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The map label for this gene is lhgO [H]

Identifier: 91788568

GI number: 91788568

Start: 2851754

End: 2852848

Strand: Reverse

Name: lhgO [H]

Synonym: Bpro_2706

Alternate gene names: 91788568

Gene position: 2852848-2851754 (Counterclockwise)

Preceding gene: 91788569

Following gene: 91788566

Centisome position: 54.86

GC content: 64.02

Gene sequence:

>1095_bases
ATGGACCAGATCGATTGCGTGGTGATAGGTGCAGGCGTGGTGGGCCTTGCGGTGGCGCGCGCGCTGGCATTGCAAGGCCG
CGAGGTGATGGTGCTGGAGGCGGCAGACGCGATTGGCTCCGGCACCAGCTCGCGCAACAGTGAAGTGATTCACGCCGGCA
TCTACTATGCGCAAGGCTCGCTCAAGGCCAGGCTGTGCGTGGAGGGCAAGGACCTGCTCTACGCCTACTGCGCCGAGCGA
GGCATAGGCCACAGCCGCTGCGGTAAATTGATCGTGGCAAGCGCCGAGCCGCAGGTGGCTCAGCTACGCGGCATTATCGA
CAAGGCTGCGGCCAACGGCGTGCGCGACCTGGTGCTGCTCACGCGTGACGAAGCCCAGTCGCTGGAGCCGCAACTGGCGT
GCGTGGCGGCTGTGCATTCGCCCAGCACCGGCATTGTCGACAGCCATGGCCTGATGCTGGCACTGCAGGGAGATCTGGAG
AATGCTGGCGGCCTTGTGGTGTTGAATTCGCCGTTGGACCGCGCGGTGTGTTCGCAAGATGCTATTACTTTGATCGCTGA
AGACGGTACGGAACTGCAAGCTAAAACCGTGGTCAATGCCGCGGGCCTGCATGCGCAATCCCTCGCCCGGCGTTTTGCCG
GCCTGGCCGGTCACCATGTGCCGCCCAGTCATTACGCCAAGGGCAATTACTTCACCCTGTCGGGCCGTTCACCGTTCAGC
CGGCTGATTTATCCGGTACCGGAAGCTGCGGGCCTGGGCGTGCATCTCACGATCGATCTGGGCGGGCAGGCGAAATTCGG
GCCGGATGTGCAATGGGTCAACTCGCCCGATGACCTGGTGGTGGACCCCGCACGCGGCGAGGCGTTTTATGCGGAGGTGC
GCAAGTACTGGCCGGCGCTCCAGGATGGGGCGCTGATTCCGGGTTACGCCGGCATTCGCCCCAAAATCCAGGCGCCGGAC
GAACCGGCCAGGGACTTCCTGATTCAGGGCCCGGATGTGCATGGCATCCCCGGGCTGGTGAACCTGTTTGGCATTGAGTC
GCCGGGCCTGACCAGCTCGCTGGCGATTGGCAGCTACGTCAGCCGGTTGCTGTAG

Upstream 100 bases:

>100_bases
GCTTGGCCTGCCGACGGTGTTTGTGCTGGAAGGCGGTTATGCCGCCACCGCGCTGGGCACCAATGCGGTGAATGTGATTG
AAGGATTTGAGGGCATCTGA

Downstream 100 bases:

>100_bases
AGATTGGAGATTGCTGTACCGGCGCCGTGGGCGCAGTGGAAAGAGCGTTTGTGGCTGAGCGCTTCGGGCTTCAGATTACT
GCGCCGTCCAGCCGCCGTCC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MDQIDCVVIGAGVVGLAVARALALQGREVMVLEAADAIGSGTSSRNSEVIHAGIYYAQGSLKARLCVEGKDLLYAYCAER
GIGHSRCGKLIVASAEPQVAQLRGIIDKAAANGVRDLVLLTRDEAQSLEPQLACVAAVHSPSTGIVDSHGLMLALQGDLE
NAGGLVVLNSPLDRAVCSQDAITLIAEDGTELQAKTVVNAAGLHAQSLARRFAGLAGHHVPPSHYAKGNYFTLSGRSPFS
RLIYPVPEAAGLGVHLTIDLGGQAKFGPDVQWVNSPDDLVVDPARGEAFYAEVRKYWPALQDGALIPGYAGIRPKIQAPD
EPARDFLIQGPDVHGIPGLVNLFGIESPGLTSSLAIGSYVSRLL

Sequences:

>Translated_364_residues
MDQIDCVVIGAGVVGLAVARALALQGREVMVLEAADAIGSGTSSRNSEVIHAGIYYAQGSLKARLCVEGKDLLYAYCAER
GIGHSRCGKLIVASAEPQVAQLRGIIDKAAANGVRDLVLLTRDEAQSLEPQLACVAAVHSPSTGIVDSHGLMLALQGDLE
NAGGLVVLNSPLDRAVCSQDAITLIAEDGTELQAKTVVNAAGLHAQSLARRFAGLAGHHVPPSHYAKGNYFTLSGRSPFS
RLIYPVPEAAGLGVHLTIDLGGQAKFGPDVQWVNSPDDLVVDPARGEAFYAEVRKYWPALQDGALIPGYAGIRPKIQAPD
EPARDFLIQGPDVHGIPGLVNLFGIESPGLTSSLAIGSYVSRLL
>Mature_364_residues
MDQIDCVVIGAGVVGLAVARALALQGREVMVLEAADAIGSGTSSRNSEVIHAGIYYAQGSLKARLCVEGKDLLYAYCAER
GIGHSRCGKLIVASAEPQVAQLRGIIDKAAANGVRDLVLLTRDEAQSLEPQLACVAAVHSPSTGIVDSHGLMLALQGDLE
NAGGLVVLNSPLDRAVCSQDAITLIAEDGTELQAKTVVNAAGLHAQSLARRFAGLAGHHVPPSHYAKGNYFTLSGRSPFS
RLIYPVPEAAGLGVHLTIDLGGQAKFGPDVQWVNSPDDLVVDPARGEAFYAEVRKYWPALQDGALIPGYAGIRPKIQAPD
EPARDFLIQGPDVHGIPGLVNLFGIESPGLTSSLAIGSYVSRLL

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=272, Percent_Identity=34.9264705882353, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI87082148, Length=371, Percent_Identity=27.2237196765499, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17565764, Length=408, Percent_Identity=30.3921568627451, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24585081, Length=265, Percent_Identity=36.2264150943396, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38104; Mature: 38104

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQIDCVVIGAGVVGLAVARALALQGREVMVLEAADAIGSGTSSRNSEVIHAGIYYAQGS
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECHHHCCCCCCCCCCEEEEEEEEECCC
LKARLCVEGKDLLYAYCAERGIGHSRCGKLIVASAEPQVAQLRGIIDKAAANGVRDLVLL
CEEEEEECCCHHHHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEE
TRDEAQSLEPQLACVAAVHSPSTGIVDSHGLMLALQGDLENAGGLVVLNSPLDRAVCSQD
ECCHHHCCCCCEEEEEEECCCCCCCEECCCEEEEEECCCCCCCCEEEECCCHHHHHHCCC
AITLIAEDGTELQAKTVVNAAGLHAQSLARRFAGLAGHHVPPSHYAKGNYFTLSGRSPFS
CEEEEECCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHH
RLIYPVPEAAGLGVHLTIDLGGQAKFGPDVQWVNSPDDLVVDPARGEAFYAEVRKYWPAL
HHEECCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCC
QDGALIPGYAGIRPKIQAPDEPARDFLIQGPDVHGIPGLVNLFGIESPGLTSSLAIGSYV
CCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCHHHEEECCCCCCCHHHHHHHHH
SRLL
HHHC
>Mature Secondary Structure
MDQIDCVVIGAGVVGLAVARALALQGREVMVLEAADAIGSGTSSRNSEVIHAGIYYAQGS
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECHHHCCCCCCCCCCEEEEEEEEECCC
LKARLCVEGKDLLYAYCAERGIGHSRCGKLIVASAEPQVAQLRGIIDKAAANGVRDLVLL
CEEEEEECCCHHHHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEEE
TRDEAQSLEPQLACVAAVHSPSTGIVDSHGLMLALQGDLENAGGLVVLNSPLDRAVCSQD
ECCHHHCCCCCEEEEEEECCCCCCCEECCCEEEEEECCCCCCCCEEEECCCHHHHHHCCC
AITLIAEDGTELQAKTVVNAAGLHAQSLARRFAGLAGHHVPPSHYAKGNYFTLSGRSPFS
CEEEEECCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHH
RLIYPVPEAAGLGVHLTIDLGGQAKFGPDVQWVNSPDDLVVDPARGEAFYAEVRKYWPAL
HHEECCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCC
QDGALIPGYAGIRPKIQAPDEPARDFLIQGPDVHGIPGLVNLFGIESPGLTSSLAIGSYV
CCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCHHHEEECCCCCCCHHHHHHHHH
SRLL
HHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]