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The map label for this gene is gyaR [H]

Identifier: 91789385

GI number: 91789385

Start: 3733695

End: 3734642

Strand: Reverse

Name: gyaR [H]

Synonym: Bpro_3531

Alternate gene names: 91789385

Gene position: 3734642-3733695 (Counterclockwise)

Preceding gene: 91789387

Following gene: 91789384

Centisome position: 71.82

GC content: 66.14

Gene sequence:

>948_bases
TTGTCCAAACCCGAAATCCTGGCCGTTGCCAAGCTGCCGCCTTACCTGATCGAGCCGCTGCGCGAGATTTTTGTCGTGCA
TGAACAAATCCATCAAACCGACCCGGCGGCGTTTGCCGCTGCCGCCGGACGTATCCGCGCCATCGTCGGCAGCGGTGAGT
CCAAGGTGCCGCGTTCGCTGATGGCGCAATTGCCGGCGCTGGAAATGATTTCCATCATGGGCGTGGGCTACGACGGCGTG
GATGTCACTGCGGCGCTGGAGCGCAACATTCGGGTGACGCACACGCCCGGCGTGCTGAATGACGACGTGGCCGATCTGGC
GATCGGGCTGATGCTGAGCGTGGCGCGCCGCATACCGCAAGCCGACCAGTATGTGCGCAGTGGCCGCTGGCCTGAGGGGC
CGATGCCGCTGGCGCGCAAGGTGTCCGGGGAGCGTCTGGGCATTGTGGGTCTGGGCCGCATTGGCCAGGCCATCGCCACC
CGGGCAGAGGCCTTTGGCATGTCGGTGGCGTACACCGCCCGCAGCCGCAAGGCGGAACTGCCCTATGCCTACTACCCGAG
CGCCCAGGCGCTGGCCGCCGAAGTCGATTTTCTGGTGCTGATCACGCCGGGTGGCGCCGGCACGCGCAAGCTGATCAATG
CCGATGTGCTCAAGGCGCTGGGCCCGCAGGGTTATCTGATCAATGTGGCGCGTGGTTCGGTGGTCGATGAAGCGGCGCTT
GTCGAGGCGCTGCAGCAGGGCGTGATCGCCGGTGCCGCGCTGGACGTGTTCGAGAACGAGCCTGTCGTGCCATCCGCGCT
GTGGACCCTGGACAACGTGGTGCTGGCGCCGCACATTGGCAGCGCCACGCGGCAGACGCGCGGCGCGATGGCCGACTTGG
CGGCCTCTAATCTGCGCGCCCATTTTGCGGGTGAACCCCTGCTGACGCCAGTACCCGAATGCCAGTAA

Upstream 100 bases:

>100_bases
GGGTTTGCATGGATGCCAATCGAGGCTCAATCATATGATGATAAGACAATAGTGGCCCATTATGGCAATTCGTCAAGCCT
GTTGAACTGAGGAGATTCCC

Downstream 100 bases:

>100_bases
AAGCTCGGGGTTTTCCATAGGTTTTCGGGGCTCTAATCATCATATGATAGCAACGCAATTGACTCCCCGAACATGATCAA
AAACGTCCACGGCAACACGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSKPEILAVAKLPPYLIEPLREIFVVHEQIHQTDPAAFAAAAGRIRAIVGSGESKVPRSLMAQLPALEMISIMGVGYDGV
DVTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQADQYVRSGRWPEGPMPLARKVSGERLGIVGLGRIGQAIAT
RAEAFGMSVAYTARSRKAELPYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVARGSVVDEAAL
VEALQQGVIAGAALDVFENEPVVPSALWTLDNVVLAPHIGSATRQTRGAMADLAASNLRAHFAGEPLLTPVPECQ

Sequences:

>Translated_315_residues
MSKPEILAVAKLPPYLIEPLREIFVVHEQIHQTDPAAFAAAAGRIRAIVGSGESKVPRSLMAQLPALEMISIMGVGYDGV
DVTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQADQYVRSGRWPEGPMPLARKVSGERLGIVGLGRIGQAIAT
RAEAFGMSVAYTARSRKAELPYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVARGSVVDEAAL
VEALQQGVIAGAALDVFENEPVVPSALWTLDNVVLAPHIGSATRQTRGAMADLAASNLRAHFAGEPLLTPVPECQ
>Mature_314_residues
SKPEILAVAKLPPYLIEPLREIFVVHEQIHQTDPAAFAAAAGRIRAIVGSGESKVPRSLMAQLPALEMISIMGVGYDGVD
VTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQADQYVRSGRWPEGPMPLARKVSGERLGIVGLGRIGQAIATR
AEAFGMSVAYTARSRKAELPYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVARGSVVDEAALV
EALQQGVIAGAALDVFENEPVVPSALWTLDNVVLAPHIGSATRQTRGAMADLAASNLRAHFAGEPLLTPVPECQ

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=41.1290322580645, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI23308577, Length=239, Percent_Identity=35.1464435146443, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=33.4600760456274, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=33.4600760456274, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=33.4600760456274, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI87082289, Length=309, Percent_Identity=41.4239482200647, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789279, Length=226, Percent_Identity=34.070796460177, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081824, Length=196, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=33.2075471698113, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=28.3582089552239, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=32.9317269076305, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=30, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=30, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321253, Length=336, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=171, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=39.3700787401575, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=39.3700787401575, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=39.3700787401575, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=39.3700787401575, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=39.3700787401575, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=35.0157728706625, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI28571528, Length=295, Percent_Identity=35.9322033898305, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=33.6, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=34.2412451361868, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=34.2412451361868, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=34.2412451361868, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=34.2412451361868, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=34.2412451361868, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19921140, Length=247, Percent_Identity=32.7935222672065, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33289; Mature: 33158

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPEILAVAKLPPYLIEPLREIFVVHEQIHQTDPAAFAAAAGRIRAIVGSGESKVPRSL
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCCCHHHH
MAQLPALEMISIMGVGYDGVDVTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQ
HHHCCHHHHHHHHCCCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCH
ADQYVRSGRWPEGPMPLARKVSGERLGIVGLGRIGQAIATRAEAFGMSVAYTARSRKAEL
HHHHHHCCCCCCCCCCHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCCCC
PYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVARGSVVDEAAL
CEEECCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VEALQQGVIAGAALDVFENEPVVPSALWTLDNVVLAPHIGSATRQTRGAMADLAASNLRA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHH
HFAGEPLLTPVPECQ
HCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKPEILAVAKLPPYLIEPLREIFVVHEQIHQTDPAAFAAAAGRIRAIVGSGESKVPRSL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCCCHHHH
MAQLPALEMISIMGVGYDGVDVTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQ
HHHCCHHHHHHHHCCCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCH
ADQYVRSGRWPEGPMPLARKVSGERLGIVGLGRIGQAIATRAEAFGMSVAYTARSRKAEL
HHHHHHCCCCCCCCCCHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCCCC
PYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVARGSVVDEAAL
CEEECCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VEALQQGVIAGAALDVFENEPVVPSALWTLDNVVLAPHIGSATRQTRGAMADLAASNLRA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHH
HFAGEPLLTPVPECQ
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA