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The map label for this gene is moaA [H]

Identifier: 91788157

GI number: 91788157

Start: 2380439

End: 2381566

Strand: Reverse

Name: moaA [H]

Synonym: Bpro_2288

Alternate gene names: 91788157

Gene position: 2381566-2380439 (Counterclockwise)

Preceding gene: 91788158

Following gene: 91788156

Centisome position: 45.8

GC content: 62.68

Gene sequence:

>1128_bases
ATGACGACAGACAAAATCATTCCGCTGGCAGATATCCGCTACGCAAGCCGCGTGCCGCATATCCCTGCCCGTCTGCAGGC
CCCGTCGGGCCTGTTGAGCGACACCCTGGGCCGGCCGCTGCGCGATTTGCGCATCAGCGTGACGGATCGCTGCAACTTCC
GCTGCAGCTACTGCATGCCGCGCGAGGTCTTTGACAAGGACTACGCTTTTTTGCCGCAGAGCTCCCTGCTGAGCTTTGAG
GAAATCACCCGGCTGGCCAAAATTTTTGTGGCACATGGGGTGGAGAAAATCCGGTTGACCGGTGGCGAGCCGCTATTGCG
CAAGCACCTCGAGGTGCTGATCGAGATGCTGGCAAAACTGCAAACACCGGATGGCAGGCCGCTGGACATCACGCTGACCA
CCAATGCATCGCTGCTCGCCAAAAAAGCGCAGGCGCTCAAGGATGCCGGCCTGCAGCGCGTCACTGTGAGCCTGGACGGG
CTGGACGATGCCACGTTCCGCCGCATGAACGATGTGGACTTTCCTGTGGCCGATGTGCTCAAGGGGATTGAAGTGGCCCA
GAACGTGGGCCTGGCCCCCCTGAAGATCAACATGGTGGTCAAGCGCGGCACCAACGATGCCGAGATACTCCCCATGGCGC
GGCACTTCCGGAACACCGGCGCAGTGCTGCGCTTTATTGAATACATGGACGTGGGCGCCACCAACGGCTGGCGCATGGAC
GAGGTGCTGCCGTCGGCACAGGTGATTGAACGTCTCAACGCCGAATTCCCGCTGGTCGCCATCGACCCGAACTACACCGG
CGAAACGGCAGAGCGCTGGCGCTATGCCGACGGCGCGGGCGAGATCGGCGTGATCAGCAGTGTTACCCAGGCCTTTTGCA
GCGACTGCAACCGGGCACGGCTGTCGACCGAAGGCAAACTGTTTCTGTGCCTGTTTGCCAGTCAGGGGCATGACCTGCGC
GCCCTGCTGCGCGGTGGTTTTGCCGACGACCAGATCGCCGCGGCAGTCAGCCACATCTGGCAGGCCCGCACCGACCGTTA
TTCGGAGTTGCGCGCGGCCCTGCCGGCAGACGCCAGCCCGCCCGATGGCACGCTCAAGCGGGTTGAAATGAGCTACATCG
GGGGCTGA

Upstream 100 bases:

>100_bases
GCAAAGTCAGGGTCAATAACGCTCAGCGCCTGGGGATAAGGGCGGAACTTTGCCGCTTGGGCGGGCCAATGGAGTAAATT
CTCCCTTTGGGCCCACCACG

Downstream 100 bases:

>100_bases
ACCCAGGACCGCGGAAATATGACCGCCATGCTTTCCACGGCGGATAATGCACTACCCTGCTGTGGGACTGCTTTTCCTGG
GAGTCCCCGCGGAAAATTAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTTDKIIPLADIRYASRVPHIPARLQAPSGLLSDTLGRPLRDLRISVTDRCNFRCSYCMPREVFDKDYAFLPQSSLLSFE
EITRLAKIFVAHGVEKIRLTGGEPLLRKHLEVLIEMLAKLQTPDGRPLDITLTTNASLLAKKAQALKDAGLQRVTVSLDG
LDDATFRRMNDVDFPVADVLKGIEVAQNVGLAPLKINMVVKRGTNDAEILPMARHFRNTGAVLRFIEYMDVGATNGWRMD
EVLPSAQVIERLNAEFPLVAIDPNYTGETAERWRYADGAGEIGVISSVTQAFCSDCNRARLSTEGKLFLCLFASQGHDLR
ALLRGGFADDQIAAAVSHIWQARTDRYSELRAALPADASPPDGTLKRVEMSYIGG

Sequences:

>Translated_375_residues
MTTDKIIPLADIRYASRVPHIPARLQAPSGLLSDTLGRPLRDLRISVTDRCNFRCSYCMPREVFDKDYAFLPQSSLLSFE
EITRLAKIFVAHGVEKIRLTGGEPLLRKHLEVLIEMLAKLQTPDGRPLDITLTTNASLLAKKAQALKDAGLQRVTVSLDG
LDDATFRRMNDVDFPVADVLKGIEVAQNVGLAPLKINMVVKRGTNDAEILPMARHFRNTGAVLRFIEYMDVGATNGWRMD
EVLPSAQVIERLNAEFPLVAIDPNYTGETAERWRYADGAGEIGVISSVTQAFCSDCNRARLSTEGKLFLCLFASQGHDLR
ALLRGGFADDQIAAAVSHIWQARTDRYSELRAALPADASPPDGTLKRVEMSYIGG
>Mature_374_residues
TTDKIIPLADIRYASRVPHIPARLQAPSGLLSDTLGRPLRDLRISVTDRCNFRCSYCMPREVFDKDYAFLPQSSLLSFEE
ITRLAKIFVAHGVEKIRLTGGEPLLRKHLEVLIEMLAKLQTPDGRPLDITLTTNASLLAKKAQALKDAGLQRVTVSLDGL
DDATFRRMNDVDFPVADVLKGIEVAQNVGLAPLKINMVVKRGTNDAEILPMARHFRNTGAVLRFIEYMDVGATNGWRMDE
VLPSAQVIERLNAEFPLVAIDPNYTGETAERWRYADGAGEIGVISSVTQAFCSDCNRARLSTEGKLFLCLFASQGHDLRA
LLRGGFADDQIAAAVSHIWQARTDRYSELRAALPADASPPDGTLKRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=316, Percent_Identity=36.3924050632911, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI22027536, Length=316, Percent_Identity=36.3924050632911, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1786999, Length=347, Percent_Identity=31.700288184438, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=32.0359281437126, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=324, Percent_Identity=32.0987654320988, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=32.9305135951662, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28574490, Length=331, Percent_Identity=33.8368580060423, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI28574488, Length=319, Percent_Identity=33.8557993730408, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41412; Mature: 41281

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDKIIPLADIRYASRVPHIPARLQAPSGLLSDTLGRPLRDLRISVTDRCNFRCSYCMP
CCCCCCCCHHHHHHHHCCCCCCHHCCCCCCHHHHHHCCCHHHHEEEEECCCCCEECCCCC
REVFDKDYAFLPQSSLLSFEEITRLAKIFVAHGVEKIRLTGGEPLLRKHLEVLIEMLAKL
HHHHCCCHHCCCHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
QTPDGRPLDITLTTNASLLAKKAQALKDAGLQRVTVSLDGLDDATFRRMNDVDFPVADVL
CCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHH
KGIEVAQNVGLAPLKINMVVKRGTNDAEILPMARHFRNTGAVLRFIEYMDVGATNGWRMD
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
EVLPSAQVIERLNAEFPLVAIDPNYTGETAERWRYADGAGEIGVISSVTQAFCSDCNRAR
HHCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
LSTEGKLFLCLFASQGHDLRALLRGGFADDQIAAAVSHIWQARTDRYSELRAALPADASP
CCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDGTLKRVEMSYIGG
CCCHHHEEEHHHCCC
>Mature Secondary Structure 
TTDKIIPLADIRYASRVPHIPARLQAPSGLLSDTLGRPLRDLRISVTDRCNFRCSYCMP
CCCCCCCHHHHHHHHCCCCCCHHCCCCCCHHHHHHCCCHHHHEEEEECCCCCEECCCCC
REVFDKDYAFLPQSSLLSFEEITRLAKIFVAHGVEKIRLTGGEPLLRKHLEVLIEMLAKL
HHHHCCCHHCCCHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
QTPDGRPLDITLTTNASLLAKKAQALKDAGLQRVTVSLDGLDDATFRRMNDVDFPVADVL
CCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCCCHHHHH
KGIEVAQNVGLAPLKINMVVKRGTNDAEILPMARHFRNTGAVLRFIEYMDVGATNGWRMD
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
EVLPSAQVIERLNAEFPLVAIDPNYTGETAERWRYADGAGEIGVISSVTQAFCSDCNRAR
HHCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
LSTEGKLFLCLFASQGHDLRALLRGGFADDQIAAAVSHIWQARTDRYSELRAALPADASP
CCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDGTLKRVEMSYIGG
CCCHHHEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]