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The map label for this gene is glmU

Identifier: 91786575

GI number: 91786575

Start: 681833

End: 683275

Strand: Direct

Name: glmU

Synonym: Bpro_0671

Alternate gene names: 91786575

Gene position: 681833-683275 (Clockwise)

Preceding gene: 91786573

Following gene: 91786577

Centisome position: 13.11

GC content: 66.74

Gene sequence:

>1443_bases
ATGGCAACCCCAATTGATGTCGTCATCATGGCCGCGGGCAAAGGCACGCGGATGAAAAGCGCCTTGCCCAAAGTGTTGCA
CCAATTGGGCGGTCGTGCCTTGCTGGCGCATGTGATCGATTGCGCTGCCCGATTATCGGCCCGCCAGGCGGTGGTCATCG
CGGGGCACGGCGCTGCAGATGTTGAGGCCGCCTGCGCCCACCTGACGCGGGCTGCAGGCGATGCGCGCCAGGACCTGAGC
CTGAAGTTTGCGCGGCAGGAGCCGCAGCTCGGCACCGGCCACGCGGTGCAGCAGGCCCTGCCGCTGCTGGCCGACGACGG
CGTCACGCTGGTGCTGTCGGGCGACGTTCCGCTGACGCAGCCCGCCACGCTGCGGGCCCTGCTGGAGCAGTGCGACGGCC
AGCGGCTGGCGCTGCTCACGCTGAACATGGCCGATCCCACCGGCTACGGGCGCATCGTGCGCGCCGGGACGCAGGCCACT
GCCCAGGCTTCATCACAGGTCAGGGCCATCGTCGAGCACAAGGATGCCACCGAGGCCCAGCGCGGTATCCATGAAATCTA
CAGCGGCATCATGGCCGTGCCCACCCGCTTGCTGCGCGGCTGGATCCATCGGCTGGACAACAAGAATGTGCAAAGCGAGT
ACTACCTCACCGACATCGTGAAGTTCGCCGTGGCCGATGGGGTGGCTGTGGTGGCGCACCAGATCACCGATGCGGCGCAG
GTCGCGGGCGTCAACAGCCCGGTGCAGCTGGCCGAACTGGAGCGCGTTTACCAGCTGAGGCAGGCCACGGCCCTGATGGA
GCAGGGCGTGCGGCTGGCCGACCCGGCCCGTTTTGACGTGCGCGGTACGCTGCAATGCGGCCAGGATGTCGAGATTGATG
TGAACTGCGTGTTCGCCGGCCAGGTCAGCCTGGGCGAAGGCGTGCGCATCGGCGCCAACTGCGTGATTGCCAACGCCACG
ATTGCGGCCGGCGCGGTGATCCACCCATTTACCCACATCGACGGTGAAAAGCTGGGCGTGCAGGTGGGCGAGGGTGCACT
GATTGGCCCGTTTGCCCGGCTGCGGCCGGGTGCCCAGCTGGGCGCTGAAGTGCACATCGGCAACTTTGTCGAAGTGAAGA
ATTCCACCCTGGCCAAAGGCGCCAAGGCCAACCACCTGGCCTACCTGGGCGATGCCACCGTGGGCGAGCGCGTCAACTAC
GGCGCGGGCAGCATCACCGCCAACTACGACGGTGCCAACAAGCACCGCACGGTGATTGAGGCCGATGTGCATATCGGCAG
CAACTGCGTGTTGGTGGCGCCGGTGACGATAGGGCAGGGCGGCACGGTGGGCGGCGGCTCCACCATCACCAAGGACACGC
CCCCGGGCGCGCTCAGCGTGGCGCGCGGCAAGCAAGTCAGCCTGCCCAACTGGAAAAGGCCTGTGAAGGTTAGCAAGGGA
TAA

Upstream 100 bases:

>100_bases
GGCCAGTGCCAGCACACCGATAATCCGGATGAAACGGTTCAGCCTTGTCTGTGCCGCCGGGCCCGAATGCCCCTTCATCC
CAAAATTAACAGGAAACTTC

Downstream 100 bases:

>100_bases
GGCTTCTTTCCTCTTCCTCAGTTCGGGCTGGGCTTGTCGAGGCTGTTTTGTTCTGGTGAGTGCGCTTTTTGCTGAGGGCT
GCTGGCCGGGTCTCGCCCCG

Product: UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MATPIDVVIMAAGKGTRMKSALPKVLHQLGGRALLAHVIDCAARLSARQAVVIAGHGAADVEAACAHLTRAAGDARQDLS
LKFARQEPQLGTGHAVQQALPLLADDGVTLVLSGDVPLTQPATLRALLEQCDGQRLALLTLNMADPTGYGRIVRAGTQAT
AQASSQVRAIVEHKDATEAQRGIHEIYSGIMAVPTRLLRGWIHRLDNKNVQSEYYLTDIVKFAVADGVAVVAHQITDAAQ
VAGVNSPVQLAELERVYQLRQATALMEQGVRLADPARFDVRGTLQCGQDVEIDVNCVFAGQVSLGEGVRIGANCVIANAT
IAAGAVIHPFTHIDGEKLGVQVGEGALIGPFARLRPGAQLGAEVHIGNFVEVKNSTLAKGAKANHLAYLGDATVGERVNY
GAGSITANYDGANKHRTVIEADVHIGSNCVLVAPVTIGQGGTVGGGSTITKDTPPGALSVARGKQVSLPNWKRPVKVSKG

Sequences:

>Translated_480_residues
MATPIDVVIMAAGKGTRMKSALPKVLHQLGGRALLAHVIDCAARLSARQAVVIAGHGAADVEAACAHLTRAAGDARQDLS
LKFARQEPQLGTGHAVQQALPLLADDGVTLVLSGDVPLTQPATLRALLEQCDGQRLALLTLNMADPTGYGRIVRAGTQAT
AQASSQVRAIVEHKDATEAQRGIHEIYSGIMAVPTRLLRGWIHRLDNKNVQSEYYLTDIVKFAVADGVAVVAHQITDAAQ
VAGVNSPVQLAELERVYQLRQATALMEQGVRLADPARFDVRGTLQCGQDVEIDVNCVFAGQVSLGEGVRIGANCVIANAT
IAAGAVIHPFTHIDGEKLGVQVGEGALIGPFARLRPGAQLGAEVHIGNFVEVKNSTLAKGAKANHLAYLGDATVGERVNY
GAGSITANYDGANKHRTVIEADVHIGSNCVLVAPVTIGQGGTVGGGSTITKDTPPGALSVARGKQVSLPNWKRPVKVSKG
>Mature_479_residues
ATPIDVVIMAAGKGTRMKSALPKVLHQLGGRALLAHVIDCAARLSARQAVVIAGHGAADVEAACAHLTRAAGDARQDLSL
KFARQEPQLGTGHAVQQALPLLADDGVTLVLSGDVPLTQPATLRALLEQCDGQRLALLTLNMADPTGYGRIVRAGTQATA
QASSQVRAIVEHKDATEAQRGIHEIYSGIMAVPTRLLRGWIHRLDNKNVQSEYYLTDIVKFAVADGVAVVAHQITDAAQV
AGVNSPVQLAELERVYQLRQATALMEQGVRLADPARFDVRGTLQCGQDVEIDVNCVFAGQVSLGEGVRIGANCVIANATI
AAGAVIHPFTHIDGEKLGVQVGEGALIGPFARLRPGAQLGAEVHIGNFVEVKNSTLAKGAKANHLAYLGDATVGERVNYG
AGSITANYDGANKHRTVIEADVHIGSNCVLVAPVTIGQGGTVGGGSTITKDTPPGALSVARGKQVSLPNWKRPVKVSKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=476, Percent_Identity=47.4789915966387, Blast_Score=424, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_POLSJ (Q12FR3)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547527.1
- ProteinModelPortal:   Q12FR3
- SMR:   Q12FR3
- STRING:   Q12FR3
- GeneID:   4011131
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0671
- NMPDR:   fig|296591.1.peg.479
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q12FR3
- ProtClustDB:   CLSK951126
- BioCyc:   PSP296591:BPRO_0671-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50096; Mature: 49965

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS00101 HEXAPEP_TRANSFERASES; PS01019 ARF

Important sites: ACT_SITE 385-385 BINDING 86-86 BINDING 150-150 BINDING 172-172 BINDING 409-409 BINDING 427-427 BINDING 445-445 BINDING 462-462

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPIDVVIMAAGKGTRMKSALPKVLHQLGGRALLAHVIDCAARLSARQAVVIAGHGAAD
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCH
VEAACAHLTRAAGDARQDLSLKFARQEPQLGTGHAVQQALPLLADDGVTLVLSGDVPLTQ
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCCC
PATLRALLEQCDGQRLALLTLNMADPTGYGRIVRAGTQATAQASSQVRAIVEHKDATEAQ
CHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHH
RGIHEIYSGIMAVPTRLLRGWIHRLDNKNVQSEYYLTDIVKFAVADGVAVVAHQITDAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VAGVNSPVQLAELERVYQLRQATALMEQGVRLADPARFDVRGTLQCGQDVEIDVNCVFAG
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCCCCEEEEEEEEEC
QVSLGEGVRIGANCVIANATIAAGAVIHPFTHIDGEKLGVQVGEGALIGPFARLRPGAQL
CEECCCCEEECCEEEEECCHHHCCCEECCCCCCCCCCCCEEECCCCEECCHHHCCCCHHC
GAEVHIGNFVEVKNSTLAKGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIE
CCEEEECCEEEECCCHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEE
ADVHIGSNCVLVAPVTIGQGGTVGGGSTITKDTPPGALSVARGKQVSLPNWKRPVKVSKG
EEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure 
ATPIDVVIMAAGKGTRMKSALPKVLHQLGGRALLAHVIDCAARLSARQAVVIAGHGAAD
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCH
VEAACAHLTRAAGDARQDLSLKFARQEPQLGTGHAVQQALPLLADDGVTLVLSGDVPLTQ
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCCC
PATLRALLEQCDGQRLALLTLNMADPTGYGRIVRAGTQATAQASSQVRAIVEHKDATEAQ
CHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHH
RGIHEIYSGIMAVPTRLLRGWIHRLDNKNVQSEYYLTDIVKFAVADGVAVVAHQITDAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VAGVNSPVQLAELERVYQLRQATALMEQGVRLADPARFDVRGTLQCGQDVEIDVNCVFAG
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEECCCCCEEEEEEEEEC
QVSLGEGVRIGANCVIANATIAAGAVIHPFTHIDGEKLGVQVGEGALIGPFARLRPGAQL
CEECCCCEEECCEEEEECCHHHCCCEECCCCCCCCCCCCEEECCCCEECCHHHCCCCHHC
GAEVHIGNFVEVKNSTLAKGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIE
CCEEEECCEEEECCCHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEE
ADVHIGSNCVLVAPVTIGQGGTVGGGSTITKDTPPGALSVARGKQVSLPNWKRPVKVSKG
EEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA