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The map label for this gene is fadD [C]

Identifier: 91789681

GI number: 91789681

Start: 4027364

End: 4029169

Strand: Reverse

Name: fadD [C]

Synonym: Bpro_3837

Alternate gene names: 91789681

Gene position: 4029169-4027364 (Counterclockwise)

Preceding gene: 91789682

Following gene: 91789680

Centisome position: 77.48

GC content: 61.79

Gene sequence:

>1806_bases
ATGACTGAGATGACCTACACACTGACACTGCCCCAGATGCTGCGAGAGCAGGCACAGCGCCGCACCGCTTCAGTGGCGAT
CCGCCAGAAGGAACACGGCATCTGGAAGCCGCTGACCTGGGGCCACTACTTTCAGCGCGCACAACAGGTGGGCCTGGGTT
TGCGTGCTGCGGGCTTGTCAGAGGGTGGCCATGTGGGCGTGCTGTCCGAGAACCGTGTCGAGTGGGTGCTGACCCAGTTA
GGCGCGGGTCTGGTCGGGGGCGTCACGGTGGGCGTCTACCCGACCAGCCCGACCAACGAGATTGCCTATGTACTGGCCCA
CGCGGATGCCGAGGTGGTGATCTGCGAAGACCAGGAACAGTCTGACAAGGTGCTTGACGCACGCGACCTGCTGCCCCAGC
TCAGGAAAATTGTGATGATTGAACGGAAAGGGCTGGCAGAGACGAAGGCGCGCGCACCCGCGCTGGTGATGGGCTTTGAG
GAGCTCGAAGCGCTCGGCGTGGCGTCCCTGGATGCTTCGCATATTGAGTCAGTGCTGGCCCATCAACAACTTCAAGACAC
CGCACTCATCATCTACACCTCGGGCTCTACCGGCAAACCCAAAGGCGCAATGATCAGTTACGGCAACATCGCGGCCATGG
CGCCGGGCGTGATTGAACGACTGGGCCTGACCGCGCAGACCTCGCACCTGTCCTACCTGCCGCTGTGCCATGTGGCCGAG
CAGATGCTGACTGCCTTTGTGCCGCTGTACCTGGGCTCACGCGTGGATTTTGGTGAATCAATCCGCACCGTGCAGGAAGA
CCTGCGCGAAGTCGCGCCCACCATGTTTCTGGGCGTACCGCGCATCTGGGAAAAGCTGCACTCAGCCATCTCCATCAAGA
TGCATGAGTCGGGCGGGCTGCGCCAACGTTTGTTCGATGCAGGCCTGCGCGCATGTGCGCCGTTCGCACACAAGGCGGCG
CACCAGCGCTCATTGGGCGAAAAGCTGTGCTTTGCCTTTTATTACGGCCTGATCTTCCGGGCCCTGCAGAACTTCATCGG
CCTGCGCCAGGCCCGCGTGGCGCTGACCGGTGCCGCACCGGTTTCGCCGGCCATTGTGCAGTTCTTTCGCACGCTGGGCG
TGCCGCTGGTCGAGGTCTATGGCATGACGGAATCCAGCGGCATGGTGCTGGGCCAACGGAACGACCAGGTGGTTTTTGGC
ACCGTCGGCGTGCCGACCCTGGGCGTTGAGCACCGGCTCTCAAGCCAGGGTGAACTGCAGATTCGTGGCGGCGTGGTGTT
CAAGGGCTATTACAAAAACGCAGAGGCCACCGCATCCAGCATTGTGGACGGCTGGCTGCACACCGGCGACGTCGTCGAAG
AAAGGGGCGGCTCGCTGCGCATCGTCGACCGGCTCAAGGACATCATGATCACCGCCGGCGGCAAGAACCTGACGCCGTCG
GAAATCGAAAACACCATGAAGGGCAGCCTGTTCATCAAGGAATGCGTGATCGTCGCCGACGCGCGCAAGTTCGTCGGTGC
GCTGATCCAGATCGACTACGACGCCGTGGCGCAATGGGCGGAGTCGCGCAACGTGACCTTTACGCATTTCCGCTCGCTGG
TTGAAACGGCCGAGGTGCGTGAACTGGTTCAAGCCGAAGTGGACAAGGGCAACGCCCTGCTGGCCGAAGTGTCACGTATC
CGGCGCTTTCATTTGCTGACCAAGGAGCTGGACCACGATGACGGTGAAGTTACGGCGACCATGAAGGTGCGCCGGGCCAG
CATCTACAAAACCTATGCGGCCGAAATTGAGGCGCTGTACCGCTGA

Upstream 100 bases:

>100_bases
GGCGGCGCCAGGAGCTTCAAGGATCTCAAGCATTACAAGCGCCGCAAGCGCTGGCTGTCATAAGCCCCCAGCACCGCACC
AAACCACCGGACCTTCTTTC

Downstream 100 bases:

>100_bases
ACGCTACGCAAACTCCATCTCGCCACGGCATCCCGCTCCACCCTACCCCACAGGAATTGAAATATCTTGACTGCTCGAAA
GCTCGTCTCCCCCTGGGCCC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MTEMTYTLTLPQMLREQAQRRTASVAIRQKEHGIWKPLTWGHYFQRAQQVGLGLRAAGLSEGGHVGVLSENRVEWVLTQL
GAGLVGGVTVGVYPTSPTNEIAYVLAHADAEVVICEDQEQSDKVLDARDLLPQLRKIVMIERKGLAETKARAPALVMGFE
ELEALGVASLDASHIESVLAHQQLQDTALIIYTSGSTGKPKGAMISYGNIAAMAPGVIERLGLTAQTSHLSYLPLCHVAE
QMLTAFVPLYLGSRVDFGESIRTVQEDLREVAPTMFLGVPRIWEKLHSAISIKMHESGGLRQRLFDAGLRACAPFAHKAA
HQRSLGEKLCFAFYYGLIFRALQNFIGLRQARVALTGAAPVSPAIVQFFRTLGVPLVEVYGMTESSGMVLGQRNDQVVFG
TVGVPTLGVEHRLSSQGELQIRGGVVFKGYYKNAEATASSIVDGWLHTGDVVEERGGSLRIVDRLKDIMITAGGKNLTPS
EIENTMKGSLFIKECVIVADARKFVGALIQIDYDAVAQWAESRNVTFTHFRSLVETAEVRELVQAEVDKGNALLAEVSRI
RRFHLLTKELDHDDGEVTATMKVRRASIYKTYAAEIEALYR

Sequences:

>Translated_601_residues
MTEMTYTLTLPQMLREQAQRRTASVAIRQKEHGIWKPLTWGHYFQRAQQVGLGLRAAGLSEGGHVGVLSENRVEWVLTQL
GAGLVGGVTVGVYPTSPTNEIAYVLAHADAEVVICEDQEQSDKVLDARDLLPQLRKIVMIERKGLAETKARAPALVMGFE
ELEALGVASLDASHIESVLAHQQLQDTALIIYTSGSTGKPKGAMISYGNIAAMAPGVIERLGLTAQTSHLSYLPLCHVAE
QMLTAFVPLYLGSRVDFGESIRTVQEDLREVAPTMFLGVPRIWEKLHSAISIKMHESGGLRQRLFDAGLRACAPFAHKAA
HQRSLGEKLCFAFYYGLIFRALQNFIGLRQARVALTGAAPVSPAIVQFFRTLGVPLVEVYGMTESSGMVLGQRNDQVVFG
TVGVPTLGVEHRLSSQGELQIRGGVVFKGYYKNAEATASSIVDGWLHTGDVVEERGGSLRIVDRLKDIMITAGGKNLTPS
EIENTMKGSLFIKECVIVADARKFVGALIQIDYDAVAQWAESRNVTFTHFRSLVETAEVRELVQAEVDKGNALLAEVSRI
RRFHLLTKELDHDDGEVTATMKVRRASIYKTYAAEIEALYR
>Mature_600_residues
TEMTYTLTLPQMLREQAQRRTASVAIRQKEHGIWKPLTWGHYFQRAQQVGLGLRAAGLSEGGHVGVLSENRVEWVLTQLG
AGLVGGVTVGVYPTSPTNEIAYVLAHADAEVVICEDQEQSDKVLDARDLLPQLRKIVMIERKGLAETKARAPALVMGFEE
LEALGVASLDASHIESVLAHQQLQDTALIIYTSGSTGKPKGAMISYGNIAAMAPGVIERLGLTAQTSHLSYLPLCHVAEQ
MLTAFVPLYLGSRVDFGESIRTVQEDLREVAPTMFLGVPRIWEKLHSAISIKMHESGGLRQRLFDAGLRACAPFAHKAAH
QRSLGEKLCFAFYYGLIFRALQNFIGLRQARVALTGAAPVSPAIVQFFRTLGVPLVEVYGMTESSGMVLGQRNDQVVFGT
VGVPTLGVEHRLSSQGELQIRGGVVFKGYYKNAEATASSIVDGWLHTGDVVEERGGSLRIVDRLKDIMITAGGKNLTPSE
IENTMKGSLFIKECVIVADARKFVGALIQIDYDAVAQWAESRNVTFTHFRSLVETAEVRELVQAEVDKGNALLAEVSRIR
RFHLLTKELDHDDGEVTATMKVRRASIYKTYAAEIEALYR

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=630, Percent_Identity=29.3650793650794, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI27477105, Length=644, Percent_Identity=27.1739130434783, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI42794760, Length=596, Percent_Identity=28.6912751677852, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI42794758, Length=596, Percent_Identity=28.6912751677852, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI42794756, Length=596, Percent_Identity=28.6912751677852, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI57165410, Length=597, Percent_Identity=27.3031825795645, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI40807491, Length=601, Percent_Identity=28.4525790349418, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI57165412, Length=597, Percent_Identity=27.3031825795645, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI42794754, Length=628, Percent_Identity=25.1592356687898, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI42794752, Length=628, Percent_Identity=25.1592356687898, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI4758332, Length=628, Percent_Identity=24.6815286624204, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI12669909, Length=628, Percent_Identity=24.6815286624204, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI187761345, Length=549, Percent_Identity=24.2258652094718, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=549, Percent_Identity=24.2258652094718, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI156151445, Length=496, Percent_Identity=24.7983870967742, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788107, Length=463, Percent_Identity=25.2699784017279, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693145, Length=473, Percent_Identity=23.2558139534884, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788595, Length=376, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510401, Length=604, Percent_Identity=27.8145695364238, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17556552, Length=618, Percent_Identity=25.5663430420712, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17541856, Length=598, Percent_Identity=25.5852842809365, Blast_Score=185, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17564090, Length=543, Percent_Identity=24.6777163904236, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17553312, Length=604, Percent_Identity=24.5033112582781, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25147511, Length=626, Percent_Identity=23.482428115016, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI193204819, Length=624, Percent_Identity=24.0384615384615, Blast_Score=149, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=472, Percent_Identity=24.1525423728814, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=466, Percent_Identity=25.3218884120172, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=499, Percent_Identity=24.0480961923848, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=499, Percent_Identity=24.0480961923848, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=499, Percent_Identity=24.0480961923848, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI133901848, Length=236, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=174, Percent_Identity=32.7586206896552, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320852, Length=585, Percent_Identity=25.4700854700855, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6322182, Length=551, Percent_Identity=24.8638838475499, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323903, Length=606, Percent_Identity=23.7623762376238, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324893, Length=553, Percent_Identity=24.4122965641953, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17933690, Length=631, Percent_Identity=28.0507131537242, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI19921316, Length=666, Percent_Identity=27.3273273273273, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281366413, Length=621, Percent_Identity=28.1803542673108, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24666501, Length=621, Percent_Identity=28.1803542673108, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24666497, Length=621, Percent_Identity=28.1803542673108, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI62471681, Length=636, Percent_Identity=23.5849056603774, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62471687, Length=636, Percent_Identity=23.5849056603774, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24586634, Length=636, Percent_Identity=23.5849056603774, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI22026970, Length=636, Percent_Identity=23.5849056603774, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62471689, Length=636, Percent_Identity=23.5849056603774, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62471679, Length=636, Percent_Identity=23.5849056603774, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62471683, Length=636, Percent_Identity=23.5849056603774, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62471685, Length=636, Percent_Identity=23.5849056603774, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24586636, Length=636, Percent_Identity=23.5849056603774, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24581924, Length=496, Percent_Identity=26.6129032258064, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355181, Length=480, Percent_Identity=23.9583333333333, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 65942; Mature: 65811

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMTYTLTLPQMLREQAQRRTASVAIRQKEHGIWKPLTWGHYFQRAQQVGLGLRAAGLS
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEECCCC
EGGHVGVLSENRVEWVLTQLGAGLVGGVTVGVYPTSPTNEIAYVLAHADAEVVICEDQEQ
CCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCC
SDKVLDARDLLPQLRKIVMIERKGLAETKARAPALVMGFEELEALGVASLDASHIESVLA
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECHHHHHHHCCHHCCHHHHHHHHH
HQQLQDTALIIYTSGSTGKPKGAMISYGNIAAMAPGVIERLGLTAQTSHLSYLPLCHVAE
HHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHCCHHHHHHCCCEECCCCCCCHHHHHHH
QMLTAFVPLYLGSRVDFGESIRTVQEDLREVAPTMFLGVPRIWEKLHSAISIKMHESGGL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEECCCCCH
RQRLFDAGLRACAPFAHKAAHQRSLGEKLCFAFYYGLIFRALQNFIGLRQARVALTGAAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
VSPAIVQFFRTLGVPLVEVYGMTESSGMVLGQRNDQVVFGTVGVPTLGVEHRLSSQGELQ
CCHHHHHHHHHHCCCEEEHCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHCCCCCCEE
IRGGVVFKGYYKNAEATASSIVDGWLHTGDVVEERGGSLRIVDRLKDIMITAGGKNLTPS
EECCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCEEHHHHHHHHEEECCCCCCCHH
EIENTMKGSLFIKECVIVADARKFVGALIQIDYDAVAQWAESRNVTFTHFRSLVETAEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ELVQAEVDKGNALLAEVSRIRRFHLLTKELDHDDGEVTATMKVRRASIYKTYAAEIEALY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure 
TEMTYTLTLPQMLREQAQRRTASVAIRQKEHGIWKPLTWGHYFQRAQQVGLGLRAAGLS
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEECCCC
EGGHVGVLSENRVEWVLTQLGAGLVGGVTVGVYPTSPTNEIAYVLAHADAEVVICEDQEQ
CCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECCCCC
SDKVLDARDLLPQLRKIVMIERKGLAETKARAPALVMGFEELEALGVASLDASHIESVLA
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECHHHHHHHCCHHCCHHHHHHHHH
HQQLQDTALIIYTSGSTGKPKGAMISYGNIAAMAPGVIERLGLTAQTSHLSYLPLCHVAE
HHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHCCHHHHHHCCCEECCCCCCCHHHHHHH
QMLTAFVPLYLGSRVDFGESIRTVQEDLREVAPTMFLGVPRIWEKLHSAISIKMHESGGL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEECCCCCH
RQRLFDAGLRACAPFAHKAAHQRSLGEKLCFAFYYGLIFRALQNFIGLRQARVALTGAAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
VSPAIVQFFRTLGVPLVEVYGMTESSGMVLGQRNDQVVFGTVGVPTLGVEHRLSSQGELQ
CCHHHHHHHHHHCCCEEEHCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHCCCCCCEE
IRGGVVFKGYYKNAEATASSIVDGWLHTGDVVEERGGSLRIVDRLKDIMITAGGKNLTPS
EECCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCEEHHHHHHHHEEECCCCCCCHH
EIENTMKGSLFIKECVIVADARKFVGALIQIDYDAVAQWAESRNVTFTHFRSLVETAEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ELVQAEVDKGNALLAEVSRIRRFHLLTKELDHDDGEVTATMKVRRASIYKTYAAEIEALY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]