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The map label for this gene is prs [H]

Identifier: 91787189

GI number: 91787189

Start: 1334894

End: 1335868

Strand: Reverse

Name: prs [H]

Synonym: Bpro_1293

Alternate gene names: 91787189

Gene position: 1335868-1334894 (Counterclockwise)

Preceding gene: 91787190

Following gene: 91787188

Centisome position: 25.69

GC content: 60.82

Gene sequence:

>975_bases
ATGCAAACGCACCACCCCGACTTCATGGTTTTCACCGGCAATGCCAACCCCAGCATGGCCTCCGAGATCGCCCAGCACCT
GGGCATTTCACTGGGCGCTGCCCATGTGGGGCGTTTTTCCGACGGTGAGGTCACCGTTGAAATCCAGCAAAACGTGCGGG
CCCGTGACGTGTTTGTGGTGCAGTCGACCTGTGCGCCGACCAATGACAACCTGATGGAACTGCTCATCATGGTCGACGCG
CTCAAACGGGCCTCGGCCGAGCGCATTGCCGCCGTGATTCCTTATTTCGGCTATGCCCGGCAGGACCGCCGCCCGCGTTC
GGCACGCGTGCCGATCACGGCCAAAGTGGTGGCCAACATGCTGCAGGCCGTAGGCGTGTCGCGCGTCCTGACGATGGATC
TGCATGCCGACCAGATCCAGGGCTTTTTTGATATTCCGGTGGACAACATTTATGCGTCGCCGGTGCTGCTGGGCGATTTG
CGCCAGAAGAATTACACCGACCTGATGGTGGTTTCGCCCGACGTGGGCGGCGTGGTGCGTGCCCGCGCGCTGGCCAAGCA
GCTCGGCTGCGACATGGCCATCATCGACAAGCGCCGTCCCAAGGCCAACGTGTCGGAAGTGATGCACGTGATCGGTGATA
TCGAAGGCCGCAACTGCGTGATCATGGACGACATGATCGACACGGCCGGCACGCTGGTCAAGGCCGCCGAGGTGCTCAAG
GAGCGTGGCGCCCAAAAGGTTTACGCGTATTGCACCCATCCGATTTTCTCGGGCCCGGCCATCTCGCGTATCGCCCAGGG
CGACGCGCTCGATGAGGTGGTGATCACCAACACCATTCCCTTGAGCCAGAACGCGCAAACGTGCAAAAAAATTCGCCAGC
TTTCCGTGGCACCGCTGATCGCCGAGACGATCCAGCGCATTGCCAAGGGAGAGTCGGTCATGAGTTTGTTTTCGGACCAG
GACAACCTGTTCTGA

Upstream 100 bases:

>100_bases
TGTTTCCCCGGTGCGTGATGTTGCCGCGCGCAAGTTGATTCGATAAAAAATTTCCGTCGCGTTCAAGTCCTCTTCAAGTT
CGATTTCAGCTGGGCCTCAC

Downstream 100 bases:

>100_bases
TCTGAAACAAAAAGGTGGCTGCGCAACCCCAGGGGTTGGGCAGCCTTTTTATGTCGGGGTGAGCTGGTCGCGGCCTGCCC
CTTAATGGAGAAGATTATGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQTHHPDFMVFTGNANPSMASEIAQHLGISLGAAHVGRFSDGEVTVEIQQNVRARDVFVVQSTCAPTNDNLMELLIMVDA
LKRASAERIAAVIPYFGYARQDRRPRSARVPITAKVVANMLQAVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYTDLMVVSPDVGGVVRARALAKQLGCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAQKVYAYCTHPIFSGPAISRIAQGDALDEVVITNTIPLSQNAQTCKKIRQLSVAPLIAETIQRIAKGESVMSLFSDQ
DNLF

Sequences:

>Translated_324_residues
MQTHHPDFMVFTGNANPSMASEIAQHLGISLGAAHVGRFSDGEVTVEIQQNVRARDVFVVQSTCAPTNDNLMELLIMVDA
LKRASAERIAAVIPYFGYARQDRRPRSARVPITAKVVANMLQAVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYTDLMVVSPDVGGVVRARALAKQLGCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAQKVYAYCTHPIFSGPAISRIAQGDALDEVVITNTIPLSQNAQTCKKIRQLSVAPLIAETIQRIAKGESVMSLFSDQ
DNLF
>Mature_324_residues
MQTHHPDFMVFTGNANPSMASEIAQHLGISLGAAHVGRFSDGEVTVEIQQNVRARDVFVVQSTCAPTNDNLMELLIMVDA
LKRASAERIAAVIPYFGYARQDRRPRSARVPITAKVVANMLQAVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYTDLMVVSPDVGGVVRARALAKQLGCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAQKVYAYCTHPIFSGPAISRIAQGDALDEVVITNTIPLSQNAQTCKKIRQLSVAPLIAETIQRIAKGESVMSLFSDQ
DNLF

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=48.5714285714286, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=47.9365079365079, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=47.3186119873817, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=48.2539682539683, Blast_Score=302, Evalue=2e-82,
Organism=Homo sapiens, GI194018537, Length=354, Percent_Identity=35.5932203389831, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4506133, Length=348, Percent_Identity=35.9195402298851, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=31.5436241610738, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=31.5436241610738, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=31.5436241610738, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=31.5436241610738, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=64.5367412140575, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=47.3015873015873, Blast_Score=310, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=47.3015873015873, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=47.3015873015873, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=47.588424437299, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=34.0175953079179, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=44.8717948717949, Blast_Score=269, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=303, Percent_Identity=45.5445544554455, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=44.7284345047923, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=43.3673469387755, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=38.5964912280702, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355239, Length=321, Percent_Identity=48.2866043613707, Blast_Score=302, Evalue=2e-82,
Organism=Drosophila melanogaster, GI45551540, Length=343, Percent_Identity=45.1895043731778, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24651458, Length=363, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651456, Length=363, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281362873, Length=363, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651454, Length=363, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651462, Length=208, Percent_Identity=36.5384615384615, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24651464, Length=208, Percent_Identity=36.5384615384615, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45552010, Length=208, Percent_Identity=36.5384615384615, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35343; Mature: 35343

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTHHPDFMVFTGNANPSMASEIAQHLGISLGAAHVGRFSDGEVTVEIQQNVRARDVFVV
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCEEEEEEE
QSTCAPTNDNLMELLIMVDALKRASAERIAAVIPYFGYARQDRRPRSARVPITAKVVANM
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHH
LQAVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYTDLMVVSPDVGGVVR
HHHHCHHHEEEEECCHHHHCCEEECCHHHHCCCCHHHHHHCCCCCCEEEEECCCCCHHHH
ARALAKQLGCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLK
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAQKVYAYCTHPIFSGPAISRIAQGDALDEVVITNTIPLSQNAQTCKKIRQLSVAPLI
HCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
AETIQRIAKGESVMSLFSDQDNLF
HHHHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTHHPDFMVFTGNANPSMASEIAQHLGISLGAAHVGRFSDGEVTVEIQQNVRARDVFVV
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCEEEEEEE
QSTCAPTNDNLMELLIMVDALKRASAERIAAVIPYFGYARQDRRPRSARVPITAKVVANM
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHH
LQAVGVSRVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYTDLMVVSPDVGGVVR
HHHHCHHHEEEEECCHHHHCCEEECCHHHHCCCCHHHHHHCCCCCCEEEEECCCCCHHHH
ARALAKQLGCDMAIIDKRRPKANVSEVMHVIGDIEGRNCVIMDDMIDTAGTLVKAAEVLK
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAQKVYAYCTHPIFSGPAISRIAQGDALDEVVITNTIPLSQNAQTCKKIRQLSVAPLI
HCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
AETIQRIAKGESVMSLFSDQDNLF
HHHHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]