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The map label for this gene is uxuB [H]

Identifier: 91789810

GI number: 91789810

Start: 4162997

End: 4164418

Strand: Reverse

Name: uxuB [H]

Synonym: Bpro_3970

Alternate gene names: 91789810

Gene position: 4164418-4162997 (Counterclockwise)

Preceding gene: 91789811

Following gene: 91789802

Centisome position: 80.08

GC content: 68.14

Gene sequence:

>1422_bases
ATGCAGCCATTGAACCAAGCCACACTGACGCAGTTGACGGACTCTGCGCTTGCCACACCATCGCCTGTTCAACTGCCGCG
CTACCGCCGCACCGATGCCCGCGTGGGCGTGGTGCATCTGGGGCTGGGCGCTTTTCATCGCGCCCACCAGGCCATGGTGT
TTGATGCCCTGTTGCAGCGCGGCGACCCGCGTTGGGGCGTGCTGGGCGTGGCCATGCGCACGACCGAACTGGCCGATGCG
CTGACCGCGCAAGATGGGCTGTATGCGGTGCAGGTGGCCAGTCGCGAGGCGCTGCGCTGGCAGGTGGTCGGCTCGGTGTT
GCAGGCCTGTGTGGCGGCGCGTGAGCCTGCGCAGGTGGTGGCGGCCATGGCCGCACCCGGCACGCGCTGGGTGACGCTGA
CGGTGACCGAAAAAGGCTATGGCCCGGCGCTGGCGGCCTTGCTGGTGCAGGGGCTGGCGGCGCGCCGTGCAGCGGGTCTG
GGCGGGCTGACGATCGCGTCCTGCGACAACCTCTCCGACAACGGCCGCAAGCTGCAGCAACTGTGTGTGGATGCGGCGCA
GCACGATGCTGCGCTGGCGCAGTGGATTGACACCGCCTGCGCCTTCCCCAACAGCATGGTCGACCGCATTGTTCCGGCCG
CCACCGCACAGCATCGCAGCGATGCGGCACAGGCGCTGGGACTGGCGGATGCCTGCGCCCTGGGCACCGAAGAATTTTGG
GAGTGGGTGATCGAGCGCCGCTTTGTCGACGACGCGGATGGCGACGCGCTGGCGGCTGTCGGGGTCCAGGTGGTGGCAGA
CGTCAAACCCTTTGAGGAGGCCAAGCTGCGCATGCTCAACGGCAGTCACACGGCCATCGCGTTGATCGGTGCGGTGCTGG
GTGTGCCCACGGTGGCCGACTGCATTGCCCGGCCTGACATCCACCGTTTTGTTCGCAGCCTGATGACCGAGGTGGTGATG
CCGCATCTGCAGCGTCCCGGGCTGCCCGCCTACCGCGATGCCTTGCTGGCGCGCTTTGCCAATCCCGAACTCCGGCACAA
GGTGCACCAGATCGCCACTGACAGCTCGCTCAAGATTCCGCTGCGCTGGCAAGCGACGGTGCTGGCGCAACTGGCGGCGA
ACGGCTCGATCGAGCCCCTGGCGCTGGCCGCGGCGGTGTGGATGCGCTACCTGCTGGGCGCCGATGAACAAGGCCAGGCT
TATGCCATCTCGGACCCGCTGGGGCAGGCCTTGCAGGCCACCGCGCAGCGGCGCCGGGACGATGTGGCTGGCACGGTGCG
TGCGCTGCTCGCTGTGAGCTCGATATGGGGCGAGGTGTTACCGCACGACGTACGCTGGACCGCGCGCGTGGAACACTGGT
TGCAGGTCATTCGGCGCCAGGGTGTCGCCGCTGCGCTGGCGCAGCTGCATCCGTCAGACTGA

Upstream 100 bases:

>100_bases
TGGCAGCCAGGGTTTCACCGACACTGGCGAGCGGCTGCCCATTGCCTTCGGCAGCTTTGCCGCCATCCGCACCGTCGATT
TTCCATCCACCTGATCACCT

Downstream 100 bases:

>100_bases
GTCCTTGCCGGGACTCGGCGCACGGGTTGCGCCGCACGCACCGCTGCGGCCTGTTCGCACCGCGGTCGGGGTGCGAACAG
GCGCGGGCTCACTCAATCGA

Product: mannitol dehydrogenase-like protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQPLNQATLTQLTDSALATPSPVQLPRYRRTDARVGVVHLGLGAFHRAHQAMVFDALLQRGDPRWGVLGVAMRTTELADA
LTAQDGLYAVQVASREALRWQVVGSVLQACVAAREPAQVVAAMAAPGTRWVTLTVTEKGYGPALAALLVQGLAARRAAGL
GGLTIASCDNLSDNGRKLQQLCVDAAQHDAALAQWIDTACAFPNSMVDRIVPAATAQHRSDAAQALGLADACALGTEEFW
EWVIERRFVDDADGDALAAVGVQVVADVKPFEEAKLRMLNGSHTAIALIGAVLGVPTVADCIARPDIHRFVRSLMTEVVM
PHLQRPGLPAYRDALLARFANPELRHKVHQIATDSSLKIPLRWQATVLAQLAANGSIEPLALAAAVWMRYLLGADEQGQA
YAISDPLGQALQATAQRRRDDVAGTVRALLAVSSIWGEVLPHDVRWTARVEHWLQVIRRQGVAAALAQLHPSD

Sequences:

>Translated_473_residues
MQPLNQATLTQLTDSALATPSPVQLPRYRRTDARVGVVHLGLGAFHRAHQAMVFDALLQRGDPRWGVLGVAMRTTELADA
LTAQDGLYAVQVASREALRWQVVGSVLQACVAAREPAQVVAAMAAPGTRWVTLTVTEKGYGPALAALLVQGLAARRAAGL
GGLTIASCDNLSDNGRKLQQLCVDAAQHDAALAQWIDTACAFPNSMVDRIVPAATAQHRSDAAQALGLADACALGTEEFW
EWVIERRFVDDADGDALAAVGVQVVADVKPFEEAKLRMLNGSHTAIALIGAVLGVPTVADCIARPDIHRFVRSLMTEVVM
PHLQRPGLPAYRDALLARFANPELRHKVHQIATDSSLKIPLRWQATVLAQLAANGSIEPLALAAAVWMRYLLGADEQGQA
YAISDPLGQALQATAQRRRDDVAGTVRALLAVSSIWGEVLPHDVRWTARVEHWLQVIRRQGVAAALAQLHPSD
>Mature_473_residues
MQPLNQATLTQLTDSALATPSPVQLPRYRRTDARVGVVHLGLGAFHRAHQAMVFDALLQRGDPRWGVLGVAMRTTELADA
LTAQDGLYAVQVASREALRWQVVGSVLQACVAAREPAQVVAAMAAPGTRWVTLTVTEKGYGPALAALLVQGLAARRAAGL
GGLTIASCDNLSDNGRKLQQLCVDAAQHDAALAQWIDTACAFPNSMVDRIVPAATAQHRSDAAQALGLADACALGTEEFW
EWVIERRFVDDADGDALAAVGVQVVADVKPFEEAKLRMLNGSHTAIALIGAVLGVPTVADCIARPDIHRFVRSLMTEVVM
PHLQRPGLPAYRDALLARFANPELRHKVHQIATDSSLKIPLRWQATVLAQLAANGSIEPLALAAAVWMRYLLGADEQGQA
YAISDPLGQALQATAQRRRDDVAGTVRALLAVSSIWGEVLPHDVRWTARVEHWLQVIRRQGVAAALAQLHPSD

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=495, Percent_Identity=37.1717171717172, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1788497, Length=483, Percent_Identity=36.4389233954451, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1787823, Length=475, Percent_Identity=38.1052631578947, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI48994885, Length=467, Percent_Identity=26.9807280513919, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790028, Length=226, Percent_Identity=26.9911504424779, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324401, Length=504, Percent_Identity=32.1428571428571, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6320765, Length=504, Percent_Identity=32.1428571428571, Blast_Score=253, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 50764; Mature: 50764

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLNQATLTQLTDSALATPSPVQLPRYRRTDARVGVVHLGLGAFHRAHQAMVFDALLQR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHC
GDPRWGVLGVAMRTTELADALTAQDGLYAVQVASREALRWQVVGSVLQACVAAREPAQVV
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAMAAPGTRWVTLTVTEKGYGPALAALLVQGLAARRAAGLGGLTIASCDNLSDNGRKLQQ
HHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
LCVDAAQHDAALAQWIDTACAFPNSMVDRIVPAATAQHRSDAAQALGLADACALGTEEFW
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EWVIERRFVDDADGDALAAVGVQVVADVKPFEEAKLRMLNGSHTAIALIGAVLGVPTVAD
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
CIARPDIHRFVRSLMTEVVMPHLQRPGLPAYRDALLARFANPELRHKVHQIATDSSLKIP
HHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEE
LRWQATVLAQLAANGSIEPLALAAAVWMRYLLGADEQGQAYAISDPLGQALQATAQRRRD
EEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHH
DVAGTVRALLAVSSIWGEVLPHDVRWTARVEHWLQVIRRQGVAAALAQLHPSD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
>Mature Secondary Structure
MQPLNQATLTQLTDSALATPSPVQLPRYRRTDARVGVVHLGLGAFHRAHQAMVFDALLQR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHC
GDPRWGVLGVAMRTTELADALTAQDGLYAVQVASREALRWQVVGSVLQACVAAREPAQVV
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAMAAPGTRWVTLTVTEKGYGPALAALLVQGLAARRAAGLGGLTIASCDNLSDNGRKLQQ
HHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
LCVDAAQHDAALAQWIDTACAFPNSMVDRIVPAATAQHRSDAAQALGLADACALGTEEFW
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EWVIERRFVDDADGDALAAVGVQVVADVKPFEEAKLRMLNGSHTAIALIGAVLGVPTVAD
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
CIARPDIHRFVRSLMTEVVMPHLQRPGLPAYRDALLARFANPELRHKVHQIATDSSLKIP
HHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEE
LRWQATVLAQLAANGSIEPLALAAAVWMRYLLGADEQGQAYAISDPLGQALQATAQRRRD
EEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHH
DVAGTVRALLAVSSIWGEVLPHDVRWTARVEHWLQVIRRQGVAAALAQLHPSD
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]