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The map label for this gene is gltA [H]

Identifier: 91789456

GI number: 91789456

Start: 3806265

End: 3807575

Strand: Direct

Name: gltA [H]

Synonym: Bpro_3605

Alternate gene names: 91789456

Gene position: 3806265-3807575 (Clockwise)

Preceding gene: 91789455

Following gene: 91789457

Centisome position: 73.19

GC content: 61.17

Gene sequence:

>1311_bases
ATGAAGCTAGCTGACAACAAAGCCACCCTGTCCTTCAGCAACGGCAGCCCGAGCGTCGATTTGCCCGTTTACCACGGCAG
TGTGGGCCCGGACGTTGTGGACATTCGCAAGCTGTACGCCCAGACAGGCATGTTCACCTACGACCCCGGTTTCCTGTCAA
CGGCTTCCTGCCAGTCCGCCATCACCTACATCGACGGCGACAAGGGTGAACTGCTGTACCGCGGCTACCCCATCGAGCAG
CTCGCCACCACCTGCGACTACATGGAAACCTGCCATCTGCTGCTGTACGGCGAGTTGCCCAACGGTGACCAGAAGAAGGA
CTTTGTCAGCCGCGTGACCAACCACACCATGGTCAACGAGCAGATGCAGTTCTTCCTGCGCGGTTTCCGCCGTGATGCGC
ACCCGATGGCCATCATGACCGGCCTGGTCGGCGCGCTGTCTGCGTTCTATCACGACAGTACCGACATCACCAACCCCGAG
CACCGCGAGATCGCCGCGATCCGGCTGATCGCCAAGATGCCGACGCTGGTCGCCATGGCCTACAAGTACACCGTGGGCCA
GCCCTACATGTACCCGAAGAACAACCTGAGCTACGCCGGCAACTTCCTGCACATGATGTTTGCCACGCCCTGCGAAGAGT
ACAAGGTCAGCCCGGTGCTGGAACGCGCACTCGACCGCATCTTCATCCTGCACGCAGACCACGAGCAGAACGCCTCGACT
TCCACGGTTCGCCTGTGCGGTTCGTCGGGTACCAATCCGTTTGCCGCCATTGCGGCCGGTGTGGCCTGCCTGTGGGGCCC
GGCGCACGGCGGCGCCAACGAAGCTGCGCTGAACATGCTCGGCGACATCCAGAAAAATGGCGGCGTCGAGAAAATCGGCG
ACTTCATCAAGCAGGTCAAGGACAAGAACTCCGGCGTCAAGCTGATGGGCTTCGGTCACCGCGTTTACAAAAACTACGAC
CCGCGCGCCAAGCTGATGCAGGAAACCTGCAAGGAAGTGCTGCACGAGATGGGCCTGGAAAACGACCCGCTGTTCAAGCT
GGCGATGGCCCTGGAAAAAATCGCGCTGGAAGACGACTACTTCGTGTCCCGCAAGCTCTACCCGAACGTGGACTTCTATT
CCGGCATCGTGCAGCGCGCCATCGGCATTCCCGTGCCGCTGTTCACCGCAATCTTCGCGCTGGCCCGCACCGTCGGATGG
ATCGCCCAGCTCAACGAGATGATTGGCGACCCCGAGTACAAGATCGGCCGCCCGCGCCAGCTGTTCACCGGCTCGATTCC
GCGTGACGTCAAGCCCATGGCCCAGCGTTAA

Upstream 100 bases:

>100_bases
GCCTCTACTTCCGAAGCGCTTGAGGTTTTAAACTTGCTGCGTACCGCAGCGGCCGGCCGCGTGGCTGTTTCCATGTGATT
TGATACGAAAGAAGCGAGAA

Downstream 100 bases:

>100_bases
CGACCGGGGTACCCGCCCCAGACGTTTCTACAGAGCCCGCCCGATGGCAACATTGGCGGGCTTTTTGTATTTTTGTATTT
TTACTGCCCTTCCCCCCGAA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKLADNKATLSFSNGSPSVDLPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTASCQSAITYIDGDKGELLYRGYPIEQ
LATTCDYMETCHLLLYGELPNGDQKKDFVSRVTNHTMVNEQMQFFLRGFRRDAHPMAIMTGLVGALSAFYHDSTDITNPE
HREIAAIRLIAKMPTLVAMAYKYTVGQPYMYPKNNLSYAGNFLHMMFATPCEEYKVSPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLGDIQKNGGVEKIGDFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCKEVLHEMGLENDPLFKLAMALEKIALEDDYFVSRKLYPNVDFYSGIVQRAIGIPVPLFTAIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFTGSIPRDVKPMAQR

Sequences:

>Translated_436_residues
MKLADNKATLSFSNGSPSVDLPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTASCQSAITYIDGDKGELLYRGYPIEQ
LATTCDYMETCHLLLYGELPNGDQKKDFVSRVTNHTMVNEQMQFFLRGFRRDAHPMAIMTGLVGALSAFYHDSTDITNPE
HREIAAIRLIAKMPTLVAMAYKYTVGQPYMYPKNNLSYAGNFLHMMFATPCEEYKVSPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLGDIQKNGGVEKIGDFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCKEVLHEMGLENDPLFKLAMALEKIALEDDYFVSRKLYPNVDFYSGIVQRAIGIPVPLFTAIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFTGSIPRDVKPMAQR
>Mature_436_residues
MKLADNKATLSFSNGSPSVDLPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTASCQSAITYIDGDKGELLYRGYPIEQ
LATTCDYMETCHLLLYGELPNGDQKKDFVSRVTNHTMVNEQMQFFLRGFRRDAHPMAIMTGLVGALSAFYHDSTDITNPE
HREIAAIRLIAKMPTLVAMAYKYTVGQPYMYPKNNLSYAGNFLHMMFATPCEEYKVSPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLGDIQKNGGVEKIGDFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCKEVLHEMGLENDPLFKLAMALEKIALEDDYFVSRKLYPNVDFYSGIVQRAIGIPVPLFTAIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFTGSIPRDVKPMAQR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=353, Percent_Identity=29.4617563739377, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786939, Length=434, Percent_Identity=62.2119815668203, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1786527, Length=379, Percent_Identity=29.8153034300792, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=408, Percent_Identity=25.2450980392157, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=368, Percent_Identity=26.6304347826087, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=26.027397260274, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=363, Percent_Identity=26.7217630853994, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640126, Length=436, Percent_Identity=27.2935779816514, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640124, Length=436, Percent_Identity=27.2935779816514, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356863, Length=399, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48460; Mature: 48460

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLADNKATLSFSNGSPSVDLPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTASCQSA
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHC
ITYIDGDKGELLYRGYPIEQLATTCDYMETCHLLLYGELPNGDQKKDFVSRVTNHTMVNE
EEEEECCCCCEEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAIMTGLVGALSAFYHDSTDITNPEHREIAAIRLIAKMPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKYTVGQPYMYPKNNLSYAGNFLHMMFATPCEEYKVSPVLERALDRIFILHADHEQNAST
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLGDIQKNGGVEKIGDFIKQVK
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DKNSGVKLMGFGHRVYKNYDPRAKLMQETCKEVLHEMGLENDPLFKLAMALEKIALEDDY
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
FVSRKLYPNVDFYSGIVQRAIGIPVPLFTAIFALARTVGWIAQLNEMIGDPEYKIGRPRQ
EECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LFTGSIPRDVKPMAQR
HHCCCCCCCCCHHHCC
>Mature Secondary Structure
MKLADNKATLSFSNGSPSVDLPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTASCQSA
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHC
ITYIDGDKGELLYRGYPIEQLATTCDYMETCHLLLYGELPNGDQKKDFVSRVTNHTMVNE
EEEEECCCCCEEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAIMTGLVGALSAFYHDSTDITNPEHREIAAIRLIAKMPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKYTVGQPYMYPKNNLSYAGNFLHMMFATPCEEYKVSPVLERALDRIFILHADHEQNAST
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLGDIQKNGGVEKIGDFIKQVK
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DKNSGVKLMGFGHRVYKNYDPRAKLMQETCKEVLHEMGLENDPLFKLAMALEKIALEDDY
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
FVSRKLYPNVDFYSGIVQRAIGIPVPLFTAIFALARTVGWIAQLNEMIGDPEYKIGRPRQ
EECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
LFTGSIPRDVKPMAQR
HHCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]