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The map label for this gene is cysG [H]

Identifier: 91788627

GI number: 91788627

Start: 2908486

End: 2909241

Strand: Reverse

Name: cysG [H]

Synonym: Bpro_2765

Alternate gene names: 91788627

Gene position: 2909241-2908486 (Counterclockwise)

Preceding gene: 91788628

Following gene: 91788626

Centisome position: 55.94

GC content: 67.86

Gene sequence:

>756_bases
ATGACGTTTGAGGCACAGGAGCACACCGGCCGCGGATTCGTGTCCATCGTGGGTGCAGGCCCGGGCCCGGTCGATTTGAT
GACGCTGCGGGCATTCGACCGGCTTCAGCGGGCCGAGGTGGTGGTGCACGACCGCCTGATCGCGCCGGAGGTACTGGCTT
TGATTCCCGTGGCCGCCCAGCGTGTGTATGTGGGCAAGGCCCTGGGCAACCATGCGGTGCCGCAGGGCGGCATCCATGAC
TTGCTGGTTCAGCATGCGCGCCTGGGCAAACGGGTGGTGCGCCTCAAGGGCGGTGATCCCTATGTGTTTGGGCGCGGGGG
CGAAGAGGTGCAGGCCTTGCAGGCGGCGGCTATTGCCTTTGAAGTGGTGCCGGGGGTGACCGCAGCCAGTGGCTGCTCGG
CGGCGGCGGGTATTCCGCTGACCCACCGCGACCTGGCGGGCAGCTGCGTATTTCTGCCCGGCCACCTGGCTGACGACGAA
GCCACGCACGACTGGCAGGCCTTGGCGCGTCCGGGCCAGACCCGTGTTTTTTACATGGGCGTACAGCGCCTGGCGCAGAT
TGCCCACCAGCTCATCGCGCATGGCCTGGCACCCGATACCCCGGCCGCCATCGTGCGCGACGGTGCCCGCGCCACGCAGA
CCGTCATCGCCACCGGGCTGCGCGACCTGGTGGCGCGCGCGCCGGCGTATGGTCCCCAGCCCGGCTTGCTCATCATTGGT
GAGACCGTGCAACTCAGCCCCCATTTCAACCTTTAG

Upstream 100 bases:

>100_bases
AACGTCACGCCCGCCAACATGGACCGCATCATTGACCAGCATCTGGTGGGCGGGCAGCCCGTGGCTGATCTGGTGTTCCA
TCAGGGTCCGGGGGACTGCC

Downstream 100 bases:

>100_bases
GTGATTGCCATGCAGATTGAAACCCCACCGTCCGACAAGCCCTATGACAAACCCGGGGGTGAACGCCGCGGCATCGTCAT
CGTCAATACCGGCGATGGCA

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTFEAQEHTGRGFVSIVGAGPGPVDLMTLRAFDRLQRAEVVVHDRLIAPEVLALIPVAAQRVYVGKALGNHAVPQGGIHD
LLVQHARLGKRVVRLKGGDPYVFGRGGEEVQALQAAAIAFEVVPGVTAASGCSAAAGIPLTHRDLAGSCVFLPGHLADDE
ATHDWQALARPGQTRVFYMGVQRLAQIAHQLIAHGLAPDTPAAIVRDGARATQTVIATGLRDLVARAPAYGPQPGLLIIG
ETVQLSPHFNL

Sequences:

>Translated_251_residues
MTFEAQEHTGRGFVSIVGAGPGPVDLMTLRAFDRLQRAEVVVHDRLIAPEVLALIPVAAQRVYVGKALGNHAVPQGGIHD
LLVQHARLGKRVVRLKGGDPYVFGRGGEEVQALQAAAIAFEVVPGVTAASGCSAAAGIPLTHRDLAGSCVFLPGHLADDE
ATHDWQALARPGQTRVFYMGVQRLAQIAHQLIAHGLAPDTPAAIVRDGARATQTVIATGLRDLVARAPAYGPQPGLLIIG
ETVQLSPHFNL
>Mature_250_residues
TFEAQEHTGRGFVSIVGAGPGPVDLMTLRAFDRLQRAEVVVHDRLIAPEVLALIPVAAQRVYVGKALGNHAVPQGGIHDL
LVQHARLGKRVVRLKGGDPYVFGRGGEEVQALQAAAIAFEVVPGVTAASGCSAAAGIPLTHRDLAGSCVFLPGHLADDEA
THDWQALARPGQTRVFYMGVQRLAQIAHQLIAHGLAPDTPAAIVRDGARATQTVIATGLRDLVARAPAYGPQPGLLIIGE
TVQLSPHFNL

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=50, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322922, Length=239, Percent_Identity=32.6359832635983, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26411; Mature: 26280

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEAQEHTGRGFVSIVGAGPGPVDLMTLRAFDRLQRAEVVVHDRLIAPEVLALIPVAAQ
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVYVGKALGNHAVPQGGIHDLLVQHARLGKRVVRLKGGDPYVFGRGGEEVQALQAAAIAF
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHHHH
EVVPGVTAASGCSAAAGIPLTHRDLAGSCVFLPGHLADDEATHDWQALARPGQTRVFYMG
HHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEHHH
VQRLAQIAHQLIAHGLAPDTPAAIVRDGARATQTVIATGLRDLVARAPAYGPQPGLLIIG
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
ETVQLSPHFNL
CEEEECCCCCC
>Mature Secondary Structure 
TFEAQEHTGRGFVSIVGAGPGPVDLMTLRAFDRLQRAEVVVHDRLIAPEVLALIPVAAQ
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVYVGKALGNHAVPQGGIHDLLVQHARLGKRVVRLKGGDPYVFGRGGEEVQALQAAAIAF
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHHHH
EVVPGVTAASGCSAAAGIPLTHRDLAGSCVFLPGHLADDEATHDWQALARPGQTRVFYMG
HHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEHHH
VQRLAQIAHQLIAHGLAPDTPAAIVRDGARATQTVIATGLRDLVARAPAYGPQPGLLIIG
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
ETVQLSPHFNL
CEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA