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The map label for this gene is relA [H]

Identifier: 91788565

GI number: 91788565

Start: 2847520

End: 2849772

Strand: Reverse

Name: relA [H]

Synonym: Bpro_2703

Alternate gene names: 91788565

Gene position: 2849772-2847520 (Counterclockwise)

Preceding gene: 91788566

Following gene: 91788564

Centisome position: 54.8

GC content: 63.25

Gene sequence:

>2253_bases
ATGAAAAGCAATGTGCTTGGGCCGGATGGCCCAACAGCTCCCCAGAGGCCGAACGCCTCCATCGTCACGGCCACGGCCGA
CAGCCCGCCTGACCAGCCGAATGCGCTGGCGCGCGCGCGTGCTTTTGCCGAGCCACTGATTGCCGGCGAAACGTTGGATA
CCGGTGAAAACATCCTGGCGCATGCCGATGCCGTGGCGGCCATCCTCAAAGGCATCGGCGGTTCGGAGGCCATGCAGGCG
GCCACCTACCTGGTGCATGCGTGCCAGCATCTGACCAAGCCGCAGGAAGTGATTGCCAAGGCTTTCGGAGCCAATTACGC
TGCGCTGGCGATAGAAACGACCAAGCTCGTTCATGTGCAGCGGCAGGCCCGAACGGCGGACGCCAAGGCGCAACTGCTGG
ACGATCCGGCGGCCCAGACCGAGAACGTGCGCAAGATGCTGCTGGCGTTTTCGCGCGACTTGCGGGTAGTCATGCTGCGG
CTGGCTTCGCGCCTGCAGACCTTGCGCTATTACGCGGCAACCCGGCAGTCGGCTCCGCTCGCCCTGGCCCATGAGTCACT
GCATGTGTTCGCGCCCTTGGCGAACCGCCTGGGCATCTGGCAGATCAAATGGGAAATGGAAGACCTGGCCTTCCGCTTCC
TGGAGCCTGACACCTACAAGCACACGGCGCGCCTGCTGGACGAGAAGCGTGTCGAGCGCGAAGGCTTCATGGAGTCCCTG
CGTGCGCAGCTTGAACGCGAACTGAACCAGAACGGCATTGCCGCACTGGTGCAGGGGCGGCCCAAGCACATCTATAGCAT
TGTCAAGAAGATGCGCGGCAAGTCGCTCGGTTTCGATCAGGTGTTTGACATCCGCGCCCTGCGCGTGATCGCGGCCGACA
TCAATGGCTGCTATGCAGCGCTGGGGTTTGTGCATTCGCGCTTCACGCCTGTCGCGGGCGAATTTGACGACTACATCGCC
AAGCCAAAATCCAATGGGTACCAGTCCCTGCACACCGTGGTGCGGGACGCCGCCGGCCGGGCCGTCGAAATCCAGATACG
CACCCAGGCCATGCATGACCATGCCGAGCATGGCGTGGCCGCGCACTGGGCGTACAAGGAGGCCGGCACCAAGGGCTACA
GCGGCGTCTCGGCCAGCAGCGAGTACGACGCCAAGATCGCCGTGCTGCGGCAGCTGTTGGCCTGGGAGCGCGACCTGTCC
GGCCCGGCGGCCAAGCAGGGCCTGTTCGAGGACCGCATCTACGTGCTCACACCCGACGCCGCCATTGTGGAGTTGCCTCA
GGGCGCCACGGCGGTGGACTTTGCCTACAGCGTGCACACCAGCCTGGGGCACCGCTGCCGCGGCGCGCGCATCGATGGTG
CCATGGTGCCGCTCAACACACCGCTGCAAAACGGCCAGACGGTGGAGGTGGTCACCGCCAAGGAAGGCGGCCCCTCGCGC
GACTGGCTCAATTCCGAACTGGGTTTTTTGGCCAGCCACCGGGCCAAATCGAAAGTGCGCGCATGGTTCAATGCGCTGGC
GATGGAGCAAACCGTTGCCAAAGGCCGGGAGGCGGTTGAAAAGCTGCTCCAGCGCGAGGGCAAGACCGCCATGAAGCTGG
ACGACCTTGCGCTGCAACTGGGGTTCAAGACCGCGGACGATTTGTTTGAGGTGGTTGGCAAGGACGAGCTGTCGTTGCGC
ACCATAGAAAACATGCTCAGGCCGCCGGAGCCGGTGCTGTCGCAGGATGACTACGTGCTGGCCAAAAAAGCGCGTCAGCC
CGACAAGTCCAGCCAGTCAGGCAAGGGCGGCAAGGGCAGTGTGCTTGTGGTCGGTATTGATTCGCTGCTGACCCAGCTGG
CCAAGTGCTGCAAGCCTGCACCACCGGACGAGATTTTGGGGTTCGTCACCAAGGGTAAAGGCGTGAGCATCCACCGAAGT
GACTGCAGCAACTTTCGCAACATGGCGAGTGGAAGTCCTGATCGCGTGATCGAAGTGCAGTGGAGCTCGTCGAAAACCGC
GGATGGCTCGGTTTATCCGGTAGATGTGGCCGTCGAGGCTGCCGACCGGCAAGGGCTGCTGCGCGATATTTCCGAGGTCT
TCGCCAAGGAAAAAATGAATGTGATCGGCGTGCAGACTCAATCGGTCAAGGACAACCGCGGCGGCACGGCCTGGATGACA
TTCACTGTGGAAGTGGCGCAGTCGGGCCGCCTCAACCAGGTGCTAGGCCTCGTGGCCGACGTGCCGGGCGTGCGTTCTGC
TCGCAGGCGCTGA

Upstream 100 bases:

>100_bases
TGATCGCGGACGATCAGGTCGCGGCAGTAACGGGCTTCCTGCTGGGCTGATACCGCGATCATGCGGGATGAGTCCCGGGT
AACCATTGGATAGAGTTTTC

Downstream 100 bases:

>100_bases
GTTGGCATAGAAGCCGACGCAGTGAGCGAACGTGGGGGCCAAGGTTTTTCCGCCGGGCCGCCCCCAGGAAAAATGCGCCC
CCTCGGGGGGGCAGCGAGTT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MKSNVLGPDGPTAPQRPNASIVTATADSPPDQPNALARARAFAEPLIAGETLDTGENILAHADAVAAILKGIGGSEAMQA
ATYLVHACQHLTKPQEVIAKAFGANYAALAIETTKLVHVQRQARTADAKAQLLDDPAAQTENVRKMLLAFSRDLRVVMLR
LASRLQTLRYYAATRQSAPLALAHESLHVFAPLANRLGIWQIKWEMEDLAFRFLEPDTYKHTARLLDEKRVEREGFMESL
RAQLERELNQNGIAALVQGRPKHIYSIVKKMRGKSLGFDQVFDIRALRVIAADINGCYAALGFVHSRFTPVAGEFDDYIA
KPKSNGYQSLHTVVRDAAGRAVEIQIRTQAMHDHAEHGVAAHWAYKEAGTKGYSGVSASSEYDAKIAVLRQLLAWERDLS
GPAAKQGLFEDRIYVLTPDAAIVELPQGATAVDFAYSVHTSLGHRCRGARIDGAMVPLNTPLQNGQTVEVVTAKEGGPSR
DWLNSELGFLASHRAKSKVRAWFNALAMEQTVAKGREAVEKLLQREGKTAMKLDDLALQLGFKTADDLFEVVGKDELSLR
TIENMLRPPEPVLSQDDYVLAKKARQPDKSSQSGKGGKGSVLVVGIDSLLTQLAKCCKPAPPDEILGFVTKGKGVSIHRS
DCSNFRNMASGSPDRVIEVQWSSSKTADGSVYPVDVAVEAADRQGLLRDISEVFAKEKMNVIGVQTQSVKDNRGGTAWMT
FTVEVAQSGRLNQVLGLVADVPGVRSARRR

Sequences:

>Translated_750_residues
MKSNVLGPDGPTAPQRPNASIVTATADSPPDQPNALARARAFAEPLIAGETLDTGENILAHADAVAAILKGIGGSEAMQA
ATYLVHACQHLTKPQEVIAKAFGANYAALAIETTKLVHVQRQARTADAKAQLLDDPAAQTENVRKMLLAFSRDLRVVMLR
LASRLQTLRYYAATRQSAPLALAHESLHVFAPLANRLGIWQIKWEMEDLAFRFLEPDTYKHTARLLDEKRVEREGFMESL
RAQLERELNQNGIAALVQGRPKHIYSIVKKMRGKSLGFDQVFDIRALRVIAADINGCYAALGFVHSRFTPVAGEFDDYIA
KPKSNGYQSLHTVVRDAAGRAVEIQIRTQAMHDHAEHGVAAHWAYKEAGTKGYSGVSASSEYDAKIAVLRQLLAWERDLS
GPAAKQGLFEDRIYVLTPDAAIVELPQGATAVDFAYSVHTSLGHRCRGARIDGAMVPLNTPLQNGQTVEVVTAKEGGPSR
DWLNSELGFLASHRAKSKVRAWFNALAMEQTVAKGREAVEKLLQREGKTAMKLDDLALQLGFKTADDLFEVVGKDELSLR
TIENMLRPPEPVLSQDDYVLAKKARQPDKSSQSGKGGKGSVLVVGIDSLLTQLAKCCKPAPPDEILGFVTKGKGVSIHRS
DCSNFRNMASGSPDRVIEVQWSSSKTADGSVYPVDVAVEAADRQGLLRDISEVFAKEKMNVIGVQTQSVKDNRGGTAWMT
FTVEVAQSGRLNQVLGLVADVPGVRSARRR
>Mature_750_residues
MKSNVLGPDGPTAPQRPNASIVTATADSPPDQPNALARARAFAEPLIAGETLDTGENILAHADAVAAILKGIGGSEAMQA
ATYLVHACQHLTKPQEVIAKAFGANYAALAIETTKLVHVQRQARTADAKAQLLDDPAAQTENVRKMLLAFSRDLRVVMLR
LASRLQTLRYYAATRQSAPLALAHESLHVFAPLANRLGIWQIKWEMEDLAFRFLEPDTYKHTARLLDEKRVEREGFMESL
RAQLERELNQNGIAALVQGRPKHIYSIVKKMRGKSLGFDQVFDIRALRVIAADINGCYAALGFVHSRFTPVAGEFDDYIA
KPKSNGYQSLHTVVRDAAGRAVEIQIRTQAMHDHAEHGVAAHWAYKEAGTKGYSGVSASSEYDAKIAVLRQLLAWERDLS
GPAAKQGLFEDRIYVLTPDAAIVELPQGATAVDFAYSVHTSLGHRCRGARIDGAMVPLNTPLQNGQTVEVVTAKEGGPSR
DWLNSELGFLASHRAKSKVRAWFNALAMEQTVAKGREAVEKLLQREGKTAMKLDDLALQLGFKTADDLFEVVGKDELSLR
TIENMLRPPEPVLSQDDYVLAKKARQPDKSSQSGKGGKGSVLVVGIDSLLTQLAKCCKPAPPDEILGFVTKGKGVSIHRS
DCSNFRNMASGSPDRVIEVQWSSSKTADGSVYPVDVAVEAADRQGLLRDISEVFAKEKMNVIGVQTQSVKDNRGGTAWMT
FTVEVAQSGRLNQVLGLVADVPGVRSARRR

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=621, Percent_Identity=41.2238325281804, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1790082, Length=702, Percent_Identity=33.9031339031339, Blast_Score=381, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81702; Mature: 81702

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNVLGPDGPTAPQRPNASIVTATADSPPDQPNALARARAFAEPLIAGETLDTGENILA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
HADAVAAILKGIGGSEAMQAATYLVHACQHLTKPQEVIAKAFGANYAALAIETTKLVHVQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEHHHHHHHH
RQARTADAKAQLLDDPAAQTENVRKMLLAFSRDLRVVMLRLASRLQTLRYYAATRQSAPL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
ALAHESLHVFAPLANRLGIWQIKWEMEDLAFRFLEPDTYKHTARLLDEKRVEREGFMESL
EEHHCCHHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAQLERELNQNGIAALVQGRPKHIYSIVKKMRGKSLGFDQVFDIRALRVIAADINGCYAA
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGFVHSRFTPVAGEFDDYIAKPKSNGYQSLHTVVRDAAGRAVEIQIRTQAMHDHAEHGVA
HHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCC
AHWAYKEAGTKGYSGVSASSEYDAKIAVLRQLLAWERDLSGPAAKQGLFEDRIYVLTPDA
CEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCCC
AIVELPQGATAVDFAYSVHTSLGHRCRGARIDGAMVPLNTPLQNGQTVEVVTAKEGGPSR
EEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCH
DWLNSELGFLASHRAKSKVRAWFNALAMEQTVAKGREAVEKLLQREGKTAMKLDDLALQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GFKTADDLFEVVGKDELSLRTIENMLRPPEPVLSQDDYVLAKKARQPDKSSQSGKGGKGS
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
VLVVGIDSLLTQLAKCCKPAPPDEILGFVTKGKGVSIHRSDCSNFRNMASGSPDRVIEVQ
EEEEEHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEE
WSSSKTADGSVYPVDVAVEAADRQGLLRDISEVFAKEKMNVIGVQTQSVKDNRGGTAWMT
ECCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
FTVEVAQSGRLNQVLGLVADVPGVRSARRR
EEEEECCCCCHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MKSNVLGPDGPTAPQRPNASIVTATADSPPDQPNALARARAFAEPLIAGETLDTGENILA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
HADAVAAILKGIGGSEAMQAATYLVHACQHLTKPQEVIAKAFGANYAALAIETTKLVHVQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEHHHHHHHH
RQARTADAKAQLLDDPAAQTENVRKMLLAFSRDLRVVMLRLASRLQTLRYYAATRQSAPL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
ALAHESLHVFAPLANRLGIWQIKWEMEDLAFRFLEPDTYKHTARLLDEKRVEREGFMESL
EEHHCCHHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAQLERELNQNGIAALVQGRPKHIYSIVKKMRGKSLGFDQVFDIRALRVIAADINGCYAA
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGFVHSRFTPVAGEFDDYIAKPKSNGYQSLHTVVRDAAGRAVEIQIRTQAMHDHAEHGVA
HHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCC
AHWAYKEAGTKGYSGVSASSEYDAKIAVLRQLLAWERDLSGPAAKQGLFEDRIYVLTPDA
CEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCCC
AIVELPQGATAVDFAYSVHTSLGHRCRGARIDGAMVPLNTPLQNGQTVEVVTAKEGGPSR
EEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCH
DWLNSELGFLASHRAKSKVRAWFNALAMEQTVAKGREAVEKLLQREGKTAMKLDDLALQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GFKTADDLFEVVGKDELSLRTIENMLRPPEPVLSQDDYVLAKKARQPDKSSQSGKGGKGS
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
VLVVGIDSLLTQLAKCCKPAPPDEILGFVTKGKGVSIHRSDCSNFRNMASGSPDRVIEVQ
EEEEEHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCEEEEE
WSSSKTADGSVYPVDVAVEAADRQGLLRDISEVFAKEKMNVIGVQTQSVKDNRGGTAWMT
ECCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
FTVEVAQSGRLNQVLGLVADVPGVRSARRR
EEEEECCCCCHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]