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The map label for this gene is ghrB [H]

Identifier: 91787618

GI number: 91787618

Start: 1793619

End: 1794626

Strand: Reverse

Name: ghrB [H]

Synonym: Bpro_1736

Alternate gene names: 91787618

Gene position: 1794626-1793619 (Counterclockwise)

Preceding gene: 91787619

Following gene: 91787612

Centisome position: 34.51

GC content: 67.06

Gene sequence:

>1008_bases
ATGGGCGCGCCAGCTTCACCACCCGTTCGCAAGAAGATCCTGGTCTTCCGCGAGCTGCCGCCCGACCAGCTGGCGCGCCT
GCAGGCAATGCACGAGGTCACCGTGGCCAACCCCCGCCTGCCCGGACAGCTGGCCGCATTCCACGCCGCCCTGGCCAGCG
CGGACGGCATGATCGGCTCGAGCTACGCCATCACTGCCTCCCTGCTGGCGAGCGCGCCGCAGCTCAAGGTGATTTCCAGC
GTCTCCGTCGGCGTTGACAACTACGACCTGCCCGCCCTGGCTGCGCGCGGCATCATGCTGTGCCACACGCCCGGCGTGCT
GACTGAAACCACGGCCGATACCATTTTTTCATTGATCATGGCCTCCAGCCGCCGCCTGGTGGAACTGGCCAGCCATGTGC
GCGAAGGCCGCTGGACACGCAACATCGGTGAAGACCTGTTTGGCTGGGACGTGCACGGCAAGACGCTGGGCATCCTCGGA
TTCGGCCGCATCGGCCAGGCCGTGGCACGGCGTGCCGCGCTGGGCTTCAACATGCCCGTGCTGTACCACAGCCGCCGGCC
GGTCGACGTCGCCCATGAGCTGCCCGAACTCGCCGGCAAGGCCACGCACACACCCTTCGATGAATTGCTGCAACGCGCAG
ACATCGTCGCCGCCGTGCTGCCCTTGTCGAAAGAAACCCGCGGCCTGATGGGTGCGCGCGAATTTGATTTGATGAAACCC
GGCGCCATCTTCGTCAACGGTGCGCGCGGCGCCATCGTGCAGGAAGACGCCCTGCTCAATGCGCTGGACCATGGCACGCT
GCGCGCCGCCGGTCTCGATGTATTTGCTACCGAGCCGCTGCCAATGGACTCACCGCTGCGCACCCATCCCAAGGTGACCG
CCCTGCCGCACATCGGCTCGGCCACGTTCGAGACGAGGCATGCGATGGCGGTGCTGGCGACGAGCAACCTGCTGCAGGCT
CTGGCGGGGGAGCGGCCGGGGGCGGTGTTCGCCACCGGGACTTCATAG

Upstream 100 bases:

>100_bases
GAAGCGCGGCGCCTGGATCGGCGCGCGCGCGGTGCAGGTGCTGGGCGACAGCGAAGGCCTGCCGACGCGCGCCGAACTCA
ACGCCGCAAAGCTTTAAATC

Downstream 100 bases:

>100_bases
CAGAACCAGTATCAAGTCATCATTGATGGGCCGGCCCTGCCTGCAGCCAAACCTCCGCCCAACACGCCGGCCAGGAAAGC
CTGAGAAAAATCAGTGCCTG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MGAPASPPVRKKILVFRELPPDQLARLQAMHEVTVANPRLPGQLAAFHAALASADGMIGSSYAITASLLASAPQLKVISS
VSVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIMASSRRLVELASHVREGRWTRNIGEDLFGWDVHGKTLGILG
FGRIGQAVARRAALGFNMPVLYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLMKP
GAIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEPLPMDSPLRTHPKVTALPHIGSATFETRHAMAVLATSNLLQA
LAGERPGAVFATGTS

Sequences:

>Translated_335_residues
MGAPASPPVRKKILVFRELPPDQLARLQAMHEVTVANPRLPGQLAAFHAALASADGMIGSSYAITASLLASAPQLKVISS
VSVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIMASSRRLVELASHVREGRWTRNIGEDLFGWDVHGKTLGILG
FGRIGQAVARRAALGFNMPVLYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLMKP
GAIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEPLPMDSPLRTHPKVTALPHIGSATFETRHAMAVLATSNLLQA
LAGERPGAVFATGTS
>Mature_334_residues
GAPASPPVRKKILVFRELPPDQLARLQAMHEVTVANPRLPGQLAAFHAALASADGMIGSSYAITASLLASAPQLKVISSV
SVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIMASSRRLVELASHVREGRWTRNIGEDLFGWDVHGKTLGILGF
GRIGQAVARRAALGFNMPVLYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLMKPG
AIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEPLPMDSPLRTHPKVTALPHIGSATFETRHAMAVLATSNLLQAL
AGERPGAVFATGTS

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=323, Percent_Identity=39.3188854489164, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI23308577, Length=297, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=276, Percent_Identity=31.8840579710145, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4557499, Length=276, Percent_Identity=31.8840579710145, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI145580575, Length=276, Percent_Identity=31.8840579710145, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4557497, Length=275, Percent_Identity=32, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI61743967, Length=275, Percent_Identity=32, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI87082289, Length=319, Percent_Identity=48.2758620689655, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=30.6513409961686, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081824, Length=172, Percent_Identity=36.6279069767442, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=28.4313725490196, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788660, Length=277, Percent_Identity=30.6859205776173, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=329, Percent_Identity=33.1306990881459, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=31.2977099236641, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=301, Percent_Identity=32.2259136212625, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320925, Length=267, Percent_Identity=28.4644194756554, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=267, Percent_Identity=28.4644194756554, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=254, Percent_Identity=28.740157480315, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=151, Percent_Identity=35.0993377483444, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=184, Percent_Identity=32.6086956521739, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=39.4321766561514, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=39.4321766561514, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=39.4321766561514, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=39.4321766561514, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=39.4321766561514, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574286, Length=308, Percent_Identity=37.012987012987, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=36.5758754863813, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=40.3846153846154, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=32.013201320132, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646446, Length=269, Percent_Identity=32.7137546468402, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646448, Length=269, Percent_Identity=32.7137546468402, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646452, Length=269, Percent_Identity=32.7137546468402, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646450, Length=269, Percent_Identity=32.7137546468402, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI62472511, Length=269, Percent_Identity=32.7137546468402, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35523; Mature: 35391

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPASPPVRKKILVFRELPPDQLARLQAMHEVTVANPRLPGQLAAFHAALASADGMIGS
CCCCCCCCHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
SYAITASLLASAPQLKVISSVSVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIM
HHHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
ASSRRLVELASHVREGRWTRNIGEDLFGWDVHGKTLGILGFGRIGQAVARRAALGFNMPV
HCCHHHHHHHHHHHCCCHHHHHCCHHCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLMKP
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHCCCCC
GAIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEPLPMDSPLRTHPKVTALPHIGS
CEEEEECCCCCEECHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCCCCEEECCCCCC
ATFETRHAMAVLATSNLLQALAGERPGAVFATGTS
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure 
GAPASPPVRKKILVFRELPPDQLARLQAMHEVTVANPRLPGQLAAFHAALASADGMIGS
CCCCCCCHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
SYAITASLLASAPQLKVISSVSVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIM
HHHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
ASSRRLVELASHVREGRWTRNIGEDLFGWDVHGKTLGILGFGRIGQAVARRAALGFNMPV
HCCHHHHHHHHHHHCCCHHHHHCCHHCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLMKP
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHCCCCC
GAIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEPLPMDSPLRTHPKVTALPHIGS
CEEEEECCCCCEECHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCCCCEEECCCCCC
ATFETRHAMAVLATSNLLQALAGERPGAVFATGTS
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA