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The map label for this gene is hemF

Identifier: 91787846

GI number: 91787846

Start: 2037637

End: 2038563

Strand: Direct

Name: hemF

Synonym: Bpro_1970

Alternate gene names: 91787846

Gene position: 2037637-2038563 (Clockwise)

Preceding gene: 91787845

Following gene: 91787847

Centisome position: 39.18

GC content: 61.7

Gene sequence:

>927_bases
ATGAGCATGACTGAGCTTTCAGGCGTTCGCACCTTTTTGCTGGGGCTGCAGGAGCGGGTTACCGCCGCTGTGGCCGAAGT
GGATGGCGGGGATTTCATTACCGACGCCTGGCAAAAGGAGCCGGGTGAGCCTTTGCAGGGCAACGGCATCACCAAAATCC
TGGAGAACGGCGAAGTGTTCGAGCGCGCGGGTTGCGGGTTTTCGCACGTGCAGGGCTCTCGCTTGCCGCCGTCGGCGACG
CAGCACCGGCCTGAACTGGCCGGCGCGCCCTTTGAGGCGATGGGCGTGTCGCTGGTGTTTCACCCCCGTAACCCCTACGT
GCCCACAGTGCACATGAATGTGCGCATGCTGGCCGCCACACCGGTTTCCGCCGGTCCGGCCGAGGCCGTGTGCTGGTTTG
GCGGCGGCATGGACTTGACGCCCTATTACGGTTTTGATGAGGATGCGGTGCATTTTCACCAGACCTGCAAGGACGCGCTG
GCGCCGTTCGGCGGTGACAAATATCCGCGCTTCAAACAATGGTGTGACGAGTATTTTTACCTCAAGCACCGGCAGGAGCA
GCGCGGCATCGGCGGCATATTTTTCGATGATTTCCAGGAGCTGGGCCTGGAGCAGAGTTTTGCCATGATGCAAAGCGTGG
CGGACTCCTTTCTGCCAGCCTACCTCCCCATCGTCAGGCGGCGCCAGAGCCAGCCCTATGGTGCGCGCGAGCGCGATTTT
CAGCTTTACCGACGTGGCCGCTATGTGGAGTTCAACCTGGTCTGGGACCGCGGCACCCACTTTGGCCTGCAATCGGGCGG
TCGCACCGAGTCCATTTTGATGTCCATGCCGCCGCTGGCCAGCTGGTCCTACCAGCACCGGGCTGAAGCCGGCTCGCCTG
AAGAGCGTCTGTACAAAGAGTTCCTGATCAGACGGGACTGGGTTTGA

Upstream 100 bases:

>100_bases
TGGGCACCTATGGGCACATGTTGGAGCCCTGGACGGGTGGTGCCGCAGGTAAATTCATCGATGAATTCATCGGCAAATTT
ATTGGCAAATACACGGGCAA

Downstream 100 bases:

>100_bases
GTGCCGCGTCGCCGTCACCGCAAGAGCTTGCCGCCCCGCGGGAGGTCAAGCGCATCGGCGTGTTTGGCGGGGCATTTGAC
CCGCCCCACAACGCCCACGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSMTELSGVRTFLLGLQERVTAAVAEVDGGDFITDAWQKEPGEPLQGNGITKILENGEVFERAGCGFSHVQGSRLPPSAT
QHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMLAATPVSAGPAEAVCWFGGGMDLTPYYGFDEDAVHFHQTCKDAL
APFGGDKYPRFKQWCDEYFYLKHRQEQRGIGGIFFDDFQELGLEQSFAMMQSVADSFLPAYLPIVRRRQSQPYGARERDF
QLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILMSMPPLASWSYQHRAEAGSPEERLYKEFLIRRDWV

Sequences:

>Translated_308_residues
MSMTELSGVRTFLLGLQERVTAAVAEVDGGDFITDAWQKEPGEPLQGNGITKILENGEVFERAGCGFSHVQGSRLPPSAT
QHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMLAATPVSAGPAEAVCWFGGGMDLTPYYGFDEDAVHFHQTCKDAL
APFGGDKYPRFKQWCDEYFYLKHRQEQRGIGGIFFDDFQELGLEQSFAMMQSVADSFLPAYLPIVRRRQSQPYGARERDF
QLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILMSMPPLASWSYQHRAEAGSPEERLYKEFLIRRDWV
>Mature_307_residues
SMTELSGVRTFLLGLQERVTAAVAEVDGGDFITDAWQKEPGEPLQGNGITKILENGEVFERAGCGFSHVQGSRLPPSATQ
HRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMLAATPVSAGPAEAVCWFGGGMDLTPYYGFDEDAVHFHQTCKDALA
PFGGDKYPRFKQWCDEYFYLKHRQEQRGIGGIFFDDFQELGLEQSFAMMQSVADSFLPAYLPIVRRRQSQPYGARERDFQ
LYRRGRYVEFNLVWDRGTHFGLQSGGRTESILMSMPPLASWSYQHRAEAGSPEERLYKEFLIRRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=306, Percent_Identity=45.0980392156863, Blast_Score=258, Evalue=4e-69,
Organism=Escherichia coli, GI1788777, Length=300, Percent_Identity=61.3333333333333, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320249, Length=309, Percent_Identity=43.042071197411, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17864388, Length=288, Percent_Identity=49.6527777777778, Blast_Score=272, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_POLSJ (Q12C42)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548798.1
- ProteinModelPortal:   Q12C42
- SMR:   Q12C42
- STRING:   Q12C42
- GeneID:   4015376
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1970
- NMPDR:   fig|296591.1.peg.2636
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- PhylomeDB:   Q12C42
- ProtClustDB:   PRK05330
- BioCyc:   PSP296591:BPRO_1970-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34849; Mature: 34718

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 111-111 BINDING 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTELSGVRTFLLGLQERVTAAVAEVDGGDFITDAWQKEPGEPLQGNGITKILENGEVF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCHH
ERAGCGFSHVQGSRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMLAAT
HHCCCCHHHCCCCCCCCCCHHCCCCCCCCCHHHHCEEEEEECCCCCCCEEECCEEEEEEC
PVSAGPAEAVCWFGGGMDLTPYYGFDEDAVHFHQTCKDALAPFGGDKYPRFKQWCDEYFY
CCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LKHRQEQRGIGGIFFDDFQELGLEQSFAMMQSVADSFLPAYLPIVRRRQSQPYGARERDF
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILMSMPPLASWSYQHRAEAGSPEERLYKE
HHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHEEECCCCCCCCHHHHCCCCCHHHHHHHH
FLIRRDWV
HHHHHCCC
>Mature Secondary Structure 
SMTELSGVRTFLLGLQERVTAAVAEVDGGDFITDAWQKEPGEPLQGNGITKILENGEVF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHCCCHH
ERAGCGFSHVQGSRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMLAAT
HHCCCCHHHCCCCCCCCCCHHCCCCCCCCCHHHHCEEEEEECCCCCCCEEECCEEEEEEC
PVSAGPAEAVCWFGGGMDLTPYYGFDEDAVHFHQTCKDALAPFGGDKYPRFKQWCDEYFY
CCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LKHRQEQRGIGGIFFDDFQELGLEQSFAMMQSVADSFLPAYLPIVRRRQSQPYGARERDF
HHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILMSMPPLASWSYQHRAEAGSPEERLYKE
HHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHEEECCCCCCCCHHHHCCCCCHHHHHHHH
FLIRRDWV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA