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The map label for this gene is ribB [H]

Identifier: 91788746

GI number: 91788746

Start: 3045829

End: 3046932

Strand: Direct

Name: ribB [H]

Synonym: Bpro_2885

Alternate gene names: 91788746

Gene position: 3045829-3046932 (Clockwise)

Preceding gene: 91788745

Following gene: 91788747

Centisome position: 58.57

GC content: 62.77

Gene sequence:

>1104_bases
ATGACCACTGTAATTTCCCCTGTTGAAGACATCGTTGCCGACATGCGCGCCGGCCGCATGGTTATCTTGATCGACGAAGA
AGACCGCGAAAACGAAGGCGACCTCGTCCTGGCAGCAGACCACGTCAGCGCAGAGGCCATCAACTTCATGGCCCGCTTCG
GTCGTGGCCTGATCTGCCTGACACTGACGCGCGAACGCTGCGAGTTGCTGCAATTACCCCCCATGGCCACCCGTAACGGC
ACCAAGCATTCGACCGCCTTTACCGTGTCCATTGAAGCGGCCGAAGGCGTCACCACGGGTATTTCTGCCGCTGACCGGGC
TCGCACGGTACAGGCCGCCGTAGCCAAAGACGCCAAGGTCAGCGATTTGGTGCAACCCGGCCATATCTTTCCCCTCCAGG
CTGTCGATGGCGGCGTTCTGATGCGCGCTGGCCACACCGAGGCGGGCTGTGACCTGGCGAGCATGGCCGGCTGCTCGCCG
GCCGCCGTAATTTGCGAGATCATGAAGGACGACGGCACCATGGCCCGCCTGCCTGACTTGCTCCTATTTGCCGCTGAACA
CGGCCTGAAGATTGGCACCATTGCCGACCTGATCGAACACCGCAGCCGCAACGAGTCGCTGATTGAGAAAATTGGCAGCC
GCACGCTGCAAACCGCATTCGGCGAATTTACCGTGCATGCGTTCAAGGATAAGCCCAGCCAGGGCCTGCACCTGGCACTG
GTCCGGGGTCAGTGGTCAGCGGACGATACCGTCGCCGCGCGGGTGCATGAGCCGCTGTCGGTCCTGGACGCGCTGGAGGT
CCAGCGTTCCATGCATTCGTGGAGCCTGGACCAGAGCCTGAACCATATTGCCAGGGAAGGCAAAGGCGTGGCCGTGCTGC
TGAACTGCGGCGAAAGCGCGGCGCAGTTGCTGGCCCAGTTTGAAGGCACGGCCCGTGCCAGCCAGGCGCCCGAGCGCGGC
CGCATGGACCTGCGCACCTATGGCGTGGGCGCGCAGATCTTGCGCGAATGCGGCGTGCACAAAATGAACCTCCTGGGCAA
CCCGCGCCGCATGCCCAGCATGACCGGCTATGGCCTGGAGATCGTCGGCTACATCACTCAATAA

Upstream 100 bases:

>100_bases
ACTGGCGGCAGGCTCTGAGGTCAATCTGGAAATCGACCTGATCGCGCGCTATGTTGAACGCATGCTCAAAGACACCCATT
CACCCCGAAAAAGCTGACCC

Downstream 100 bases:

>100_bases
TTCAATCATTCAAATAATTCAATCAAGGGAGTTCATTGTGTTTGGTGCAGAAAAAGGTTCAACCGACAAGCTTGACGGCC
GGAAATTTTCCATTGGCATT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTTVISPVEDIVADMRAGRMVILIDEEDRENEGDLVLAADHVSAEAINFMARFGRGLICLTLTRERCELLQLPPMATRNG
TKHSTAFTVSIEAAEGVTTGISAADRARTVQAAVAKDAKVSDLVQPGHIFPLQAVDGGVLMRAGHTEAGCDLASMAGCSP
AAVICEIMKDDGTMARLPDLLLFAAEHGLKIGTIADLIEHRSRNESLIEKIGSRTLQTAFGEFTVHAFKDKPSQGLHLAL
VRGQWSADDTVAARVHEPLSVLDALEVQRSMHSWSLDQSLNHIAREGKGVAVLLNCGESAAQLLAQFEGTARASQAPERG
RMDLRTYGVGAQILRECGVHKMNLLGNPRRMPSMTGYGLEIVGYITQ

Sequences:

>Translated_367_residues
MTTVISPVEDIVADMRAGRMVILIDEEDRENEGDLVLAADHVSAEAINFMARFGRGLICLTLTRERCELLQLPPMATRNG
TKHSTAFTVSIEAAEGVTTGISAADRARTVQAAVAKDAKVSDLVQPGHIFPLQAVDGGVLMRAGHTEAGCDLASMAGCSP
AAVICEIMKDDGTMARLPDLLLFAAEHGLKIGTIADLIEHRSRNESLIEKIGSRTLQTAFGEFTVHAFKDKPSQGLHLAL
VRGQWSADDTVAARVHEPLSVLDALEVQRSMHSWSLDQSLNHIAREGKGVAVLLNCGESAAQLLAQFEGTARASQAPERG
RMDLRTYGVGAQILRECGVHKMNLLGNPRRMPSMTGYGLEIVGYITQ
>Mature_366_residues
TTVISPVEDIVADMRAGRMVILIDEEDRENEGDLVLAADHVSAEAINFMARFGRGLICLTLTRERCELLQLPPMATRNGT
KHSTAFTVSIEAAEGVTTGISAADRARTVQAAVAKDAKVSDLVQPGHIFPLQAVDGGVLMRAGHTEAGCDLASMAGCSPA
AVICEIMKDDGTMARLPDLLLFAAEHGLKIGTIADLIEHRSRNESLIEKIGSRTLQTAFGEFTVHAFKDKPSQGLHLALV
RGQWSADDTVAARVHEPLSVLDALEVQRSMHSWSLDQSLNHIAREGKGVAVLLNCGESAAQLLAQFEGTARASQAPERGR
MDLRTYGVGAQILRECGVHKMNLLGNPRRMPSMTGYGLEIVGYITQ

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=50.7389162561576, Blast_Score=210, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=39.4230769230769, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 39487; Mature: 39356

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVISPVEDIVADMRAGRMVILIDEEDRENEGDLVLAADHVSAEAINFMARFGRGLICL
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEE
TLTRERCELLQLPPMATRNGTKHSTAFTVSIEAAEGVTTGISAADRARTVQAAVAKDAKV
EEEHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCH
SDLVQPGHIFPLQAVDGGVLMRAGHTEAGCDLASMAGCSPAAVICEIMKDDGTMARLPDL
HHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
LLFAAEHGLKIGTIADLIEHRSRNESLIEKIGSRTLQTAFGEFTVHAFKDKPSQGLHLAL
HHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEE
VRGQWSADDTVAARVHEPLSVLDALEVQRSMHSWSLDQSLNHIAREGKGVAVLLNCGESA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHH
AQLLAQFEGTARASQAPERGRMDLRTYGVGAQILRECGVHKMNLLGNPRRMPSMTGYGLE
HHHHHHHCCCHHHCCCCCCCCCEEEEECCHHHHHHHCCCEEEHHCCCCCCCCCCCCCCEE
IVGYITQ
EEEEECC
>Mature Secondary Structure 
TTVISPVEDIVADMRAGRMVILIDEEDRENEGDLVLAADHVSAEAINFMARFGRGLICL
CCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEE
TLTRERCELLQLPPMATRNGTKHSTAFTVSIEAAEGVTTGISAADRARTVQAAVAKDAKV
EEEHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCH
SDLVQPGHIFPLQAVDGGVLMRAGHTEAGCDLASMAGCSPAAVICEIMKDDGTMARLPDL
HHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
LLFAAEHGLKIGTIADLIEHRSRNESLIEKIGSRTLQTAFGEFTVHAFKDKPSQGLHLAL
HHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEE
VRGQWSADDTVAARVHEPLSVLDALEVQRSMHSWSLDQSLNHIAREGKGVAVLLNCGESA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHH
AQLLAQFEGTARASQAPERGRMDLRTYGVGAQILRECGVHKMNLLGNPRRMPSMTGYGLE
HHHHHHHCCCHHHCCCCCCCCCEEEEECCHHHHHHHCCCEEEHHCCCCCCCCCCCCCCEE
IVGYITQ
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]