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The map label for this gene is mutL [H]

Identifier: 91789069

GI number: 91789069

Start: 3394010

End: 3395992

Strand: Direct

Name: mutL [H]

Synonym: Bpro_3209

Alternate gene names: 91789069

Gene position: 3394010-3395992 (Clockwise)

Preceding gene: 91789067

Following gene: 91789070

Centisome position: 65.27

GC content: 67.98

Gene sequence:

>1983_bases
ATGGCTGCAACCATGAGCGCCCTGCCGTCAACCCTTTCGCCGCTCCAGACCTCCCCGCCCCCGCGCAAACCCATCCGCGA
GTTGCCGGACGAGCTGATCAGCCAGATCGCCGCCGGCGAGGTGGTCGAACGGCCGGCTTCGGTGGTGCGCGAACTGGTGG
ATAACGCGCTGGACGCAGGGGCCACGCAGGTGACGGTGCGACTGCTGGCCGGCGGCGTGCGGCTGATCCTCGTGGAGGAC
GACGGCCAGGGCATCCCGCGCGAAGAATTGCCGGTGGCCCTGCGGCGCCACGCCACCAGCAAGATCGCCTCGCTGCAGGA
CCTCGAAGCCGTGGGCACCATGGGCTTTCGGGGTGAGGCGCTGGCCGCCATCAACTCGATTGCCGACATGAGCCTGCTGT
CAAGAACACTTGACGGAGCCAGCGGGAACGCCGGCGAAGCCGCCCATGCCTGGCAACTCGATGGCCGCACCGGCGAGTTG
AAGCCGGCCGCGCGCTCCCGCGGCACCAGCGTGGAAGTGCGCGAACTCTTTTATGCCACCCCGGCGCGCCGCAAGTTTTT
GAAAACCGACGCCACCGAACTGGCCCATTGCATTGAAGCCGTGCGCCGCCATGCGCTGGTGCGGCCAGACGTCGGCTTTG
CCATCTGGCACGAGGGCAAGCTGGTGGAGCAATGGCGCGCCTGCCCTGGTGAACCGGCTGCGGCCCACACGCAGCGTCTG
GCCGATGTGCTGGGCAGCGACTTTGTCGAGCAATCCGTCGCGGTCTATTACGAAAGCGCGGCGCGGCGGACCGACGGGCT
GCCCGCAGTGCGCGTGTGGGGCCGCGCCGGCATTCCGGATGCTGCGCGCTCGCGCGCCGACCAGCAGTTTGCCTATGTCA
ATGGCCGCTATGTACGCGACAAGGTGCTGACCCACGCGGCACGCAGCGCCTATGAAGACGTGCTGCACGGCCATCGCCAG
CCGGTGTATGCGCTGTATGTCGAGATGGACCCGGCCCGCGTCGACGTGAACGTGCACCCGACCAAAATCGAAGTGCGCTT
TCGCGACAGCCGCGAGGTGCACCAGGCAGTGCGCCACGCCACCGAAAACGCACTGGCCACGCCTCGCTCGGCCGCTGCGG
CCAGCCCCGACGGTGCTGCAGCCGACACTGCCGCCCCCCTGATTTCCAGCGAATTTTCAGCATCAAATACCGGCTTTACC
CAGAAAACCTGGGGGCAGCCAACGATCAACTTCGCAGCAAATGGTGGCCACCGGGCGTCGGACTTCGAGGCGATGTGGCC
GGTACCGGTGCAGCCTGGCAGGCCAGCGGCAAGCGACGGCTTTTCACCCTCGCCAAGCCTCCCCCAAGGCGCCTCCTCCG
CCGGCCCGGCAGACAGCCTGCCGCCCGGCGACTGGCCGCTGGGCCGCGCCATCGCCCAACTGCAGGGCATTTACGTACTG
GCCGAGAACGCGCAGGGCCTGGTCATCGTGGACATGCACGCGGCCCACGAGCGCATCGTCTATGAACGCCTGAAAAGCCA
GATGGACAGCAGCGAAGGCGCGCACATTGCCAGCCAGCCCCTGCTGATTCCGGCCACCTTTGCCGCCAGCCCGCAGGAAG
TGGCCACCGCCGAGGCTTGCATTGAAACGCTGGCCACCCTGGGCCTGGAAATCACGCCGTTTTCCCCCAGGACCCTGGCG
GTGCGCGCCGTGCCGACCAGCCTGGCACAGGGGGACGCGGTGGAACTGGCGCGTAGCGTGCTGGCCGAGCTGGCCCAGCA
CGACGCCAGCACCGTGATCCAGCGGGCCCAGAATGAGCTGCTCTCTACCATGGCCTGCCATGGCGCCGTGCGGGCCAACC
GCAAGCTCACGATTGACGAGATGAACGCCCTGCTGCGCCAGATGGAAGCCACCGAGCGCTCCGACCAGTGCAACCACGGG
CGGCCCACCTGGCGGCAGGTGAGCATCCGGGAGCTGGACGCCCTGTTTCTGCGCGGGCGCTGA

Upstream 100 bases:

>100_bases
TGGAGAATGAAATCCATCAGATAAGTTAGCAGTTCCATGAGACGGGATTATCGGGGCTGAATAAGACAGGCTTGGCAGCC
CGCCGGCTCCGCCCCCTAAA

Downstream 100 bases:

>100_bases
ACTTTCCGCCCGCCCGCGTATCACTTATCTGCATGAAACGCTGGCACCTCTTCACTTCCTTCTGCGCGGCGCTGGCCTTG
ATGGCGGGTTGCGCCACGCT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MAATMSALPSTLSPLQTSPPPRKPIRELPDELISQIAAGEVVERPASVVRELVDNALDAGATQVTVRLLAGGVRLILVED
DGQGIPREELPVALRRHATSKIASLQDLEAVGTMGFRGEALAAINSIADMSLLSRTLDGASGNAGEAAHAWQLDGRTGEL
KPAARSRGTSVEVRELFYATPARRKFLKTDATELAHCIEAVRRHALVRPDVGFAIWHEGKLVEQWRACPGEPAAAHTQRL
ADVLGSDFVEQSVAVYYESAARRTDGLPAVRVWGRAGIPDAARSRADQQFAYVNGRYVRDKVLTHAARSAYEDVLHGHRQ
PVYALYVEMDPARVDVNVHPTKIEVRFRDSREVHQAVRHATENALATPRSAAAASPDGAAADTAAPLISSEFSASNTGFT
QKTWGQPTINFAANGGHRASDFEAMWPVPVQPGRPAASDGFSPSPSLPQGASSAGPADSLPPGDWPLGRAIAQLQGIYVL
AENAQGLVIVDMHAAHERIVYERLKSQMDSSEGAHIASQPLLIPATFAASPQEVATAEACIETLATLGLEITPFSPRTLA
VRAVPTSLAQGDAVELARSVLAELAQHDASTVIQRAQNELLSTMACHGAVRANRKLTIDEMNALLRQMEATERSDQCNHG
RPTWRQVSIRELDALFLRGR

Sequences:

>Translated_660_residues
MAATMSALPSTLSPLQTSPPPRKPIRELPDELISQIAAGEVVERPASVVRELVDNALDAGATQVTVRLLAGGVRLILVED
DGQGIPREELPVALRRHATSKIASLQDLEAVGTMGFRGEALAAINSIADMSLLSRTLDGASGNAGEAAHAWQLDGRTGEL
KPAARSRGTSVEVRELFYATPARRKFLKTDATELAHCIEAVRRHALVRPDVGFAIWHEGKLVEQWRACPGEPAAAHTQRL
ADVLGSDFVEQSVAVYYESAARRTDGLPAVRVWGRAGIPDAARSRADQQFAYVNGRYVRDKVLTHAARSAYEDVLHGHRQ
PVYALYVEMDPARVDVNVHPTKIEVRFRDSREVHQAVRHATENALATPRSAAAASPDGAAADTAAPLISSEFSASNTGFT
QKTWGQPTINFAANGGHRASDFEAMWPVPVQPGRPAASDGFSPSPSLPQGASSAGPADSLPPGDWPLGRAIAQLQGIYVL
AENAQGLVIVDMHAAHERIVYERLKSQMDSSEGAHIASQPLLIPATFAASPQEVATAEACIETLATLGLEITPFSPRTLA
VRAVPTSLAQGDAVELARSVLAELAQHDASTVIQRAQNELLSTMACHGAVRANRKLTIDEMNALLRQMEATERSDQCNHG
RPTWRQVSIRELDALFLRGR
>Mature_659_residues
AATMSALPSTLSPLQTSPPPRKPIRELPDELISQIAAGEVVERPASVVRELVDNALDAGATQVTVRLLAGGVRLILVEDD
GQGIPREELPVALRRHATSKIASLQDLEAVGTMGFRGEALAAINSIADMSLLSRTLDGASGNAGEAAHAWQLDGRTGELK
PAARSRGTSVEVRELFYATPARRKFLKTDATELAHCIEAVRRHALVRPDVGFAIWHEGKLVEQWRACPGEPAAAHTQRLA
DVLGSDFVEQSVAVYYESAARRTDGLPAVRVWGRAGIPDAARSRADQQFAYVNGRYVRDKVLTHAARSAYEDVLHGHRQP
VYALYVEMDPARVDVNVHPTKIEVRFRDSREVHQAVRHATENALATPRSAAAASPDGAAADTAAPLISSEFSASNTGFTQ
KTWGQPTINFAANGGHRASDFEAMWPVPVQPGRPAASDGFSPSPSLPQGASSAGPADSLPPGDWPLGRAIAQLQGIYVLA
ENAQGLVIVDMHAAHERIVYERLKSQMDSSEGAHIASQPLLIPATFAASPQEVATAEACIETLATLGLEITPFSPRTLAV
RAVPTSLAQGDAVELARSVLAELAQHDASTVIQRAQNELLSTMACHGAVRANRKLTIDEMNALLRQMEATERSDQCNHGR
PTWRQVSIRELDALFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=349, Percent_Identity=32.6647564469914, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI4505911, Length=394, Percent_Identity=27.6649746192893, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI189458898, Length=394, Percent_Identity=27.6649746192893, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=27.7936962750716, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=27.7936962750716, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI189458896, Length=391, Percent_Identity=25.5754475703325, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI263191589, Length=260, Percent_Identity=28.8461538461538, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI310128480, Length=294, Percent_Identity=25.8503401360544, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=24.3767313019391, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=24.3767313019391, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1790612, Length=578, Percent_Identity=37.5432525951557, Blast_Score=308, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI71991825, Length=332, Percent_Identity=34.0361445783133, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=26.0989010989011, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=370, Percent_Identity=28.3783783783784, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=380, Percent_Identity=26.0526315789474, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=742, Percent_Identity=21.4285714285714, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=342, Percent_Identity=30.1169590643275, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17136970, Length=370, Percent_Identity=26.7567567567568, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70908; Mature: 70776

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATMSALPSTLSPLQTSPPPRKPIRELPDELISQIAAGEVVERPASVVRELVDNALDAG
CCCCHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATQVTVRLLAGGVRLILVEDDGQGIPREELPVALRRHATSKIASLQDLEAVGTMGFRGEA
HHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LAAINSIADMSLLSRTLDGASGNAGEAAHAWQLDGRTGELKPAARSRGTSVEVRELFYAT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHHHHCC
PARRKFLKTDATELAHCIEAVRRHALVRPDVGFAIWHEGKLVEQWRACPGEPAAAHTQRL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHH
ADVLGSDFVEQSVAVYYESAARRTDGLPAVRVWGRAGIPDAARSRADQQFAYVNGRYVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHEEHCCCCHHHH
KVLTHAARSAYEDVLHGHRQPVYALYVEMDPARVDVNVHPTKIEVRFRDSREVHQAVRHA
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHH
TENALATPRSAAAASPDGAAADTAAPLISSEFSASNTGFTQKTWGQPTINFAANGGHRAS
HHHHHCCCCHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
DFEAMWPVPVQPGRPAASDGFSPSPSLPQGASSAGPADSLPPGDWPLGRAIAQLQGIYVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
AENAQGLVIVDMHAAHERIVYERLKSQMDSSEGAHIASQPLLIPATFAASPQEVATAEAC
EECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCHHHHHHHHHH
IETLATLGLEITPFSPRTLAVRAVPTSLAQGDAVELARSVLAELAQHDASTVIQRAQNEL
HHHHHHCCCEECCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTMACHGAVRANRKLTIDEMNALLRQMEATERSDQCNHGRPTWRQVSIRELDALFLRGR
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AATMSALPSTLSPLQTSPPPRKPIRELPDELISQIAAGEVVERPASVVRELVDNALDAG
CCCHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATQVTVRLLAGGVRLILVEDDGQGIPREELPVALRRHATSKIASLQDLEAVGTMGFRGEA
HHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LAAINSIADMSLLSRTLDGASGNAGEAAHAWQLDGRTGELKPAARSRGTSVEVRELFYAT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHHHHCC
PARRKFLKTDATELAHCIEAVRRHALVRPDVGFAIWHEGKLVEQWRACPGEPAAAHTQRL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHH
ADVLGSDFVEQSVAVYYESAARRTDGLPAVRVWGRAGIPDAARSRADQQFAYVNGRYVRD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHEEHCCCCHHHH
KVLTHAARSAYEDVLHGHRQPVYALYVEMDPARVDVNVHPTKIEVRFRDSREVHQAVRHA
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCEEEEEECCCHHHHHHHHHH
TENALATPRSAAAASPDGAAADTAAPLISSEFSASNTGFTQKTWGQPTINFAANGGHRAS
HHHHHCCCCHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
DFEAMWPVPVQPGRPAASDGFSPSPSLPQGASSAGPADSLPPGDWPLGRAIAQLQGIYVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
AENAQGLVIVDMHAAHERIVYERLKSQMDSSEGAHIASQPLLIPATFAASPQEVATAEAC
EECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCHHHHHHHHHH
IETLATLGLEITPFSPRTLAVRAVPTSLAQGDAVELARSVLAELAQHDASTVIQRAQNEL
HHHHHHCCCEECCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTMACHGAVRANRKLTIDEMNALLRQMEATERSDQCNHGRPTWRQVSIRELDALFLRGR
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]