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The map label for this gene is trpF [H]

Identifier: 91789466

GI number: 91789466

Start: 3818274

End: 3819017

Strand: Direct

Name: trpF [H]

Synonym: Bpro_3615

Alternate gene names: 91789466

Gene position: 3818274-3819017 (Clockwise)

Preceding gene: 91789465

Following gene: 91789467

Centisome position: 73.42

GC content: 59.01

Gene sequence:

>744_bases
ATGAAAACGCAAAATACCCCGCCTCCCACCCGTACCCGCATCAAGATCTGCGGCCTGACGCGGGAAGAAGATGTGGATGC
GGCTGTGGCCGCCGGCGCGGATGCGGTCGGTTTTGTCATGTACGAGCCCAGCCCGCGTTATGTGACGGCAGAGCGGGCCG
CAGAACTGGCCAGGCGCTTGCCGCCCTTTGTCACGCCGGTGCTGCTCTTCGTCAACGCTCCCCTTGCAAAAATCAGGGCT
GCCTGCGCCCATATTCCCTCGGCTTTGCTGCAATTTCATGGTGATGAAACGCCTGAAATCTGCCTGCAGGCGGGCCGGCC
TTTCATGCGCGCGGCCCGTATCCCCCTGGGTGGACATACCGCCGCAGACCCCGGCGGAAGCGAGGGGCGCTTCGATCTCG
TAAAATACGCGGAAGACTTTAAAGCAGCCCAGGCCATCTTGCTCGACGCTCATGTCGAAGGCTATGGCGGCGGCGGGAAA
ACATTCAATTGGTCACTTCTTCCTCCAAGCGTCAGCGCTCACCTCGTTTTGTCTGGTGGATTGACGCCTGCAAATGTGAC
CGATGGCATTTTGCAAGTCAGGCCGCGCTGTAAAACGCTGGCCGTTGATGTGAGCTCAGGCGTCGAGGTTTCGAAAGGAA
TCAAGAGCGCCGACAAAATCAACCAATTTGTCGCAGCCGTACGCGCTGCCGACGAGCAACTTGCGAAGACCCAAACCCAT
CATGTTCGACTACCACCAACCTGA

Upstream 100 bases:

>100_bases
ACACCAGCGGCCCGGCAAAGCCGGTTCCGCGGTGTTCCTGGACTGTGCAGCGCCACTGTCATAAGCAGCGGGTGTCGCTT
CGCGCCATGGAGGCCTCGGC

Downstream 100 bases:

>100_bases
CCCGACCGGCCATTTCGGCATTTACGGCGGCAGTTTCGTTTCCGAGACACTGACCCACGCGATCAATGAGCTGAAAGACG
CCTACGCGAAGTACCAGAAC

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKTQNTPPPTRTRIKICGLTREEDVDAAVAAGADAVGFVMYEPSPRYVTAERAAELARRLPPFVTPVLLFVNAPLAKIRA
ACAHIPSALLQFHGDETPEICLQAGRPFMRAARIPLGGHTAADPGGSEGRFDLVKYAEDFKAAQAILLDAHVEGYGGGGK
TFNWSLLPPSVSAHLVLSGGLTPANVTDGILQVRPRCKTLAVDVSSGVEVSKGIKSADKINQFVAAVRAADEQLAKTQTH
HVRLPPT

Sequences:

>Translated_247_residues
MKTQNTPPPTRTRIKICGLTREEDVDAAVAAGADAVGFVMYEPSPRYVTAERAAELARRLPPFVTPVLLFVNAPLAKIRA
ACAHIPSALLQFHGDETPEICLQAGRPFMRAARIPLGGHTAADPGGSEGRFDLVKYAEDFKAAQAILLDAHVEGYGGGGK
TFNWSLLPPSVSAHLVLSGGLTPANVTDGILQVRPRCKTLAVDVSSGVEVSKGIKSADKINQFVAAVRAADEQLAKTQTH
HVRLPPT
>Mature_247_residues
MKTQNTPPPTRTRIKICGLTREEDVDAAVAAGADAVGFVMYEPSPRYVTAERAAELARRLPPFVTPVLLFVNAPLAKIRA
ACAHIPSALLQFHGDETPEICLQAGRPFMRAARIPLGGHTAADPGGSEGRFDLVKYAEDFKAAQAILLDAHVEGYGGGGK
TFNWSLLPPSVSAHLVLSGGLTPANVTDGILQVRPRCKTLAVDVSSGVEVSKGIKSADKINQFVAAVRAADEQLAKTQTH
HVRLPPT

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=215, Percent_Identity=30.6976744186047, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 26232; Mature: 26232

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTQNTPPPTRTRIKICGLTREEDVDAAVAAGADAVGFVMYEPSPRYVTAERAAELARRL
CCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHHC
PPFVTPVLLFVNAPLAKIRAACAHIPSALLQFHGDETPEICLQAGRPFMRAARIPLGGHT
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCCCCCC
AADPGGSEGRFDLVKYAEDFKAAQAILLDAHVEGYGGGGKTFNWSLLPPSVSAHLVLSGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCEEEEEECC
LTPANVTDGILQVRPRCKTLAVDVSSGVEVSKGIKSADKINQFVAAVRAADEQLAKTQTH
CCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVRLPPT
EEECCCC
>Mature Secondary Structure
MKTQNTPPPTRTRIKICGLTREEDVDAAVAAGADAVGFVMYEPSPRYVTAERAAELARRL
CCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHHC
PPFVTPVLLFVNAPLAKIRAACAHIPSALLQFHGDETPEICLQAGRPFMRAARIPLGGHT
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCCCCCC
AADPGGSEGRFDLVKYAEDFKAAQAILLDAHVEGYGGGGKTFNWSLLPPSVSAHLVLSGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCCEEEEEECC
LTPANVTDGILQVRPRCKTLAVDVSSGVEVSKGIKSADKINQFVAAVRAADEQLAKTQTH
CCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVRLPPT
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA