Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 91788576

GI number: 91788576

Start: 2859355

End: 2860734

Strand: Direct

Name: envZ [H]

Synonym: Bpro_2714

Alternate gene names: 91788576

Gene position: 2859355-2860734 (Clockwise)

Preceding gene: 91788575

Following gene: 91788579

Centisome position: 54.98

GC content: 62.9

Gene sequence:

>1380_bases
ATGGACGCCACCAACCCGATACCGCTTGAAACTGCGCCCGCTCCGCTGGAAATGCGCCCACGTCGGGGTTTCAGCCTGTT
CTGGCGGACCTTTTTCTTTCTGGCACTGCTGCTGCTCGGCTCCATCGTGGCCTGGCTTCAAACCTTTCGCGCACTGGAAT
CGGAACCGCGCGCCATTCAAAGCGCGCAGCAACTGGCATCGATGGTGAACCTGAGCCGTGCGGCCCTGCGCTATTCGGAC
TCGATCGCCCGGGTCTCGCTGATCAAGACGCTGGCCGACGAGGAACGCGTACGCATCACGCCACGTGAACCCAAGGACAA
GTTCGAACTCTTTGAAAGCGACGACGAACTGGGCGAGCGCATCACCCAGGAACTTCAGGCGCGCCTGGGCGGCAACACTG
TTGTAGCCAGCACAGTCAATGGCCAGAAGGGTTTGTGGGTTGGCTTTGCGATTGACGGAGACGCCTACTGGCTGCTCACC
GATCCTTCCAAGATGGGACCTTCCCGCGGCAGCACCTGGGTGATCTGGCTCATCACCGCGGCCATCCTGTCGCTGGCCGG
AGCCGCCTTCATCGCGCGCCTGATCAACCGTCCGCTCAAGCAGCTGTCATTCGCGGCCAGCCGCATGCGGGACGGCGATT
TTGACGCGAGCCTGCTCGACGAAAAAGTGGCCACCAGCGAAATCCGCGAGGTCAATATCGGCTTTAACCGCATGGCCGAA
CAGCTGTCCAAAATCGAGCAGGACCGGGTCATCATGCTGGCAGGTATTTCCCATGACTTGCGCACGCCGCTGGCACGCCT
GCGGCTGGAAACCGAAATGAGCGTGGCCGACAAGGACGCGCGCGACCACATGGCGGCCGACATCACCCAGCTCGATGCCA
TCATTGACAAATTTCTCGACTACGCCCGGCCCGAACCGGCCCGCCTTGAGTCGGTGTCGCTCAATGCCGTGATCGACGCG
GCGGTATACGCCGTGGGCGACTACGACGACATGCGGGTCACAGTGAGCGTTCCCGAGAACCTGGCCGTCCTCGCCGACGA
GGTCGAACTCTCTCGTGTCATTTCCAACCTGCTTGAAAATGCCCGGCGCTACGGCAAAACAGCCGAAACCGGCGTGGCGG
TGGTCGACATTGCGGCCAAGGTCCGGGACCAGTGGGTGCTGCTCAGGGTGCGCGACCACGGCATGGGCGTGGCGCCGGAA
ACCCTGCCCAAGCTCACACGCCCGTTTTTCCGTGGCGATGCAGCCCGCACGGCCGCAACCGGTGCAGGCCTGGGCCTGGC
GATTGTCGAGAAAACAGTCCAGCGCATGGGCGGCGTGTTTGGCCTGACCAACACCGGCTCTGGCGGGCTGGCCGCGCATA
TCAAGCTGCGCAGAAGCTGA

Upstream 100 bases:

>100_bases
CACGTCTTGCAGGAGGTGCCAGCCGTCCACGCTGACCTGACCGGCACCCGGCGAGACTCACGTCCATCCTTGCGCCCTTG
CGGCATGCCTACCCACCTTT

Downstream 100 bases:

>100_bases
GGCCAGTGCCGGGTGCCCAACTCACCCAACTCACCCGAACCTGCGCGATCAAACGTATAGCCTCAATACAGCAACACCAC
GGCACGAGCCTCCATGCTCC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MDATNPIPLETAPAPLEMRPRRGFSLFWRTFFFLALLLLGSIVAWLQTFRALESEPRAIQSAQQLASMVNLSRAALRYSD
SIARVSLIKTLADEERVRITPREPKDKFELFESDDELGERITQELQARLGGNTVVASTVNGQKGLWVGFAIDGDAYWLLT
DPSKMGPSRGSTWVIWLITAAILSLAGAAFIARLINRPLKQLSFAASRMRDGDFDASLLDEKVATSEIREVNIGFNRMAE
QLSKIEQDRVIMLAGISHDLRTPLARLRLETEMSVADKDARDHMAADITQLDAIIDKFLDYARPEPARLESVSLNAVIDA
AVYAVGDYDDMRVTVSVPENLAVLADEVELSRVISNLLENARRYGKTAETGVAVVDIAAKVRDQWVLLRVRDHGMGVAPE
TLPKLTRPFFRGDAARTAATGAGLGLAIVEKTVQRMGGVFGLTNTGSGGLAAHIKLRRS

Sequences:

>Translated_459_residues
MDATNPIPLETAPAPLEMRPRRGFSLFWRTFFFLALLLLGSIVAWLQTFRALESEPRAIQSAQQLASMVNLSRAALRYSD
SIARVSLIKTLADEERVRITPREPKDKFELFESDDELGERITQELQARLGGNTVVASTVNGQKGLWVGFAIDGDAYWLLT
DPSKMGPSRGSTWVIWLITAAILSLAGAAFIARLINRPLKQLSFAASRMRDGDFDASLLDEKVATSEIREVNIGFNRMAE
QLSKIEQDRVIMLAGISHDLRTPLARLRLETEMSVADKDARDHMAADITQLDAIIDKFLDYARPEPARLESVSLNAVIDA
AVYAVGDYDDMRVTVSVPENLAVLADEVELSRVISNLLENARRYGKTAETGVAVVDIAAKVRDQWVLLRVRDHGMGVAPE
TLPKLTRPFFRGDAARTAATGAGLGLAIVEKTVQRMGGVFGLTNTGSGGLAAHIKLRRS
>Mature_459_residues
MDATNPIPLETAPAPLEMRPRRGFSLFWRTFFFLALLLLGSIVAWLQTFRALESEPRAIQSAQQLASMVNLSRAALRYSD
SIARVSLIKTLADEERVRITPREPKDKFELFESDDELGERITQELQARLGGNTVVASTVNGQKGLWVGFAIDGDAYWLLT
DPSKMGPSRGSTWVIWLITAAILSLAGAAFIARLINRPLKQLSFAASRMRDGDFDASLLDEKVATSEIREVNIGFNRMAE
QLSKIEQDRVIMLAGISHDLRTPLARLRLETEMSVADKDARDHMAADITQLDAIIDKFLDYARPEPARLESVSLNAVIDA
AVYAVGDYDDMRVTVSVPENLAVLADEVELSRVISNLLENARRYGKTAETGVAVVDIAAKVRDQWVLLRVRDHGMGVAPE
TLPKLTRPFFRGDAARTAATGAGLGLAIVEKTVQRMGGVFGLTNTGSGGLAAHIKLRRS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=336, Percent_Identity=33.0357142857143, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=33.6805555555556, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=337, Percent_Identity=26.7062314540059, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=26.4150943396226, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=28.9795918367347, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=27.4914089347079, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=28.2945736434109, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=32.9059829059829, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.4444444444444, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=320, Percent_Identity=25.625, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=26.9360269360269, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=302, Percent_Identity=27.4834437086093, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790436, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=27.1428571428571, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50460; Mature: 50460

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATNPIPLETAPAPLEMRPRRGFSLFWRTFFFLALLLLGSIVAWLQTFRALESEPRAIQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SAQQLASMVNLSRAALRYSDSIARVSLIKTLADEERVRITPREPKDKFELFESDDELGER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHH
ITQELQARLGGNTVVASTVNGQKGLWVGFAIDGDAYWLLTDPSKMGPSRGSTWVIWLITA
HHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEEECHHHCCCCCCCEEEHHHHHH
AILSLAGAAFIARLINRPLKQLSFAASRMRDGDFDASLLDEKVATSEIREVNIGFNRMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
QLSKIEQDRVIMLAGISHDLRTPLARLRLETEMSVADKDARDHMAADITQLDAIIDKFLD
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YARPEPARLESVSLNAVIDAAVYAVGDYDDMRVTVSVPENLAVLADEVELSRVISNLLEN
HCCCCCCHHHHEEHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ARRYGKTAETGVAVVDIAAKVRDQWVLLRVRDHGMGVAPETLPKLTRPFFRGDAARTAAT
HHHCCCCHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHC
GAGLGLAIVEKTVQRMGGVFGLTNTGSGGLAAHIKLRRS
CCCCHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECC
>Mature Secondary Structure
MDATNPIPLETAPAPLEMRPRRGFSLFWRTFFFLALLLLGSIVAWLQTFRALESEPRAIQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SAQQLASMVNLSRAALRYSDSIARVSLIKTLADEERVRITPREPKDKFELFESDDELGER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHH
ITQELQARLGGNTVVASTVNGQKGLWVGFAIDGDAYWLLTDPSKMGPSRGSTWVIWLITA
HHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEEECHHHCCCCCCCEEEHHHHHH
AILSLAGAAFIARLINRPLKQLSFAASRMRDGDFDASLLDEKVATSEIREVNIGFNRMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
QLSKIEQDRVIMLAGISHDLRTPLARLRLETEMSVADKDARDHMAADITQLDAIIDKFLD
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YARPEPARLESVSLNAVIDAAVYAVGDYDDMRVTVSVPENLAVLADEVELSRVISNLLEN
HCCCCCCHHHHEEHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ARRYGKTAETGVAVVDIAAKVRDQWVLLRVRDHGMGVAPETLPKLTRPFFRGDAARTAAT
HHHCCCCHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHC
GAGLGLAIVEKTVQRMGGVFGLTNTGSGGLAAHIKLRRS
CCCCHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]