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The map label for this gene is purD [H]

Identifier: 91787845

GI number: 91787845

Start: 2036235

End: 2037536

Strand: Direct

Name: purD [H]

Synonym: Bpro_1969

Alternate gene names: 91787845

Gene position: 2036235-2037536 (Clockwise)

Preceding gene: 91787844

Following gene: 91787846

Centisome position: 39.16

GC content: 64.75

Gene sequence:

>1302_bases
GTGAAAGTTCTTGTTATTGGTGGCGGCGGCCGTGAGCACGCGCTGGCCTGGAAACTGGCCCAATCGCCCAAGGTGCAGGC
GGTCTATGTGGCGCCGGGCAATGGCGGTACGGCGCTCGATGCGCGGCTGGAGAACATCAACATCACCGACGTCCAGGCGC
TGCGCGAATGGGCGGTGGCCGAGAAAATAGCCCTCACCGTGGTGGGGCCGGAGCAGCCTCTGGCGGCCGGCATTGTCGAC
GAATTCCGCGCCCATGGCCTGAGGGTGTTTGGCCCGACGAAAGCGGCCGCCCAGCTGGAGAGCTCCAAGGCGTTTTCCAA
GGCCTTCATGAAGCGCCACGGCATTCCGACGGCTGAATACGAAACCTTTACCGACGCGGTGGCGGCCCACGCCTATGTCG
ATGAAAAGGGCGCGCCCATCGTGGTCAAGGCCGATGGCCTGGCGGCCGGCAAGGGCGTGGTGGTGGCCATGACGCTGCAT
GAGGCGCATGAGGCGATCGAGTTCATGCTGGCCACCAGCCCGGACCACAACGTGCTGGGCGTCACCCACAACGAAGGGGG
CGCGCGCGTCGTCATCGAGGAGTTTTTGCAGGGCGAGGAAGCCAGTTTCATTGTCATGTGCGACGGCAAAAACGTGACCC
CCATGGCCACCAGCCAGGACCACAAGCGCCTGCTGGACGGCGACCAGGGCCCGAATACGGGCGGCATGGGCGCGTATTCA
CCGGCACCCGTGGTCACGCCGGACGTGCACGCCCGCACCATGCGCGAGATCATTCTGCCCACCATCAAGGGCATGGAAAA
AGACGGGATTCCCTTCACCGGTTTCCTGTACGCCGGCCTGATGATTGATGCCCAGGGCCGGCCCAAGACGCTCGAGTTCA
ACTGCCGCATGGGCGACCCGGAAACCCAGCCTATCATGATGCGCCTGAAAACCGATCTGTTTGACGTGATGATGGCGGCC
ACGTCCGGCGCCCTCGACCAGGTCGAACTGGACTGGGACCGCCGCCCGGCCCTCGGTGTGGTGATGGCGGCGCACGGCTA
TCCGCTCAATCCGCGCAAGGGCGATGTCATCCACGGCCTGCTCAAACCCAGCGAAGCGGCGGACGATGCGATGGTGTTCC
ACGCCGGCACCCGCAAGCAGGACAACATCACGGTGACTGCTGGCGGCCGCGTGCTGTGCGTCACCGCGCTGGGCAGCACG
GTCAAGGCGGCGCAGCAGCGTGCCTACGAGGTCGCCCAGTCAATTCAATTTGACGGCGCCCAATACCGCAAGGACATCGG
CTACAGGGCCATCAAGTCCTGA

Upstream 100 bases:

>100_bases
TGCAGCGCCGCGGTCGGGCCGTCGTCAAAGTCATTCTCGGTGTCGTCATTTTTCTTATTTTGTACCTCAGCTATTTGCTG
TTTTTTAGATTGAACCTCCC

Downstream 100 bases:

>100_bases
TGGGCACCTATGGGCACATGTTGGAGCCCTGGACGGGTGGTGCCGCAGGTAAATTCATCGATGAATTCATCGGCAAATTT
ATTGGCAAATACACGGGCAA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKVLVIGGGGREHALAWKLAQSPKVQAVYVAPGNGGTALDARLENINITDVQALREWAVAEKIALTVVGPEQPLAAGIVD
EFRAHGLRVFGPTKAAAQLESSKAFSKAFMKRHGIPTAEYETFTDAVAAHAYVDEKGAPIVVKADGLAAGKGVVVAMTLH
EAHEAIEFMLATSPDHNVLGVTHNEGGARVVIEEFLQGEEASFIVMCDGKNVTPMATSQDHKRLLDGDQGPNTGGMGAYS
PAPVVTPDVHARTMREIILPTIKGMEKDGIPFTGFLYAGLMIDAQGRPKTLEFNCRMGDPETQPIMMRLKTDLFDVMMAA
TSGALDQVELDWDRRPALGVVMAAHGYPLNPRKGDVIHGLLKPSEAADDAMVFHAGTRKQDNITVTAGGRVLCVTALGST
VKAAQQRAYEVAQSIQFDGAQYRKDIGYRAIKS

Sequences:

>Translated_433_residues
MKVLVIGGGGREHALAWKLAQSPKVQAVYVAPGNGGTALDARLENINITDVQALREWAVAEKIALTVVGPEQPLAAGIVD
EFRAHGLRVFGPTKAAAQLESSKAFSKAFMKRHGIPTAEYETFTDAVAAHAYVDEKGAPIVVKADGLAAGKGVVVAMTLH
EAHEAIEFMLATSPDHNVLGVTHNEGGARVVIEEFLQGEEASFIVMCDGKNVTPMATSQDHKRLLDGDQGPNTGGMGAYS
PAPVVTPDVHARTMREIILPTIKGMEKDGIPFTGFLYAGLMIDAQGRPKTLEFNCRMGDPETQPIMMRLKTDLFDVMMAA
TSGALDQVELDWDRRPALGVVMAAHGYPLNPRKGDVIHGLLKPSEAADDAMVFHAGTRKQDNITVTAGGRVLCVTALGST
VKAAQQRAYEVAQSIQFDGAQYRKDIGYRAIKS
>Mature_433_residues
MKVLVIGGGGREHALAWKLAQSPKVQAVYVAPGNGGTALDARLENINITDVQALREWAVAEKIALTVVGPEQPLAAGIVD
EFRAHGLRVFGPTKAAAQLESSKAFSKAFMKRHGIPTAEYETFTDAVAAHAYVDEKGAPIVVKADGLAAGKGVVVAMTLH
EAHEAIEFMLATSPDHNVLGVTHNEGGARVVIEEFLQGEEASFIVMCDGKNVTPMATSQDHKRLLDGDQGPNTGGMGAYS
PAPVVTPDVHARTMREIILPTIKGMEKDGIPFTGFLYAGLMIDAQGRPKTLEFNCRMGDPETQPIMMRLKTDLFDVMMAA
TSGALDQVELDWDRRPALGVVMAAHGYPLNPRKGDVIHGLLKPSEAADDAMVFHAGTRKQDNITVTAGGRVLCVTALGST
VKAAQQRAYEVAQSIQFDGAQYRKDIGYRAIKS

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=434, Percent_Identity=49.0783410138249, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI209869995, Length=434, Percent_Identity=49.0783410138249, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI209869993, Length=434, Percent_Identity=49.0783410138249, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI28416899, Length=434, Percent_Identity=49.0783410138249, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1790438, Length=435, Percent_Identity=63.6781609195402, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17567511, Length=432, Percent_Identity=44.9074074074074, Blast_Score=332, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6321203, Length=451, Percent_Identity=44.1241685144124, Blast_Score=343, Evalue=4e-95,
Organism=Drosophila melanogaster, GI62471619, Length=441, Percent_Identity=45.8049886621315, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24582400, Length=441, Percent_Identity=45.8049886621315, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 46321; Mature: 46321

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVIGGGGREHALAWKLAQSPKVQAVYVAPGNGGTALDARLENINITDVQALREWAVA
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHH
EKIALTVVGPEQPLAAGIVDEFRAHGLRVFGPTKAAAQLESSKAFSKAFMKRHGIPTAEY
CEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
ETFTDAVAAHAYVDEKGAPIVVKADGLAAGKGVVVAMTLHEAHEAIEFMLATSPDHNVLG
HHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHEEEEECCCCCCEEE
VTHNEGGARVVIEEFLQGEEASFIVMCDGKNVTPMATSQDHKRLLDGDQGPNTGGMGAYS
EEECCCCCEEHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
PAPVVTPDVHARTMREIILPTIKGMEKDGIPFTGFLYAGLMIDAQGRPKTLEFNCRMGDP
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHEEEEEEEECCCCCCEEEEEEECCCC
ETQPIMMRLKTDLFDVMMAATSGALDQVELDWDRRPALGVVMAAHGYPLNPRKGDVIHGL
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEE
LKPSEAADDAMVFHAGTRKQDNITVTAGGRVLCVTALGSTVKAAQQRAYEVAQSIQFDGA
CCCCCCCCCEEEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCH
QYRKDIGYRAIKS
HHHHHCCCHHHCC
>Mature Secondary Structure
MKVLVIGGGGREHALAWKLAQSPKVQAVYVAPGNGGTALDARLENINITDVQALREWAVA
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHH
EKIALTVVGPEQPLAAGIVDEFRAHGLRVFGPTKAAAQLESSKAFSKAFMKRHGIPTAEY
CEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
ETFTDAVAAHAYVDEKGAPIVVKADGLAAGKGVVVAMTLHEAHEAIEFMLATSPDHNVLG
HHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHEEEEECCCCCCEEE
VTHNEGGARVVIEEFLQGEEASFIVMCDGKNVTPMATSQDHKRLLDGDQGPNTGGMGAYS
EEECCCCCEEHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
PAPVVTPDVHARTMREIILPTIKGMEKDGIPFTGFLYAGLMIDAQGRPKTLEFNCRMGDP
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHEEEEEEEECCCCCCEEEEEEECCCC
ETQPIMMRLKTDLFDVMMAATSGALDQVELDWDRRPALGVVMAAHGYPLNPRKGDVIHGL
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEEE
LKPSEAADDAMVFHAGTRKQDNITVTAGGRVLCVTALGSTVKAAQQRAYEVAQSIQFDGA
CCCCCCCCCEEEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCH
QYRKDIGYRAIKS
HHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]