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The map label for this gene is bioA [H]

Identifier: 91786802

GI number: 91786802

Start: 918050

End: 919378

Strand: Reverse

Name: bioA [H]

Synonym: Bpro_0900

Alternate gene names: 91786802

Gene position: 919378-918050 (Counterclockwise)

Preceding gene: 91786803

Following gene: 91786801

Centisome position: 17.68

GC content: 67.04

Gene sequence:

>1329_bases
ATGGACAACACCTCGATGGTCCAGCGCAGCCTGCGGCATGTGTGGCACCCCTGCACGCAGATGAAGCTGCACGAATCGCA
ACCGCTGATTCCGGTGTCCAGGGCCGACGGGGTGTGGCTCCACGACTTTGAAGGCCACCGCTACCTCGACGGCATCAGCT
CCTGGTGGGTCAACCTGTTTGGCCACAACCACCCCCACATCCGGGCGGCGCTGATTGACCAGCTCGGCCGGCTCGATCAC
GTGATGCTGGCCGGTTTCACGCACCAGTCGGTGGTAGAGCTGTCTGAAAAGCTGGCGCAGCTGACCGGCCTGGGTCATGC
CTTTTACGGCAGCGACGGCGCCTCGGCCACCGAGATCGCGCTGAAGATGAGTGCGCACTACTGGCGCAACACCGGGCGCC
CCGGCAAATGCCGTTTTGTGGGACTGGCCGGCGGCTACCACGGCGAAACCGTGGGCGCGCTGGCCGTGACCGACATCGCC
ATTTTCCGCGAGGCCTACGCGCCGCTGGTGCGACTGGCAGCTACCGTGCCCAGCCCCGATGCCCGTTGCGCCCGGCCGGG
CGAAAGCGCTGTGGACGTGGCAGGTCGCGCTGCCGGCGCGCTGCAGGCCTGGCTCGAGCAGCACCACGCAGAAACCGCGG
CCCTCATCGTGGAGCCGCTGGTGCAGTGCGCCGCCGGCATGGCCATGCACGACGCCAGCTACCTGCGCGGGGTGCGCGCC
CTGTGTGACCGCTACGAGGTGCATCTGGTGGTGGACGAAATAGCCACCGGCTTTGGCCGCACCGGCACGATGTTTGCCCA
CCAGCAGGCTGGCATCCGGCCCGACTTCATCTGCCTCTCAAAAGGCCTGACCGGCGGCACCCTGCCGCTGTCGGCCGTGC
TGACCACCGACACGGTCTACCAGGCCTTTTACGACGACGACGTGGCGCGCGGTTTTCTGCACTCGCACTCCTATACCGGC
AACCCGCTGGCCTGCCGCGCCGCCCTGGCCACGCTGGAACTGTTCGAACAAAACGATGTGCTGGCCGGCAATGTCGCGGT
GGCGCGCAGCCTGACCGCAGCCTTCGCGCCATTGACCGCCCATCCGCGTGTCCGGAACGCCAGGCAGCTTGGCATGATCT
GGGCCTGGGATGTAGCTGATGCGCTGCCCGGTTTTTCGCGCCGCTACTACCAGCACGCGCTGGCGCAGGGTGTGCTGCTG
CGGCCGATTGGCAACACGATTTACGCCATGCCGCCGTATGTGATGGACGAGGAAAGCTCCGGTTTTCTGGCACGCGGCGC
GCTGGCGGCCCTGCAGGCCACGCTGGCCGAAGAAGCTGCGCATGGCTGA

Upstream 100 bases:

>100_bases
AGATGCCCTGAATCCACGCATCGCCCGTCACGCATCCCGCGTGCCGCCCTGCCCGCCTGCACAAGCGCTGGCCTCCACCG
TCTTTTAAACCGGAGCATCC

Downstream 100 bases:

>100_bases
GCATCCGAAAATTTCCTTTTTCGTGACCGGCACCGATACCGGCGTGGGCAAGACCCTGGTCAGTGCGGCGCTGCTGCATG
CGCTGGCCCCGCACTACCCG

Product: aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MDNTSMVQRSLRHVWHPCTQMKLHESQPLIPVSRADGVWLHDFEGHRYLDGISSWWVNLFGHNHPHIRAALIDQLGRLDH
VMLAGFTHQSVVELSEKLAQLTGLGHAFYGSDGASATEIALKMSAHYWRNTGRPGKCRFVGLAGGYHGETVGALAVTDIA
IFREAYAPLVRLAATVPSPDARCARPGESAVDVAGRAAGALQAWLEQHHAETAALIVEPLVQCAAGMAMHDASYLRGVRA
LCDRYEVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDTVYQAFYDDDVARGFLHSHSYTG
NPLACRAALATLELFEQNDVLAGNVAVARSLTAAFAPLTAHPRVRNARQLGMIWAWDVADALPGFSRRYYQHALAQGVLL
RPIGNTIYAMPPYVMDEESSGFLARGALAALQATLAEEAAHG

Sequences:

>Translated_442_residues
MDNTSMVQRSLRHVWHPCTQMKLHESQPLIPVSRADGVWLHDFEGHRYLDGISSWWVNLFGHNHPHIRAALIDQLGRLDH
VMLAGFTHQSVVELSEKLAQLTGLGHAFYGSDGASATEIALKMSAHYWRNTGRPGKCRFVGLAGGYHGETVGALAVTDIA
IFREAYAPLVRLAATVPSPDARCARPGESAVDVAGRAAGALQAWLEQHHAETAALIVEPLVQCAAGMAMHDASYLRGVRA
LCDRYEVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDTVYQAFYDDDVARGFLHSHSYTG
NPLACRAALATLELFEQNDVLAGNVAVARSLTAAFAPLTAHPRVRNARQLGMIWAWDVADALPGFSRRYYQHALAQGVLL
RPIGNTIYAMPPYVMDEESSGFLARGALAALQATLAEEAAHG
>Mature_442_residues
MDNTSMVQRSLRHVWHPCTQMKLHESQPLIPVSRADGVWLHDFEGHRYLDGISSWWVNLFGHNHPHIRAALIDQLGRLDH
VMLAGFTHQSVVELSEKLAQLTGLGHAFYGSDGASATEIALKMSAHYWRNTGRPGKCRFVGLAGGYHGETVGALAVTDIA
IFREAYAPLVRLAATVPSPDARCARPGESAVDVAGRAAGALQAWLEQHHAETAALIVEPLVQCAAGMAMHDASYLRGVRA
LCDRYEVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDTVYQAFYDDDVARGFLHSHSYTG
NPLACRAALATLELFEQNDVLAGNVAVARSLTAAFAPLTAHPRVRNARQLGMIWAWDVADALPGFSRRYYQHALAQGVLL
RPIGNTIYAMPPYVMDEESSGFLARGALAALQATLAEEAAHG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=29.1770573566085, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.9389067524116, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=434, Percent_Identity=24.6543778801843, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI226442705, Length=434, Percent_Identity=24.1935483870968, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=24.3523316062176, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786991, Length=411, Percent_Identity=38.9294403892944, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI145693181, Length=413, Percent_Identity=30.0242130750605, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1789759, Length=421, Percent_Identity=25.8907363420428, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788044, Length=412, Percent_Identity=27.4271844660194, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1787560, Length=381, Percent_Identity=30.7086614173228, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789016, Length=386, Percent_Identity=29.0155440414508, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786349, Length=327, Percent_Identity=27.5229357798165, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=417, Percent_Identity=26.8585131894484, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=209, Percent_Identity=33.0143540669856, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=23.2876712328767, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=418, Percent_Identity=23.444976076555, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=458, Percent_Identity=28.3842794759825, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=29.656862745098, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=314, Percent_Identity=28.343949044586, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=27.3399014778325, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=349, Percent_Identity=25.5014326647564, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47873; Mature: 47873

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTSMVQRSLRHVWHPCTQMKLHESQPLIPVSRADGVWLHDFEGHRYLDGISSWWVNLF
CCCHHHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHH
GHNHPHIRAALIDQLGRLDHVMLAGFTHQSVVELSEKLAQLTGLGHAFYGSDGASATEIA
CCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
LKMSAHYWRNTGRPGKCRFVGLAGGYHGETVGALAVTDIAIFREAYAPLVRLAATVPSPD
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ARCARPGESAVDVAGRAAGALQAWLEQHHAETAALIVEPLVQCAAGMAMHDASYLRGVRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LCDRYEVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDTVY
HHHHHHEEEEHHHHHHCCCCCCCEEEHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
QAFYDDDVARGFLHSHSYTGNPLACRAALATLELFEQNDVLAGNVAVARSLTAAFAPLTA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCC
HPRVRNARQLGMIWAWDVADALPGFSRRYYQHALAQGVLLRPIGNTIYAMPPYVMDEESS
CCCCCCHHHHCCEEEECHHHHCCCHHHHHHHHHHHCCEEEEECCCEEEECCCEEECCCCC
GFLARGALAALQATLAEEAAHG
CCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNTSMVQRSLRHVWHPCTQMKLHESQPLIPVSRADGVWLHDFEGHRYLDGISSWWVNLF
CCCHHHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHH
GHNHPHIRAALIDQLGRLDHVMLAGFTHQSVVELSEKLAQLTGLGHAFYGSDGASATEIA
CCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
LKMSAHYWRNTGRPGKCRFVGLAGGYHGETVGALAVTDIAIFREAYAPLVRLAATVPSPD
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ARCARPGESAVDVAGRAAGALQAWLEQHHAETAALIVEPLVQCAAGMAMHDASYLRGVRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LCDRYEVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDTVY
HHHHHHEEEEHHHHHHCCCCCCCEEEHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
QAFYDDDVARGFLHSHSYTGNPLACRAALATLELFEQNDVLAGNVAVARSLTAAFAPLTA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCC
HPRVRNARQLGMIWAWDVADALPGFSRRYYQHALAQGVLLRPIGNTIYAMPPYVMDEESS
CCCCCCHHHHCCEEEECHHHHCCCHHHHHHHHHHHCCEEEEECCCEEEECCCEEECCCCC
GFLARGALAALQATLAEEAAHG
CCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]