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The map label for this gene is aphA [H]

Identifier: 91788569

GI number: 91788569

Start: 2852849

End: 2853928

Strand: Reverse

Name: aphA [H]

Synonym: Bpro_2707

Alternate gene names: 91788569

Gene position: 2853928-2852849 (Counterclockwise)

Preceding gene: 91788570

Following gene: 91788568

Centisome position: 54.88

GC content: 63.98

Gene sequence:

>1080_bases
GTGGCGAATGCATTCAACCTCCTGGCAGACATGATTACTTTCTTCAATGACAGCCACCAGGCTCATGCCCCTGAATTCGA
ATTTTTCCGGGGAGAGCGTGTTCCATGCTTTGAGACCCCGGCGCGCGCCGAGTACGTCAAATCCAGCCTCACATCACGCG
GCCATGTGCTGCGCAGCCCGCAGATGGACAGCCGCACCGTGCTGGCCAGGGTGCATGCGCCGCGCTACCTGGCATTTCTG
GAACATGCCTGGCGGGACTGGGTCGCGCTGGAAGCCGGCAATGACCAGCGCCAGCCTTTTCCTTCGGTCTGGCCCGTGCG
TACCCTGCGCAGCGACGTAGAGCCCGTCAATTTCATTGCCCGGCTGGGCCTGTATTCGATGGACAACGGCTCGCCGCTCG
CCGCGGGCACCTGGACGGCGGCCAAGGCCGGTGCGGATGCCGCAGCCAGCGCGGCTGCTTTGCTGGCGGTAGGTGGACGA
CGTGGCGAGCAGGCCGTGTTTTGCTGCAGCCGCCCGCCCGGCCACCATGCCGGGCCGGATTTCATGGGTGGCTATTGCTT
TTTAAACAACGCGGCGGTGGCTGCCCAGGCACTGCGCGATGGCGGCGCGGCGCGGGTGGCCGTGCTCGACGTGGACTACC
ACCACGGCAACGGCACGCAAAGCATTTTTTATGACCGCGCCGATGTGCTGTTTGTCAGCCTGCACGGTGATCCGCTGACC
GAATACCCGTTCTACCTGGGCCATGCCGATGAGACCGGCGCCGGCGAGGGCGCAGGCTTCAATCTGAATCTGCCACTGCC
GGCGGGCTGCACAGCGGCGCGCTGGTTTGACGCGCTGGAGCAGGCCTGCCTTCGTATCGCGGCTTTCAAGGGTGACGCGC
TGGTGGTGTCGCTGGGACTGGACACTTTTGCCGAAGACCCCATTTCCAAATTTGCCCTGCAGGCCAGTGACTTCAGCCGC
CTGGGCGAGCGCTTGGGCAGGCTTGGCCTGCCGACGGTGTTTGTGCTGGAAGGCGGTTATGCCGCCACCGCGCTGGGCAC
CAATGCGGTGAATGTGATTGAAGGATTTGAGGGCATCTGA

Upstream 100 bases:

>100_bases
CTCGCTGGTGAGTCTCCTGCTGAAAACCGACCCGCGCCTGCTTTGATTGCCTTGATGTTTTCCCCTGGCAAACAAACGCT
GGTGCGGAGCCTGATATTGC

Downstream 100 bases:

>100_bases
ATGGACCAGATCGATTGCGTGGTGATAGGTGCAGGCGTGGTGGGCCTTGCGGTGGCGCGCGCGCTGGCATTGCAAGGCCG
CGAGGTGATGGTGCTGGAGG

Product: histone deacetylase superfamily protein protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MANAFNLLADMITFFNDSHQAHAPEFEFFRGERVPCFETPARAEYVKSSLTSRGHVLRSPQMDSRTVLARVHAPRYLAFL
EHAWRDWVALEAGNDQRQPFPSVWPVRTLRSDVEPVNFIARLGLYSMDNGSPLAAGTWTAAKAGADAAASAAALLAVGGR
RGEQAVFCCSRPPGHHAGPDFMGGYCFLNNAAVAAQALRDGGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSLHGDPLT
EYPFYLGHADETGAGEGAGFNLNLPLPAGCTAARWFDALEQACLRIAAFKGDALVVSLGLDTFAEDPISKFALQASDFSR
LGERLGRLGLPTVFVLEGGYAATALGTNAVNVIEGFEGI

Sequences:

>Translated_359_residues
MANAFNLLADMITFFNDSHQAHAPEFEFFRGERVPCFETPARAEYVKSSLTSRGHVLRSPQMDSRTVLARVHAPRYLAFL
EHAWRDWVALEAGNDQRQPFPSVWPVRTLRSDVEPVNFIARLGLYSMDNGSPLAAGTWTAAKAGADAAASAAALLAVGGR
RGEQAVFCCSRPPGHHAGPDFMGGYCFLNNAAVAAQALRDGGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSLHGDPLT
EYPFYLGHADETGAGEGAGFNLNLPLPAGCTAARWFDALEQACLRIAAFKGDALVVSLGLDTFAEDPISKFALQASDFSR
LGERLGRLGLPTVFVLEGGYAATALGTNAVNVIEGFEGI
>Mature_358_residues
ANAFNLLADMITFFNDSHQAHAPEFEFFRGERVPCFETPARAEYVKSSLTSRGHVLRSPQMDSRTVLARVHAPRYLAFLE
HAWRDWVALEAGNDQRQPFPSVWPVRTLRSDVEPVNFIARLGLYSMDNGSPLAAGTWTAAKAGADAAASAAALLAVGGRR
GEQAVFCCSRPPGHHAGPDFMGGYCFLNNAAVAAQALRDGGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSLHGDPLTE
YPFYLGHADETGAGEGAGFNLNLPLPAGCTAARWFDALEQACLRIAAFKGDALVVSLGLDTFAEDPISKFALQASDFSRL
GERLGRLGLPTVFVLEGGYAATALGTNAVNVIEGFEGI

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI153085395, Length=189, Percent_Identity=37.037037037037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI30795204, Length=194, Percent_Identity=33.5051546391753, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI30795202, Length=194, Percent_Identity=33.5051546391753, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI17158039, Length=194, Percent_Identity=33.5051546391753, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI169234807, Length=188, Percent_Identity=35.1063829787234, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI148539870, Length=188, Percent_Identity=35.1063829787234, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13128864, Length=184, Percent_Identity=36.4130434782609, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI20070354, Length=194, Percent_Identity=34.5360824742268, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62750349, Length=188, Percent_Identity=34.0425531914894, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI62750347, Length=188, Percent_Identity=34.0425531914894, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI8923769, Length=167, Percent_Identity=29.940119760479, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI262073088, Length=167, Percent_Identity=28.7425149700599, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI226529806, Length=98, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI13128860, Length=168, Percent_Identity=27.9761904761905, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540334, Length=203, Percent_Identity=34.4827586206897, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=203, Percent_Identity=34.4827586206897, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=203, Percent_Identity=34.4827586206897, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI193209491, Length=348, Percent_Identity=26.1494252873563, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=228, Percent_Identity=32.0175438596491, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=322, Percent_Identity=25.4658385093168, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534739, Length=224, Percent_Identity=26.7857142857143, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25154020, Length=197, Percent_Identity=26.3959390862944, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25154022, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561978, Length=279, Percent_Identity=25.089605734767, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=224, Percent_Identity=35.2678571428571, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321244, Length=241, Percent_Identity=26.1410788381743, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323999, Length=169, Percent_Identity=27.810650887574, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24642144, Length=195, Percent_Identity=38.974358974359, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642142, Length=195, Percent_Identity=38.974358974359, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642146, Length=195, Percent_Identity=38.974358974359, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360899, Length=194, Percent_Identity=39.1752577319588, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360799, Length=232, Percent_Identity=32.7586206896552, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24641720, Length=232, Percent_Identity=32.7586206896552, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281360801, Length=232, Percent_Identity=32.7586206896552, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24657891, Length=257, Percent_Identity=27.6264591439689, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644244, Length=170, Percent_Identity=30, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 38524; Mature: 38392

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAFNLLADMITFFNDSHQAHAPEFEFFRGERVPCFETPARAEYVKSSLTSRGHVLRSP
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECC
QMDSRTVLARVHAPRYLAFLEHAWRDWVALEAGNDQRQPFPSVWPVRTLRSDVEPVNFIA
CCCCCCEEEECCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHH
RLGLYSMDNGSPLAAGTWTAAKAGADAAASAAALLAVGGRRGEQAVFCCSRPPGHHAGPD
HHCCEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
FMGGYCFLNNAAVAAQALRDGGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSLHGDPLT
CCCCEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEECCEEEEEEECCCCCC
EYPFYLGHADETGAGEGAGFNLNLPLPAGCTAARWFDALEQACLRIAAFKGDALVVSLGL
CCCEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
DTFAEDPISKFALQASDFSRLGERLGRLGLPTVFVLEGGYAATALGTNAVNVIEGFEGI
CHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCHHHHHHCCCCC
>Mature Secondary Structure 
ANAFNLLADMITFFNDSHQAHAPEFEFFRGERVPCFETPARAEYVKSSLTSRGHVLRSP
CHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECC
QMDSRTVLARVHAPRYLAFLEHAWRDWVALEAGNDQRQPFPSVWPVRTLRSDVEPVNFIA
CCCCCCEEEECCCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHH
RLGLYSMDNGSPLAAGTWTAAKAGADAAASAAALLAVGGRRGEQAVFCCSRPPGHHAGPD
HHCCEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
FMGGYCFLNNAAVAAQALRDGGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSLHGDPLT
CCCCEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEECCEEEEEEECCCCCC
EYPFYLGHADETGAGEGAGFNLNLPLPAGCTAARWFDALEQACLRIAAFKGDALVVSLGL
CCCEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
DTFAEDPISKFALQASDFSRLGERLGRLGLPTVFVLEGGYAATALGTNAVNVIEGFEGI
CHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]