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The map label for this gene is pyrG [H]

Identifier: 91789041

GI number: 91789041

Start: 3365027

End: 3366718

Strand: Direct

Name: pyrG [H]

Synonym: Bpro_3181

Alternate gene names: 91789041

Gene position: 3365027-3366718 (Clockwise)

Preceding gene: 91789036

Following gene: 91789042

Centisome position: 64.71

GC content: 59.75

Gene sequence:

>1692_bases
ATGACCAAATTTGTCTTCGTCACCGGCGGTGTGGTGTCTTCCCTGGGCAAGGGAATCGCCTCAGCCTCCTTAGCTGCGAT
CCTTGAATCGCGAGGCCTCAAAGTCACTCTTATCAAGCTGGATCCCTACCTCAACGTGGATCCCGGCACCATGTCGCCCT
TTCAGCACGGTGAAGTTTTCGTCACTGATGACGGCGCCGAAACCGATCTGGACCTGGGCCACTACGAGCGCTTCATTGAA
ACGCGCATGCGCAAGGCCAACAACTTCACCACCGGCCAGATTTACAAAAGCGTGCTCGAAAAAGAACGTCGCGGCGACTA
TCTTGGGAAGACCGTGCAGGTCATTCCCCACGTCACCAACGAAATTCAGGAATTCATCAAGCGCGGCGCTGGCTATGAAA
CCGCTGATGCGGTCGATGTGGCGATTGTCGAAGTAGGCGGCACCGTCGGCGACATCGAATCCCTGCCCTTTCTGGAGGCC
GTGCGGCAGATGAGCCTGCGGATGGGGCCCAACAACACCGCATTTGTGCATCTGAGCTATGTGCCGTGGATTGCGGCCGC
CGGCGAACTCAAGACCAAGCCGACGCAGCACACGGCCAAGCAATTGCGCGAAATCGGCATTCAGGCCGACGTGCTGCTGT
GCCGCGCAGACCGTCGCATTCCGGCGGAAGAGCGTGAAAAAATCTCCCTCTTCTCCAACGTGCCCGAGTGGGGTGTCATT
TCCATGTGGGACGTGGACACGATTTACAAGGTCCCGCGCATGTTGCACGAGCAGGGACTGGATGGCCTGATCTGCGACAA
GCTGCGCCTGAATACGCCGCCAGCCAATCTCAAGCGCTGGGACGATCTGGTGTATGAAACCGAGCATCCCAAGACCGAGG
TCAACATTGCCATGGTTGGCAAGTATGTGGACCTCTCCGACAGCTACAAGTCGCTCAACGAGGCCCTGCGTCATGCGGGC
ATGAAAAACCATGCCAAGGTGGTCATCGAGTATTTCGACTCCGAAACCATCACCCCCGATAACGTGTCGCGCCTGGCACG
CTTCGACGGCATTCTGGTGCCTGGCGGCTTCGGTGTGCGGGGTGTCGAAGGCAAGATTTGCGCCGCCCGCTTCGCCCGTG
AAAACAAAATACCCTACCTCGGTATCTGCCTGGGCATGCAAGTGGCCACCATCGAATTTGCGCGCCACGTCGCGGGCCTG
AAAGACGCGAACAGCACCGAGTTCGACCCGGCCACCCCCAACCCCGTTATCGCGCTCATCACCGAGTGGAAAGACGCCGA
CGGCACCATCAAGACGCGCGACGCCAAGTCCGACCTGGGTGGCACCATGCGGCTTGGCGCTCAAAGCTCCGATGTCGCCA
AGGGCTCGCTGGCCCACAAAATCTATGGCGATGTGGTGACCGAGCGGCATCGCCATCGCTATGAAGCCAACGTCAACTAC
CTCGACGCCTTGCGCAAATCGGGCCTCGTCATTTCGGCGCTCACGCAGCGCGAGCACCTGACCGAGATCGTGGAATTGCC
GCAGGATGTGCACCCGTGGTTCGTGGGTGTGCAGTTTCACCCCGAATTCAAATCCACCCCCTGGGCCGGGCACCCGCTGT
TCAATGCCTACATTGCGGCGGTGCTTGAGCACCGCGTCAAGGCCGGCCAGGATGGCAAAGCCACGGCCAAGGCCCTGAAA
GCGGTGGCCTGA

Upstream 100 bases:

>100_bases
AGGAAAGCCCGGGTTTTAGTGCCTCCGCTGGCGGCCGCCGTGCGGCCAACCCGTATAATCTCCGTTTACCACCTCTGCGA
ACTTGCGGTTCGTACCTGAC

Downstream 100 bases:

>100_bases
CCATGAAACTATGCGGATTTGACATTGGTCTGAACCAGCCGTTTTTCCTGATTGCCGGACCCTGCGTGGTGGAGTCCGAA
CAGCTCCAGATGGACACGGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIE
TRMRKANNFTTGQIYKSVLEKERRGDYLGKTVQVIPHVTNEIQEFIKRGAGYETADAVDVAIVEVGGTVGDIESLPFLEA
VRQMSLRMGPNNTAFVHLSYVPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRRIPAEEREKISLFSNVPEWGVI
SMWDVDTIYKVPRMLHEQGLDGLICDKLRLNTPPANLKRWDDLVYETEHPKTEVNIAMVGKYVDLSDSYKSLNEALRHAG
MKNHAKVVIEYFDSETITPDNVSRLARFDGILVPGGFGVRGVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGL
KDANSTEFDPATPNPVIALITEWKDADGTIKTRDAKSDLGGTMRLGAQSSDVAKGSLAHKIYGDVVTERHRHRYEANVNY
LDALRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWAGHPLFNAYIAAVLEHRVKAGQDGKATAKALK
AVA

Sequences:

>Translated_563_residues
MTKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIE
TRMRKANNFTTGQIYKSVLEKERRGDYLGKTVQVIPHVTNEIQEFIKRGAGYETADAVDVAIVEVGGTVGDIESLPFLEA
VRQMSLRMGPNNTAFVHLSYVPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRRIPAEEREKISLFSNVPEWGVI
SMWDVDTIYKVPRMLHEQGLDGLICDKLRLNTPPANLKRWDDLVYETEHPKTEVNIAMVGKYVDLSDSYKSLNEALRHAG
MKNHAKVVIEYFDSETITPDNVSRLARFDGILVPGGFGVRGVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGL
KDANSTEFDPATPNPVIALITEWKDADGTIKTRDAKSDLGGTMRLGAQSSDVAKGSLAHKIYGDVVTERHRHRYEANVNY
LDALRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWAGHPLFNAYIAAVLEHRVKAGQDGKATAKALK
AVA
>Mature_562_residues
TKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYLNVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIET
RMRKANNFTTGQIYKSVLEKERRGDYLGKTVQVIPHVTNEIQEFIKRGAGYETADAVDVAIVEVGGTVGDIESLPFLEAV
RQMSLRMGPNNTAFVHLSYVPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRRIPAEEREKISLFSNVPEWGVIS
MWDVDTIYKVPRMLHEQGLDGLICDKLRLNTPPANLKRWDDLVYETEHPKTEVNIAMVGKYVDLSDSYKSLNEALRHAGM
KNHAKVVIEYFDSETITPDNVSRLARFDGILVPGGFGVRGVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGLK
DANSTEFDPATPNPVIALITEWKDADGTIKTRDAKSDLGGTMRLGAQSSDVAKGSLAHKIYGDVVTERHRHRYEANVNYL
DALRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWAGHPLFNAYIAAVLEHRVKAGQDGKATAKALKA
VA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=570, Percent_Identity=44.9122807017544, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI28559085, Length=558, Percent_Identity=43.5483870967742, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI28559083, Length=558, Percent_Identity=43.5483870967742, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI221316689, Length=558, Percent_Identity=43.5483870967742, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=550, Percent_Identity=59.8181818181818, Blast_Score=673, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=40.3624382207578, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=42.8822495606327, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322563, Length=575, Percent_Identity=41.9130434782609, Blast_Score=442, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24664469, Length=561, Percent_Identity=44.3850267379679, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21357815, Length=515, Percent_Identity=42.9126213592233, Blast_Score=400, Evalue=1e-111,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 62211; Mature: 62080

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYLNVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIETRMRKANNFTTGQIYKSVLEKERRGDYLGKTVQVIPHVTN
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQEFIKRGAGYETADAVDVAIVEVGGTVGDIESLPFLEAVRQMSLRMGPNNTAFVHLSY
HHHHHHHHCCCCCCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRRIPAEEREKISLFSNVPEWGVI
CCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
SMWDVDTIYKVPRMLHEQGLDGLICDKLRLNTPPANLKRWDDLVYETEHPKTEVNIAMVG
EEECHHHHHHHHHHHHHCCCCCEEECCEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEE
KYVDLSDSYKSLNEALRHAGMKNHAKVVIEYFDSETITPDNVSRLARFDGILVPGGFGVR
EEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCC
GVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGLKDANSTEFDPATPNPVIALI
CCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
TEWKDADGTIKTRDAKSDLGGTMRLGAQSSDVAKGSLAHKIYGDVVTERHRHRYEANVNY
EECCCCCCCEEECCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
LDALRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWAGHPLFNAYIAA
HHHHHHCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
VLEHRVKAGQDGKATAKALKAVA
HHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TKFVFVTGGVVSSLGKGIASASLAAILESRGLKVTLIKLDPYLNVDPGTMSPFQHGEVF
CEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIETRMRKANNFTTGQIYKSVLEKERRGDYLGKTVQVIPHVTN
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQEFIKRGAGYETADAVDVAIVEVGGTVGDIESLPFLEAVRQMSLRMGPNNTAFVHLSY
HHHHHHHHCCCCCCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPWIAAAGELKTKPTQHTAKQLREIGIQADVLLCRADRRIPAEEREKISLFSNVPEWGVI
CCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
SMWDVDTIYKVPRMLHEQGLDGLICDKLRLNTPPANLKRWDDLVYETEHPKTEVNIAMVG
EEECHHHHHHHHHHHHHCCCCCEEECCEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEE
KYVDLSDSYKSLNEALRHAGMKNHAKVVIEYFDSETITPDNVSRLARFDGILVPGGFGVR
EEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCC
GVEGKICAARFARENKIPYLGICLGMQVATIEFARHVAGLKDANSTEFDPATPNPVIALI
CCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
TEWKDADGTIKTRDAKSDLGGTMRLGAQSSDVAKGSLAHKIYGDVVTERHRHRYEANVNY
EECCCCCCCEEECCCHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
LDALRKSGLVISALTQREHLTEIVELPQDVHPWFVGVQFHPEFKSTPWAGHPLFNAYIAA
HHHHHHCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
VLEHRVKAGQDGKATAKALKAVA
HHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA