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The map label for this gene is uppS [H]

Identifier: 91788553

GI number: 91788553

Start: 2832790

End: 2833530

Strand: Reverse

Name: uppS [H]

Synonym: Bpro_2691

Alternate gene names: 91788553

Gene position: 2833530-2832790 (Counterclockwise)

Preceding gene: 91788554

Following gene: 91788552

Centisome position: 54.49

GC content: 61.67

Gene sequence:

>741_bases
ATGGCCACTCCCTCTCTCATCGTCCCGCATCATGTGGCCATCGTGATGGATGGCAATGGCCGCTGGGCGACCAAGCGGTT
CTTGCCGCGCATTGCCGGCCACAAGCAGGGCGTAGATTCCCTGAGCCGTTGCGTTCGCGCGTGCCTGGAGCGCGGCATTG
CCGTGCTGACGGTTTTTGCGTTTTCATCGGAAAACTGGAACCGGCCGTTCGAGGAGGTCTCTGGCCTGATGGAACTGCTG
GTTTTGTCCTTGTCCCGCGAGGTCCCCAACCTGAACGCCAGCGGGGTGCGGCTGCATTTCGTCGGAGACCGCCAGCGGCT
CTCGGAAAAAGTCCAGGCCGGGCTGGCGCAGGCCGAGCACCTGACGTCGGGCAACCATCGCCTGATTTTCAATGTGTGCT
TCAACTACGGCGGACGCTGGGATATCGCCCAGGCTGCGAAAAAGGTCGCCAGCAGTGGCGAACCGATCACCGAGCTTGCG
TTGGACCGGGCCATGGCGCTGGCCCATGTTCCTGATCCCGACCTGCTGATCCGCACGGGCGGCGAGTTGCGGATCAGCAA
CTTTTTGTTGTGGCAGGCTGCGTACTCAGAACTGCATTTTTCCGACAAGCTCTGGCCTGAATTCGATGAGGCTGCGCTCG
ATGAAGCGATTGCTGTCTTTCGCACCCGCGAGCGCCGTTTTGGCCAGACGTCGGCGCAGGTCAGCGGGCATGGCCAAAAA
ACCACTCCGAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
GTTCACGGACCGTTTCATTGCCGAGGTTGACAAACTGGTCGCCGGCAAGGAACAAGACATCATGGCGGTTTGACGCCATC
CCGTCTGGCCTGAACTGACC

Downstream 100 bases:

>100_bases
TGCTTAAACAGCGTGTGATCACGGCCATTGTCCTTTTGGCCATCTTGCTGCCTGCACTTTTCTACAAGACGCCGGTGGCC
TTTGCTGCTGTCGCGCTGGT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MATPSLIVPHHVAIVMDGNGRWATKRFLPRIAGHKQGVDSLSRCVRACLERGIAVLTVFAFSSENWNRPFEEVSGLMELL
VLSLSREVPNLNASGVRLHFVGDRQRLSEKVQAGLAQAEHLTSGNHRLIFNVCFNYGGRWDIAQAAKKVASSGEPITELA
LDRAMALAHVPDPDLLIRTGGELRISNFLLWQAAYSELHFSDKLWPEFDEAALDEAIAVFRTRERRFGQTSAQVSGHGQK
TTPKAA

Sequences:

>Translated_246_residues
MATPSLIVPHHVAIVMDGNGRWATKRFLPRIAGHKQGVDSLSRCVRACLERGIAVLTVFAFSSENWNRPFEEVSGLMELL
VLSLSREVPNLNASGVRLHFVGDRQRLSEKVQAGLAQAEHLTSGNHRLIFNVCFNYGGRWDIAQAAKKVASSGEPITELA
LDRAMALAHVPDPDLLIRTGGELRISNFLLWQAAYSELHFSDKLWPEFDEAALDEAIAVFRTRERRFGQTSAQVSGHGQK
TTPKAA
>Mature_245_residues
ATPSLIVPHHVAIVMDGNGRWATKRFLPRIAGHKQGVDSLSRCVRACLERGIAVLTVFAFSSENWNRPFEEVSGLMELLV
LSLSREVPNLNASGVRLHFVGDRQRLSEKVQAGLAQAEHLTSGNHRLIFNVCFNYGGRWDIAQAAKKVASSGEPITELAL
DRAMALAHVPDPDLLIRTGGELRISNFLLWQAAYSELHFSDKLWPEFDEAALDEAIAVFRTRERRFGQTSAQVSGHGQKT
TPKAA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=40.625, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=40.625, Blast_Score=158, Evalue=3e-39,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=49.3392070484581, Blast_Score=222, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=241, Percent_Identity=37.344398340249, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=38.2775119617225, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=31.651376146789, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=39.7129186602871, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27194; Mature: 27063

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPSLIVPHHVAIVMDGNGRWATKRFLPRIAGHKQGVDSLSRCVRACLERGIAVLTVFA
CCCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEE
FSSENWNRPFEEVSGLMELLVLSLSREVPNLNASGVRLHFVGDRQRLSEKVQAGLAQAEH
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
LTSGNHRLIFNVCFNYGGRWDIAQAAKKVASSGEPITELALDRAMALAHVPDPDLLIRTG
HCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
GELRISNFLLWQAAYSELHFSDKLWPEFDEAALDEAIAVFRTRERRFGQTSAQVSGHGQK
CCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
TTPKAA
CCCCCC
>Mature Secondary Structure 
ATPSLIVPHHVAIVMDGNGRWATKRFLPRIAGHKQGVDSLSRCVRACLERGIAVLTVFA
CCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEE
FSSENWNRPFEEVSGLMELLVLSLSREVPNLNASGVRLHFVGDRQRLSEKVQAGLAQAEH
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
LTSGNHRLIFNVCFNYGGRWDIAQAAKKVASSGEPITELALDRAMALAHVPDPDLLIRTG
HCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
GELRISNFLLWQAAYSELHFSDKLWPEFDEAALDEAIAVFRTRERRFGQTSAQVSGHGQK
CCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCC
TTPKAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]