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The map label for this gene is copA [H]

Identifier: 91789339

GI number: 91789339

Start: 3685712

End: 3687127

Strand: Direct

Name: copA [H]

Synonym: Bpro_3485

Alternate gene names: 91789339

Gene position: 3685712-3687127 (Clockwise)

Preceding gene: 91789338

Following gene: 91789340

Centisome position: 70.88

GC content: 61.37

Gene sequence:

>1416_bases
ATGACAAACAGAAGAAATTTTTTGACCGGCGCGGGCGCACTGACCTCCGCCGTGGCCGCAGCAGCAGTCAGCCGGGTGGC
GATGGCCGCCCTGCCGGAACCGGTCCTGCAGACAAAACCCGACACCATGCCGCCGCTCGTTCCCGCCACGGGCCGCCCCT
ACAACCCGGTGGTCACGCTCAATGGCTGGACGCTGCCCTGGCGCATGAACAATGGCGTCAAGGAATTCCACCTGGTGGCC
GAACCGGTGGTGCGCGAGATGTCACCCGGATTCAAGGCGCACCTCTGGGGCTACAACGGCCAGAGCCCCGGCCCGACCAT
TGAAGTGGTGGAAGGCGACCGGGTGCGCATTTTTGTTACCAACAAGCTGCCCGAGCACACCAGCATTCACTGGCACGGCC
AGCGCCTGCCCAACGGCATGGACGGCGTGGCGGGCCTGACCCAGCCCGCCATTCCGGTCGGCAAGACCTTTGTCTACGAA
TTCGTGGCCCGGCGCCCGGGCACCTTTATGTACCATCCGCATGCCGACGAGATGACGCAGATGGCCATGGGCATGATGGG
CTTCTGGATCACCCACCCGAAAGCGAAGCATCCGCTGATCGACGAGGTCAACCGTGACTTCGTGTTCCTGCTCAATGCCT
ATGACATAGACCCCGGCGCCTACACGCCCAAGATCATGACCATGCTCGACTTCAACCTCTGGAGCTGGAACAGCCGGGTC
TTTCCGGGCATTGACCCGCTGGTGGTGCGCAAGAACGACAAGGTGCGCATCCGCATCGGCAACCTGACCATGACCAATCA
CCCGATGCACCTGCATGGGCATGAGTTTCTGGTGACCGGCACCGATGGCGGCCCCACCCCAAAATCAACCCGCTGGCCCG
AGGTGACGACCGATGTCGCTGTCGGCCAGATGCGGCAAATCGAGTTCCTGGCCGACGAAGAGGGCGACTGGGCTTTTCAC
TGCCACAAGAGCCACCACACCATGAACGCCATGGGCCATGACGTGCCGACCCTCATTGGCGTAGACCACCGCAAAGTGGT
GAAGGACATCACCAACGTCATCCCCGACTACATGGTGATGGGCGAGCGCGGCATGGCCGACATGGCCGAGATGGAAATGC
CTTTGCCGGACAACACCGAAAGGATGATGACCGGCGCAGGCCCCTTCGGCTCAGTCGAAATGGGCGGCATGTTCAGCATG
GTCAAGGTACGCAAAGACCAAAAACCCGGCGACTACAAAGACCCTGGCTGGTACAAGCACCCGGTGGGTGAAGTCGCCTA
TGAATGGACAGGTTCGCTGCCCAATCCGGCACGCTTTGCAGCCGAGGGCGGCCAATCCATGAAAGCACAGAACATGCCCC
TGAAAGAAGTCGAAGTTCAGGTCCGCAAGCCCTCCATGGGCAACATGAAGCATTGA

Upstream 100 bases:

>100_bases
AAGCCAACCGCCACGCTGATGGCAGCGCCCACGTCAGGTGGCGGCGGCGACGGGGCCGGTCACTGATGACCCGCCGCACA
GACCAATCAATGGAATCGAC

Downstream 100 bases:

>100_bases
CAGAGTTGAAGCAATATCCTGGAGGAAATGTCATGAAAATTGTCATGAAAATCTCAAAAGCCACTCAAAAAGCCACTCAA
TTAGCAGCGGCGTGCACCCT

Product: twin-arginine translocation pathway signal protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTNRRNFLTGAGALTSAVAAAAVSRVAMAALPEPVLQTKPDTMPPLVPATGRPYNPVVTLNGWTLPWRMNNGVKEFHLVA
EPVVREMSPGFKAHLWGYNGQSPGPTIEVVEGDRVRIFVTNKLPEHTSIHWHGQRLPNGMDGVAGLTQPAIPVGKTFVYE
FVARRPGTFMYHPHADEMTQMAMGMMGFWITHPKAKHPLIDEVNRDFVFLLNAYDIDPGAYTPKIMTMLDFNLWSWNSRV
FPGIDPLVVRKNDKVRIRIGNLTMTNHPMHLHGHEFLVTGTDGGPTPKSTRWPEVTTDVAVGQMRQIEFLADEEGDWAFH
CHKSHHTMNAMGHDVPTLIGVDHRKVVKDITNVIPDYMVMGERGMADMAEMEMPLPDNTERMMTGAGPFGSVEMGGMFSM
VKVRKDQKPGDYKDPGWYKHPVGEVAYEWTGSLPNPARFAAEGGQSMKAQNMPLKEVEVQVRKPSMGNMKH

Sequences:

>Translated_471_residues
MTNRRNFLTGAGALTSAVAAAAVSRVAMAALPEPVLQTKPDTMPPLVPATGRPYNPVVTLNGWTLPWRMNNGVKEFHLVA
EPVVREMSPGFKAHLWGYNGQSPGPTIEVVEGDRVRIFVTNKLPEHTSIHWHGQRLPNGMDGVAGLTQPAIPVGKTFVYE
FVARRPGTFMYHPHADEMTQMAMGMMGFWITHPKAKHPLIDEVNRDFVFLLNAYDIDPGAYTPKIMTMLDFNLWSWNSRV
FPGIDPLVVRKNDKVRIRIGNLTMTNHPMHLHGHEFLVTGTDGGPTPKSTRWPEVTTDVAVGQMRQIEFLADEEGDWAFH
CHKSHHTMNAMGHDVPTLIGVDHRKVVKDITNVIPDYMVMGERGMADMAEMEMPLPDNTERMMTGAGPFGSVEMGGMFSM
VKVRKDQKPGDYKDPGWYKHPVGEVAYEWTGSLPNPARFAAEGGQSMKAQNMPLKEVEVQVRKPSMGNMKH
>Mature_470_residues
TNRRNFLTGAGALTSAVAAAAVSRVAMAALPEPVLQTKPDTMPPLVPATGRPYNPVVTLNGWTLPWRMNNGVKEFHLVAE
PVVREMSPGFKAHLWGYNGQSPGPTIEVVEGDRVRIFVTNKLPEHTSIHWHGQRLPNGMDGVAGLTQPAIPVGKTFVYEF
VARRPGTFMYHPHADEMTQMAMGMMGFWITHPKAKHPLIDEVNRDFVFLLNAYDIDPGAYTPKIMTMLDFNLWSWNSRVF
PGIDPLVVRKNDKVRIRIGNLTMTNHPMHLHGHEFLVTGTDGGPTPKSTRWPEVTTDVAVGQMRQIEFLADEEGDWAFHC
HKSHHTMNAMGHDVPTLIGVDHRKVVKDITNVIPDYMVMGERGMADMAEMEMPLPDNTERMMTGAGPFGSVEMGGMFSMV
KVRKDQKPGDYKDPGWYKHPVGEVAYEWTGSLPNPARFAAEGGQSMKAQNMPLKEVEVQVRKPSMGNMKH

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=103, Percent_Identity=36.8932038834951, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323703, Length=96, Percent_Identity=45.8333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=105, Percent_Identity=40.9523809523809, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859919, Length=104, Percent_Identity=41.3461538461538, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574104, Length=116, Percent_Identity=40.5172413793103, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 52535; Mature: 52404

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRRNFLTGAGALTSAVAAAAVSRVAMAALPEPVLQTKPDTMPPLVPATGRPYNPVVTL
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCEEEE
NGWTLPWRMNNGVKEFHLVAEPVVREMSPGFKAHLWGYNGQSPGPTIEVVEGDRVRIFVT
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEE
NKLPEHTSIHWHGQRLPNGMDGVAGLTQPAIPVGKTFVYEFVARRPGTFMYHPHADEMTQ
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHH
MAMGMMGFWITHPKAKHPLIDEVNRDFVFLLNAYDIDPGAYTPKIMTMLDFNLWSWNSRV
HHHHHHHHEEECCCCCCCCHHHCCCCEEEEEEEEECCCCCCCCEEEEEEECEEECCCCEE
FPGIDPLVVRKNDKVRIRIGNLTMTNHPMHLHGHEFLVTGTDGGPTPKSTRWPEVTTDVA
CCCCCEEEEECCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCCCCCCHHHHH
VGQMRQIEFLADEEGDWAFHCHKSHHTMNAMGHDVPTLIGVDHRKVVKDITNVIPDYMVM
HCCCEEEEEEECCCCCEEEEEECCCCCHHHCCCCCCEEECCCHHHHHHHHHHHCCHHEEE
GERGMADMAEMEMPLPDNTERMMTGAGPFGSVEMGGMFSMVKVRKDQKPGDYKDPGWYKH
CCCCCHHHHHCCCCCCCCHHHHEECCCCCCCEECCCCEEEEHHHCCCCCCCCCCCCCCCC
PVGEVAYEWTGSLPNPARFAAEGGQSMKAQNMPLKEVEVQVRKPSMGNMKH
CHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
TNRRNFLTGAGALTSAVAAAAVSRVAMAALPEPVLQTKPDTMPPLVPATGRPYNPVVTL
CCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCEEEE
NGWTLPWRMNNGVKEFHLVAEPVVREMSPGFKAHLWGYNGQSPGPTIEVVEGDRVRIFVT
CCEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEE
NKLPEHTSIHWHGQRLPNGMDGVAGLTQPAIPVGKTFVYEFVARRPGTFMYHPHADEMTQ
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHH
MAMGMMGFWITHPKAKHPLIDEVNRDFVFLLNAYDIDPGAYTPKIMTMLDFNLWSWNSRV
HHHHHHHHEEECCCCCCCCHHHCCCCEEEEEEEEECCCCCCCCEEEEEEECEEECCCCEE
FPGIDPLVVRKNDKVRIRIGNLTMTNHPMHLHGHEFLVTGTDGGPTPKSTRWPEVTTDVA
CCCCCEEEEECCCEEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCCCCCCCCHHHHH
VGQMRQIEFLADEEGDWAFHCHKSHHTMNAMGHDVPTLIGVDHRKVVKDITNVIPDYMVM
HCCCEEEEEEECCCCCEEEEEECCCCCHHHCCCCCCEEECCCHHHHHHHHHHHCCHHEEE
GERGMADMAEMEMPLPDNTERMMTGAGPFGSVEMGGMFSMVKVRKDQKPGDYKDPGWYKH
CCCCCHHHHHCCCCCCCCHHHHEECCCCCCCEECCCCEEEEHHHCCCCCCCCCCCCCCCC
PVGEVAYEWTGSLPNPARFAAEGGQSMKAQNMPLKEVEVQVRKPSMGNMKH
CHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]