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The map label for this gene is lepB [H]

Identifier: 91789487

GI number: 91789487

Start: 3837770

End: 3838747

Strand: Reverse

Name: lepB [H]

Synonym: Bpro_3637

Alternate gene names: 91789487

Gene position: 3838747-3837770 (Counterclockwise)

Preceding gene: 91789488

Following gene: 91789486

Centisome position: 73.82

GC content: 57.87

Gene sequence:

>978_bases
ATGGGCAACACCATGAGTTCCATCACCGCGTTGGTGCTGGCGGCGTTTGTCGGCTACGGGGGTGCCTGGTATCTGGGCGC
AGTGGAGGGCAACTTCTCGCTGCTGCTTTTCCTGGCAACTGTGGTCACCGGCATTTACTGGCTGGCGGAGCGGTTTTATT
TCCTCCCGCAGCGGCGCAAGGCTGTTGCCGTACTTGAACAGACCGCGGCCAAGCGCCAGGCCGAGCTGGCCAAAATGGGT
ATCAGCCAGGTTGACAGCAATGTCAGCGAAGCCAGAACCCGGCTCATCATGCAGCCCTGGTGGCTGGACTGGACCGCCGG
CCTGTTCCCGGTGATTGTGGTGGTCTTCCTGCTGCGTTCCTTTCTGTTTGAGCCTTTCAAGATCCCGTCGGGCTCCATGA
TCCCGACCCTGCTCATCAATGACCTGATTCTGGTCAACAAATTCCACTACGGTGTGCGCCTGCCCGTCATCAACACCAAG
CTGTTTGACAACCACAGCCCGCAGCGCGGGGATGTGATGGTGTTCCGCTACCCCCCCAAGCCCAGTCTGGACTACATCAA
GCGCGTGGTCGGTGTGCCCGGAGACGAGGTGGCTTACCTCAACAAGAAGCTGACCATCAATGGCAAGCCGCTGCCCAAAA
CGTCTTTGGCCGATTTCTTCGATGAAGATGCGCTGCGCTACGCCAAGCAGTTTCAGGAAACGAATAGCGCACGGACGTAC
CGCCTGCTCAATGACGACGACCGGCCGGCCTTTGTGGCCGGCGCGGAGGACTTTCCGTTCAAGCAAAATTGCCGTTACAG
TAGCGAGGGCGTGGTCTGCAAGGTGCCGGAAGGGCACTACTTCATGATGGGTGACAACCGCGATAATTCGCTGGATTCCC
GCTATTGGGGCTTTGTCCCCGAGAAAAACATCGTGGGCAAGGCCTTTTTTGTCTGGATGAACTTCGGCAACCTCAAACGC
ATCGGTTCTTTTCAGTAA

Upstream 100 bases:

>100_bases
TTCTCGAAAAACAAAAAGCGGGCAAGAAGCGCATGAAACAAATCGGTTCGGTGGAGGTGCCCCAAGAGGCTTTCCTCGCC
ATATTGCAGGTAGAAGAATA

Downstream 100 bases:

>100_bases
TTGCGGCACGGCGTAGGCGCTCCGGGGGTGATCAAGCGGTCACCCGCGGGGGCCACCCTGCCAGAGCAGGAGAAAAAATG
AAACATCAGCAACGTGGCAT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MGNTMSSITALVLAAFVGYGGAWYLGAVEGNFSLLLFLATVVTGIYWLAERFYFLPQRRKAVAVLEQTAAKRQAELAKMG
ISQVDSNVSEARTRLIMQPWWLDWTAGLFPVIVVVFLLRSFLFEPFKIPSGSMIPTLLINDLILVNKFHYGVRLPVINTK
LFDNHSPQRGDVMVFRYPPKPSLDYIKRVVGVPGDEVAYLNKKLTINGKPLPKTSLADFFDEDALRYAKQFQETNSARTY
RLLNDDDRPAFVAGAEDFPFKQNCRYSSEGVVCKVPEGHYFMMGDNRDNSLDSRYWGFVPEKNIVGKAFFVWMNFGNLKR
IGSFQ

Sequences:

>Translated_325_residues
MGNTMSSITALVLAAFVGYGGAWYLGAVEGNFSLLLFLATVVTGIYWLAERFYFLPQRRKAVAVLEQTAAKRQAELAKMG
ISQVDSNVSEARTRLIMQPWWLDWTAGLFPVIVVVFLLRSFLFEPFKIPSGSMIPTLLINDLILVNKFHYGVRLPVINTK
LFDNHSPQRGDVMVFRYPPKPSLDYIKRVVGVPGDEVAYLNKKLTINGKPLPKTSLADFFDEDALRYAKQFQETNSARTY
RLLNDDDRPAFVAGAEDFPFKQNCRYSSEGVVCKVPEGHYFMMGDNRDNSLDSRYWGFVPEKNIVGKAFFVWMNFGNLKR
IGSFQ
>Mature_324_residues
GNTMSSITALVLAAFVGYGGAWYLGAVEGNFSLLLFLATVVTGIYWLAERFYFLPQRRKAVAVLEQTAAKRQAELAKMGI
SQVDSNVSEARTRLIMQPWWLDWTAGLFPVIVVVFLLRSFLFEPFKIPSGSMIPTLLINDLILVNKFHYGVRLPVINTKL
FDNHSPQRGDVMVFRYPPKPSLDYIKRVVGVPGDEVAYLNKKLTINGKPLPKTSLADFFDEDALRYAKQFQETNSARTYR
LLNDDDRPAFVAGAEDFPFKQNCRYSSEGVVCKVPEGHYFMMGDNRDNSLDSRYWGFVPEKNIVGKAFFVWMNFGNLKRI
GSFQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=325, Percent_Identity=39.3846153846154, Blast_Score=213, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36893; Mature: 36762

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTMSSITALVLAAFVGYGGAWYLGAVEGNFSLLLFLATVVTGIYWLAERFYFLPQRRK
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AVAVLEQTAAKRQAELAKMGISQVDSNVSEARTRLIMQPWWLDWTAGLFPVIVVVFLLRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FLFEPFKIPSGSMIPTLLINDLILVNKFHYGVRLPVINTKLFDNHSPQRGDVMVFRYPPK
HCCCCCCCCCCCCHHHHHHHHHHHEEEECCCEEEEEEEEEECCCCCCCCCCEEEEECCCC
PSLDYIKRVVGVPGDEVAYLNKKLTINGKPLPKTSLADFFDEDALRYAKQFQETNSARTY
CCHHHHHHHHCCCCCCEEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
RLLNDDDRPAFVAGAEDFPFKQNCRYSSEGVVCKVPEGHYFMMGDNRDNSLDSRYWGFVP
EEECCCCCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCC
EKNIVGKAFFVWMNFGNLKRIGSFQ
CCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GNTMSSITALVLAAFVGYGGAWYLGAVEGNFSLLLFLATVVTGIYWLAERFYFLPQRRK
CCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AVAVLEQTAAKRQAELAKMGISQVDSNVSEARTRLIMQPWWLDWTAGLFPVIVVVFLLRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FLFEPFKIPSGSMIPTLLINDLILVNKFHYGVRLPVINTKLFDNHSPQRGDVMVFRYPPK
HCCCCCCCCCCCCHHHHHHHHHHHEEEECCCEEEEEEEEEECCCCCCCCCCEEEEECCCC
PSLDYIKRVVGVPGDEVAYLNKKLTINGKPLPKTSLADFFDEDALRYAKQFQETNSARTY
CCHHHHHHHHCCCCCCEEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
RLLNDDDRPAFVAGAEDFPFKQNCRYSSEGVVCKVPEGHYFMMGDNRDNSLDSRYWGFVP
EEECCCCCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCC
EKNIVGKAFFVWMNFGNLKRIGSFQ
CCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]