Click here to switch to the map view.

The map label for this gene is aphA [H]

Identifier: 91786326

GI number: 91786326

Start: 429121

End: 430149

Strand: Reverse

Name: aphA [H]

Synonym: Bpro_0416

Alternate gene names: 91786326

Gene position: 430149-429121 (Counterclockwise)

Preceding gene: 91786327

Following gene: 91786325

Centisome position: 8.27

GC content: 68.32

Gene sequence:

>1029_bases
ATGAAAGTCGTCTACAGCGATCAGCACAAAGACCACGACCCGCAGCTCTTCATGGTGCGCGGTCGATTGAAGCGCAGCAA
CGAACAGCCGGAACGCGCCTTTCGCCTGCTGTCGGCGGTCCAGGAAGGTGGCCATGACGTCATCGCCTGCGAAGACTTCG
GCGCGGGCCCGCGTGCCGCCATCCACACGCCGGAGTACCTGCGCTTTCTCGAAACCGCTTACGAGCGATGGCAAGGGCTG
GACGACCCCTCGCAAGAGGTCATGCCCAACATCCATCCCTTTCCCGGCGAGCCCTGCACCTACCCCGAGAGCGTGGTGGG
CCAGGCCGGATTCCACATGGGAGACAACGCCTGCTCCATCGGCCCGCATACCTGGCAGGCGGCCACCGCCTCGGCCCACG
TGGCCACGCATGCCGCGCAGCTGGTGGCGGACGGCGAGCGCGCGGCCTACGCGCTGTGCCGCCCACCGGGCCACCATGCC
TACGCGGACCGGGCGAACGGCTTTTGCTACCTGAACAACGTGGCCATCGCCGCGCAGCACCTGCGCCGGGTGCACGACCG
CGTCGCCATTCTCGACATCGACGTGCACCACGGCAACGGCACGCAGGGCATCTTCTACCGCCGCCCGGACGTACTGACCA
TTTCACTGCATGGCGACCCGCGCAACTTCACGCCCTTCTTCACCGGCCATGCGCACGAGCGGGGTGAAGGCGCAGGCCTG
GGCTACAACATCAACAAGCCGCTGGCGCTGGGCACCGGCATCGACGGCTACCTGCCGGCGTTGCGCGATGCCTGCCTGAG
CGTGCGCGCCTTCGCGCCCGGCGCGCTGGTGGTGGCGCTGGGCCTGGACGCGCACGAGCACGACCCGTACAAGGGCATGA
AGATCACAACGCCCGGCTTCGCGCTGCTGCTCGCCGAGATCGCCCGCCTGGGCCTGCCGACCGTGCTGGTGCAGGAAGGG
GGCTACCTGTCCGACGACCTCGGCCCCAATCTCGCCAGCGCACTGCGCGGCTTTGCGGGCGTGGCATGA

Upstream 100 bases:

>100_bases
TGCATCTGGACGATGCCTGGCAGCATGTGCGGGCGCTGTTCGTGAAGCAGCACGGCGCCGCGTCCGCATCTTCCAACCCC
TGATTCCGAGGACCCCTTCG

Downstream 100 bases:

>100_bases
CGGTCGCCACCGCCACCTCCGTTTTCGCCGTCGATTTCGACGAATCCGAGGTCTTGAGCGAGACCTCCCCGCAACTCGAC
CCCGCATGGGTCCACGCCCT

Product: histone deacetylase superfamily protein protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKVVYSDQHKDHDPQLFMVRGRLKRSNEQPERAFRLLSAVQEGGHDVIACEDFGAGPRAAIHTPEYLRFLETAYERWQGL
DDPSQEVMPNIHPFPGEPCTYPESVVGQAGFHMGDNACSIGPHTWQAATASAHVATHAAQLVADGERAAYALCRPPGHHA
YADRANGFCYLNNVAIAAQHLRRVHDRVAILDIDVHHGNGTQGIFYRRPDVLTISLHGDPRNFTPFFTGHAHERGEGAGL
GYNINKPLALGTGIDGYLPALRDACLSVRAFAPGALVVALGLDAHEHDPYKGMKITTPGFALLLAEIARLGLPTVLVQEG
GYLSDDLGPNLASALRGFAGVA

Sequences:

>Translated_342_residues
MKVVYSDQHKDHDPQLFMVRGRLKRSNEQPERAFRLLSAVQEGGHDVIACEDFGAGPRAAIHTPEYLRFLETAYERWQGL
DDPSQEVMPNIHPFPGEPCTYPESVVGQAGFHMGDNACSIGPHTWQAATASAHVATHAAQLVADGERAAYALCRPPGHHA
YADRANGFCYLNNVAIAAQHLRRVHDRVAILDIDVHHGNGTQGIFYRRPDVLTISLHGDPRNFTPFFTGHAHERGEGAGL
GYNINKPLALGTGIDGYLPALRDACLSVRAFAPGALVVALGLDAHEHDPYKGMKITTPGFALLLAEIARLGLPTVLVQEG
GYLSDDLGPNLASALRGFAGVA
>Mature_342_residues
MKVVYSDQHKDHDPQLFMVRGRLKRSNEQPERAFRLLSAVQEGGHDVIACEDFGAGPRAAIHTPEYLRFLETAYERWQGL
DDPSQEVMPNIHPFPGEPCTYPESVVGQAGFHMGDNACSIGPHTWQAATASAHVATHAAQLVADGERAAYALCRPPGHHA
YADRANGFCYLNNVAIAAQHLRRVHDRVAILDIDVHHGNGTQGIFYRRPDVLTISLHGDPRNFTPFFTGHAHERGEGAGL
GYNINKPLALGTGIDGYLPALRDACLSVRAFAPGALVVALGLDAHEHDPYKGMKITTPGFALLLAEIARLGLPTVLVQEG
GYLSDDLGPNLASALRGFAGVA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI17158039, Length=214, Percent_Identity=40.6542056074766, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI30795204, Length=214, Percent_Identity=40.6542056074766, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI30795202, Length=214, Percent_Identity=40.6542056074766, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148539870, Length=214, Percent_Identity=39.2523364485981, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI169234807, Length=214, Percent_Identity=39.2523364485981, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI153085395, Length=195, Percent_Identity=41.025641025641, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI13128864, Length=228, Percent_Identity=35.5263157894737, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI8923769, Length=285, Percent_Identity=30.1754385964912, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=41.5384615384615, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=41.5384615384615, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI20070354, Length=227, Percent_Identity=35.2422907488987, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI262073088, Length=195, Percent_Identity=33.8461538461538, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI13128860, Length=168, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI226529806, Length=146, Percent_Identity=39.7260273972603, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13128862, Length=219, Percent_Identity=29.6803652968037, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI293336691, Length=147, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073092, Length=202, Percent_Identity=30.6930693069307, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540334, Length=185, Percent_Identity=41.0810810810811, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=185, Percent_Identity=41.0810810810811, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI193206283, Length=185, Percent_Identity=41.0810810810811, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17537347, Length=245, Percent_Identity=32.6530612244898, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193209491, Length=210, Percent_Identity=37.6190476190476, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=281, Percent_Identity=27.4021352313167, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=166, Percent_Identity=35.5421686746988, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17561978, Length=168, Percent_Identity=32.7380952380952, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25154022, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25154020, Length=201, Percent_Identity=27.8606965174129, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=218, Percent_Identity=33.4862385321101, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=168, Percent_Identity=33.9285714285714, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=214, Percent_Identity=28.0373831775701, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=155, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24642142, Length=232, Percent_Identity=39.2241379310345, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24642146, Length=232, Percent_Identity=39.2241379310345, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24642144, Length=232, Percent_Identity=39.2241379310345, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360899, Length=232, Percent_Identity=39.2241379310345, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281360799, Length=213, Percent_Identity=40.3755868544601, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281360801, Length=213, Percent_Identity=40.3755868544601, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641720, Length=213, Percent_Identity=40.3755868544601, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24644244, Length=166, Percent_Identity=34.9397590361446, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24657891, Length=274, Percent_Identity=27.7372262773723, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36983; Mature: 36983

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVYSDQHKDHDPQLFMVRGRLKRSNEQPERAFRLLSAVQEGGHDVIACEDFGAGPRAA
CEEEECCCCCCCCCCEEEEECHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
IHTPEYLRFLETAYERWQGLDDPSQEVMPNIHPFPGEPCTYPESVVGQAGFHMGDNACSI
CCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GPHTWQAATASAHVATHAAQLVADGERAAYALCRPPGHHAYADRANGFCYLNNVAIAAQH
CCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCHHHCCCCEEEECHHHHHHHH
LRRVHDRVAILDIDVHHGNGTQGIFYRRPDVLTISLHGDPRNFTPFFTGHAHERGEGAGL
HHHHHCCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEECCCCCCCCCCCCC
GYNINKPLALGTGIDGYLPALRDACLSVRAFAPGALVVALGLDAHEHDPYKGMKITTPGF
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCHH
ALLLAEIARLGLPTVLVQEGGYLSDDLGPNLASALRGFAGVA
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVVYSDQHKDHDPQLFMVRGRLKRSNEQPERAFRLLSAVQEGGHDVIACEDFGAGPRAA
CEEEECCCCCCCCCCEEEEECHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
IHTPEYLRFLETAYERWQGLDDPSQEVMPNIHPFPGEPCTYPESVVGQAGFHMGDNACSI
CCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GPHTWQAATASAHVATHAAQLVADGERAAYALCRPPGHHAYADRANGFCYLNNVAIAAQH
CCCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCHHHCCCCEEEECHHHHHHHH
LRRVHDRVAILDIDVHHGNGTQGIFYRRPDVLTISLHGDPRNFTPFFTGHAHERGEGAGL
HHHHHCCEEEEEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEECCCCCCCCCCCCC
GYNINKPLALGTGIDGYLPALRDACLSVRAFAPGALVVALGLDAHEHDPYKGMKITTPGF
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCHH
ALLLAEIARLGLPTVLVQEGGYLSDDLGPNLASALRGFAGVA
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]