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The map label for this gene is thlA [H]

Identifier: 91787462

GI number: 91787462

Start: 1625827

End: 1627011

Strand: Direct

Name: thlA [H]

Synonym: Bpro_1577

Alternate gene names: 91787462

Gene position: 1625827-1627011 (Clockwise)

Preceding gene: 91787461

Following gene: 91787463

Centisome position: 31.26

GC content: 66.41

Gene sequence:

>1185_bases
ATGTCACGTGAAGTTGTTGTAGTCAGCGGTGTACGCACCGCCATTGGTACCTATGGCGGCAGCCTGAAGGATATTTCCCC
CACCGAACTGGCCGCGCAGGTTGTGCGCGAATCACTGGCGCGCGCCGGCGTCGAGGGGAGCGACGTGGGCCATGTGGTGT
TTGGCCATGTGGTCAATACCGAGCCCAAAGACATGTACCTGTCGCGCGTCGCCGCCATCAACGGCGGCTGCGCCGAGGGT
ACGCCGGCGTTCAATGTCAACCGCCTGTGCGGCTCCGGCCTGCAGGCCATCATTTCGGCCAGCCAGTCCATTTTGCTGGG
CGATACCGACGTGGCCATCGGCGGCGGCGCCGAGAACATGAGCCGCGGCCCCTATGCCAGCCTGTCGGCGCGCTGGGGCG
CCCGCATGGGTGACAGCACGATGGTCGACATGGTGGTGGGCGCGCTGCACGACCCCTTCCAGAAAATTCACATGGGCGTG
ACCGCCGAGAACATCGCCGCCAAGTGGGGCATCAGCCGTGAAGAGCAGGACGCGATTGCCGTCGAAAGCCACAACCGCGC
CCAGCGCGCCACCGAGGCCGGTTACTTCAAGGACCAGATCGTCCCCGTCATGCTGAAAAGCAAAAAGGGCGAGGTGGCCT
ACGTCACCGACGAGCATTTCCGTGCCGGCTGCACGCTGGCCGACATGGCCAAGCTCAAACCGGTGTTCATCAAGGAAAAC
GGCACCGTCACCGCCGGCAACGCCTCCGGCATCAACGACGCGGCCGCCGCCGTGGTGCTGATGGAAGCCGGCACCGCCAA
GGCCCGCGGCGCCAAGCCGCTGGCCCGCCTGGTGGCCTACGCCCACGCCGGCGTGGACCCCCAGTACATGGGCATTGGCC
CGGTGCCCGCCACGCGACTGGCGCTGAAAAAGGCCGGCCTCACGGTGAACGACCTGGACGTGATCGAGGCCAACGAAGCC
TTTGCCGCCCAGGCCTGCGCCGTCACGCGCGAGCTGGGGCTGGACCCGGCCAAGGTCAACCCCAACGGCTCGGGCATCTC
GCTGGGCCACCCGATTGGCGCCACCGGCGCGCTGATCACGGTGAAAGCCCTGTACGAGCTGCAGCGCATCGGGGGCCGCT
ACGCGCTGGTAACGATGTGCATAGGCGGCGGTCAGGGCATTGCGGCGATTTTTGAGCGGATGTAA

Upstream 100 bases:

>100_bases
TTCCGCGCTGTCCAGCCAGCATGGAGCAGCATTGAGCTGATGCCCATGAGCCGCAAAATTCGATAGAACCAATTCTTTCA
TCTAACCGGAGAAACGAGCC

Downstream 100 bases:

>100_bases
GGGCGGTGGGCGCGTCCGTGCCAGCTGAGAAATCGAACCCATGAGGCAACAACCCGATCCATGGGGCGAACTTTTTCTGA
CAAACCGACTTGATTTCAGC

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSREVVVVSGVRTAIGTYGGSLKDISPTELAAQVVRESLARAGVEGSDVGHVVFGHVVNTEPKDMYLSRVAAINGGCAEG
TPAFNVNRLCGSGLQAIISASQSILLGDTDVAIGGGAENMSRGPYASLSARWGARMGDSTMVDMVVGALHDPFQKIHMGV
TAENIAAKWGISREEQDAIAVESHNRAQRATEAGYFKDQIVPVMLKSKKGEVAYVTDEHFRAGCTLADMAKLKPVFIKEN
GTVTAGNASGINDAAAAVVLMEAGTAKARGAKPLARLVAYAHAGVDPQYMGIGPVPATRLALKKAGLTVNDLDVIEANEA
FAAQACAVTRELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRIGGRYALVTMCIGGGQGIAAIFERM

Sequences:

>Translated_394_residues
MSREVVVVSGVRTAIGTYGGSLKDISPTELAAQVVRESLARAGVEGSDVGHVVFGHVVNTEPKDMYLSRVAAINGGCAEG
TPAFNVNRLCGSGLQAIISASQSILLGDTDVAIGGGAENMSRGPYASLSARWGARMGDSTMVDMVVGALHDPFQKIHMGV
TAENIAAKWGISREEQDAIAVESHNRAQRATEAGYFKDQIVPVMLKSKKGEVAYVTDEHFRAGCTLADMAKLKPVFIKEN
GTVTAGNASGINDAAAAVVLMEAGTAKARGAKPLARLVAYAHAGVDPQYMGIGPVPATRLALKKAGLTVNDLDVIEANEA
FAAQACAVTRELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRIGGRYALVTMCIGGGQGIAAIFERM
>Mature_393_residues
SREVVVVSGVRTAIGTYGGSLKDISPTELAAQVVRESLARAGVEGSDVGHVVFGHVVNTEPKDMYLSRVAAINGGCAEGT
PAFNVNRLCGSGLQAIISASQSILLGDTDVAIGGGAENMSRGPYASLSARWGARMGDSTMVDMVVGALHDPFQKIHMGVT
AENIAAKWGISREEQDAIAVESHNRAQRATEAGYFKDQIVPVMLKSKKGEVAYVTDEHFRAGCTLADMAKLKPVFIKENG
TVTAGNASGINDAAAAVVLMEAGTAKARGAKPLARLVAYAHAGVDPQYMGIGPVPATRLALKKAGLTVNDLDVIEANEAF
AAQACAVTRELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRIGGRYALVTMCIGGGQGIAAIFERM

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=45.4314720812183, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=45.2685421994885, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=40.3553299492386, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=41, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=36, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=30.3571428571429, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=45.6632653061224, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=46.2686567164179, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=45.9798994974874, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=40.0503778337531, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=34.3825665859564, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.0358056265985, Blast_Score=347, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=35.1010101010101, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=34.010152284264, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=30.4964539007092, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=27.5, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=37.844611528822, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=34.7394540942928, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=45.4081632653061, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=43.2569974554707, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=38.5390428211587, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=32.8671328671329, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24585051, Length=401, Percent_Identity=23.9401496259352, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40843; Mature: 40712

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREVVVVSGVRTAIGTYGGSLKDISPTELAAQVVRESLARAGVEGSDVGHVVFGHVVNT
CCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
EPKDMYLSRVAAINGGCAEGTPAFNVNRLCGSGLQAIISASQSILLGDTDVAIGGGAENM
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
SRGPYASLSARWGARMGDSTMVDMVVGALHDPFQKIHMGVTAENIAAKWGISREEQDAIA
CCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCCCEEE
VESHNRAQRATEAGYFKDQIVPVMLKSKKGEVAYVTDEHFRAGCTLADMAKLKPVFIKEN
EECCCHHHHHHHCCCHHHCCEEEEEECCCCCEEEEECCHHHCCCCHHHHHHCCEEEEECC
GTVTAGNASGINDAAAAVVLMEAGTAKARGAKPLARLVAYAHAGVDPQYMGIGPVPATRL
CEEEECCCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHH
ALKKAGLTVNDLDVIEANEAFAAQACAVTRELGLDPAKVNPNGSGISLGHPIGATGALIT
HHHHCCCEECCCEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCCHHHH
VKALYELQRIGGRYALVTMCIGGGQGIAAIFERM
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SREVVVVSGVRTAIGTYGGSLKDISPTELAAQVVRESLARAGVEGSDVGHVVFGHVVNT
CCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
EPKDMYLSRVAAINGGCAEGTPAFNVNRLCGSGLQAIISASQSILLGDTDVAIGGGAENM
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
SRGPYASLSARWGARMGDSTMVDMVVGALHDPFQKIHMGVTAENIAAKWGISREEQDAIA
CCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCCCEEE
VESHNRAQRATEAGYFKDQIVPVMLKSKKGEVAYVTDEHFRAGCTLADMAKLKPVFIKEN
EECCCHHHHHHHCCCHHHCCEEEEEECCCCCEEEEECCHHHCCCCHHHHHHCCEEEEECC
GTVTAGNASGINDAAAAVVLMEAGTAKARGAKPLARLVAYAHAGVDPQYMGIGPVPATRL
CEEEECCCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHHHH
ALKKAGLTVNDLDVIEANEAFAAQACAVTRELGLDPAKVNPNGSGISLGHPIGATGALIT
HHHHCCCEECCCEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCCHHHH
VKALYELQRIGGRYALVTMCIGGGQGIAAIFERM
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]