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The map label for this gene is sdhA [H]

Identifier: 91789453

GI number: 91789453

Start: 3803345

End: 3805141

Strand: Direct

Name: sdhA [H]

Synonym: Bpro_3602

Alternate gene names: 91789453

Gene position: 3803345-3805141 (Clockwise)

Preceding gene: 91789452

Following gene: 91789454

Centisome position: 73.14

GC content: 62.6

Gene sequence:

>1797_bases
ATGACCGCTACCTCCAAACTCCCCAAGCGTAAATTTGACGTTGTGATCGTCGGTGCCGGCGGCTCCGGCATGCGCGCTTC
GCTGCAGCTCGCACGCGCCGGCCTGAACGTGGCCGTGCTGTCCAAGGTGTTCCCCACGCGCTCCCATACGGTGGCCGCAC
AAGGCGGCATTGGCGCCTCGCTCGGCAACATGTCGGAAGACAACTGGCACTATCACTTCTTCGACACCGTCAAGGGTTCC
GACTGGCTCGGCGACCAGGACGCGATTGAATACATGTGCCGTGAAGCACCCAAGGTGGTGTACGACCTCGAACACATGGG
CATGCCGTTCGACCGCAACCCGGATGGCACGATTTACCAGCGCCCCTTCGGCGGCCATACCGCCAACTACGGCGAAAAGC
CGGTGCAGCGCGCCTGCGCCGCTGCCGATCGCACCGGCCACGCCATGCTGCACACGCTGTACCAGCAAAACGTCAAGGAA
AAAACCAGCTTCTTCGTGGAATGGCTGGCCATGGACCTGATCCGCGACGCCGATGGCGATGTCGTGGGCGTGACCGCACT
GGAAATGGAAACCGGTGACGTGCATATCTTCGAAGCCAAGACCACCCTGCTAGCCACCGGTGGCGCCGGCCGCATTTTTG
CCGCATCCACCAACGCGTTCATCAACACCGGCGACGGCCTGGGCATGGCCGCGCGTGCCGGCATCCCGCTGGAAGACATG
GAGTTCTGGCAGTTCCACCCCACCGGCGTGCATGGCGCCGGCGTGCTGCTGACCGAGGGCTGCCGCGGCGAAGGCGCCAT
TTTGCGCAACAGCAACGGCGAACGCTTCATGGAGCGCTATGCGCCCGCCTACAAGGATCTGGCGCCGCGTGACTACGTAT
CGCGCTGCATGGATCAGGAAATCAAGGAAGGTCGCGGCTGCGGTCCCAACAAGGACTACATCAATCTTGACATGACCCAC
CTGGGCGCCGAGACCATCATGAAGCGCCTGCCGTCGGTGTTCGAGATTGGCCACAACTTTGCCAACGTCGACATCACCAA
GGAGCCAATCCCCGTGGTGCCCACCATCCACTACCAGATGGGCGGCATTCCGACCAACATCCATGGCCAGGTGGTCACGC
AGAACGCCGACAACAAGAGCGAAGTCGTCAACGGCCTCTATGCCGTGGGCGAATGCTCCTGCGTCAGCGTGCACGGCGCC
AACCGCCTGGGCACCAATTCGCTGCTGGACCTGCTGGTGTTCGGCCGCGCTGCCGGCAACCACATTGTTGAATTCAACAA
CGCCAACAAAATGCACAAACCGCTGCCAGCCGACGCGGCCGACCTGACGCTGGCGCGTATCGCACGGCTGGACAACGCGA
GTGGCGGCGAGTATGCCCAGGATGTGGCCAACGACATCCGCACGGCCATGCAGACGCATGCCGGCGTGTTCCGCACCCAG
GCCCTGATGGACGAGGGCGTCACCAAAATCGCGGCCTTGCGCGAACGTGTGAAGAACATCGGCCTGAAGGACAAGTCAAA
AATCTTCAACACCGCACGCATCGAAGCACTGGAAGTGGAAAACCTGATCGAGGCGGCAGAGGCCACCATCGTGTCGGCCG
CTGCCCGCCATGAAAGCCGGGGCGCGCACTCGGTTGATGACTACGGCGATACGCCAGAGCATCCCAATGGCCGCAACGAC
ACCGACTGGCACAAGCACACGCTGTGGCACAGCGAGGGCAGCCGCCTGAGCTACAAGCCCGTGCAGATGAAGCCGCTGAC
GGTTGAGTCCGTGCCGCTCAAAGTGCGCAGCTTCTAA

Upstream 100 bases:

>100_bases
GGTGGCGTGCGCCGGCTGGGGCATCCAGGTCCTGTGGCGCCTGTGAGGCCCGTTTAAAGCACCGCTGACCGCCCCCGACT
AAAAAGATTCCCAAATAAAC

Downstream 100 bases:

>100_bases
GCGCAAGCCAAGCGAACCAGTCAAGCCAACAAGACCGCGAGAAACGCCCCATGTCAAAACGTACCTTCCAGATCTACCGC
TACGACCCGGACACCGACGC

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTATSKLPKRKFDVVIVGAGGSGMRASLQLARAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFFDTVKGS
DWLGDQDAIEYMCREAPKVVYDLEHMGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKE
KTSFFVEWLAMDLIRDADGDVVGVTALEMETGDVHIFEAKTTLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLEDM
EFWQFHPTGVHGAGVLLTEGCRGEGAILRNSNGERFMERYAPAYKDLAPRDYVSRCMDQEIKEGRGCGPNKDYINLDMTH
LGAETIMKRLPSVFEIGHNFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVTQNADNKSEVVNGLYAVGECSCVSVHGA
NRLGTNSLLDLLVFGRAAGNHIVEFNNANKMHKPLPADAADLTLARIARLDNASGGEYAQDVANDIRTAMQTHAGVFRTQ
ALMDEGVTKIAALRERVKNIGLKDKSKIFNTARIEALEVENLIEAAEATIVSAAARHESRGAHSVDDYGDTPEHPNGRND
TDWHKHTLWHSEGSRLSYKPVQMKPLTVESVPLKVRSF

Sequences:

>Translated_598_residues
MTATSKLPKRKFDVVIVGAGGSGMRASLQLARAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFFDTVKGS
DWLGDQDAIEYMCREAPKVVYDLEHMGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKE
KTSFFVEWLAMDLIRDADGDVVGVTALEMETGDVHIFEAKTTLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLEDM
EFWQFHPTGVHGAGVLLTEGCRGEGAILRNSNGERFMERYAPAYKDLAPRDYVSRCMDQEIKEGRGCGPNKDYINLDMTH
LGAETIMKRLPSVFEIGHNFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVTQNADNKSEVVNGLYAVGECSCVSVHGA
NRLGTNSLLDLLVFGRAAGNHIVEFNNANKMHKPLPADAADLTLARIARLDNASGGEYAQDVANDIRTAMQTHAGVFRTQ
ALMDEGVTKIAALRERVKNIGLKDKSKIFNTARIEALEVENLIEAAEATIVSAAARHESRGAHSVDDYGDTPEHPNGRND
TDWHKHTLWHSEGSRLSYKPVQMKPLTVESVPLKVRSF
>Mature_597_residues
TATSKLPKRKFDVVIVGAGGSGMRASLQLARAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFFDTVKGSD
WLGDQDAIEYMCREAPKVVYDLEHMGMPFDRNPDGTIYQRPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKEK
TSFFVEWLAMDLIRDADGDVVGVTALEMETGDVHIFEAKTTLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLEDME
FWQFHPTGVHGAGVLLTEGCRGEGAILRNSNGERFMERYAPAYKDLAPRDYVSRCMDQEIKEGRGCGPNKDYINLDMTHL
GAETIMKRLPSVFEIGHNFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVTQNADNKSEVVNGLYAVGECSCVSVHGAN
RLGTNSLLDLLVFGRAAGNHIVEFNNANKMHKPLPADAADLTLARIARLDNASGGEYAQDVANDIRTAMQTHAGVFRTQA
LMDEGVTKIAALRERVKNIGLKDKSKIFNTARIEALEVENLIEAAEATIVSAAARHESRGAHSVDDYGDTPEHPNGRNDT
DWHKHTLWHSEGSRLSYKPVQMKPLTVESVPLKVRSF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=49.9148211243612, Blast_Score=579, Evalue=1e-165,
Organism=Escherichia coli, GI1786942, Length=594, Percent_Identity=54.8821548821549, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1790597, Length=569, Percent_Identity=41.1247803163445, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=32.7402135231317, Blast_Score=240, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=49.1496598639456, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=50.2555366269165, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=50.9212730318258, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=51.5912897822446, Blast_Score=588, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=25.9713701431493, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322511, Length=481, Percent_Identity=24.3243243243243, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=50.8278145695364, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=50.8278145695364, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=50.8278145695364, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24663005, Length=611, Percent_Identity=46.9721767594108, Blast_Score=550, Evalue=1e-156,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65196; Mature: 65065

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSKLPKRKFDVVIVGAGGSGMRASLQLARAGLNVAVLSKVFPTRSHTVAAQGGIGAS
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCC
LGNMSEDNWHYHFFDTVKGSDWLGDQDAIEYMCREAPKVVYDLEHMGMPFDRNPDGTIYQ
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCCCCCEEE
RPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKEKTSFFVEWLAMDLIRDADGD
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VVGVTALEMETGDVHIFEAKTTLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLEDM
EEEEEEEEEECCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCCC
EFWQFHPTGVHGAGVLLTEGCRGEGAILRNSNGERFMERYAPAYKDLAPRDYVSRCMDQE
HHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHCCCCHHHHHHHHHHH
IKEGRGCGPNKDYINLDMTHLGAETIMKRLPSVFEIGHNFANVDITKEPIPVVPTIHYQM
HHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHCCCEEECEECCCCCCCCEEEEEEC
GGIPTNIHGQVVTQNADNKSEVVNGLYAVGECSCVSVHGANRLGTNSLLDLLVFGRAAGN
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
HIVEFNNANKMHKPLPADAADLTLARIARLDNASGGEYAQDVANDIRTAMQTHAGVFRTQ
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALMDEGVTKIAALRERVKNIGLKDKSKIFNTARIEALEVENLIEAAEATIVSAAARHESR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAHSVDDYGDTPEHPNGRNDTDWHKHTLWHSEGSRLSYKPVQMKPLTVESVPLKVRSF
CCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCEEECCCCEECCEEECCCCEEEECC
>Mature Secondary Structure 
TATSKLPKRKFDVVIVGAGGSGMRASLQLARAGLNVAVLSKVFPTRSHTVAAQGGIGAS
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCC
LGNMSEDNWHYHFFDTVKGSDWLGDQDAIEYMCREAPKVVYDLEHMGMPFDRNPDGTIYQ
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCCCCCEEE
RPFGGHTANYGEKPVQRACAAADRTGHAMLHTLYQQNVKEKTSFFVEWLAMDLIRDADGD
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VVGVTALEMETGDVHIFEAKTTLLATGGAGRIFAASTNAFINTGDGLGMAARAGIPLEDM
EEEEEEEEEECCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCCC
EFWQFHPTGVHGAGVLLTEGCRGEGAILRNSNGERFMERYAPAYKDLAPRDYVSRCMDQE
HHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHCCCCHHHHHHHHHHH
IKEGRGCGPNKDYINLDMTHLGAETIMKRLPSVFEIGHNFANVDITKEPIPVVPTIHYQM
HHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHCCCEEECEECCCCCCCCEEEEEEC
GGIPTNIHGQVVTQNADNKSEVVNGLYAVGECSCVSVHGANRLGTNSLLDLLVFGRAAGN
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
HIVEFNNANKMHKPLPADAADLTLARIARLDNASGGEYAQDVANDIRTAMQTHAGVFRTQ
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALMDEGVTKIAALRERVKNIGLKDKSKIFNTARIEALEVENLIEAAEATIVSAAARHESR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAHSVDDYGDTPEHPNGRNDTDWHKHTLWHSEGSRLSYKPVQMKPLTVESVPLKVRSF
CCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCEEECCCCEECCEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA