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The map label for this gene is ubiA

Identifier: 91786384

GI number: 91786384

Start: 490086

End: 490946

Strand: Direct

Name: ubiA

Synonym: Bpro_0474

Alternate gene names: 91786384

Gene position: 490086-490946 (Clockwise)

Preceding gene: 91786383

Following gene: 91786388

Centisome position: 9.42

GC content: 63.41

Gene sequence:

>861_bases
ATGCTGCGCCGCAAACTGGGTCTTTACCTTGCGCTGATCCGCTGGAACCGTCCGGCGGGCTGGCTGCTGCTGCTCTGGCC
TACGCTGTCGGCGCTATGGGTGGCCTCGCACGGCTTTCCGGGCTGGCACTTGCTGACGGTGTTCACGCTGGGAACCATCC
TGATGCGCAGCGCGGGCTGTTGTGTCAACGATGTGGCGGACCGGGACTTTGACCGGCATGTCAAGCGCACGGCCCAGCGG
CCGGTCACCAGCGGCCAGGTGTCGGTGCGGGAGGCGCTGGTGCTGGGTGCCGTGCTGGCCCTGCTGGCGTTCGGCCTGGT
GCTGACCACCAATGCCGCCACCATCGCCTGGTCCTTTGCTGCGCTGGCCGTGACGCTGGCGTACCCCTTTGCAAAGCGTT
ATGTGTCCATGCCGCAGGCGGTGCTGGGCGTGGCTTTCAGTTTTGGCATTCCGATGGCATTTGCCGCCGTGCAGTCCCGC
GTGCCGCTGCTGGCCTGGGTTCTGCTATTGGGCAACCTGTGCTGGGTGATTGCCTACGACACCGAGTACGCCATGGTGGA
CCGCGACGATGACCTGAAGATAGGCATGAAAACCTCGGCCATCACGCTGGGGCGGTTCGATGTGGCGGGGGTCATGCTCA
GTTACCTGGTGTACCTGTCGGTTTGGGCTCTGGCCCTTGCCGACATTCCGCAAGCAGCTATTTATTGGATGGCAATCGGG
CTGGCAGGGCTGCAGGCGCTGTGGCATGGCTGGCTGATCCGCAAGCGTGAGCGCGACGATTGCTTCAAGGCGTTTCGTCT
CAATCACTGGCTGGGCTTCACGGTGTTTGCCGGTATTGCCCTGTCCTATCTGGCAGCTTGA

Upstream 100 bases:

>100_bases
TGGATGCGCTGTTTCGTATCTCCAGACCGGTCAGCGGGGCCTACCTGTGGTGTCCGCCCATGCAGGCTGGCCGGCTCGAT
CTGCGGCAGCTCGGCTTGTG

Downstream 100 bases:

>100_bases
GTCCGGCTGACCAGCCTGCATTGAAAAAGAAAAAGCCCGCGCGCGGCGGACCCGGTATCAGGCTGGTTGTTTGAACACGA
TCAGGCGGCGCCGAACTCGT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGCCVNDVADRDFDRHVKRTAQR
PVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFAALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSR
VPLLAWVLLLGNLCWVIAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIG
LAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA

Sequences:

>Translated_286_residues
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGCCVNDVADRDFDRHVKRTAQR
PVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFAALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSR
VPLLAWVLLLGNLCWVIAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIG
LAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA
>Mature_286_residues
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGCCVNDVADRDFDRHVKRTAQR
PVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFAALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSR
VPLLAWVLLLGNLCWVIAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIG
LAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=284, Percent_Identity=34.5070422535211, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1790473, Length=281, Percent_Identity=50.1779359430605, Blast_Score=247, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17553718, Length=286, Percent_Identity=33.2167832167832, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565247, Length=285, Percent_Identity=31.5789473684211, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17553720, Length=342, Percent_Identity=29.5321637426901, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=37.5886524822695, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=37.1428571428571, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324370, Length=296, Percent_Identity=31.4189189189189, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21355567, Length=284, Percent_Identity=35.2112676056338, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_POLSJ (Q12GA4)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547336.1
- STRING:   Q12GA4
- GeneID:   4011497
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0474
- NMPDR:   fig|296591.1.peg.4473
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   Q12GA4
- ProtClustDB:   CLSK2777250
- BioCyc:   PSP296591:BPRO_0474-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 31637; Mature: 31637

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13b522b0)-; HASH(0x13b3cb78)-; HASH(0x132f10b8)-; HASH(0x132195f8)-; HASH(0x13b2777c)-; HASH(0x13aa8768)-; HASH(0x13f282ac)-; HASH(0x140e4af8)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGC
CCCHHHHHHEEEEEECCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
CVNDVADRDFDRHVKRTAQRPVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFA
CHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSRVPLLAWVLLLGNLCWVIAYD
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCEEEEEEC
TEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIG
CCEEEECCCCCCEECCEECEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGC
CCCHHHHHHEEEEEECCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
CVNDVADRDFDRHVKRTAQRPVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFA
CHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSRVPLLAWVLLLGNLCWVIAYD
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCEEEEEEC
TEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIG
CCEEEECCCCCCEECCEECEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA