| Definition | Polaromonas sp. JS666 chromosome, complete genome. |
|---|---|
| Accession | NC_007948 |
| Length | 5,200,264 |
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The map label for this gene is sdh [H]
Identifier: 91788216
GI number: 91788216
Start: 2446676
End: 2447476
Strand: Reverse
Name: sdh [H]
Synonym: Bpro_2349
Alternate gene names: 91788216
Gene position: 2447476-2446676 (Counterclockwise)
Preceding gene: 91788218
Following gene: 91788215
Centisome position: 47.06
GC content: 61.8
Gene sequence:
>801_bases ATGACAAACCCCAGTTCTAAGAAAATCGCTCTTGTCACAGGGGCTTCTTCCGGCATCGGAGCCGTCTATGCGGACCGCCT CGCCGCGCGTGGATACGATCTTATCCTTGTCGCCCGGCGCGCTGATCGCCTGGCAGCCCTTTGCGCCCAGGTCTCTAAGG CGCACGGTATCAAGGCCGAGCCGATCGTGGCCGACCTGACCAAAGATGAGGATCTGGCGCGGATCGAGACGATTCTGTCC ACCAATGAGGACGTGCGCGTCCTGGTGAACAACGCCGGCATTGCGCGACTGGGGCCGCTTGCTCAGAGGTCTGCAAACGA CGCACTGTCGCAGATTGCGCTCAACATCACAGCGTTGACGCGCCTGACCCAGGCGGTGGTACCCGCGTTCATCGGCAGAA ACCAGGGCGTAATCATCAATATCGCTTCTGTCCTGGCCATCCATTCGATGCCCATCAGCGCCGTCTACAGCGGCACCAAG GCCTTCGTACTGCAGTACAGCCGCGGTCTGCAGCAAGAACTTGCCGAAACCGGGGTGAAGGTCCAGCTGGTCCTGCCTGC ATCGACAGCCACCGAGATCTGGGACCTGTCGGGCGTCCCGCTGGCGGCCCTCAACAAGGAGGCCTTGATGACGACCGAGC ACATGGTCGATGCGGCGCTCGCGGGCTTCGACCAGGGTGAAACGATCACGTGGCCCTCAGTCGCCGATGCCAGCCTGTGG GACAAGTACGAGGCAGCCCGATCCGAACTGTTCGCGAGCACCCAGGTTGGAACGCCGGCTCCTCGCTACAACATTCTCTG A
Upstream 100 bases:
>100_bases ATGGTTGAGTACTGCACTATTTATCGTTTGCGCGCAATCGGTCATACATTTGAGCCCTCAACCTTTTAGTTGAGCACTCA ATTTTATTGGAAAACTATCA
Downstream 100 bases:
>100_bases GTCCAGCTAACGGAACGTTACGGCTCTTCCTCTTCTCCCCATTTTCCATTTTCCATTTTCCATTTTCCATTTTCCATTTT CCATTTTCTCAAGGACAGAC
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 266; Mature: 265
Protein sequence:
>266_residues MTNPSSKKIALVTGASSGIGAVYADRLAARGYDLILVARRADRLAALCAQVSKAHGIKAEPIVADLTKDEDLARIETILS TNEDVRVLVNNAGIARLGPLAQRSANDALSQIALNITALTRLTQAVVPAFIGRNQGVIINIASVLAIHSMPISAVYSGTK AFVLQYSRGLQQELAETGVKVQLVLPASTATEIWDLSGVPLAALNKEALMTTEHMVDAALAGFDQGETITWPSVADASLW DKYEAARSELFASTQVGTPAPRYNIL
Sequences:
>Translated_266_residues MTNPSSKKIALVTGASSGIGAVYADRLAARGYDLILVARRADRLAALCAQVSKAHGIKAEPIVADLTKDEDLARIETILS TNEDVRVLVNNAGIARLGPLAQRSANDALSQIALNITALTRLTQAVVPAFIGRNQGVIINIASVLAIHSMPISAVYSGTK AFVLQYSRGLQQELAETGVKVQLVLPASTATEIWDLSGVPLAALNKEALMTTEHMVDAALAGFDQGETITWPSVADASLW DKYEAARSELFASTQVGTPAPRYNIL >Mature_265_residues TNPSSKKIALVTGASSGIGAVYADRLAARGYDLILVARRADRLAALCAQVSKAHGIKAEPIVADLTKDEDLARIETILST NEDVRVLVNNAGIARLGPLAQRSANDALSQIALNITALTRLTQAVVPAFIGRNQGVIINIASVLAIHSMPISAVYSGTKA FVLQYSRGLQQELAETGVKVQLVLPASTATEIWDLSGVPLAALNKEALMTTEHMVDAALAGFDQGETITWPSVADASLWD KYEAARSELFASTQVGTPAPRYNIL
Specific function: Catalyzes the oxidation of the hydroxyl group of serine to form 2-aminomalonate semialdehyde which is spontaneously converted into 2-aminoacetaldehyde and CO(2). Also acts on D- serine, L-glycerate, D-glycerate and 2-methyl-DL-serine. Does not act on O-me
COG id: COG0300
COG function: function code R; Short-chain dehydrogenases of various substrate specificities
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4557649, Length=184, Percent_Identity=34.7826086956522, Blast_Score=112, Evalue=4e-25, Organism=Homo sapiens, GI7705855, Length=194, Percent_Identity=31.9587628865979, Blast_Score=107, Evalue=7e-24, Organism=Homo sapiens, GI226371731, Length=188, Percent_Identity=31.3829787234043, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI7706318, Length=190, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI109715829, Length=195, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI40254992, Length=187, Percent_Identity=28.3422459893048, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI210032110, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=27.2251308900524, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI7657478, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI142976729, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787820, Length=232, Percent_Identity=31.0344827586207, Blast_Score=88, Evalue=7e-19, Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=34.2105263157895, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1786701, Length=197, Percent_Identity=28.4263959390863, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI87082100, Length=189, Percent_Identity=32.2751322751323, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1790717, Length=184, Percent_Identity=30.9782608695652, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI87082160, Length=187, Percent_Identity=26.7379679144385, Blast_Score=65, Evalue=5e-12, Organism=Escherichia coli, GI1789208, Length=187, Percent_Identity=29.9465240641711, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17557668, Length=191, Percent_Identity=31.413612565445, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI25152911, Length=191, Percent_Identity=30.8900523560209, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17560176, Length=191, Percent_Identity=31.413612565445, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI71994604, Length=193, Percent_Identity=32.1243523316062, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17560220, Length=217, Percent_Identity=34.1013824884793, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17559552, Length=191, Percent_Identity=29.8429319371728, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI71994600, Length=196, Percent_Identity=31.6326530612245, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17559104, Length=233, Percent_Identity=30.4721030042918, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI212646214, Length=217, Percent_Identity=26.7281105990783, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562990, Length=211, Percent_Identity=33.6492890995261, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI193204405, Length=214, Percent_Identity=33.6448598130841, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17560150, Length=217, Percent_Identity=34.1013824884793, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=30.1020408163265, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17544670, Length=203, Percent_Identity=30.0492610837438, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17562904, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17562906, Length=208, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17531453, Length=217, Percent_Identity=30.8755760368664, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17565030, Length=206, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17538486, Length=196, Percent_Identity=32.1428571428571, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17562908, Length=219, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI115534694, Length=190, Percent_Identity=30.5263157894737, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17560332, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=197, Percent_Identity=34.5177664974619, Blast_Score=94, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6319635, Length=191, Percent_Identity=28.2722513089005, Blast_Score=83, Evalue=4e-17, Organism=Saccharomyces cerevisiae, GI6322067, Length=198, Percent_Identity=31.3131313131313, Blast_Score=82, Evalue=7e-17, Organism=Drosophila melanogaster, GI161076933, Length=186, Percent_Identity=36.5591397849462, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24584748, Length=186, Percent_Identity=36.5591397849462, Blast_Score=119, Evalue=3e-27, Organism=Drosophila melanogaster, GI24584744, Length=187, Percent_Identity=34.7593582887701, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI28574402, Length=187, Percent_Identity=34.7593582887701, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI24640442, Length=189, Percent_Identity=34.9206349206349, Blast_Score=109, Evalue=2e-24, Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=37.3737373737374, Blast_Score=100, Evalue=9e-22, Organism=Drosophila melanogaster, GI24644339, Length=193, Percent_Identity=34.7150259067358, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI23397609, Length=194, Percent_Identity=35.5670103092784, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=33.160621761658, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI24584752, Length=186, Percent_Identity=28.494623655914, Blast_Score=84, Evalue=9e-17, Organism=Drosophila melanogaster, GI24643142, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24641388, Length=216, Percent_Identity=32.4074074074074, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24649181, Length=235, Percent_Identity=26.3829787234043, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24640492, Length=184, Percent_Identity=28.2608695652174, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.276 [H]
Molecular weight: Translated: 28162; Mature: 28030
Theoretical pI: Translated: 6.28; Mature: 6.28
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTNPSSKKIALVTGASSGIGAVYADRLAARGYDLILVARRADRLAALCAQVSKAHGIKAE CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCC PIVADLTKDEDLARIETILSTNEDVRVLVNNAGIARLGPLAQRSANDALSQIALNITALT CEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHHHHHH RLTQAVVPAFIGRNQGVIINIASVLAIHSMPISAVYSGTKAFVLQYSRGLQQELAETGVK HHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCE VQLVLPASTATEIWDLSGVPLAALNKEALMTTEHMVDAALAGFDQGETITWPSVADASLW EEEEECCCCCHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHH DKYEAARSELFASTQVGTPAPRYNIL HHHHHHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure TNPSSKKIALVTGASSGIGAVYADRLAARGYDLILVARRADRLAALCAQVSKAHGIKAE CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCC PIVADLTKDEDLARIETILSTNEDVRVLVNNAGIARLGPLAQRSANDALSQIALNITALT CEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHHHHHH RLTQAVVPAFIGRNQGVIINIASVLAIHSMPISAVYSGTKAFVLQYSRGLQQELAETGVK HHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCE VQLVLPASTATEIWDLSGVPLAALNKEALMTTEHMVDAALAGFDQGETITWPSVADASLW EEEEECCCCCHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHH DKYEAARSELFASTQVGTPAPRYNIL HHHHHHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11743193; 11743194 [H]