91789928

Gene position: 4298222-4299157 (Clockwise)

Preceding gene: 91789927

Following gene: 91789929

Centisome position: 82.65

GC content: 58.76

Gene sequence:

>936_bases
ATGAGCGCCGTATGGATGGACGAACAGGTTGAGAGTTCTGCACGGGTGCAGAACAGCCTGAAGATCGAGCGTGAGGACCA
CAAGCTTGAAAAGCGCCTGTGCCGCGAAGTCGGCCGTGCGATTGTCGACTTCAACATGATTGAAGAGGGCGACAAGGTGA
TGGTGTGCGTCTCTGGCGGCAAAGACAGCTACGCCATGCTCGACATTTTGCTGAAACTGCAAAAGCGCGCGCCCATCAGG
TTCGACCTGATCGCCGTCAACCTGGACCAGAAGCAGCCTGGCTTCCCGAAGCATGTGCTGCCTGACTACCTGGGCAAGCT
GGACGTGCCTTTCCACATTGAAAACCAGGACACCTACAGCATCGTCAAGCGCGTGATTCCGGAAGGCAAAACACTGTGCT
CGCTGTGCTCGCGCCTGCGGCGGGGCATTTTGTACCGTGTGGCGGGCGAACTCGGCGCCACCAAGATCGCGCTGGGCCAT
CACCGTGACGACATGCTGCAGACATTCTTCCTGAACATGTTTTTTGCGGCCAAACTCAAGGGCATGCCACCCAAGCTGGT
CAGCGATGACGGCAAGAACATTGTGATCCGGCCCATGGCCTATGTGCCTGAAAAAGACCTGACGCGCTGGGCCCAGGTGC
GCGACTTCCCCATCATTCCGTGCACGCTCTGCGGCAGCCAGGAAAACCTGCAGCGCAAGCAGGTCGGCAACATGCTGCGC
GAGTGGGAGAAAAAGCACTCGGGGCGGCTGGAGAACATGTTTTCTGCGCTGCAGAACATCGTGCCCTCGCACCTGATGGA
CAGCAAGCGCCATGACTTCAAGAACATCCGGACCACCGGTGTTGCCGATGCCGAAGGGGACAAGGCATTTGACGCGGAAG
AGTTCAGCGAGCCGCAGCGACCCGGCCTTTCCGTGATTGACATCGCATCGCGCTGA

Upstream 100 bases:

>100_bases
TGCCCGGCGTGCTGGGGGTGCGGGTGAGGATTGCCAAACTTGAAATTTTTGACGACTGCGAAGTAGCCATTCGCGTCGAG
ACAGGACAGTGGTGACACCG

Downstream 100 bases:

>100_bases
GCAACAAAATATTCAGAAAAGTTAGCCTGCAGCCCTTATGAAACGAGCATTTTTAGCTGCTATTTCAATAGCATTTCTCG
CGTTCCTCATGGGAGGCTGC

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSAVWMDEQVESSARVQNSLKIEREDHKLEKRLCREVGRAIVDFNMIEEGDKVMVCVSGGKDSYAMLDILLKLQKRAPIR
FDLIAVNLDQKQPGFPKHVLPDYLGKLDVPFHIENQDTYSIVKRVIPEGKTLCSLCSRLRRGILYRVAGELGATKIALGH
HRDDMLQTFFLNMFFAAKLKGMPPKLVSDDGKNIVIRPMAYVPEKDLTRWAQVRDFPIIPCTLCGSQENLQRKQVGNMLR
EWEKKHSGRLENMFSALQNIVPSHLMDSKRHDFKNIRTTGVADAEGDKAFDAEEFSEPQRPGLSVIDIASR

Sequences:

>Translated_311_residues
MSAVWMDEQVESSARVQNSLKIEREDHKLEKRLCREVGRAIVDFNMIEEGDKVMVCVSGGKDSYAMLDILLKLQKRAPIR
FDLIAVNLDQKQPGFPKHVLPDYLGKLDVPFHIENQDTYSIVKRVIPEGKTLCSLCSRLRRGILYRVAGELGATKIALGH
HRDDMLQTFFLNMFFAAKLKGMPPKLVSDDGKNIVIRPMAYVPEKDLTRWAQVRDFPIIPCTLCGSQENLQRKQVGNMLR
EWEKKHSGRLENMFSALQNIVPSHLMDSKRHDFKNIRTTGVADAEGDKAFDAEEFSEPQRPGLSVIDIASR
>Mature_310_residues
SAVWMDEQVESSARVQNSLKIEREDHKLEKRLCREVGRAIVDFNMIEEGDKVMVCVSGGKDSYAMLDILLKLQKRAPIRF
DLIAVNLDQKQPGFPKHVLPDYLGKLDVPFHIENQDTYSIVKRVIPEGKTLCSLCSRLRRGILYRVAGELGATKIALGHH
RDDMLQTFFLNMFFAAKLKGMPPKLVSDDGKNIVIRPMAYVPEKDLTRWAQVRDFPIIPCTLCGSQENLQRKQVGNMLRE
WEKKHSGRLENMFSALQNIVPSHLMDSKRHDFKNIRTTGVADAEGDKAFDAEEFSEPQRPGLSVIDIASR

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=276, Percent_Identity=66.6666666666667, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI193211090, Length=266, Percent_Identity=31.203007518797, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17540090, Length=222, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651972, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_POLSJ (Q124R0)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_550880.1
- ProteinModelPortal:   Q124R0
- SMR:   Q124R0
- STRING:   Q124R0
- GeneID:   4013261
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_4089
- NMPDR:   fig|296591.1.peg.4155
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   Q124R0
- ProtClustDB:   PRK10696
- BioCyc:   PSP296591:BPRO_4089-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 35409; Mature: 35277

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVWMDEQVESSARVQNSLKIEREDHKLEKRLCREVGRAIVDFNMIEEGDKVMVCVSGG
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
KDSYAMLDILLKLQKRAPIRFDLIAVNLDQKQPGFPKHVLPDYLGKLDVPFHIENQDTYS
CCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCHHH
IVKRVIPEGKTLCSLCSRLRRGILYRVAGELGATKIALGHHRDDMLQTFFLNMFFAAKLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
GMPPKLVSDDGKNIVIRPMAYVPEKDLTRWAQVRDFPIIPCTLCGSQENLQRKQVGNMLR
CCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
EWEKKHSGRLENMFSALQNIVPSHLMDSKRHDFKNIRTTGVADAEGDKAFDAEEFSEPQR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PGLSVIDIASR
CCCEEEEECCC
>Mature Secondary Structure 
SAVWMDEQVESSARVQNSLKIEREDHKLEKRLCREVGRAIVDFNMIEEGDKVMVCVSGG
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
KDSYAMLDILLKLQKRAPIRFDLIAVNLDQKQPGFPKHVLPDYLGKLDVPFHIENQDTYS
CCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCHHH
IVKRVIPEGKTLCSLCSRLRRGILYRVAGELGATKIALGHHRDDMLQTFFLNMFFAAKLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
GMPPKLVSDDGKNIVIRPMAYVPEKDLTRWAQVRDFPIIPCTLCGSQENLQRKQVGNMLR
CCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
EWEKKHSGRLENMFSALQNIVPSHLMDSKRHDFKNIRTTGVADAEGDKAFDAEEFSEPQR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCC
PGLSVIDIASR
CCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA