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The map label for this gene is mdh [H]

Identifier: 91789449

GI number: 91789449

Start: 3800113

End: 3801099

Strand: Reverse

Name: mdh [H]

Synonym: Bpro_3598

Alternate gene names: 91789449

Gene position: 3801099-3800113 (Counterclockwise)

Preceding gene: 91789462

Following gene: 91789448

Centisome position: 73.09

GC content: 61.6

Gene sequence:

>987_bases
ATGAGCAAAAAACCCGTCCGTGTTGCCGTCACTGGTGCAGCTGGTCAAATCGGTTATGCCTTGTTGTTCCGTATCGCCTC
TGGCGAGATGCTCGGCAAGGACCAGCCCGTCATTCTGCAATTGCTCGAAGTGCCGGTTGAAGGCCCCCAGAAAGCGCTCA
AGGGCGTGATGATGGAGCTTGACGACTGCGCATTCCCGCTGCTGGCCGGCATGGAGGCGCACAGTGACCCGATGACCGCG
TTCAAGGATGCCGACTACGCGCTGCTGGTCGGTTCGCGCCCGCGCGGCCCCGGCATGGAGCGCGCTGAACTGCTGGCCGT
CAACGGCGCCATCTTCACCGCGCAAGGCAAAGCCCTCAACGCCGTGGCCAGCCGCAACGTCAAGGTGCTGGTGGTCGGCA
ATCCGGCCAATACCAACGCCTACATCGCCATGAAGAGCGCGCCCGACCTGCCGCGCAAGAACTTCACCGCCATGCTGCGC
CTGGATCACAACCGTGCCGCCAGCCAGATCGCTGCCAAGACCGGCAAGGCCGTGGCTGACATTGAAAAACTCACCGTCTG
GGGCAACCACTCGCCCACGATGTACGCCGACTACCGTTTTGCCACCATCAACGGCGAAAGCGTGGCCAAGATGATCAACG
ACCAGGAATGGAACGCCAATGTGTTCCTGCCCACCGTGGGCAAGCGTGGCGCCGCCATCATTGAAGCCCGTGGTTTGTCG
TCGGCGGCCTCGGCTGCCAACGCCGCCATCGACCACATGCGCGACTGGGCTCTCGGCACCAATGGCAAATGGGTCACCAT
GGGCATCCCGTCGGACGGCCAGTATGGCATCCCGAAAGACACGATGTTCGGTTTCCCCGTGACCTGCGAAAACGGCGAGT
ACAAACTGGTCGAAGGCCTGGAGATTGACGCGTTCAGCCAGGAGCGTATCAACAAGACGCTGGAAGAATTGCAAGGCGAG
CAGGCCGGCGTTGCCCATTTGCTTTAA

Upstream 100 bases:

>100_bases
CCCGCCTGGATTGACCTGAAATCTCCAGGCTGGCGCCAAACATCTCACGCCGTTCACACCGCTTTTCAACCGATTTTCAA
ACTTCCTGGAGTCCTCAATC

Downstream 100 bases:

>100_bases
AGCAGTGAGCATAGTGCGCCGCGCCGGGCCGCCCCAAGCAAGCACAGCCCCCTCGGGGGGCAGCGAAGTACGCGAAGCGA
CAAGCGTGGGGGCCAGTGTT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSKKPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEVPVEGPQKALKGVMMELDDCAFPLLAGMEAHSDPMTA
FKDADYALLVGSRPRGPGMERAELLAVNGAIFTAQGKALNAVASRNVKVLVVGNPANTNAYIAMKSAPDLPRKNFTAMLR
LDHNRAASQIAAKTGKAVADIEKLTVWGNHSPTMYADYRFATINGESVAKMINDQEWNANVFLPTVGKRGAAIIEARGLS
SAASAANAAIDHMRDWALGTNGKWVTMGIPSDGQYGIPKDTMFGFPVTCENGEYKLVEGLEIDAFSQERINKTLEELQGE
QAGVAHLL

Sequences:

>Translated_328_residues
MSKKPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEVPVEGPQKALKGVMMELDDCAFPLLAGMEAHSDPMTA
FKDADYALLVGSRPRGPGMERAELLAVNGAIFTAQGKALNAVASRNVKVLVVGNPANTNAYIAMKSAPDLPRKNFTAMLR
LDHNRAASQIAAKTGKAVADIEKLTVWGNHSPTMYADYRFATINGESVAKMINDQEWNANVFLPTVGKRGAAIIEARGLS
SAASAANAAIDHMRDWALGTNGKWVTMGIPSDGQYGIPKDTMFGFPVTCENGEYKLVEGLEIDAFSQERINKTLEELQGE
QAGVAHLL
>Mature_327_residues
SKKPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEVPVEGPQKALKGVMMELDDCAFPLLAGMEAHSDPMTAF
KDADYALLVGSRPRGPGMERAELLAVNGAIFTAQGKALNAVASRNVKVLVVGNPANTNAYIAMKSAPDLPRKNFTAMLRL
DHNRAASQIAAKTGKAVADIEKLTVWGNHSPTMYADYRFATINGESVAKMINDQEWNANVFLPTVGKRGAAIIEARGLSS
AASAANAAIDHMRDWALGTNGKWVTMGIPSDGQYGIPKDTMFGFPVTCENGEYKLVEGLEIDAFSQERINKTLEELQGEQ
AGVAHLL

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family [H]

Homologues:

Organism=Homo sapiens, GI5174539, Length=332, Percent_Identity=49.3975903614458, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI89886456, Length=337, Percent_Identity=23.7388724035608, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561064, Length=323, Percent_Identity=51.0835913312694, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI32566798, Length=261, Percent_Identity=51.7241379310345, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI32566800, Length=169, Percent_Identity=46.7455621301775, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583394, Length=324, Percent_Identity=52.1604938271605, Blast_Score=310, Evalue=6e-85,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR010945
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 35086; Mature: 34955

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEVPVEGPQKALKGVMMEL
CCCCCEEEEEECCCCHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
DDCAFPLLAGMEAHSDPMTAFKDADYALLVGSRPRGPGMERAELLAVNGAIFTAQGKALN
HHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCEEEEECCCEEE
AVASRNVKVLVVGNPANTNAYIAMKSAPDLPRKNFTAMLRLDHNRAASQIAAKTGKAVAD
HHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHH
IEKLTVWGNHSPTMYADYRFATINGESVAKMINDQEWNANVFLPTVGKRGAAIIEARGLS
HEEEEEECCCCCCEEEEEEEEEECHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
SAASAANAAIDHMRDWALGTNGKWVTMGIPSDGQYGIPKDTMFGFPVTCENGEYKLVEGL
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
EIDAFSQERINKTLEELQGEQAGVAHLL
EECCCCHHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure 
SKKPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLEVPVEGPQKALKGVMMEL
CCCCEEEEEECCCCHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
DDCAFPLLAGMEAHSDPMTAFKDADYALLVGSRPRGPGMERAELLAVNGAIFTAQGKALN
HHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCEEEEECCCEEE
AVASRNVKVLVVGNPANTNAYIAMKSAPDLPRKNFTAMLRLDHNRAASQIAAKTGKAVAD
HHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHH
IEKLTVWGNHSPTMYADYRFATINGESVAKMINDQEWNANVFLPTVGKRGAAIIEARGLS
HEEEEEECCCCCCEEEEEEEEEECHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
SAASAANAAIDHMRDWALGTNGKWVTMGIPSDGQYGIPKDTMFGFPVTCENGEYKLVEGL
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
EIDAFSQERINKTLEELQGEQAGVAHLL
EECCCCHHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA