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The map label for this gene is trpA

Identifier: 91789468

GI number: 91789468

Start: 3820335

End: 3821153

Strand: Direct

Name: trpA

Synonym: Bpro_3617

Alternate gene names: 91789468

Gene position: 3820335-3821153 (Clockwise)

Preceding gene: 91789467

Following gene: 91789469

Centisome position: 73.46

GC content: 63.13

Gene sequence:

>819_bases
ATGAGCCGCATTGCTTCTACCTTTTCCGCGCTGAAAAGCCAGGGCCGCAAGGCCCTGATTCCCTACGTCACCGCAGGCTT
CCCCTTCGCCGATATCACGCCTGAGCTGATGCACAGCATGGTGGCCGGCGGCGCCGATGTGATTGAGCTGGGCGTGCCTT
TCTCGGACCCGAGCGCCGACGGCCCGGTGATCCAGAAAGCCGGAGAAAAAGCCCTGGCCCTCGGCATCGGCCTGGCCCAG
GTGCTGGAGATGGTGCGTGTCTTCCGTCAAAAGGACGGCACCACGCCGGTGGTCCTGATGGGCTATGCCAACCCGGTGGA
GCGCTACGACATCAAGCACGGCGGCAGCGCAACGGAAAGCGCCTTTATCCGCGACGCCGCACAAGCGGGTGTGGATGGTG
TGCTGATCGTCGACTACCCGCCCGAGGAGTGCGTGGAATTTGCCGCTCGCCTGCGCGCCCACAACATGGACCTGATATTT
TTGCTGGCGCCCACTTCTACCTCCGCGCGCATGGCGCAGGTTGCCGAAGTCGCCAGCGGTTATGTGTACTATGTTTCGCT
CAAGGGCGTGACCGGGGCCGGTACGCTGGATGTCGATGCCGTGGAGGCCATGCTGCCGCGCATCCGCCAGCACGTGAAGG
TGCCTGTCGGCGTGGGTTTTGGCATTCGCGACGCAGCGACCGCCAAAGCCATCGGCAAGGTGGCGGATGCGGTCGTGATC
GGCAGCAAGATCATCCAGTTGATCGAAAACCAGCCGCGAGACAAGGTTGCGACCGTGGCCCGCGACTTTCTGAAAGAAAT
CCGTGCGGCTCTGGACTGA

Upstream 100 bases:

>100_bases
GCGAACAACCAAAGGAATTTTCCGACGGGCCGCCCCTAGGAAAATTAGCCCCCTCGGGGGGCAGCGCAGTACGCGAAGCG
ACAAGCGTGGGGGCCAGGAA

Downstream 100 bases:

>100_bases
TTTTCAGCCATCCAAAGCCGGCGCATAATTGCGCTTTTCGCGCGGCGACAGCCGCTGCGACGGCGAACGCGCTTGACGCA
GAAGCATCTCAACAAGGACT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSRIASTFSALKSQGRKALIPYVTAGFPFADITPELMHSMVAGGADVIELGVPFSDPSADGPVIQKAGEKALALGIGLAQ
VLEMVRVFRQKDGTTPVVLMGYANPVERYDIKHGGSATESAFIRDAAQAGVDGVLIVDYPPEECVEFAARLRAHNMDLIF
LLAPTSTSARMAQVAEVASGYVYYVSLKGVTGAGTLDVDAVEAMLPRIRQHVKVPVGVGFGIRDAATAKAIGKVADAVVI
GSKIIQLIENQPRDKVATVARDFLKEIRAALD

Sequences:

>Translated_272_residues
MSRIASTFSALKSQGRKALIPYVTAGFPFADITPELMHSMVAGGADVIELGVPFSDPSADGPVIQKAGEKALALGIGLAQ
VLEMVRVFRQKDGTTPVVLMGYANPVERYDIKHGGSATESAFIRDAAQAGVDGVLIVDYPPEECVEFAARLRAHNMDLIF
LLAPTSTSARMAQVAEVASGYVYYVSLKGVTGAGTLDVDAVEAMLPRIRQHVKVPVGVGFGIRDAATAKAIGKVADAVVI
GSKIIQLIENQPRDKVATVARDFLKEIRAALD
>Mature_271_residues
SRIASTFSALKSQGRKALIPYVTAGFPFADITPELMHSMVAGGADVIELGVPFSDPSADGPVIQKAGEKALALGIGLAQV
LEMVRVFRQKDGTTPVVLMGYANPVERYDIKHGGSATESAFIRDAAQAGVDGVLIVDYPPEECVEFAARLRAHNMDLIFL
LAPTSTSARMAQVAEVASGYVYYVSLKGVTGAGTLDVDAVEAMLPRIRQHVKVPVGVGFGIRDAATAKAIGKVADAVVIG
SKIIQLIENQPRDKVATVARDFLKEIRAALD

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=274, Percent_Identity=34.6715328467153, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321412, Length=266, Percent_Identity=39.0977443609023, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_POLSJ (Q126M0)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_550420.1
- ProteinModelPortal:   Q126M0
- SMR:   Q126M0
- STRING:   Q126M0
- GeneID:   4013724
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_3617
- NMPDR:   fig|296591.1.peg.5155
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- PhylomeDB:   Q126M0
- ProtClustDB:   PRK13111
- BioCyc:   PSP296591:BPRO_3617-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28780; Mature: 28648

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIASTFSALKSQGRKALIPYVTAGFPFADITPELMHSMVAGGADVIELGVPFSDPSAD
CCHHHHHHHHHHHCCCEEECCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQKAGEKALALGIGLAQVLEMVRVFRQKDGTTPVVLMGYANPVERYDIKHGGSATES
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCCHHH
AFIRDAAQAGVDGVLIVDYPPEECVEFAARLRAHNMDLIFLLAPTSTSARMAQVAEVASG
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
YVYYVSLKGVTGAGTLDVDAVEAMLPRIRQHVKVPVGVGFGIRDAATAKAIGKVADAVVI
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GSKIIQLIENQPRDKVATVARDFLKEIRAALD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRIASTFSALKSQGRKALIPYVTAGFPFADITPELMHSMVAGGADVIELGVPFSDPSAD
CHHHHHHHHHHHCCCEEECCEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQKAGEKALALGIGLAQVLEMVRVFRQKDGTTPVVLMGYANPVERYDIKHGGSATES
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCCHHH
AFIRDAAQAGVDGVLIVDYPPEECVEFAARLRAHNMDLIFLLAPTSTSARMAQVAEVASG
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
YVYYVSLKGVTGAGTLDVDAVEAMLPRIRQHVKVPVGVGFGIRDAATAKAIGKVADAVVI
EEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GSKIIQLIENQPRDKVATVARDFLKEIRAALD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA