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The map label for this gene is pyrD [H]

Identifier: 91788719

GI number: 91788719

Start: 3013038

End: 3014090

Strand: Direct

Name: pyrD [H]

Synonym: Bpro_2858

Alternate gene names: 91788719

Gene position: 3013038-3014090 (Clockwise)

Preceding gene: 91788717

Following gene: 91788720

Centisome position: 57.94

GC content: 62.68

Gene sequence:

>1053_bases
ATGTCCCTGCTCCCCTATGCCCTGGCCCGTCCCTTTTTATTTGGGCTCGACCCTGAAACGGCCCACGAGCTGACCATGGC
CTCGCTGGCACGCACCCAAGGCACCCCGCTGTCGCTGGCATGGTGCTCCAGCCGCGTGAACGACCCGATCGCGCTGGCCG
GCCTGAAGTTTGCCAACCGCGTGGGCCTGGCAGCCGGACTTGACAAGAATGCCCGCTGCATCGATGGCTTGGCGGCCATG
GGGTTTGGCTTTGTCGAAGTCGGCACCGTCACGCCCAAGGGGCAGCCCGGCAACCCCAAGCCACGCATGTTCCGCTTGCC
CGAGGCCAATGCGCTGATCAATCGCCTGGGCTTCAACAATGACGGGCTGGACGCCTTTTTAGCCAACGTGCAGCAGTCCC
GCGTTCGCAGGCAGAACACGCCCAACCCGCTGATCCTGGGCCTGAACATCGGCAAAAACGCCGTCACGCCGATTGAAAAC
GCGGTGGATGACTACCTGACCTGCCTGGATGGCGTATACCCCCATGCCGACTACGTCACCGTCAACATCTCCAGCCCCAA
CACCAAAAACCTGCGCGCGCTGCAAAGCGACGAAGCCCTCGACGCATTACTGGGCCGGATTGCCGAGCGGCGCGAATCCC
TCGCCAGACAACATGGCAAACGCGTGCCAATTTTTGTGAAGATCGCCCCCGACCTTGACGAAGCCCAGGTCGACGTGATT
GCCGCCACGCTGAAGCGCCATGCCATGGACGGCGTGGTTGCCACCAACACCACGCTGAGCCGCGATGCGGTCAAAGGGCT
GCGTCACGCCGAAGAGGCCGGTGGACTAAGCGGCGCCCCCGTACTCGAAGCCAGCAACCGCGTCATCCGCCAGCTGCGTG
CCGCGCTCGGTGCAGGCTTTCCCATCATTGGCGTTGGCGGTGTGATGAGCGGACAGGATGCCGTCTCCAAAATCAGGGCC
GGTGCGGACGTGGTGCAGATTTACACCGGCCTCATCTACAAAGGCCCGGAACTGGTGAACGAAGCGGCACTTGCGATCAA
AAAGAATCGTTGA

Upstream 100 bases:

>100_bases
GTAAGGATGAGAGGTTGGTTTTTGCGACAATCGGAGCCGATGTCCGGGCCACGCCCGGTCAACTCACAGCAAGTAGCTTC
AAATCAAGTCGAATTATCCA

Downstream 100 bases:

>100_bases
CCCCACACGTTTGTGAGCCGTGTCTTGAAGTCGCGCATTGGAGCTGCGCATTGAGGTGTCAGAGGGATCGCTTGCGTTTG
CACCTGTTTGGAATCAAACT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSLLPYALARPFLFGLDPETAHELTMASLARTQGTPLSLAWCSSRVNDPIALAGLKFANRVGLAAGLDKNARCIDGLAAM
GFGFVEVGTVTPKGQPGNPKPRMFRLPEANALINRLGFNNDGLDAFLANVQQSRVRRQNTPNPLILGLNIGKNAVTPIEN
AVDDYLTCLDGVYPHADYVTVNISSPNTKNLRALQSDEALDALLGRIAERRESLARQHGKRVPIFVKIAPDLDEAQVDVI
AATLKRHAMDGVVATNTTLSRDAVKGLRHAEEAGGLSGAPVLEASNRVIRQLRAALGAGFPIIGVGGVMSGQDAVSKIRA
GADVVQIYTGLIYKGPELVNEAALAIKKNR

Sequences:

>Translated_350_residues
MSLLPYALARPFLFGLDPETAHELTMASLARTQGTPLSLAWCSSRVNDPIALAGLKFANRVGLAAGLDKNARCIDGLAAM
GFGFVEVGTVTPKGQPGNPKPRMFRLPEANALINRLGFNNDGLDAFLANVQQSRVRRQNTPNPLILGLNIGKNAVTPIEN
AVDDYLTCLDGVYPHADYVTVNISSPNTKNLRALQSDEALDALLGRIAERRESLARQHGKRVPIFVKIAPDLDEAQVDVI
AATLKRHAMDGVVATNTTLSRDAVKGLRHAEEAGGLSGAPVLEASNRVIRQLRAALGAGFPIIGVGGVMSGQDAVSKIRA
GADVVQIYTGLIYKGPELVNEAALAIKKNR
>Mature_349_residues
SLLPYALARPFLFGLDPETAHELTMASLARTQGTPLSLAWCSSRVNDPIALAGLKFANRVGLAAGLDKNARCIDGLAAMG
FGFVEVGTVTPKGQPGNPKPRMFRLPEANALINRLGFNNDGLDAFLANVQQSRVRRQNTPNPLILGLNIGKNAVTPIENA
VDDYLTCLDGVYPHADYVTVNISSPNTKNLRALQSDEALDALLGRIAERRESLARQHGKRVPIFVKIAPDLDEAQVDVIA
ATLKRHAMDGVVATNTTLSRDAVKGLRHAEEAGGLSGAPVLEASNRVIRQLRAALGAGFPIIGVGGVMSGQDAVSKIRAG
ADVVQIYTGLIYKGPELVNEAALAIKKNR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=46.1309523809524, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1787177, Length=341, Percent_Identity=50.1466275659824, Blast_Score=332, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17509475, Length=288, Percent_Identity=43.0555555555556, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.9878048780488, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.9878048780488, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37251; Mature: 37120

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLPYALARPFLFGLDPETAHELTMASLARTQGTPLSLAWCSSRVNDPIALAGLKFANR
CCCCCHHHHCCCEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEHHHHHHHH
VGLAAGLDKNARCIDGLAAMGFGFVEVGTVTPKGQPGNPKPRMFRLPEANALINRLGFNN
HHHHHCCCCCCHHHHHHHHHCCCEEEECEECCCCCCCCCCCCEEECCCHHHHHHHCCCCC
DGLDAFLANVQQSRVRRQNTPNPLILGLNIGKNAVTPIENAVDDYLTCLDGVYPHADYVT
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
VNISSPNTKNLRALQSDEALDALLGRIAERRESLARQHGKRVPIFVKIAPDLDEAQVDVI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
AATLKRHAMDGVVATNTTLSRDAVKGLRHAEEAGGLSGAPVLEASNRVIRQLRAALGAGF
HHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
PIIGVGGVMSGQDAVSKIRAGADVVQIYTGLIYKGPELVNEAALAIKKNR
CEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHEECCC
>Mature Secondary Structure 
SLLPYALARPFLFGLDPETAHELTMASLARTQGTPLSLAWCSSRVNDPIALAGLKFANR
CCCCHHHHCCCEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEHHHHHHHH
VGLAAGLDKNARCIDGLAAMGFGFVEVGTVTPKGQPGNPKPRMFRLPEANALINRLGFNN
HHHHHCCCCCCHHHHHHHHHCCCEEEECEECCCCCCCCCCCCEEECCCHHHHHHHCCCCC
DGLDAFLANVQQSRVRRQNTPNPLILGLNIGKNAVTPIENAVDDYLTCLDGVYPHADYVT
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
VNISSPNTKNLRALQSDEALDALLGRIAERRESLARQHGKRVPIFVKIAPDLDEAQVDVI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHH
AATLKRHAMDGVVATNTTLSRDAVKGLRHAEEAGGLSGAPVLEASNRVIRQLRAALGAGF
HHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
PIIGVGGVMSGQDAVSKIRAGADVVQIYTGLIYKGPELVNEAALAIKKNR
CEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA