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The map label for this gene is adk [H]

Identifier: 91788812

GI number: 91788812

Start: 3112958

End: 3113614

Strand: Direct

Name: adk [H]

Synonym: Bpro_2952

Alternate gene names: 91788812

Gene position: 3112958-3113614 (Clockwise)

Preceding gene: 91788811

Following gene: 91788814

Centisome position: 59.86

GC content: 58.3

Gene sequence:

>657_bases
ATGAGACTGATTTTGTTGGGCGCGCCTGGCGCAGGAAAAGGGACGCAAGCGACCTTCATCTGCCAAAAATACGGCATTCC
CCAGATTTCCACCGGCGATATGCTTCGTGCAGCCGTCAAGGCAGGAACCCCGTTGGGCGTTGAAGCCAAAAAAATCATGG
ATGCTGGCGCGCTTGTCAGTGATGACCTGATCATCAACCTGGTAAAGGAACGTATCGCCCAGCCCGACTGTGCAAAGGGT
TTCTTGTTTGACGGTTTTCCCCGCACCATTCCCCAGGCCGACGCCATGAAAGCTGCCGGCGTGAAGATCGACTACGTGCT
TGAAATCGATGTGCCTTTTGAAGCCATCATCGAGCGCATGAGCGGGCGCCGCTCACACACGGCATCGGGCCGCACCTACC
ACGTGAAATACAACCCGCCCAAGGTCGAAGGCAAGGACGACGTCACCGGTGAGCCGCTGATCCAGCGCGAAGACGACAAG
GAAGAGACCGTGCGCAAGCGGCTGGAGGTGTACAGCGCGCAAACCCGCCCCTTGGTGGAGTACTACTCAAGCTGGGCAAA
AACTTCGCCCCAGGCAGCCCCCAAATACCGCGCCATCAGCGGCATGGGCGGTGTGGATGAGATCACCGAAAGAGCCTTCC
AGGCCCTGTCAAGCTGA

Upstream 100 bases:

>100_bases
CGTGACGTGCCCCTCAACACCTGACAAGCAGCCCATGGAGATACCGGCGCGCCGGACTCCCGGGTTGCCTTCCTGAATTC
ATAAAAATCCGAGGACATCC

Downstream 100 bases:

>100_bases
GGCGACCCGAAAGGCCTTCGGGCCATCCTGAAGACGGCATGGCGCCGGGCCTCAGCCCAGCAAACGAAGCATCAGGTCTA
TCCGCGCCTTCACCGGACTC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLILLGAPGAGKGTQATFICQKYGIPQISTGDMLRAAVKAGTPLGVEAKKIMDAGALVSDDLIINLVKERIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKIDYVLEIDVPFEAIIERMSGRRSHTASGRTYHVKYNPPKVEGKDDVTGEPLIQREDDK
EETVRKRLEVYSAQTRPLVEYYSSWAKTSPQAAPKYRAISGMGGVDEITERAFQALSS

Sequences:

>Translated_218_residues
MRLILLGAPGAGKGTQATFICQKYGIPQISTGDMLRAAVKAGTPLGVEAKKIMDAGALVSDDLIINLVKERIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKIDYVLEIDVPFEAIIERMSGRRSHTASGRTYHVKYNPPKVEGKDDVTGEPLIQREDDK
EETVRKRLEVYSAQTRPLVEYYSSWAKTSPQAAPKYRAISGMGGVDEITERAFQALSS
>Mature_218_residues
MRLILLGAPGAGKGTQATFICQKYGIPQISTGDMLRAAVKAGTPLGVEAKKIMDAGALVSDDLIINLVKERIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKIDYVLEIDVPFEAIIERMSGRRSHTASGRTYHVKYNPPKVEGKDDVTGEPLIQREDDK
EETVRKRLEVYSAQTRPLVEYYSSWAKTSPQAAPKYRAISGMGGVDEITERAFQALSS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=48.9247311827957, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=48.9247311827957, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=47.8021978021978, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=41.8478260869565, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=41.8478260869565, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=41.8478260869565, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=41.8478260869565, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI22749187, Length=187, Percent_Identity=30.4812834224599, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI4502011, Length=181, Percent_Identity=32.5966850828729, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=28.6995515695067, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144899, Length=183, Percent_Identity=26.775956284153, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=25.2380952380952, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI237858799, Length=151, Percent_Identity=26.4900662251656, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21450759, Length=151, Percent_Identity=26.4900662251656, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=67.7884615384615, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=47.8494623655914, Blast_Score=188, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=208, Percent_Identity=33.1730769230769, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=28.8770053475936, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=29.3478260869565, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=47.029702970297, Blast_Score=202, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=45.1612903225806, Blast_Score=154, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=29.1005291005291, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=49.7267759562842, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=45.6043956043956, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=45.6043956043956, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=29.5774647887324, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=29.5774647887324, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23792; Mature: 23792

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQATFICQKYGIPQISTGDMLRAAVKAGTPLGVEAKKIMDAGALVS
CEEEEEECCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHH
DDLIINLVKERIAQPDCAKGFLFDGFPRTIPQADAMKAAGVKIDYVLEIDVPFEAIIERM
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHTASGRTYHVKYNPPKVEGKDDVTGEPLIQREDDKEETVRKRLEVYSAQTRPLVE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
YYSSWAKTSPQAAPKYRAISGMGGVDEITERAFQALSS
HHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQATFICQKYGIPQISTGDMLRAAVKAGTPLGVEAKKIMDAGALVS
CEEEEEECCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHH
DDLIINLVKERIAQPDCAKGFLFDGFPRTIPQADAMKAAGVKIDYVLEIDVPFEAIIERM
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHTASGRTYHVKYNPPKVEGKDDVTGEPLIQREDDKEETVRKRLEVYSAQTRPLVE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
YYSSWAKTSPQAAPKYRAISGMGGVDEITERAFQALSS
HHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA