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The map label for this gene is proC [H]

Identifier: 91786385

GI number: 91786385

Start: 491027

End: 491863

Strand: Reverse

Name: proC [H]

Synonym: Bpro_0475

Alternate gene names: 91786385

Gene position: 491863-491027 (Counterclockwise)

Preceding gene: 91786386

Following gene: 91786379

Centisome position: 9.46

GC content: 69.3

Gene sequence:

>837_bases
ATGAGCACCCCAAACCCAGGCAGCAACGAACACATCGCCTTCATCGGCGGCGGCAACATGGCCAGCGCCGTCATTGGCGG
CCTGCTCAAGCAGGGCCTTCCGGCCGGGCAGATCCAGGTGGTGGAACCTTTTGCCGAGCAGCGGGCCAGGCTTGTGCAGC
AGTTCGGCGTGGCGGTCAGCGACGCCCCGGGCGCTTCGCTGAGCAGCGCCGGCCTGGTCGTCTGGGCCGTCAAGCCCCAG
ACCTTCAAGGAGGCGGCAGCGCAAGCCCGCGCCCACACCCAGGCCGCCCTGCACCTGAGCGTGGCCGCCGGCATCCGCTC
GGACAGCATTGCGCAGTGGCTGGGCACCGAGCGCGTGGTGCGCTCCATGCCCAACACGCCGGCACTGGTGGGCAAGGGCA
TGACGGCCCTGTTTGCCCGCCCCGCCGCCACCGCCGCGGACCGTGCGGCGGTCGAACGCGTGATCCAGACCACCGGTGAG
TATTTGTGGCTGAACGACGAAGTGCAGCTGGATGCCGTGACCGCGCTGTCCGGCTCCGGGCCAGCCTATGTGTTTTACTT
CCTTGAGGCCATGATCCAGGCCGGCACGGACATGGGCCTGGAACCCGAGCAGGCCCGCAAGCTGGCCGTGGGAACCTTCG
TCGGCGCGTCGGCGCTGGCCCACGCATCGGACGAGCCGCTCGAAGTCCTGCGCGCCCGCGTCACCTCCAAGGGCGGCACC
ACCTATGCGGCCCTCACCTCGATGGAGCAGGCAGGCATCAAGCAGCAGTTCATGCAGGCCATCGAGGCCGCCCGGCAACG
CGCTGGCGAATTGGGTGACGAGTTCGGCGCCGCCTGA

Upstream 100 bases:

>100_bases
GGCAGACGGTGCTTCCGTAAGCCCGGGCCTGCCGGGTCGGCGACAATTCGTTTTCGGGCGGAAACTTCAACGCCGCCGAA
CTAAAGCGAGCGACACGAAC

Downstream 100 bases:

>100_bases
TCGTGTTCAAACAACCAGCCTGATACCGGGTCCGCCGCGCGCGGGCTTTTTCTTTTTCAATGCAGGCTGGTCAGCCGGAC
TCAAGCTGCCAGATAGGACA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSTPNPGSNEHIAFIGGGNMASAVIGGLLKQGLPAGQIQVVEPFAEQRARLVQQFGVAVSDAPGASLSSAGLVVWAVKPQ
TFKEAAAQARAHTQAALHLSVAAGIRSDSIAQWLGTERVVRSMPNTPALVGKGMTALFARPAATAADRAAVERVIQTTGE
YLWLNDEVQLDAVTALSGSGPAYVFYFLEAMIQAGTDMGLEPEQARKLAVGTFVGASALAHASDEPLEVLRARVTSKGGT
TYAALTSMEQAGIKQQFMQAIEAARQRAGELGDEFGAA

Sequences:

>Translated_278_residues
MSTPNPGSNEHIAFIGGGNMASAVIGGLLKQGLPAGQIQVVEPFAEQRARLVQQFGVAVSDAPGASLSSAGLVVWAVKPQ
TFKEAAAQARAHTQAALHLSVAAGIRSDSIAQWLGTERVVRSMPNTPALVGKGMTALFARPAATAADRAAVERVIQTTGE
YLWLNDEVQLDAVTALSGSGPAYVFYFLEAMIQAGTDMGLEPEQARKLAVGTFVGASALAHASDEPLEVLRARVTSKGGT
TYAALTSMEQAGIKQQFMQAIEAARQRAGELGDEFGAA
>Mature_277_residues
STPNPGSNEHIAFIGGGNMASAVIGGLLKQGLPAGQIQVVEPFAEQRARLVQQFGVAVSDAPGASLSSAGLVVWAVKPQT
FKEAAAQARAHTQAALHLSVAAGIRSDSIAQWLGTERVVRSMPNTPALVGKGMTALFARPAATAADRAAVERVIQTTGEY
LWLNDEVQLDAVTALSGSGPAYVFYFLEAMIQAGTDMGLEPEQARKLAVGTFVGASALAHASDEPLEVLRARVTSKGGTT
YAALTSMEQAGIKQQFMQAIEAARQRAGELGDEFGAA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=30.2583025830258, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=30.5970149253731, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=30.5970149253731, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=29.9625468164794, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=32.8413284132841, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=27.112676056338, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=241, Percent_Identity=31.1203319502075, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=36.2264150943396, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=30.5755395683453, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=37.8698224852071, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28905; Mature: 28774

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPNPGSNEHIAFIGGGNMASAVIGGLLKQGLPAGQIQVVEPFAEQRARLVQQFGVAVS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCEEC
DAPGASLSSAGLVVWAVKPQTFKEAAAQARAHTQAALHLSVAAGIRSDSIAQWLGTERVV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RSMPNTPALVGKGMTALFARPAATAADRAAVERVIQTTGEYLWLNDEVQLDAVTALSGSG
HHCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEEECCCC
PAYVFYFLEAMIQAGTDMGLEPEQARKLAVGTFVGASALAHASDEPLEVLRARVTSKGGT
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
TYAALTSMEQAGIKQQFMQAIEAARQRAGELGDEFGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STPNPGSNEHIAFIGGGNMASAVIGGLLKQGLPAGQIQVVEPFAEQRARLVQQFGVAVS
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCEEC
DAPGASLSSAGLVVWAVKPQTFKEAAAQARAHTQAALHLSVAAGIRSDSIAQWLGTERVV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RSMPNTPALVGKGMTALFARPAATAADRAAVERVIQTTGEYLWLNDEVQLDAVTALSGSG
HHCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEEECCCC
PAYVFYFLEAMIQAGTDMGLEPEQARKLAVGTFVGASALAHASDEPLEVLRARVTSKGGT
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
TYAALTSMEQAGIKQQFMQAIEAARQRAGELGDEFGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]