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The map label for this gene is ywrD [H]

Identifier: 91787698

GI number: 91787698

Start: 1883543

End: 1885162

Strand: Direct

Name: ywrD [H]

Synonym: Bpro_1819

Alternate gene names: 91787698

Gene position: 1883543-1885162 (Clockwise)

Preceding gene: 91787697

Following gene: 91787703

Centisome position: 36.22

GC content: 66.54

Gene sequence:

>1620_bases
ATGAAATACACACCCATGCCCATTCCATCCGCCATGGACTTCACGAATCCCTATGCCTCGGCACGTTCTGCCGTGCTGGG
GCGCAACGTTGTCAGTACCTCGCAGCCACTCGCCGCACAGGCTGGCCTGCGCATGCTTCTTGCCGGAGGCAATGCCGTTG
ACGCCGCCATCGCCACGGCGATGGCGTTGACGGTTGTCGAGCCGACCGGCTGCGGCCTCGGCAGCGATGGCTTCGCGATT
GTCTGGGACGGCAAGGAGTTGCACGGTCTGAACGCCTCCGGCCGTTCGCCCGCGGCCTGGTCAGCCGACCGTTTCGCCGG
CCACGGCGCAATGCCCGACAAAGGTTGGGAGGCCGTCACGGTGCCTGGTGCCGTTTCGGCCTGGAGCGCACTGTCGCGCC
GTTTCGGCCGCCTGCCATTCACCGCCCTGGCCGCGCCTGCCATTGATTACGCCCGCAACGGCTTTGCGGTATCGCCGGTC
ATCGCGCATTTATGGGCGCTGGGCGGGGCGCGGCTGGGCGAGCAGCCCGGCTTTGCCGAATGCTTTTTGCCCGACGGCCG
CGCCCCGCGCGCGGGGGAATTGTTTCGCAGCGAGGCCCATGCGAGCACGCTGGAGGCCATTGCCGAAAGCCATGGCGAGG
CGTTTTACCGCGGCGCGGTGGCCCAGCGCATCGCGGCCCATGCCAGGGCCCATGGCGCGGCGCTGACGGAGGACGATCTG
GCCAACCACCGCGCCGACTGGTGCGGCACGCTGGCTCAGCCCTTCGCTGGCTCCGTGGTGCACGAACTGCCGCCGAATGG
GCAGGGCATTGCAGCCTTGATGGCGCTGGGCATGATGGAGGCATTGGGTATTGGCAACCAGCCGCCCGACCATGTTGATA
CGGTGCACCTGTCGATTGAGGCGATGAAACTCGCGCTGGCAGACCTGCATCAATACAACGCCGACATTGACGCCATGCAG
ATCCCGCCCAGCGCGCTGCTGGCCCCAGCCTACCTGGCCGAGCGAGCCAGGCTGATTGACCGCCACCGCGCTGCCGACCC
CGGCCATGGTGCGCCCAAGCCGGGCGGCACCGTCTATGTGGCAACGGCGGACGCCTCCGGCATGATGGTCTCCTTCATCC
AGTCCAACTACATGGGATTTGGCTCGGGCGTTGTCGTGCCGGGCACCGGCGTCAGCCTGCAGAACCGGGGCCATGGCTTT
TCTTTGGAACAGGGGCATGCCAATCAGGTAGGGCCTGCCAAGCGCCCTTCGCACACCATCATTCCGGCGTTCGCCATGCA
TGCCGATGGCACGCCGCAAATGGCCTTCGGTGTGATGGGGGGGCCGATGCAGTCACAAGGCCATGTGCAAATGGCCTTGC
GCGTGCTCCACTACGGGCAGAACCCGCAAGCCGCGGCCGATGCGCCGCGCTGGCGCGTGACGGGCGGACGCAAGGTGGCC
GTTGAACCGAACTTTGACGCCGACGTGGTTCGCGAGCTTGCTGCGCGCGGGCATGAAGTCACTGTAGAGCGCGGTAATGG
TGTTTTTGCCTTTGGTGGCGCGCAGCTGGTGTACAAGCGTGGCGACAGCTACGTCGCAGGCTCCGACCCGCGCAAGGACG
GCCAGGCCGTGGCATTCTGA

Upstream 100 bases:

>100_bases
AACCCGCCCCACCGGGCACGCCCGCACAGTTCGCCGAGATGGTGTCTGCCGACAGCCAGCGCTGGGCGCGCATCATTCGC
GAACGCAAGATCACCCTTGA

Downstream 100 bases:

>100_bases
TTTCCTGAACATCGACCTTATCGTGATCGCCGGGTTGACCGCGCTGGGCTGCGTTGGCGACTGCCTGGCCAACAGGCGGA
GCCGGACGCGCGCCGACCCC

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MKYTPMPIPSAMDFTNPYASARSAVLGRNVVSTSQPLAAQAGLRMLLAGGNAVDAAIATAMALTVVEPTGCGLGSDGFAI
VWDGKELHGLNASGRSPAAWSADRFAGHGAMPDKGWEAVTVPGAVSAWSALSRRFGRLPFTALAAPAIDYARNGFAVSPV
IAHLWALGGARLGEQPGFAECFLPDGRAPRAGELFRSEAHASTLEAIAESHGEAFYRGAVAQRIAAHARAHGAALTEDDL
ANHRADWCGTLAQPFAGSVVHELPPNGQGIAALMALGMMEALGIGNQPPDHVDTVHLSIEAMKLALADLHQYNADIDAMQ
IPPSALLAPAYLAERARLIDRHRAADPGHGAPKPGGTVYVATADASGMMVSFIQSNYMGFGSGVVVPGTGVSLQNRGHGF
SLEQGHANQVGPAKRPSHTIIPAFAMHADGTPQMAFGVMGGPMQSQGHVQMALRVLHYGQNPQAAADAPRWRVTGGRKVA
VEPNFDADVVRELAARGHEVTVERGNGVFAFGGAQLVYKRGDSYVAGSDPRKDGQAVAF

Sequences:

>Translated_539_residues
MKYTPMPIPSAMDFTNPYASARSAVLGRNVVSTSQPLAAQAGLRMLLAGGNAVDAAIATAMALTVVEPTGCGLGSDGFAI
VWDGKELHGLNASGRSPAAWSADRFAGHGAMPDKGWEAVTVPGAVSAWSALSRRFGRLPFTALAAPAIDYARNGFAVSPV
IAHLWALGGARLGEQPGFAECFLPDGRAPRAGELFRSEAHASTLEAIAESHGEAFYRGAVAQRIAAHARAHGAALTEDDL
ANHRADWCGTLAQPFAGSVVHELPPNGQGIAALMALGMMEALGIGNQPPDHVDTVHLSIEAMKLALADLHQYNADIDAMQ
IPPSALLAPAYLAERARLIDRHRAADPGHGAPKPGGTVYVATADASGMMVSFIQSNYMGFGSGVVVPGTGVSLQNRGHGF
SLEQGHANQVGPAKRPSHTIIPAFAMHADGTPQMAFGVMGGPMQSQGHVQMALRVLHYGQNPQAAADAPRWRVTGGRKVA
VEPNFDADVVRELAARGHEVTVERGNGVFAFGGAQLVYKRGDSYVAGSDPRKDGQAVAF
>Mature_539_residues
MKYTPMPIPSAMDFTNPYASARSAVLGRNVVSTSQPLAAQAGLRMLLAGGNAVDAAIATAMALTVVEPTGCGLGSDGFAI
VWDGKELHGLNASGRSPAAWSADRFAGHGAMPDKGWEAVTVPGAVSAWSALSRRFGRLPFTALAAPAIDYARNGFAVSPV
IAHLWALGGARLGEQPGFAECFLPDGRAPRAGELFRSEAHASTLEAIAESHGEAFYRGAVAQRIAAHARAHGAALTEDDL
ANHRADWCGTLAQPFAGSVVHELPPNGQGIAALMALGMMEALGIGNQPPDHVDTVHLSIEAMKLALADLHQYNADIDAMQ
IPPSALLAPAYLAERARLIDRHRAADPGHGAPKPGGTVYVATADASGMMVSFIQSNYMGFGSGVVVPGTGVSLQNRGHGF
SLEQGHANQVGPAKRPSHTIIPAFAMHADGTPQMAFGVMGGPMQSQGHVQMALRVLHYGQNPQAAADAPRWRVTGGRKVA
VEPNFDADVVRELAARGHEVTVERGNGVFAFGGAQLVYKRGDSYVAGSDPRKDGQAVAF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=25.9328358208955, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=25.9328358208955, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=25.9328358208955, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=25.9328358208955, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI113429324, Length=520, Percent_Identity=25.1923076923077, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=25.3333333333333, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=25.3211009174312, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=25.2747252747253, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI153266907, Length=539, Percent_Identity=24.1187384044527, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI109148539, Length=541, Percent_Identity=26.4325323475046, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1789856, Length=528, Percent_Identity=28.7878787878788, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI212646519, Length=498, Percent_Identity=25.3012048192771, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI72000294, Length=498, Percent_Identity=25.3012048192771, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=502, Percent_Identity=24.9003984063745, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=546, Percent_Identity=23.6263736263736, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193208247, Length=480, Percent_Identity=23.5416666666667, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193208245, Length=480, Percent_Identity=23.5416666666667, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24642670, Length=543, Percent_Identity=25.9668508287293, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24642666, Length=543, Percent_Identity=25.9668508287293, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45551474, Length=543, Percent_Identity=25.9668508287293, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077880, Length=543, Percent_Identity=25.9668508287293, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077878, Length=543, Percent_Identity=25.9668508287293, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077496, Length=489, Percent_Identity=26.3803680981595, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859893, Length=502, Percent_Identity=25.0996015936255, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18859741, Length=547, Percent_Identity=25.9597806215722, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56179; Mature: 56179

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTPMPIPSAMDFTNPYASARSAVLGRNVVSTSQPLAAQAGLRMLLAGGNAVDAAIATA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCHHHHHCCEEEEECCCHHHHHHHHH
MALTVVEPTGCGLGSDGFAIVWDGKELHGLNASGRSPAAWSADRFAGHGAMPDKGWEAVT
HHHEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEE
VPGAVSAWSALSRRFGRLPFTALAAPAIDYARNGFAVSPVIAHLWALGGARLGEQPGFAE
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCCCEE
CFLPDGRAPRAGELFRSEAHASTLEAIAESHGEAFYRGAVAQRIAAHARAHGAALTEDDL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ANHRADWCGTLAQPFAGSVVHELPPNGQGIAALMALGMMEALGIGNQPPDHVDTVHLSIE
HHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHH
AMKLALADLHQYNADIDAMQIPPSALLAPAYLAERARLIDRHRAADPGHGAPKPGGTVYV
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
ATADASGMMVSFIQSNYMGFGSGVVVPGTGVSLQNRGHGFSLEQGHANQVGPAKRPSHTI
EECCCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEE
IPAFAMHADGTPQMAFGVMGGPMQSQGHVQMALRVLHYGQNPQAAADAPRWRVTGGRKVA
EEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEE
VEPNFDADVVRELAARGHEVTVERGNGVFAFGGAQLVYKRGDSYVAGSDPRKDGQAVAF
ECCCCCHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKYTPMPIPSAMDFTNPYASARSAVLGRNVVSTSQPLAAQAGLRMLLAGGNAVDAAIATA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCHHHHHCCEEEEECCCHHHHHHHHH
MALTVVEPTGCGLGSDGFAIVWDGKELHGLNASGRSPAAWSADRFAGHGAMPDKGWEAVT
HHHEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEE
VPGAVSAWSALSRRFGRLPFTALAAPAIDYARNGFAVSPVIAHLWALGGARLGEQPGFAE
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCCCEE
CFLPDGRAPRAGELFRSEAHASTLEAIAESHGEAFYRGAVAQRIAAHARAHGAALTEDDL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ANHRADWCGTLAQPFAGSVVHELPPNGQGIAALMALGMMEALGIGNQPPDHVDTVHLSIE
HHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHH
AMKLALADLHQYNADIDAMQIPPSALLAPAYLAERARLIDRHRAADPGHGAPKPGGTVYV
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
ATADASGMMVSFIQSNYMGFGSGVVVPGTGVSLQNRGHGFSLEQGHANQVGPAKRPSHTI
EECCCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEE
IPAFAMHADGTPQMAFGVMGGPMQSQGHVQMALRVLHYGQNPQAAADAPRWRVTGGRKVA
EEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEE
VEPNFDADVVRELAARGHEVTVERGNGVFAFGGAQLVYKRGDSYVAGSDPRKDGQAVAF
ECCCCCHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]